PDB: 82 件ウェブページステータス検索Chemie searchBIRD

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4JAX	Crystal structure of dimeric KlHxk1 in crystal form X 分子名称: GLYCEROL, Hexokinase, PHOSPHATE ION 著者 Kuettner, E.B, Strater, N, Kettner, K, Otto, A, Lilie, H, Golbik, R.P, Kriegel, T.M. 登録日 2013-02-19 公開日 2013-05-01 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 In vivo phosphorylation and in vitro autophosphorylation-inactivation of Kluyveromyces lactis hexokinase KlHxk1. Biochem.Biophys.Res.Commun., 435, 2013
4L3Q	Crystal structure of glucokinase-activator complex 分子名称: 6-{3-[(1-methyl-1H-imidazol-2-yl)sulfanyl]phenyl}pyridin-2(1H)-one, Glucokinase, alpha-D-glucopyranose 著者 Gajiwala, K.S, Filipski, K.J. 登録日 2013-06-06 公開日 2013-07-24 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif. Bioorg.Med.Chem.Lett., 23, 2013
4LC9	Structural Basis for Regulation of Human Glucokinase by Glucokinase Regulatory Protein 分子名称: 6-O-phosphono-beta-D-fructofuranose, Glucokinase, Glucokinase regulatory protein, ... 著者 Beck, T, Miller, B.G. 登録日 2013-06-21 公開日 2013-09-04 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Structural basis for regulation of human glucokinase by glucokinase regulatory protein. Biochemistry, 52, 2013
4MLE	Human Glucokinase in Complex with Novel Amino Thiazole Activator 分子名称: 3-(benzyloxy)-N-(4-methyl-1,3-thiazol-2-yl)pyridin-2-amine, Glucokinase, alpha-D-glucopyranose 著者 Voegtli, W.C. 登録日 2013-09-06 公開日 2013-09-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Identification of a New Class of Glucokinase Activators through Structure-Based Design. J.Med.Chem., 56, 2013
4MLH	Human Glucokinase in Complex with a Novel Amino Thiazole Allosteric Activator 分子名称: 3-(benzyloxy)-5-methyl-N-(4-methyl-1,3-thiazol-2-yl)pyridin-2-amine, Glucokinase, alpha-D-glucopyranose 著者 Voegtli, W.C. 登録日 2013-09-06 公開日 2013-09-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Identification of a New Class of Glucokinase Activators through Structure-Based Design. J.Med.Chem., 56, 2013
4NO7	Human Glucokinase in complex with a nanomolar activator. 分子名称: (2R)-2-[3-chloro-4-(methylsulfonyl)phenyl]-3-[(1R)-3-oxocyclopentyl]-N-(pyrazin-2-yl)propanamide, Glucokinase, alpha-D-glucopyranose 著者 Petit, P, Ferry, G, Antoine, M, Boutin, J.A, Kotschy, A, Perron-Sierra, F, Mamelli, L, Vuillard, L. 登録日 2013-11-19 公開日 2014-10-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The active conformation of human glucokinase is not altered by allosteric activators. Acta Crystallogr. D Biol. Crystallogr., 67, 2011
4QS7	Arabidopsis Hexokinase 1 (AtHXK1) structure in glucose-bound form 分子名称: Hexokinase-1, beta-D-glucopyranose 著者 Feng, J, Zhao, S, Liu, L. 登録日 2014-07-03 公開日 2015-02-11 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.001 Å) 主引用文献 Biochemical and structural study of Arabidopsis hexokinase 1 Acta Crystallogr.,Sect.D, 71, 2015
4QS8	Arabidopsis Hexokinase 1 (AtHXK1) structure in ligand-free form 分子名称: Hexokinase-1 著者 Feng, J, Zhao, S, Liu, L. 登録日 2014-07-03 公開日 2015-02-11 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.798 Å) 主引用文献 Biochemical and structural study of Arabidopsis hexokinase 1 Acta Crystallogr.,Sect.D, 71, 2015
