PDB: 297 件ウェブページステータス検索Chemie searchBIRD

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7Q3X	Crystal structure of Malate dehydrogenase from Haloarcula marismortui with Potassium and Chloride ions 分子名称: CHLORIDE ION, Malate dehydrogenase, POTASSIUM ION 著者 Bertrand, Q, Roche, J, Girard, E, Madern, D. 登録日 2021-10-29 公開日 2022-02-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Resurrection of Ancestral Malate Dehydrogenases Reveals the Evolutionary History of Haloarchaeal Proteins. To Be Published
1O6Z	1.95 A resolution structure of (R207S,R292S) mutant of malate dehydrogenase from the halophilic archaeon Haloarcula marismortui (holo form) 分子名称: CHLORIDE ION, MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Irimia, A, Ebel, C, Madern, D, Richard, S.B, Cosenza, L.W, Zaccai, G, Vellieux, F.M.D. 登録日 2002-10-22 公開日 2003-02-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 The Oligomeric States of Haloarcula Marismortui Malate Dehydrogenase are Modulated by Solvent Components as Shown by Crystallographic and Biochemical Studies J.Mol.Biol., 326, 2003
4ROS	Crystal structure of Methylobacterium extorquens malate dehydrogenase complexed with oxaloacetate and adenosine-5-diphosphoribose 分子名称: ADENOSINE-5-DIPHOSPHORIBOSE, CALCIUM ION, Malate dehydrogenase, ... 著者 Gonzalez, J.M, Marti-Arbona, R, Unkefer, C.J. 登録日 2014-10-28 公開日 2014-12-17 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal structure of Methylobacterium extorquens malate dehydrogenase complexed with oxaloacetate and adenosine-5-diphosphoribose To be Published
6BB0	Lactate Dehydrogenase in complex with inhibitor (R)-3-((2-chlorophenyl)thio)-6-(3-((4-fluorophenyl)amino)phenyl)-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2H-pyran-2-one 分子名称: (6S)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(2-hydroxyphenyl)-6-phenyl-5,6-dihydro-2H-pyran-2-one, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, L-lactate dehydrogenase A chain, ... 著者 Ultsch, M, Eigenbrot, C. 登録日 2017-10-16 公開日 2018-10-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase To Be Published
5W8I	Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 23 and Zinc 分子名称: 2-[3-(3,4-difluorophenyl)-5-hydroxy-1H-pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid, CITRIC ACID, DIMETHYL SULFOXIDE, ... 著者 Lukacs, C.M, Abendroth, J. 登録日 2017-06-21 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). J. Med. Chem., 60, 2017
1PZE	T.gondii LDH1 apo form 分子名称: lactate dehydrogenase 著者 Kavanagh, K.L, Elling, R.A, Wilson, D.K. 登録日 2003-07-10 公開日 2004-02-24 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structure of Toxoplasma gondii LDH1: Active-Site Differences from Human Lactate Dehydrogenases and the Structural Basis for Efficient APAD+ Use. Biochemistry, 43, 2004
4AJO	rat LDHA in complex with 2-((4-(4-((3-((2-methyl-1,3-benzothiazol-6yl) amino)-3-oxo-propyl)amino)-4-oxo-butyl)phenyl)methyl)propanedioic acid 分子名称: DIMETHYL SULFOXIDE, GLYCEROL, L-LACTATE DEHYDROGENASE A CHAIN, ... 著者 Tucker, J.A, Brassington, C, Hassall, G, Watson, M, Ward, R, Tart, J, Davies, G, Caputo, A, Pearson, S. 登録日 2012-02-16 公開日 2012-03-21 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 The Design and Synthesis of Novel Lactate Dehydrogenase a Inhibitors by Fragment-Based Lead Generation J.Med.Chem., 55, 2012
2XXJ	Penta mutant of lactate dehydrogenase from Thermus thermophilus, ternary complex 分子名称: L-LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID, ... 著者 Tickle, J, de Mendoza Barbera, E, Vellieux, F.M.D. 登録日 2010-11-10 公開日 2010-11-24 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.964 Å) 主引用文献 Lactate Dehydrogenase from T. Thermophilus, Penta- Mutant (Ternary Complex) To be Published
5A1T	Trichomonas vaginalis lactate dehydrogenase in complex with NADH and oxamate 分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, L-LACTATE DEHYDROGENASE, OXAMIC ACID 著者 Steindel, P.A, Chen, E.H, Theobald, D.L. 登録日 2015-05-05 公開日 2016-03-02 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Gradual Neofunctionalization in the Convergent Evolution of Trichomonad Lactate and Malate Dehydrogenases. Protein Sci., 25, 2016
4Q3N	Crystal structure of MGS-M5, a lactate dehydrogenase enzyme from a Medee basin deep-sea metagenome library 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, CHLORIDE ION, ... 著者 Stogios, P.J, Xu, X, Cui, H, Alcaide, M, Ferrer, M, Savchenko, A. 登録日 2014-04-11 公開日 2015-02-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Pressure adaptation is linked to thermal adaptation in salt-saturated marine habitats. Environ Microbiol, 17, 2015
6ITL	Crystal structure of malate dehydrogenase from Mannheimia succiniciproducens in complex with NAD 分子名称: GLYCEROL, Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Seo, H, Kim, K.-J. 登録日 2018-11-23 公開日 2019-11-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Enhanced succinic acid production by Mannheimia employing optimal malate dehydrogenase. Nat Commun, 11, 2020
7XQN	InDel-mutant malate dehydrogenase from E. coli 分子名称: Malate dehydrogenase 著者 Toledo-Patino, S, Laurino, P. 登録日 2022-05-08 公開日 2022-12-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Insertions and deletions mediated functional divergence of Rossmann fold enzymes. Proc.Natl.Acad.Sci.USA, 119, 2022
