7EJ2
 
 | | human voltage-gated potassium channel KV1.3 H451N mutant | | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Potassium voltage-gated channel subfamily A member 3, Voltage-gated potassium channel subunit beta-2 | | Authors: | Liu, S, Zhao, Y, Tian, C. | | Deposit date: | 2021-04-01 | | Release date: | 2021-06-09 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structures of wild-type and H451N mutant human lymphocyte potassium channel K V 1.3.
Cell Discov, 7, 2021
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7EJ1
 | | human voltage-gated potassium channel KV1.3 | | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Potassium voltage-gated channel subfamily A member 3, Voltage-gated potassium channel subunit beta-2 | | Authors: | Liu, S, Zhao, Y, Tian, C. | | Deposit date: | 2021-04-01 | | Release date: | 2021-06-09 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structures of wild-type and H451N mutant human lymphocyte potassium channel K V 1.3.
Cell Discov, 7, 2021
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7F0J
 | | CryoEM structure of human Kv4.2 | | Descriptor: | Potassium voltage-gated channel subfamily D member 2, ZINC ION | | Authors: | Kise, Y, Nureki, O. | | Deposit date: | 2021-06-04 | | Release date: | 2021-10-13 | | Last modified: | 2022-02-16 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural basis of gating modulation of Kv4 channel complexes.
Nature, 599, 2021
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7F3F
 | | CryoEM structure of human Kv4.2-KChIP1 complex | | Descriptor: | Isoform 2 of Kv channel-interacting protein 1, Potassium voltage-gated channel subfamily D member 2 | | Authors: | Kise, Y, Nureki, O. | | Deposit date: | 2021-06-16 | | Release date: | 2021-10-13 | | Last modified: | 2022-02-16 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis of gating modulation of Kv4 channel complexes.
Nature, 599, 2021
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7W3Y
 | | CryoEM structure of human Kv4.3 | | Descriptor: | Isoform 2 of Potassium voltage-gated channel subfamily D member 3 | | Authors: | Ma, D.M, Guo, J.T. | | Deposit date: | 2021-11-26 | | Release date: | 2022-11-02 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural basis for the gating modulation of Kv4.3 by auxiliary subunits.
Cell Res., 32, 2022
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7W6S
 | | CryoEM structure of human KChIP2-Kv4.3 complex | | Descriptor: | Isoform 2 of Potassium voltage-gated channel subfamily D member 3, Kv channel-interacting protein 2 | | Authors: | Ma, D.M, Guo, J.T. | | Deposit date: | 2021-12-02 | | Release date: | 2022-11-02 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structural basis for the gating modulation of Kv4.3 by auxiliary subunits.
Cell Res., 32, 2022
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7W6T
 | | CryoEM structure of human KChIP1-Kv4.3-DPP6 complex | | Descriptor: | Dipeptidyl aminopeptidase-like protein 6, Isoform 2 of Potassium voltage-gated channel subfamily D member 3, Kv channel-interacting protein 1 | | Authors: | Ma, D.M, Guo, J.T. | | Deposit date: | 2021-12-02 | | Release date: | 2022-11-02 | | Method: | ELECTRON MICROSCOPY (3.85 Å) | | Cite: | Structural basis for the gating modulation of Kv4.3 by auxiliary subunits.
Cell Res., 32, 2022
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7W6N
 | | CryoEM structure of human KChIP1-Kv4.3 complex | | Descriptor: | Isoform 2 of Potassium voltage-gated channel subfamily D member 3, Kv channel-interacting protein 1 | | Authors: | Ma, D.M, Guo, J.T. | | Deposit date: | 2021-12-02 | | Release date: | 2022-11-02 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural basis for the gating modulation of Kv4.3 by auxiliary subunits.
Cell Res., 32, 2022
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8QUD
 | | Cryo-EM Structure of Human Kv3.1 in Complex with Modulator AUT5 | | Descriptor: | (5R)-5-ethyl-3-(6-spiro[2H-1-benzofuran-3,1'-cyclopropane]-4-yloxypyridin-3-yl)imidazolidine-2,4-dione, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Chi, G, Mckinley, G, Marsden, B, Pike, A.C.W, Ye, M, Brooke, L.M, Bakshi, S, Lakshminarayana, B, Pilati, N, Marasco, A, Gunthorpe, M, Alvaro, G.S, Large, C.H, Williams, E, Sauer, D.B. | | Deposit date: | 2023-10-16 | | Release date: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | The binding and mechanism of a positive allosteric modulator of Kv3 channels.
Nat Commun, 15, 2024
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8QUC
 | | Cryo-EM Structure of Human Kv3.1 in Complex with Modulator AUT1 | | Descriptor: | (5R)-5-ethyl-3-[6-(3-methoxy-4-methyl-phenoxy)pyridin-3-yl]imidazolidine-2,4-dione, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Chi, G, Mckinley, G, Marsden, B, Pike, A.C.W, Ye, M, Brooke, L.M, Bakshi, S, Pilati, N, Marasco, A, Gunthorpe, M, Alvaro, G, Large, C, Lakshminaraya, B, Williams, E, Sauer, D.B. | | Deposit date: | 2023-10-16 | | Release date: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | The binding and mechanism of a positive allosteric modulator of Kv3 channels.
