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5Y1K	Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-(3-(2-chlorobenzyl)ureido)-N-hydroxy-4-methylpentanamide Descriptor: (2S)-2-[(2-chlorophenyl)methylcarbamoylamino]-4-methyl-N-oxidanyl-pentanamide, GLYCEROL, M1 family aminopeptidase, ... Authors: Marapaka, A.K, Zhang, Y, Addlagatta, A. Deposit date: 2017-07-20 Release date: 2018-08-01 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Development of peptidomimetic hydroxamates as PfA-M1 and PfA-M17 dual inhibitors: Biological evaluation and structural characterization by cocrystallization Chin.Chem.Lett., 33, 2022
5Y3I	Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-N-hydroxy-4-methyl-2-(3-(3-methylbenzyl)ureido)pentanamide Descriptor: (2R)-4-methyl-2-[(3-methylphenyl)methylcarbamoylamino]-N-oxidanyl-pentanamide, GLYCEROL, M1 family aminopeptidase, ... Authors: Marapaka, A.K, Zhang, Y, Addlagatta, A. Deposit date: 2017-07-28 Release date: 2018-08-08 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-N-hydroxy-4-methyl-2-(3-(3-methylbenzyl)ureido)pentanamide To Be Published
5YQB	Crystal structure of E.coli aminopeptidase N in complex with Puromycin Descriptor: (2R,3R,4S,5S)-4-AMINO-2-[6-(DIMETHYLAMINO)-9H-PURIN-9-YL]-5-(HYDROXYMETHYL)TETRAHYDRO-3-FURANOL, Aminopeptidase N, GLYCEROL, ... Authors: Marapaka, A.K, Ganji, R.J, Reddi, R, Addlagatta, A. Deposit date: 2017-11-06 Release date: 2018-11-14 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Puromycin, a selective inhibitor of PSA acts as a substrate for other M1 family aminopeptidases: Biochemical and structural basis Int.J.Biol.Macromol., 165, 2020
5Y1Q	Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-(3-(3-chlorobenzyl)ureido)-N-hydroxy-4-methylpentanamide Descriptor: (2S)-2-[(3-chlorophenyl)methylcarbamoylamino]-4-methyl-N-oxidanyl-pentanamide, M1 family aminopeptidase, MAGNESIUM ION, ... Authors: Marapaka, A.K, Zhang, Y, Addlagatta, A. Deposit date: 2017-07-21 Release date: 2018-08-01 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Development of peptidomimetic hydroxamates as PfA-M1 and PfA-M17 dual inhibitors: Biological evaluation and structural characterization by cocrystallization Chin.Chem.Lett., 33, 2022
5Y1S	Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-(3-(3,4-dimethylbenzyl)ureido)-N-hydroxy-4-methylpentanamide Descriptor: (2R)-2-[(3,4-dimethylphenyl)methylcarbamoylamino]-4-methyl-N-oxidanyl-pentanamide, (2S)-2-[(3,4-dimethylphenyl)methylcarbamoylamino]-4-methyl-N-oxidanyl-pentanamide, GLYCEROL, ... Authors: Marapaka, A.K, Zhang, Y, Addlagatta, A. Deposit date: 2017-07-21 Release date: 2018-08-01 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.66 Å) Cite: Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-(3-(3,4-dimethylbenzyl)ureido)-N-hydroxy-4-methylpentanamide To Be Published
5Y1V	Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-(3-(2,6-diethylphenyl)ureido)- N-hydroxy-4-methylpentanamide Descriptor: (2R)-2-[(2,6-diethylphenyl)carbamoylamino]-4-methyl-N-oxidanyl-pentanamide, GLYCEROL, M1 family aminopeptidase, ... Authors: Marapaka, A.K, Zhang, Y, Addlagatta, A. Deposit date: 2017-07-21 Release date: 2018-08-01 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.62 Å) Cite: Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-(3-(2,6-diethylphenyl)ureido)- N-hydroxy-4-methylpentanamide To Be Published
5YO1	Structure of ePepN E298A mutant in complex with Puromycin Descriptor: Aminopeptidase N, GLYCEROL, PUROMYCIN, ... Authors: Ganji, R.J, Reddi, R, Marapaka, A.K, Addlagatta, A. Deposit date: 2017-10-26 Release date: 2018-11-07 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Puromycin, a selective inhibitor of PSA acts as a substrate for other M1 family aminopeptidases: Biochemical and structural basis Int.J.Biol.Macromol., 165, 2020
5Y19	Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-((2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido)- N-hydroxy-4-methylpentanamide. Descriptor: (2S)-2-[[(2S,3R)-3-azanyl-2-oxidanyl-4-phenyl-butanoyl]amino]-4-methyl-N-oxidanyl-pentanamide, GLYCEROL, M1 family aminopeptidase, ... Authors: Marapaka, A.K, Zhang, Y, Addlagatta, A. Deposit date: 2017-07-19 Release date: 2018-08-01 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-((2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido)- N-hydroxy-4-methylpentanamide. To Be Published
5Y1W	Crystal structure of Plasmodium falciparum aminopeptidase N with Magnesium bound to active site Zinc Descriptor: GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ... Authors: Marapaka, A.K, Addlagatta, A. Deposit date: 2017-07-21 Release date: 2018-08-01 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Crystal structure of Plasmodium falciparum aminopeptidase N with Magnesium bound to active site Zinc To Be Published
5Y1X	Crystal structure of Plasmodium falciparum aminopeptidase N in complex with actinonin Descriptor: ACTINONIN, GLYCEROL, M1 family aminopeptidase, ... Authors: Marapaka, A.K, Addlagatta, A. Deposit date: 2017-07-21 Release date: 2018-08-01 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Crystal structure of Plasmodium falciparum aminopeptidase N in complex with actinonin To Be Published
