PDB: 220 resultsInfo pagesStatus searchChemie searchBIRD

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7F4E	Crystal structure of Hst2 in complex with H3K9bz peptide Descriptor: Histone H3, NAD-dependent protein deacetylase HST2, ZINC ION Authors: Wang, D, Yan, F, Chen, Y. Deposit date: 2021-06-18 Release date: 2022-03-16 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Global profiling of regulatory elements in the histone benzoylation pathway. Nat Commun, 13, 2022
7F51	Crystal structure of Hst2 in complex with 2'-O-Benzoyl ADP Ribose Descriptor: NAD-dependent protein deacetylase HST2, ZINC ION, [(2R,3R,4R,5R)-5-[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-2,4-bis(oxidanyl)oxolan-3-yl] benzoate Authors: Wang, D, Yan, F, Chen, Y. Deposit date: 2021-06-21 Release date: 2022-03-16 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Global profiling of regulatory elements in the histone benzoylation pathway. Nat Commun, 13, 2022
5YQO	Crystal structure of Sirt2 in complex with selective inhibitor L5C Descriptor: N-[4-[[3-[2-(4,6-dimethylpyrimidin-2-yl)sulfanylethanoylamino]phenyl]methoxy]phenyl]-1-methyl-pyrazole-4-carboxamide, NAD-dependent protein deacetylase sirtuin-2, ZINC ION Authors: Wang, H, Yu, Y, Li, G, Chen, Q. Deposit date: 2017-11-07 Release date: 2018-10-17 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.483 Å) Cite: X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. Eur J Med Chem, 155, 2018
5YQL	Crystal structure of Sirt2 in complex with selective inhibitor A2I Descriptor: 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[3-(phenoxymethyl)phenyl]ethanamide, BETA-MERCAPTOETHANOL, NAD-dependent protein deacetylase sirtuin-2, ... Authors: Wang, H, Yu, Y, Li, G, Chen, Q. Deposit date: 2017-11-07 Release date: 2018-10-17 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.601 Å) Cite: X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. Eur J Med Chem, 155, 2018
5YQM	Crystal structure of Sirt2 in complex with selective inhibitor A29 Descriptor: 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-(4-phenylsulfanylphenyl)ethanamide, BETA-MERCAPTOETHANOL, NAD-dependent protein deacetylase sirtuin-2, ... Authors: Wang, H, Yu, Y, Li, G, chen, Q. Deposit date: 2017-11-07 Release date: 2018-10-17 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (1.735 Å) Cite: X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. Eur J Med Chem, 155, 2018
5Z93	Crystal Structure of SIRT3 in complex with H3K9bhb peptide Descriptor: Gene for histone H3 (germline gene), NAD-dependent protein deacetylase sirtuin-3, mitochondrial, ... Authors: Zhang, X, Li, H. Deposit date: 2018-02-02 Release date: 2019-02-06 Method: X-RAY DIFFRACTION (1.945 Å) Cite: Crystal Structure of SIRT3 in complex with H3K9bhb peptide To Be Published
5D7Q	Crystal structure of human Sirt2 in complex with ADPR and CHIC35 Descriptor: (6S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide, NAD-dependent protein deacetylase sirtuin-2, ZINC ION, ... Authors: Rumpf, T, Gerhardt, S, Einsle, O, Jung, M. Deposit date: 2015-08-14 Release date: 2015-12-02 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking. Acta Crystallogr.,Sect.F, 71, 2015
3U31	Plasmodium falciparum Sir2A preferentially hydrolyzes medium and long chain fatty acyl lysine Descriptor: GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Transcriptional regulatory protein sir2 homologue, ... Authors: Zhou, Y, Hao, Q. Deposit date: 2011-10-04 Release date: 2011-11-09 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Plasmodium falciparum Sir2A Preferentially Hydrolyzes Medium and Long Chain Fatty Acyl Lysine Acs Chem.Biol., 2011
