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6WOX	Thermus thermophilus RNA polymerase initially transcribing complex with 2'dCTP Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*GP*CP*AP*G)-3'), ... Authors: Shin, Y, Murakami, K.S. Deposit date: 2020-04-26 Release date: 2020-06-10 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.14 Å) Cite: The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases. Nat Commun, 12, 2021
6WOY	Thermus thermophilus RNA polymerase initially transcribing complex with 3'dCTP Descriptor: 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*GP*CP*AP*G)-3'), ... Authors: Shin, Y, Murakami, K.S. Deposit date: 2020-04-26 Release date: 2020-06-10 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3 Å) Cite: The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases. Nat Commun, 12, 2021
6WMR	F. tularensis RNAPs70-(MglA-SspA)-iglA DNA complex Descriptor: DNA NT-strand, DNA NT-strand downstream, DNA T-strand, ... Authors: Travis, B.A, Brennan, R.G, Schumacher, M.A. Deposit date: 2020-04-21 Release date: 2020-11-11 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.46 Å) Cite: Structural Basis for Virulence Activation of Francisella tularensis. Mol.Cell, 81, 2021
7L7B	Clostridioides difficile RNAP with fidaxomicin Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Boyaci, H, Campbell, E.A, Darst, S.A, Chen, J. Deposit date: 2020-12-28 Release date: 2022-02-02 Last modified: 2022-05-04 Method: ELECTRON MICROSCOPY (3.26 Å) Cite: Basis of narrow-spectrum activity of fidaxomicin on Clostridioides difficile. Nature, 604, 2022
7LQ4	Rr (RsiG)2-(c-di-GMP)2-WhiG complex Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), RsiG, WhiG Authors: Schumacher, M.A, Brennan, R.G. Deposit date: 2021-02-12 Release date: 2021-07-14 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Evolution of a sigma-(c-di-GMP)-anti-sigma switch. Proc.Natl.Acad.Sci.USA, 118, 2021
6XH7	CueR-TAC without RNA Descriptor: COPPER (II) ION, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Liu, B, Shi, W, Yang, Y. Deposit date: 2020-06-18 Release date: 2021-04-14 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural basis of copper-efflux-regulator-dependent transcription activation. Iscience, 24, 2021
6XH8	CueR-transcription activation complex with RNA transcript Descriptor: COPPER (II) ION, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Liu, B, Shi, W, Yang, Y. Deposit date: 2020-06-18 Release date: 2021-04-14 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Structural basis of copper-efflux-regulator-dependent transcription activation. Iscience, 24, 2021
6XLM	Cryo-EM structure of E.coli RNAP-DNA elongation complex 1 (RDe1) in EcmrR-dependent transcription Descriptor: 9-nt RNA transcript, CHAPSO, DNA-directed RNA polymerase subunit alpha, ... Authors: Yang, Y, Liu, C, Liu, B. Deposit date: 2020-06-28 Release date: 2021-04-07 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural visualization of transcription activated by a multidrug-sensing MerR family regulator. Nat Commun, 12, 2021
6XLL	Cryo-EM structure of E. coli RNAP-promoter initial transcribing complex with 5-nt RNA transcript (RPitc-5nt) Descriptor: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Yang, Y, Liu, C, Liu, B. Deposit date: 2020-06-28 Release date: 2021-04-07 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Structural visualization of transcription activated by a multidrug-sensing MerR family regulator. Nat Commun, 12, 2021
6XL9	Cryo-EM structure of EcmrR-RNAP-promoter initial transcribing complex with 3-nt RNA transcript (EcmrR-RPitc-3nt) Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Yang, Y, Liu, C, Shi, W, Liu, B. Deposit date: 2020-06-28 Release date: 2021-04-07 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Structural visualization of transcription activated by a multidrug-sensing MerR family regulator. Nat Commun, 12, 2021
6XLJ	Cryo-EM structure of EcmrR-RNAP-promoter initial transcribing complex with 4-nt RNA transcript (EcmrR-RPitc-4nt) Descriptor: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Yang, Y, Liu, C, Liu, B. Deposit date: 2020-06-28 Release date: 2021-04-07 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Structural visualization of transcription activated by a multidrug-sensing MerR family regulator. Nat Commun, 12, 2021
6XL5	Cryo-EM structure of EcmrR-RNAP-promoter open complex (EcmrR-RPo) Descriptor: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Yang, Y, Liu, C, Liu, B. Deposit date: 2020-06-28 Release date: 2021-04-07 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Structural visualization of transcription activated by a multidrug-sensing MerR family regulator. Nat Commun, 12, 2021
7MKJ	Cryo-EM structure of Escherichia coli RNA polymerase bound to T7A1 promoter DNA Descriptor: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Saecker, R.M, Darst, S.A, Chen, J. Deposit date: 2021-04-23 Release date: 2021-09-29 Last modified: 2021-10-13 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
