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3ZXR	Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with tri-substituted imidazole inhibitor (3-(2-tert-butyl- 5-(pyridin-4-yl)-1H-imidazol-4-yl)quinoline) and L-methionine-S- sulfoximine phosphate. Descriptor: 3-(2-TERT-BUTYL-5-(PYRIDIN-4-YL)-1H-IMIDAZOL-4-YL)QUINOLINE, CHLORIDE ION, GLUTAMINE SYNTHETASE 1, ... Authors: Nilsson, M.T, Mowbray, S.L. Deposit date: 2011-08-15 Release date: 2012-04-04 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Trisubstituted Imidazoles as Mycobacterium Tuberculosis Glutamine Synthetase Inhibitors. J.Med.Chem., 55, 2012
3ZXV	Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with tri-substituted imidazole inhibitor (4-(2-tert-butyl- 4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl)pyridin-2-amine) and L- methionine-S-sulfoximine phosphate Descriptor: 4-(2-TERT-BUTYL-4-(6-METHOXYNAPHTHALEN-2-YL)-3H-IMIDAZOL-4-YL)PYRIDIN-2-AMINE, CHLORIDE ION, GLUTAMINE SYNTHETASE 1, ... Authors: Nilsson, M.T, Mowbray, S.L. Deposit date: 2011-08-16 Release date: 2012-04-04 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Trisubstituted Imidazoles as Mycobacterium Tuberculosis Glutamine Synthetase Inhibitors. J.Med.Chem., 55, 2012
2UU7	Crystal structure of apo glutamine synthetase from dog (Canis familiaris) Descriptor: CHLORIDE ION, GLUTAMINE SYNTHETASE, MAGNESIUM ION Authors: Krajewski, W.W, Jones, T.A, Mowbray, S.L. Deposit date: 2007-02-28 Release date: 2007-10-16 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal Structures of Mammalian Glutamine Synthetases Illustrate Substrate-Induced Conformational Changes and Provide Opportunities for Drug and Herbicide Design. J.Mol.Biol., 375, 2008
4ACF	CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH IMIDAZOPYRIDINE INHIBITOR ((4-(6-BROMO-3-(BUTYLAMINO)IMIDAZO(1,2-A)PYRIDIN-2-YL)PHENOXY) ACETIC ACID) AND L-METHIONINE-S-SULFOXIMINE PHOSPHATE. Descriptor: CHLORIDE ION, GLUTAMINE SYNTHETASE 1, L-METHIONINE-S-SULFOXIMINE PHOSPHATE, ... Authors: Nilsson, M.T, Mowbray, S.L. Deposit date: 2011-12-15 Release date: 2012-10-24 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Synthesis, Biological Evaluation and X-Ray Crystallographic Studies of Imidazo(1,2-A)Pyridine-Based Mycobacterium Tuberculosis Glutamine Synthetase Inhibitors Medchemcomm, 3, 2012
2WGS	Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with a purine analogue inhibitor. Descriptor: 1-(3,4-dichlorobenzyl)-3,7-dimethyl-8-morpholin-4-yl-3,7-dihydro-1H-purine-2,6-dione, CHLORIDE ION, GLUTAMINE SYNTHETASE 1 Authors: Nilsson, M.T, Krajewski, W.W, Jones, T.A, Mowbray, S.L. Deposit date: 2009-04-27 Release date: 2009-09-01 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Structural Basis for the Inhibition of Mycobacterium Tuberculosis Glutamine Synthetase by Novel ATP-Competitive Inhibitors. J.Mol.Biol., 393, 2009
2WHI	Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with a purine analogue inhibitor and L-methionine-S- sulfoximine phosphate. Descriptor: 1-(3,4-dichlorobenzyl)-3,7-dimethyl-8-morpholin-4-yl-3,7-dihydro-1H-purine-2,6-dione, CHLORIDE ION, GLUTAMINE SYNTHETASE 1, ... Authors: Nilsson, M.T, Krajewski, W.W, Jones, T.A, Mowbray, S.L. Deposit date: 2009-05-05 Release date: 2009-09-01 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural Basis for the Inhibition of Mycobacterium Tuberculosis Glutamine Synthetase by Novel ATP-Competitive Inhibitors. J.Mol.Biol., 393, 2009
4BAX	Crystal structure of glutamine synthetase from Streptomyces coelicolor Descriptor: GLUTAMINE SYNTHETASE, SODIUM ION Authors: Zeth, K. Deposit date: 2012-09-16 Release date: 2013-03-27 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Structure of Glutamine Synthetase from Streptomyces Coelicolor To be Published
2GLS	REFINED ATOMIC MODEL OF GLUTAMINE SYNTHETASE AT 3.5 ANGSTROMS RESOLUTION Descriptor: GLUTAMINE SYNTHETASE, MANGANESE (II) ION Authors: Eisenberg, D, Almassy, R.J, Yamashita, M.M. Deposit date: 1989-05-19 Release date: 1989-10-15 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Refined atomic model of glutamine synthetase at 3.5 A resolution. J.Biol.Chem., 264, 1989
