5Z9L
 
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5Z9Q
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5Z4O
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5Z9B
 | | Bacterial GyrB ATPase domain in complex with (3,4-dichlorophenyl)hydrazine | | 分子名称: | (3,4-dichlorophenyl)hydrazine, 1H-benzimidazol-2-amine, DNA gyrase subunit B, ... | | 著者 | Huang, X, Zhou, H. | | 登録日 | 2018-02-02 | | 公開日 | 2018-12-12 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes
Medchemcomm, 9, 2018
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5Z9M
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5Z4H
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5Z9P
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6CJI
 | | Candida albicans Hsp90 nucleotide binding domain | | 分子名称: | 1,2-ETHANEDIOL, Heat shock protein 90 homolog | | 著者 | Hutchinson, A, Loppnau, P, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Hui, R, STRUCTURAL GENOMICS CONSORTIUM, S.G.C, Pizarro, J.C, Structural Genomics Consortium (SGC) | | 登録日 | 2018-02-26 | | 公開日 | 2019-01-30 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | | 主引用文献 | Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.
Nat Commun, 10, 2019
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6CJR
 | | Candida albicans Hsp90 nucleotide binding domain in complex with SNX-2112 | | 分子名称: | 1,2-ETHANEDIOL, 4-[6,6-dimethyl-4-oxidanylidene-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]-2-[(4-oxidanylcyclohexyl)amino]benzamide, Heat shock protein 90 homolog | | 著者 | Kirkpatrick, M.G, Pizarro, J.C. | | 登録日 | 2018-02-26 | | 公開日 | 2019-01-30 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.
Nat Commun, 10, 2019
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6CJJ
 | | Candida albicans Hsp90 nucleotide binding domain in complex with ADP | | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, Heat shock protein 90 homolog, ... | | 著者 | Hutchinson, A, Loppnau, P, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Hui, R, STRUCTURAL GENOMICS CONSORTIUM, S.G.C, Pizarro, J.C, Structural Genomics Consortium (SGC) | | 登録日 | 2018-02-26 | | 公開日 | 2019-01-30 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.
Nat Commun, 10, 2019
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6CJS
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6CJP
 | | Candida albicans Hsp90 nucleotide binding domain in complex with radicicol | | 分子名称: | (1aR,2Z,4E,6E,14R,15aR)-9,11-dihydroxy-6-{[(4-methoxyphenyl)methoxy]imino}-14-methyl-1a,6,7,14,15,15a-hexahydro-12H-oxireno[e][2]benzoxacyclotetradecin-12-one, Heat shock protein 90 homolog | | 著者 | Nation, C, Pizarro, J.C. | | 登録日 | 2018-02-26 | | 公開日 | 2019-01-30 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.
Nat Commun, 10, 2019
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6CJL
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6F96
 | | Crystal Structure of E. coli GyraseB 24kDa in complex with 6-[(ethylcarbamoyl)amino]-4-[(4-methoxyphenyl)amino]-N-(pyridin-3-yl)pyridine-3-carboxamide | | 分子名称: | 6-(ethylcarbamoylamino)-4-[(4-methoxyphenyl)amino]-~{N}-pyridin-3-yl-pyridine-3-carboxamide, DNA gyrase subunit B | | 著者 | Narramore, S.K, Stevenson, C.E.M, Lawson, D.M, Maxwell, A, Fishwick, C.W.G. | | 登録日 | 2017-12-14 | | 公開日 | 2019-01-30 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase.
Bioorg.Med.Chem., 27, 2019
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6GAV
 | | Extremely 'open' clamp structure of DNA gyrase: role of the Corynebacteriales GyrB specific insert | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA gyrase subunit B,DNA gyrase subunit A | | 著者 | Petrella, S, Capton, E, Alzari, P.M, Aubry, A, MAyer, C. | | 登録日 | 2018-04-12 | | 公開日 | 2019-02-20 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity.
Structure, 27, 2019
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6GAU
 | | Extremely 'open' clamp structure of DNA gyrase: role of the Corynebacteriales GyrB specific insert | | 分子名称: | DNA gyrase subunit B,DNA gyrase subunit A, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | 著者 | Petrella, S, Capton, E, Alzari, P.M, Aubry, A, Mayer, C. | | 登録日 | 2018-04-12 | | 公開日 | 2019-02-20 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity.
Structure, 27, 2019
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6DK8
 | | RetS kinase region without cobalt | | 分子名称: | NICKEL (II) ION, RetS (Regulator of Exopolysaccharide and Type III Secretion) | | 著者 | Mancl, J.M, Schubot, F.D. | | 登録日 | 2018-05-29 | | 公開日 | 2019-03-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Helix Cracking Regulates the Critical Interaction between RetS and GacS in Pseudomonas aeruginosa.