7MKE	Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR promoter DNA (class 2) Descriptor: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Saecker, R.M, Darst, S.A, Chen, J. Deposit date: 2021-04-23 Release date: 2021-09-29 Last modified: 2021-10-13 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
7MKD	Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR promoter DNA (class 1) Descriptor: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Saecker, R.M, Darst, S.A, Chen, J. Deposit date: 2021-04-23 Release date: 2021-09-29 Last modified: 2021-10-13 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
7MKI	Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR (-5G to C) promoter DNA Descriptor: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Saecker, R.M, Darst, S.A, Chen, J. Deposit date: 2021-04-23 Release date: 2021-09-29 Last modified: 2021-10-13 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
7MLB	Crystal structure of Thermus thermophilus transcription initiation complex with 5nt RNA Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*AP*GP*GP*GP*AP*TP*GP*CP*AP*G)-3'), DNA (5'-D(P*CP*TP*GP*CP*AP*TP*CP*CP*CP*TP*GP*AP*GP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Liu, Y, Ebright, R.H. Deposit date: 2021-04-28 Release date: 2022-02-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
4JKR	Crystal Structure of E. coli RNA Polymerase in complex with ppGpp Descriptor: DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA', DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Zuo, Y, Wang, Y, Steitz, T.A. Deposit date: 2013-03-11 Release date: 2013-05-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (4.2 Å) Cite: The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex. Mol.Cell, 50, 2013
7MLI	Crystal structure of Thermus thermophilus reiterative transcription complex with 5nt oligo-C RNA Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*CP*TP*AP*CP*GP*GP*AP*TP*G)-3'), DNA (5'-D(P*CP*AP*TP*CP*CP*GP*TP*AP*GP*GP*GP*CP*GP*GP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Liu, Y, Ebright, R.H. Deposit date: 2021-04-28 Release date: 2022-02-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
7MLJ	Crystal structure of Thermus thermophilus reiterative transcription complex with 4nt oligo-G RNA Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*GP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA (5'-D(P*CP*AP*TP*CP*CP*GP*TP*GP*CP*CP*CP*TP*GP*AP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Liu, Y, Ebright, R.H. Deposit date: 2021-04-28 Release date: 2022-02-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.75 Å) Cite: Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
4JK1	X-ray crystal structure of Escherichia coli sigma70 holoenzyme in complex with Guanosine tetraphosphate (ppGpp) Descriptor: Escherichia coli RNA polymerase alpha subunit, Escherichia coli RNA polymerase beta subunit, Escherichia coli RNA polymerase beta' subunit, ... Authors: Murakami, K.S. Deposit date: 2013-03-09 Release date: 2013-04-10 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.9 Å) Cite: Differential regulation by ppGpp versus pppGpp in Escherichia coli. Nucleic Acids Res., 41, 2013
4JK2	X-ray crystal structure of Escherichia coli sigma70 holoenzyme in complex with guanosine pentaphosphate (pppGpp) Descriptor: Escherichia coli RNA polymerase alpha subunit, Escherichia coli RNA polymerase beta subunit, Escherichia coli RNA polymerase beta' subunit, ... Authors: Murakami, K.S. Deposit date: 2013-03-09 Release date: 2013-04-17 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (4.201 Å) Cite: Differential regulation by ppGpp versus pppGpp in Escherichia coli. Nucleic Acids Res., 41, 2013
4KMU	X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Rifampin Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Murakami, K.S. Deposit date: 2013-05-08 Release date: 2013-05-22 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.85 Å) Cite: X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins. J.Med.Chem., 56, 2013
7N4E	Escherichia coli sigma 70-dependent paused transcription elongation complex Descriptor: 5'-R(*UP*UP*CP*GP*GP*AP*GP*AP*GP*GP*UP*A)-3', DNA (61-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Molodtsov, V, Su, M, Ebright, R.H. Deposit date: 2021-06-04 Release date: 2022-06-15 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Structural and mechanistic basis of sigma-dependent transcriptional pausing. Proc.Natl.Acad.Sci.USA, 119, 2022
4KN4	X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Benzoxazinorifamycin-2b Descriptor: Benzoxazinorifamycin-2b, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Murakami, K.S. Deposit date: 2013-05-08 Release date: 2013-05-22 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.965 Å) Cite: X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins. J.Med.Chem., 56, 2013

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