3OM9	T. Gondii bradyzoite-specific LDH (LDH1) in complex with NAD and OXQ 分子名称: 4-HYDROXY-1,2,5-OXADIAZOLE-3-CARBOXYLIC ACID, Lactate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Susko, M.S, Wilson, D.K. 登録日 2010-08-26 公開日 2010-10-27 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 T.Gondii bradyzoite-specific LDH (LDH1) in complex with NAD and OXQ To be Published
1WZE	Structural basis for alteration of cofactor specificity of Malate dehydrogenase from Thermus flavus 分子名称: Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Tomita, T, Fushinobu, S, Kuzuyama, T, Nishiyama, M. 登録日 2005-03-04 公開日 2006-03-14 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for alteration of cofactor specificity of malate dehydrogenase from Thermus flavus to be published
6CEP	Sus scrofa heart L-lactate dehydrogenase ternary complex with NADH and oxamate 分子名称: L-lactate dehydrogenase B chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID 著者 Hoffer, E.D, Andrews, B, Dunham, C.M, Dyer, R.B. 登録日 2018-02-12 公開日 2018-06-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Small molecule cores demonstrate non-competitive inhibition of lactate dehydrogenase. Medchemcomm, 9, 2018
9LDT	DESIGN AND SYNTHESIS OF NEW ENZYMES BASED ON THE LACTATE DEHYDROGENASE FRAMEWORK 分子名称: LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID, ... 著者 Dunn, C.R, Holbrook, J.J, Muirhead, H. 登録日 1991-11-26 公開日 1993-10-31 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Design and synthesis of new enzymes based on the lactate dehydrogenase framework. Philos.Trans.R.Soc.London,Ser.B, 332, 1991
1LLD	MOLECULAR BASIS OF ALLOSTERIC ACTIVATION OF BACTERIAL L-LACTATE DEHYDROGENASE 分子名称: L-LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Iwata, S, Ohta, T. 登録日 1992-06-08 公開日 1994-01-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Molecular basis of allosteric activation of bacterial L-lactate dehydrogenase. J.Mol.Biol., 230, 1993
1WZI	Structural basis for alteration of cofactor specificity of Malate dehydrogenase from Thermus flavus 分子名称: Malate dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Tomita, T, Fushinobu, S, Kuzuyama, T, Nishiyama, M. 登録日 2005-03-05 公開日 2006-03-14 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for alteration of cofactor specificity of malate dehydrogenase from Thermus flavus to be published
3VPH	L-lactate dehydrogenase from Thermus caldophilus GK24 complexed with oxamate, NADH and FBP 分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, L-lactate dehydrogenase, ... 著者 Arai, K, Ohno, T, Miyanaga, A, Fushinobu, S, Taguchi, H. 登録日 2012-03-01 公開日 2013-03-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The core of allosteric motion in Thermus caldophilus L-lactate dehydrogenase. J.Biol.Chem., 2014
6LDH	REFINED CRYSTAL STRUCTURE OF DOGFISH M4 APO-LACTATE DEHYDROGENASE 分子名称: M4 APO-LACTATE DEHYDROGENASE, SULFATE ION 著者 Abad-Zapatero, C, Rossmann, M.G. 登録日 1987-11-25 公開日 1989-07-12 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Refined crystal structure of dogfish M4 apo-lactate dehydrogenase. J.Mol.Biol., 198, 1987
6Q13	CRYSTAL STRUCTURE OF LDHA IN COMPLEX WITH COMPOUND NCGC00420737-09 AT 2.00 A RESOLUTION 分子名称: 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-{3-[(5-methylthiophen-2-yl)ethynyl]phenyl}-1H-pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid, ... 著者 Davies, D.R, Dranow, D.M. 登録日 2019-08-02 公開日 2020-09-23 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties. J.Med.Chem., 63, 2020
1GUZ	Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases 分子名称: MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Dalhus, B, Sarinen, M, Sauer, U.H, Eklund, P, Johansson, K, Karlsson, A, Ramaswamy, S, Bjork, A, Synstad, B, Naterstad, K, Sirevag, R, Eklund, H. 登録日 2002-02-04 公開日 2002-02-21 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases J.Mol.Biol., 318, 2002
5ZI2	MDH3 wild type, nad-form 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, GLYCEROL, ... 著者 Moriyama, S, Nishio, K, Mizushima, T. 登録日 2018-03-14 公開日 2018-10-24 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of glyoxysomal malate dehydrogenase (MDH3) from Saccharomyces cerevisiae. Acta Crystallogr F Struct Biol Commun, 74, 2018
6ITK	Crystal structure of malate dehydrogenase from Corynebacterium glutamicum ATCC 13032 in complex with NAD and malate 分子名称: (2S)-2-hydroxybutanedioic acid, Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Seo, H, Kim, K.-J. 登録日 2018-11-23 公開日 2019-11-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Enhanced succinic acid production by Mannheimia employing optimal malate dehydrogenase. Nat Commun, 11, 2020
6R8G	Crystal structure of malate dehydrogenase from Plasmodium Falciparum in complex with 4-(3,4-difluorophenyl)thiazol-2-amine 分子名称: 4-[3,4-bis(fluoranyl)phenyl]-1,3-thiazol-2-amine, Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... 著者 Romero, A.R, Calderone, V, Gentili, M, Lunev, S, Groves, M, Popowicz, G, Domling, A, Sattler, M. 登録日 2019-04-01 公開日 2020-04-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A Fragment-Based Approach Identifies an Allosteric Pocket that Impacts Malate Dehydrogenase Activity Commun Biol, 2021

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