4J3B	A naturally variable residue in the S1 subsite of M1-family aminopeptidases modulates catalytic properties and promotes functional specialization Descriptor: ARGININE, M1 family aminopeptidase, MAGNESIUM ION, ... Authors: Dalal, S, Ragheb, D.R.T, Schubot, F.D, Klemba, M. Deposit date: 2013-02-05 Release date: 2013-08-07 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: A naturally variable residue in the s1 subsite of m1 family aminopeptidases modulates catalytic properties and promotes functional specialization. J.Biol.Chem., 288, 2013
4Z7I	Crystal structure of insulin regulated aminopeptidase in complex with ligand Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DG025 transition-state analogue enzyme inhibitor, ... Authors: Mpakali, A, Saridakis, E, Harlos, K, Zhao, Y, Stratikos, E. Deposit date: 2015-04-07 Release date: 2015-08-26 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.31 Å) Cite: Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing. J Immunol., 195, 2015
4K5P	Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum Descriptor: GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ... Authors: McGowan, S. Deposit date: 2013-04-15 Release date: 2013-06-12 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56, 2013
4ZW5	X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9f Descriptor: M1 family aminopeptidase, MAGNESIUM ION, ZINC ION, ... Authors: Drinkwater, N, McGowan, S. Deposit date: 2015-05-19 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016
4ZX5	X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10q Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ... Authors: Drinkwater, N, McGowan, S. Deposit date: 2015-05-20 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016
4ZW6	X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9q Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ... Authors: Drinkwater, N, McGowan, S. Deposit date: 2015-05-19 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016
4ZW3	X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9b Descriptor: GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ... Authors: Drinkwater, N, McGowan, S. Deposit date: 2015-05-19 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016
4ZX4	X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10o Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ... Authors: Drinkwater, N, McGowan, S. Deposit date: 2015-05-20 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016
4K5M	Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum Descriptor: GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ... Authors: McGowan, S. Deposit date: 2013-04-14 Release date: 2013-06-12 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56, 2013
4K5L	Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum Descriptor: M1 family aminopeptidase, MAGNESIUM ION, ZINC ION, ... Authors: McGowan, S. Deposit date: 2013-04-14 Release date: 2013-06-12 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56, 2013
4K5O	Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum Descriptor: GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ... Authors: McGowan, S. Deposit date: 2013-04-15 Release date: 2013-06-12 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56, 2013
4KX8	Crystal structure of human aminopeptidase A complexed with amastatin Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Yang, Y, Liu, C, Lin, Y.Y, Li, F. Deposit date: 2013-05-24 Release date: 2013-07-31 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural insights into central hypertension regulation by human aminopeptidase a. J.Biol.Chem., 288, 2013
4KXB	Crystal structure of human aminopeptidase A complexed with bestatin Descriptor: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Yang, Y, Liu, C, Lin, Y.Y, Li, F. Deposit date: 2013-05-24 Release date: 2013-07-31 Last modified: 2022-12-21 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural insights into central hypertension regulation by human aminopeptidase a. J.Biol.Chem., 288, 2013
5AEN	Structure of human Leukotriene A4 hydrolase in complex with inhibitor dimethyl(2- (4-phenoxyphenoxy)ethyl)amine Descriptor: IMIDAZOLE, LEUKOTRIENE A-4 HYDROLASE, N,N-dimethyl-2-(4-phenoxyphenoxy)ethanamine, ... Authors: Moser, D, Wittmann, S.K, Kramer, J, Blocher, R, Achenbach, J, Pogoryelov, D, Proschak, E. Deposit date: 2015-01-06 Release date: 2015-02-11 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.864 Å) Cite: Peng: A Neural Gas-Based Approach for Pharmacophore Elucidation. Method Design, Validation and Virtual Screening for Novel Ligands of Lta4H. J.Chem.Inf.Model., 55, 2015
4K5N	Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum Descriptor: GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ... Authors: McGowan, S. Deposit date: 2013-04-15 Release date: 2013-06-12 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56, 2013

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