Nat Commun, 15, 2024
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8SDA
 | | CryoEM structure of rat Kv2.1(1-598) L403A mutant in nanodiscs | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel subfamily B member 1 | | Authors: | Tan, X, Swartz, K.J. | | Deposit date: | 2023-04-06 | | Release date: | 2023-09-27 | | Last modified: | 2023-10-25 | | Method: | ELECTRON MICROSCOPY (3.32 Å) | | Cite: | Inactivation of the Kv2.1 channel through electromechanical coupling.
Nature, 622, 2023
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8SD3
 | | CryoEM structure of rat Kv2.1(1-598) wild type in nanodiscs | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel subfamily B member 1 | | Authors: | Tan, X, Swartz, K.J. | | Deposit date: | 2023-04-06 | | Release date: | 2023-09-27 | | Last modified: | 2023-10-25 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | Inactivation of the Kv2.1 channel through electromechanical coupling.
Nature, 622, 2023
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8TEO
 | | Shaker in low K+ (4mM K+) | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel protein Shaker | | Authors: | Tan, X, Swartz, K.J. | | Deposit date: | 2023-07-06 | | Release date: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (2.39 Å) | | Cite: | Eukaryotic Kv channel Shaker inactivates through selectivity filter dilation rather than collapse.
Sci Adv, 9, 2023
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7UKC
 | | Human Kv4.2-KChIP2 channel complex in an inactivated state, class 1, transmembrane region | | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2 | | Authors: | Zhao, H, Dai, Y, Lee, C.H. | | Deposit date: | 2022-04-01 | | Release date: | 2022-06-29 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
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7UKH
 | | Human Kv4.2-KChIP2-DPP6 channel complex in an open state, intracellular region | | Descriptor: | CALCIUM ION, Isoform 2 of Kv channel-interacting protein 2, Potassium voltage-gated channel subfamily D member 2, ... | | Authors: | Zhao, H, Dai, Y, Lee, C.H. | | Deposit date: | 2022-04-01 | | Release date: | 2022-06-29 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (2.33 Å) | | Cite: | Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
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7UKE
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7UKG
 | | Human Kv4.2-KChIP2-DPP6 channel complex in an open state, transmembrane region | | Descriptor: | Dipeptidyl-peptidase 6, POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2 | | Authors: | Zhao, H, Dai, Y, Lee, C.H. | | Deposit date: | 2022-04-01 | | Release date: | 2022-06-29 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (2.24 Å) | | Cite: | Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
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7UKD
 | | Human Kv4.2-KChIP2 channel complex in an inactivated state, class 2, transmembrane region | | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2 | | Authors: | Zhao, H, Dai, Y, Lee, C.H. | | Deposit date: | 2022-04-01 | | Release date: | 2022-06-29 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (2.88 Å) | | Cite: | Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
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7UK5
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7UKF
 | | Human Kv4.2-KChIP2 channel complex in a putative resting state, transmembrane region | | Descriptor: | MERCURY (II) ION, POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2 | | Authors: | Zhao, H, Dai, Y, Lee, C.H. | | Deposit date: | 2022-04-01 | | Release date: | 2022-06-29 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (3.02 Å) | | Cite: | Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
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8U7Z
 | | KCTD5/Cullin3/Gbeta1gamma2 Complex: Local Refinment of KCTD5(CTD)/Gbeta1gamma2 | | Descriptor: | BTB/POZ domain-containing protein KCTD5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | | Authors: | Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G. | | Deposit date: | 2023-09-15 | | Release date: | 2023-10-11 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (2.97 Å) | | Cite: | Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8U81
 | | KCTD5/Cullin3/Gbeta1gamma2 Complex: State A From Composite RELION Multi-body Refinement Map | | Descriptor: | BTB/POZ domain-containing protein KCTD5, Cullin-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G. | | Deposit date: | 2023-09-15 | | Release date: | 2023-10-11 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.82 Å) | | Cite: | Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8U82
 | | KCTD5/Cullin3/Gbeta1gamma2 Complex: State B From Composite RELION Multi-body Refinement Map | | Descriptor: | BTB/POZ domain-containing protein KCTD5, Cullin-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G. | | Deposit date: | 2023-09-15 | | Release date: | 2023-10-11 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.84 Å) | | Cite: | Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8U83
 | | KCTD5/Cullin3/Gbeta1gamma2 Complex: State C From Composite RELION Multi-body Refinement Map | | Descriptor: | BTB/POZ domain-containing protein KCTD5, Cullin-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G. | | Deposit date: | 2023-09-15 | | Release date: | 2023-10-11 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.975 Å) | | Cite: | Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8U80
 | | KCTD5/Cullin3/Gbeta1gamma2 Complex: Local Refinment of KCTD5(BTB)/Cullin3(NTD) | | Descriptor: | BTB/POZ domain-containing protein KCTD5, Cullin-3 | | Authors: | Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G. | | Deposit date: | 2023-09-15 | | Release date: | 2023-10-11 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex.
Proc.Natl.Acad.Sci.USA, 121, 2024
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