5Z9L

Bacterial GyrB ATPase domain in complex with a chemical fragment

Summary for 5Z9L

• Entry DOI: 10.2210/pdb5z9l/pdb
• Descriptor: DNA gyrase subunit B, PHOSPHATE ION, 2-fluoro-4-hydroxybenzonitrile, ... (5 entities in total)
• Functional Keywords: dna topoisomerase, antibacterial, drug target, fragment-base lead discovery, isomerase
• Biological source: Escherichia coli (strain K12)
• Total number of polymer chains: 2
• Total formula weight: 46198.20

Authors

Huang, X.,Zhou, H. (deposition date: 2018-02-03, release date: 2018-12-12, Last modification date: 2023-11-22)

• Primary citation: Huang, X.,Guo, J.,Liu, Q.,Gu, Q.,Xu, J.,Zhou, H.; Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes; Medchemcomm, 9:1619-1629, 2018; PubMed: 30429968; DOI: 10.1039/c8md00148k

Experimental method

X-RAY DIFFRACTION (1.6 Å)