4QS9	Arabidopsis Hexokinase 1 (AtHXK1) mutant S177A structure in glucose-bound form 分子名称: Hexokinase-1, beta-D-glucopyranose 著者 Feng, J, Zhao, S, Liu, L. 登録日 2014-07-03 公開日 2015-02-11 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.103 Å) 主引用文献 Biochemical and structural study of Arabidopsis hexokinase 1 Acta Crystallogr.,Sect.D, 71, 2015
4RCH	Discovery of 2-Pyridyl Ureas as Glucokinase Activators 分子名称: 1-{3-[(2-ethylpyridin-3-yl)oxy]-5-(pyridin-2-ylsulfanyl)pyridin-2-yl}-3-methylurea, Glucokinase, alpha-D-glucopyranose 著者 Voegtli, W, Vigers, G.P.A. 登録日 2014-09-16 公開日 2014-10-08 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery of 2-pyridylureas as glucokinase activators. J.Med.Chem., 57, 2014
5HEX	Crystal Structure of Human Hexokinase 2 with cmpd 30, a 2-amino-6-benzenesulfonamide glucosamine 分子名称: 2-[(3-bromobenzene-1-carbonyl)amino]-6-{[(4-carboxy-5-methylfuran-2-yl)sulfonyl]amino}-2,6-dideoxy-alpha-D-glucopyranos e, Hexokinase-2 著者 Campobasso, N, Zhao, B, Smallwood, A. 登録日 2016-01-06 公開日 2016-03-30 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.734 Å) 主引用文献 Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors. Acs Med.Chem.Lett., 7, 2016
5HFU	Crystal Structure of Human Hexokinase 2 with cmpd 27, a 2-amido-6-benzenesulfonamide glucosamine 分子名称: Hexokinase-2, ~{N}-[(2~{S},3~{R},4~{R},5~{S},6~{R})-6-[[(4-cyanophenyl)sulfonylamino]methyl]-2,4,5-tris(oxidanyl)oxan-3-yl]-3-phenyl-benzamide 著者 Campobasso, N, Zhao, B, Smallwood, A. 登録日 2016-01-07 公開日 2016-03-30 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.923 Å) 主引用文献 Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors. Acs Med.Chem.Lett., 7, 2016
5HG1	Crystal Structure of Human Hexokinase 2 with cmpd 1, a C-2-substituted glucosamine 分子名称: 2-deoxy-2-{[(2E)-3-(3,4-dichlorophenyl)prop-2-enoyl]amino}-alpha-D-glucopyranose, 6-O-phosphono-beta-D-glucopyranose, CITRATE ANION, ... 著者 Campobasso, N, Zhao, B, Smallwood, A. 登録日 2016-01-07 公開日 2016-03-30 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.76 Å) 主引用文献 Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors. Acs Med.Chem.Lett., 7, 2016
5V4W	Human glucokinase in complex with novel indazole activator. 分子名称: (2S)-2-[4-(cyclopropylsulfonyl)-1H-indazol-1-yl]-N-(5-fluoro-1,3-thiazol-2-yl)-3-(oxan-4-yl)propanamide, Glucokinase, IODIDE ION, ... 著者 Skene, R.J, Hosfield, D.J. 登録日 2017-03-10 公開日 2017-05-31 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators. Bioorg. Med. Chem. Lett., 27, 2017
5V4X	Human glucokinase in complex with novel pyrazole activator. 分子名称: (2S)-3-cyclohexyl-2-[4-(cyclopentylsulfonyl)-2-oxopyridin-1(2H)-yl]-N-(1,3-thiazol-2-yl)propanamide, Glucokinase, IODIDE ION, ... 著者 Skene, R.J, Hosfiled, D.J. 登録日 2017-03-10 公開日 2017-05-31 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators. Bioorg. Med. Chem. Lett., 27, 2017
5ZQT	Crystal structure of Oryza sativa hexokinase 6 分子名称: Hexokinase-6, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Matsudaira, K, Mochizuki, S, Yoshida, H, Kamitori, S, Akimitsu, K. 登録日 2018-04-20 公開日 2019-04-24 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.84 Å) 主引用文献 Crystal structure of Oryza sativa hexokinase 6 To Be Published