1F1H	CRYSTAL STRUCTURE OF GLUTAMINE SYNTHETASE FROM SALMONELLA TYPHIMURIUM WITH THALLIUM IONS Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... Authors: Gill, H.S, Eisenberg, D. Deposit date: 2000-05-19 Release date: 2001-04-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.67 Å) Cite: The crystal structure of phosphinothricin in the active site of glutamine synthetase illuminates the mechanism of enzymatic inhibition. Biochemistry, 40, 2001
1F52	CRYSTAL STRUCTURE OF GLUTAMINE SYNTHETASE FROM SALMONELLA TYPHIMURIUM CO-CRYSTALLIZED WITH ADP Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-DIPHOSPHATE, GLUTAMINE SYNTHETASE, ... Authors: Gill, H.S, Pfluegl, G.M.U, Eisenberg, D. Deposit date: 2000-06-12 Release date: 2000-06-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.49 Å) Cite: The crystal structure of phosphinothricin in the active site of glutamine synthetase illuminates the mechanism of enzymatic inhibition. Biochemistry, 40, 2001
1FPY	CRYSTAL STRUCTURE OF GLUTAMINE SYNTHETASE FROM SALMONELLA TYPHIMURIUM WITH INHIBITOR PHOSPHINOTHRICIN Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLUTAMINE SYNTHETASE, MANGANESE (II) ION, ... Authors: Gill, H.S, Eisenberg, D. Deposit date: 2000-08-31 Release date: 2001-04-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.89 Å) Cite: The crystal structure of phosphinothricin in the active site of glutamine synthetase illuminates the mechanism of enzymatic inhibition. Biochemistry, 40, 2001
8OOZ	Glutamine synthetase from Methermicoccus shengliensis in complex with MgATP at 2.7 A resolution Descriptor: ADENOSINE-5'-TRIPHOSPHATE, FORMIC ACID, GLYCEROL, ... Authors: Mueller, M.-C, Lemaire, O.N, Wagner, T. Deposit date: 2023-04-06 Release date: 2024-01-24 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Differences in regulation mechanisms of glutamine synthetases from methanogenic archaea unveiled by structural investigations. Commun Biol, 7, 2024
8OOW	Glutamine synthetase from Methermicoccus shengliensis at a resolution of 2.64 A Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Glutamine synthetase, ... Authors: Mueller, M.-C, Lemaire, O.N, Wagner, T. Deposit date: 2023-04-06 Release date: 2024-01-24 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.64 Å) Cite: Differences in regulation mechanisms of glutamine synthetases from methanogenic archaea unveiled by structural investigations. Commun Biol, 7, 2024
8OOX	Glutamine synthetase from Methermicoccus shengliensis at a resolution of 3.09 A Descriptor: CITRIC ACID, GLYCEROL, Glutamine synthetase, ... Authors: Mueller, M.-C, Lemaire, O.N, Wagner, T. Deposit date: 2023-04-06 Release date: 2024-01-24 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (3.09 Å) Cite: Differences in regulation mechanisms of glutamine synthetases from methanogenic archaea unveiled by structural investigations. Commun Biol, 7, 2024
8PVG	Structure of E. coli glutamine synthetase determined by cryoEM at 100 keV Descriptor: Glutamine synthetase Authors: McMullan, G, Naydenova, K, Mihaylov, D, Peet, M.J, Wilson, H, Yamashita, K, Dickerson, J.L, Chen, S, Cannone, G, Lee, Y, Hutchings, K.A, Gittins, O, Sobhy, M, Wells, T, El-Gomati, M.M, Dalby, J, Meffert, M, Schulze-Briese, C, Henderson, R, Russo, C.J. Deposit date: 2023-07-17 Release date: 2023-11-29 Last modified: 2023-12-06 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structure determination by cryoEM at 100 keV. Proc.Natl.Acad.Sci.USA, 120, 2023
1HTO	CRYSTALLOGRAPHIC STRUCTURE OF A RELAXED GLUTAMINE SYNTHETASE FROM MYCOBACTERIUM TUBERCULOSIS Descriptor: ADENOSINE MONOPHOSPHATE, CITRIC ACID, GLUTAMINE SYNTHETASE, ... Authors: Gill, H.S, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) Deposit date: 2001-01-01 Release date: 2002-07-24 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Multicopy crystallographic refinement of a relaxed glutamine synthetase from Mycobacterium tuberculosis highlights flexible loops in the enzymatic mechanism and its regulation. Biochemistry, 41, 2002