Structure, 27, 2019
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6DK7
 | | RetS histidine kinase region with cobalt | | 分子名称: | COBALT (II) ION, RetS (Regulator of Exopolysaccharide and Type III Secretion) | | 著者 | Mancl, J.M, Schubot, F.D. | | 登録日 | 2018-05-29 | | 公開日 | 2019-03-20 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Helix Cracking Regulates the Critical Interaction between RetS and GacS in Pseudomonas aeruginosa.
Structure, 27, 2019
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6ENH
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6ENG
 | | Crystal structure of the 43K ATPase domain of Escherichia coli gyrase B in complex with an aminocoumarin | | 分子名称: | CHLORIDE ION, Coumermycin A1, DNA gyrase subunit B, ... | | 著者 | Vanden Broeck, A, McEwen, A.G, Lamour, V. | | 登録日 | 2017-10-04 | | 公開日 | 2019-04-10 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural Basis for DNA Gyrase Interaction with Coumermycin A1.
J.Med.Chem., 62, 2019
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5ZXM
 | | Crystal Structure of GyraseB N-terminal at 1.93A Resolution | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA gyrase subunit B, ... | | 著者 | Tiwari, P, Gupta, D, Sachdeva, E, Sharma, S, Singh, T.P, Ethayathulla, A.S, Kaur, P. | | 登録日 | 2018-05-21 | | 公開日 | 2019-05-22 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.938 Å) | | 主引用文献 | Structural insights into the transient closed conformation and pH dependent ATPase activity of S.Typhi GyraseB N- terminal domain.
Arch.Biochem.Biophys., 701, 2021
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6F8J
 | | Crystal Structure of E. coli GyraseB 24kDa in complex with 6-[(ethylcarbamoyl)amino]-4-(1H-pyrazol-1-yl)-N-(pyridin-3-yl)pyridine-3-carboxamide | | 分子名称: | 6-(ethylcarbamoylamino)-4-pyrazol-1-yl-~{N}-pyridin-3-yl-pyridine-3-carboxamide, DNA gyrase subunit B | | 著者 | Narramore, S.K, Stevenson, C.E.M, Lawson, D.M, Maxwell, A, Fishwick, C.W.G. | | 登録日 | 2017-12-13 | | 公開日 | 2019-06-26 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase.
Bioorg.Med.Chem., 27, 2019
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6F86
 | | Crystal Structure of E. coli GyraseB 24kDa in complex with 4-(4-bromo-1H-pyrazol-1-yl)-6-[(ethylcarbamoyl)amino]-N-(pyridin-3-yl)pyridine-3-carboxamide | | 分子名称: | 4-(4-bromanylpyrazol-1-yl)-6-(ethylcarbamoylamino)-~{N}-pyridin-3-yl-pyridine-3-carboxamide, DNA gyrase subunit B | | 著者 | Narramore, S.K, Stevenson, C.E.M, Lawson, D.M, Maxwell, A, Fishwick, C.W.G. | | 登録日 | 2017-12-12 | | 公開日 | 2019-06-26 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase.
Bioorg.Med.Chem., 27, 2019
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6F94
 | | Crystal Structure of E. coli GyraseB 24kDa in complex with 6-[(ethylcarbamoyl)amino]-4-[(3-methyphenyl)amino]-N-(3-methyphenyl)pyridine-3-carboxamide | | 分子名称: | 6-(ethylcarbamoylamino)-~{N}-(3-methylphenyl)-4-[(3-methylphenyl)amino]pyridine-3-carboxamide, DNA gyrase subunit B | | 著者 | Narramore, S.K, Stevenson, C.E.M, Lawson, D.M, Maxwell, A, Fishwick, C.W.G. | | 登録日 | 2017-12-14 | | 公開日 | 2019-06-26 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase.
Bioorg.Med.Chem., 27, 2019
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6RKW
 | | CryoEM structure of the complete E. coli DNA Gyrase complex bound to a 130 bp DNA duplex | | 分子名称: | (3~{R})-3-[[4-(3,4-dihydro-2~{H}-pyrano[2,3-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.0^{4,12}]dodeca-6,8(12),9-triene-5,11-dione, DNA (58-MER), DNA (62-MER), ... | | 著者 | Vanden Broeck, A, Lamour, V. | | 登録日 | 2019-04-30 | | 公開日 | 2019-11-06 | | 最終更新日 | 2020-11-18 | | 実験手法 | ELECTRON MICROSCOPY (6.6 Å) | | 主引用文献 | Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex.
Nat Commun, 10, 2019
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