5Z94	Crystal Structure of SIRT3 in complex with H3K4bhb peptide Descriptor: CITRIC ACID, GLYCEROL, Gene for histone H3 (germline gene), ... Authors: Zhang, X, Li, H. Deposit date: 2018-02-02 Release date: 2019-02-06 Method: X-RAY DIFFRACTION (1.899 Å) Cite: Crystal Structure of SIRT3 in complex with H3K4bhb peptide To Be Published
6ACL	histone lysine desuccinylase Sirt5 in complex with succinyl peptide H2AK95 Descriptor: NAD-dependent protein deacylase sirtuin-5, mitochondrial, ZINC ION, ... Authors: Hang, T.R, Chen, W.B. Deposit date: 2018-07-26 Release date: 2019-07-24 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.92 Å) Cite: complex structure of histone lysine desuccinylase Sirt5 with succinyl peptide H2AK95 To Be Published
6ACP	histone lysine desuccinylase Sirt5 in complex with succinyl peptide H4K91 Descriptor: NAD-dependent protein deacylase sirtuin-5, mitochondrial, ZINC ION, ... Authors: Hang, T.R, Chen, W.B. Deposit date: 2018-07-26 Release date: 2019-07-24 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: complex structure of histone lysine desuccinylase Sirt5 with succinyl peptide H4K91 To Be Published
6ACE	histone lysine desuccinylase Sirt5 in complex with succinyl peptide H3K122 Descriptor: GLYCEROL, NAD-dependent protein deacylase sirtuin-5, mitochondrial, ... Authors: Hang, T.R, Chen, W.B. Deposit date: 2018-07-26 Release date: 2019-07-24 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.98 Å) Cite: complex structure of histone lysine desuccinylase Sirt5 with succinyl peptide H3K122 To Be Published
5ZGC	Crystal Structure of SIRT3 in complex with H4K16bhb peptide Descriptor: Histone H4K16bhb peptide, NAD-dependent protein deacetylase sirtuin-3, mitochondrial, ... Authors: Li, H, Zhang, X. Deposit date: 2018-03-08 Release date: 2019-04-03 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Crystal Structure of SIRT3 in complex with H4K16bhb peptide To be published
6ACO	histone lysine desuccinylase Sirt5 in complex with succinyl peptide H2BK120 Descriptor: CHLORIDE ION, GLYCEROL, NAD-dependent protein deacylase sirtuin-5, ... Authors: Hang, T.R, Chen, W.B. Deposit date: 2018-07-26 Release date: 2019-07-24 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.71 Å) Cite: complex structure of histone lysine desuccinylase Sirt5 with succinyl peptide H2BK120 To Be Published
3RIG	Sirt5 is an NAD-dependent protein lysine demalonylase and desuccinylase Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, NAD-dependent deacetylase sirtuin-5, ZINC ION, ... Authors: Zhou, Y. Deposit date: 2011-04-13 Release date: 2011-11-23 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2 Å) Cite: Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase Science, 334, 2011
3U3D	Plasmodium falciparum Sir2A preferentially hydrolyzes medium and long chain fatty acyl lysine Descriptor: GLYCEROL, Transcriptional regulatory protein sir2 homologue, ZINC ION, ... Authors: Zhou, Y, Hao, Q. Deposit date: 2011-10-05 Release date: 2011-11-09 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Plasmodium falciparum Sir2A Preferentially Hydrolyzes Medium and Long Chain Fatty Acyl Lysine Acs Chem.Biol., 2011
3PKI	Human SIRT6 crystal structure in complex with ADP ribose Descriptor: NAD-dependent deacetylase sirtuin-6, SULFATE ION, UNKNOWN ATOM OR ION, ... Authors: Pan, P.W, Dong, A, Qiu, W, Loppnau, P, Wang, J, Ravichandran, M, Bochkarev, A, Bountra, C, Weigelt, J, Arrowsmith, C.H, Min, J, Edwards, A.M, Structural Genomics Consortium (SGC) Deposit date: 2010-11-11 Release date: 2011-01-26 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Structure and biochemical functions of SIRT6. J.Biol.Chem., 286, 2011