1HTQ	Multicopy crystallographic structure of a relaxed glutamine synthetase from Mycobacterium tuberculosis Descriptor: ADENOSINE MONOPHOSPHATE, CITRIC ACID, MANGANESE (II) ION, ... Authors: Gill, H.S, Pfluegl, G.M, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) Deposit date: 2001-01-01 Release date: 2002-07-24 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Multicopy crystallographic refinement of a relaxed glutamine synthetase from Mycobacterium tuberculosis highlights flexible loops in the enzymatic mechanism and its regulation. Biochemistry, 41, 2002
8TFC	Cryo-EM structure of Methanosarcina mazie glutamine synthetase captured as partial oligomer Descriptor: Glutamine synthetase Authors: Schumacher, M.A. Deposit date: 2023-07-09 Release date: 2023-11-15 Last modified: 2023-11-29 Method: ELECTRON MICROSCOPY (6.9 Å) Cite: M. mazei glutamine synthetase and glutamine synthetase-GlnK1 structures reveal enzyme regulation by oligomer modulation. Nat Commun, 14, 2023
4IS4	The glutamine synthetase from the dicotyledonous plant M. truncatula is a decamer Descriptor: Glutamine synthetase Authors: Seabra, A.R, Carvalho, H, Pereira, P.J.B. Deposit date: 2013-01-16 Release date: 2014-04-09 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.35 Å) Cite: The structures of cytosolic and plastid-located glutamine synthetases from Medicago truncatula reveal a common and dynamic architecture. Acta Crystallogr.,Sect.D, 70, 2014
7U5N	Cryo-EM Structure of Glutamine Synthetase Descriptor: Glutamine synthetase, MANGANESE (II) ION Authors: Morgan, C.E, Yu, E.W, Zhang, Z. Deposit date: 2022-03-02 Release date: 2022-12-14 Last modified: 2023-01-11 Method: ELECTRON MICROSCOPY (2.58 Å) Cite: Toward structural-omics of the bovine retinal pigment epithelium. Cell Rep, 41, 2022
7V4J	Cryo-EM Structure of Camellia sinensis glutamine synthetase CsGSIb inactive Pentamer State I Descriptor: Glutamine synthetase Authors: Xu, W, Chen, Y, Xing, Q, Huang, C. Deposit date: 2021-08-13 Release date: 2022-05-18 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Assembly status transition offers an avenue for activity modulation of a supramolecular enzyme. Elife, 10, 2021
7V4I	Cryo-EM Structure of Camellia sinensis glutamine synthetase CsGSIb decamer assembly Descriptor: Glutamine synthetase Authors: Xu, W, Chen, Y, Xing, Q, Huang, C. Deposit date: 2021-08-13 Release date: 2022-05-18 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Assembly status transition offers an avenue for activity modulation of a supramolecular enzyme. Elife, 10, 2021
7V4K	Cryo-EM Structure of Camellia sinensis glutamine synthetase CsGSIb inactive Pentamer State II Descriptor: Glutamine synthetase Authors: Xu, W, Chen, Y, Xing, Q, Huang, C. Deposit date: 2021-08-13 Release date: 2022-05-18 Method: ELECTRON MICROSCOPY Cite: Assembly status transition offers an avenue for activity modulation of a supramolecular enzyme. Elife, 10, 2021
7V4L	Cryo-EM Structure of Camellia sinensis glutamine synthetase CsGSIb inactive Pentamer State III Descriptor: Glutamine synthetase Authors: Xu, W, Chen, Y, Xing, Q, Huang, C. Deposit date: 2021-08-13 Release date: 2022-05-18 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Assembly status transition offers an avenue for activity modulation of a supramolecular enzyme. Elife, 10, 2021
7W85	Structural of the filamentous Escherichia coli glutamine synthetase Descriptor: Glutamine synthetase, NICKEL (II) ION Authors: Huang, P.-C, Chen, S.-K, Wu, K.-P. Deposit date: 2021-12-07 Release date: 2022-04-06 Last modified: 2022-06-15 Method: ELECTRON MICROSCOPY (2.94 Å) Cite: Structural basis for the helical filament formation of Escherichia coli glutamine synthetase. Protein Sci., 31, 2022

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