6E0E	Crystal structure of Glucokinase in complex with compound 6 分子名称: 2-({2-[(4-methyl-1,3-thiazol-2-yl)amino]pyridin-3-yl}oxy)benzonitrile, Glucokinase, alpha-D-glucopyranose 著者 Hinklin, R.J, Baer, B.R, Boyd, S.A, Chicarelli, M.D, Condroski, K.R, DeWolf, W.E, Fischer, J, Frank, M, Hingorani, G.P, Lee, P.A, Neitzel, N.A, Pratt, S.A, Singh, A, Sullivan, F.X, Turner, T, Voegtli, W.C, Wallace, E.M, Williams, L, Aicher, T.D. 登録日 2018-07-06 公開日 2019-07-10 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator. Bioorg.Med.Chem., 28, 2020
6E0I	Crystal structure of Glucokinase in complex with compound 72 分子名称: 1-{4-[5-({3-[(2-methylpyridin-3-yl)oxy]-5-[(pyridin-2-yl)sulfanyl]pyridin-2-yl}amino)-1,2,4-thiadiazol-3-yl]piperidin-1 -yl}ethan-1-one, DIMETHYL SULFOXIDE, Glucokinase, ... 著者 Hinklin, R.J, Baer, B.R, Boyd, S.A, Chicarelli, M.D, Condroski, K.R, DeWolf, W.E, Fischer, J, Frank, M, Hingorani, G.P, Lee, P.A, Neitzel, N.A, Pratt, S.A, Singh, A, Sullivan, F.X, Turner, T, Voegtli, W.C, Wallace, E.M, Williams, L, Aicher, T.D. 登録日 2018-07-06 公開日 2019-07-10 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator. Bioorg.Med.Chem., 28, 2020
6JJ4	Crystal structure of OsHXK6-apo form 分子名称: Hexokinase-6 著者 He, C, Wei, P, Chen, J, Wang, H, Wan, Y, Zhou, J, Zhu, Y, Huang, W, Yin, L. 登録日 2019-02-25 公開日 2019-07-03 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of OsHXK6-apo To Be Published
6JJ7	Crystal structure of OsHXK6-Glc complex 分子名称: Rice hexokinase 6, beta-D-glucopyranose 著者 He, C, Wei, P, Chen, J, Wang, H, Wan, Y, Zhou, J, Zhu, Y, Huang, W, Yin, L. 登録日 2019-02-25 公開日 2019-07-03 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of OsHXK6-Glc complex To Be Published
6JJ8	Crystal structure of OsHXK6-ATP-Mg2+ complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... 著者 He, C, Wei, P, Chen, J, Wang, H, Wan, Y, Zhou, J, Zhu, Y, Huang, W, Yin, L. 登録日 2019-02-25 公開日 2019-07-03 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of OsHXK6-ATP-Mg2+ complex To Be Published
6JJ9	Crystal structure of OsHXK6-Glc-ATP-Mg2+ complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, Hexokinase-6, MAGNESIUM ION, ... 著者 He, C, Wei, P, Chen, J, Wang, H, Wan, Y, Zhou, J, Zhu, Y, Huang, W, Yin, L. 登録日 2019-02-25 公開日 2019-07-03 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal structure of OsHXK6-Glc-ATP-Mg2+ complex To Be Published
6KRJ	Crystal structure of Hexokinase 分子名称: Phosphotransferase 著者 Sun, M.F, Wang, Y.H, Liao, S.Q, Yuan, H. 登録日 2019-08-22 公開日 2020-09-02 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Crystal structure of Hexokinase To Be Published
6KSR	Crystal structure of Hexokinase from Eimeria tenella 分子名称: Phosphotransferase, alpha-D-galactopyranose 著者 Yuan, H, Sun, M.F, Wang, Y.H, Liao, S.Q. 登録日 2019-08-25 公開日 2020-09-02 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.37 Å) 主引用文献 Crystal structure of Hexokinase from Eimeria tenella To Be Published
6P4X	Crystal Structure of the S. cerevisiae glucokinase, Glk1 分子名称: Glucokinase-1, PHOSPHATE ION 著者 Stoddard, P.R, Garner, E.C, Murray, A.W. 登録日 2019-05-28 公開日 2020-03-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.59 Å) 主引用文献 Polymerization in the actin ATPase clan regulates hexokinase activity in yeast. Science, 367, 2020

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