3RIY	Sirt5 is an NAD-dependent protein lysine demalonylase and desuccinylase Descriptor: NAD-dependent deacetylase sirtuin-5, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ZINC ION, ... Authors: Zhou, Y, Hao, Q. Deposit date: 2011-04-14 Release date: 2011-11-23 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase Science, 334, 2011
5DY5	Crystal structure of human Sirt2 in complex with a SirReal probe fragment Descriptor: (R,R)-2,3-BUTANEDIOL, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Rumpf, T, Gerhardt, S, Einsle, O, Jung, M. Deposit date: 2015-09-24 Release date: 2016-01-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structure-Based Development of an Affinity Probe for Sirtuin 2. Angew.Chem.Int.Ed.Engl., 55, 2016
3PDH	Structure of Sir2Tm bound to a propionylated peptide Descriptor: Cellular tumor antigen p53 18-residue peptide, NAD-dependent deacetylase, ZINC ION Authors: Wolberger, C, Bheda, P. Deposit date: 2010-10-22 Release date: 2011-01-19 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure of Sir2Tm bound to a propionylated peptide. Protein Sci., 20, 2011
3PKJ	Human SIRT6 crystal structure in complex with 2'-N-Acetyl ADP ribose Descriptor: NAD-dependent deacetylase sirtuin-6, SULFATE ION, UNKNOWN ATOM OR ION, ... Authors: Pan, P.W, Dong, A, Qiu, W, Loppnau, P, Wang, J, Ravichandran, M, Walker, J.R, Bountra, C, Weigelt, J, Arrowsmith, C.H, Min, J, Edwards, A.M, Structural Genomics Consortium (SGC) Deposit date: 2010-11-11 Release date: 2011-01-26 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Structure and biochemical functions of SIRT6. J.Biol.Chem., 286, 2011
5D7P	Crystal structure of human Sirt2 in complex with ADPR and EX-243 Descriptor: (1S)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1- carboxamide, DI(HYDROXYETHYL)ETHER, NAD-dependent protein deacetylase sirtuin-2, ... Authors: Rumpf, T, Gerhardt, S, Einsle, O, Jung, M. Deposit date: 2015-08-14 Release date: 2015-12-02 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking. Acta Crystallogr.,Sect.F, 71, 2015
3ZGO	Re-refined structure of the human Sirt2 apoform Descriptor: 1,2-ETHANEDIOL, ETHANOL, HEXAETHYLENE GLYCOL, ... Authors: Moniot, S, Steegborn, C. Deposit date: 2012-12-18 Release date: 2013-03-20 Last modified: 2019-11-06 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Crystal Structure Analysis of Human Sirt2 and its Adp-Ribose Complex J.Struct.Biol., 182, 2013
5DY4	Crystal structure of human Sirt2 in complex with a brominated 2nd generation SirReal inhibitor and NAD+ Descriptor: N-{5-[(7-bromonaphthalen-1-yl)methyl]-1,3-thiazol-2-yl}-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamide, NAD-dependent protein deacetylase sirtuin-2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... Authors: Rumpf, T, Gerhardt, S, Einsle, O, Jung, M. Deposit date: 2015-09-24 Release date: 2016-01-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study. J.Med.Chem., 59, 2016
3ZG6	The novel de-long chain fatty acid function of human sirt6 Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, GLYCEROL, NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-6, ... Authors: Wang, Y, Hao, Q. Deposit date: 2012-12-15 Release date: 2013-04-03 Last modified: 2013-04-17 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Sirt6 Regulates Tnf-Alpha Secretion Through Hydrolysis of Long-Chain Fatty Acyl Lysine Nature, 496, 2013

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