Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

8ADV
DownloadVisualize
BU of 8adv by Molmil
Lipidic alpha-synuclein fibril - polymorph L1B
Descriptor: Alpha-synuclein
Authors:Frieg, B, Antonschmidt, L, Dienemann, C, Geraets, J.A, Najbauer, E.E, Matthes, D, de Groot, B.L, Andreas, L.B, Becker, S, Griesinger, C, Schroeder, G.F.
Deposit date:2022-07-11
Release date:2022-10-12
Last modified:2022-11-23
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:The 3D structure of lipidic fibrils of alpha-synuclein.
Nat Commun, 13, 2022
8ADS
DownloadVisualize
BU of 8ads by Molmil
Lipidic alpha-synuclein fibril - polymorph L2B
Descriptor: Alpha-synuclein
Authors:Frieg, B, Antonschmidt, L, Dienemann, C, Geraets, J.A, Najbauer, E.E, Matthes, D, de Groot, B.L, Andreas, L.B, Becker, S, Griesinger, C, Schroeder, G.F.
Deposit date:2022-07-11
Release date:2022-10-12
Last modified:2022-11-23
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:The 3D structure of lipidic fibrils of alpha-synuclein.
Nat Commun, 13, 2022
8AEX
DownloadVisualize
BU of 8aex by Molmil
Lipidic alpha-synuclein fibril - polymorph L3A
Descriptor: Alpha-synuclein
Authors:Frieg, B, Antonschmidt, L, Dienemann, C, Geraets, J.A, Najbauer, E.E, Matthes, D, de Groot, B.L, Andreas, L.B, Becker, S, Griesinger, C, Schroeder, G.F.
Deposit date:2022-07-14
Release date:2022-10-12
Last modified:2022-11-23
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:The 3D structure of lipidic fibrils of alpha-synuclein.
Nat Commun, 13, 2022
8ADU
DownloadVisualize
BU of 8adu by Molmil
Lipidic alpha-synuclein fibril - polymorph L1A
Descriptor: Alpha-synuclein
Authors:Frieg, B, Antonschmidt, L, Dienemann, C, Geraets, J.A, Najbauer, E.E, Matthes, D, de Groot, B.L, Andreas, L.B, Becker, S, Griesinger, C, Schroeder, G.F.
Deposit date:2022-07-11
Release date:2022-10-12
Last modified:2022-11-23
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:The 3D structure of lipidic fibrils of alpha-synuclein.
Nat Commun, 13, 2022
8ADW
DownloadVisualize
BU of 8adw by Molmil
Lipidic alpha-synuclein fibril - polymorph L1C
Descriptor: Alpha-synuclein
Authors:Frieg, B, Antonschmidt, L, Dienemann, C, Geraets, J.A, Najbauer, E.E, Matthes, D, de Groot, B.L, Andreas, L.B, Becker, S, Griesinger, C, Schroeder, G.F.
Deposit date:2022-07-11
Release date:2022-10-12
Last modified:2022-11-23
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:The 3D structure of lipidic fibrils of alpha-synuclein.
Nat Commun, 13, 2022
8BQV
DownloadVisualize
BU of 8bqv by Molmil
Cryo-EM structure of alpha-synuclein singlet filament from Juvenile-onset synucleinopathy
Descriptor: Alpha-synuclein, Unknown protein
Authors:Yang, Y, Garringer, J.H, Shi, Y, Lovestam, S, Peak-Chew, S.Y, Zhang, X.J, Kotecha, A, Bacioglu, M, Koto, A, Takao, M, Spillantini, G.M, Ghetti, B, Vidal, R, Murzin, G.A, Scheres, H.W.S, Goedert, M.
Deposit date:2023-01-18
Release date:2023-02-22
Last modified:2023-05-03
Method:ELECTRON MICROSCOPY (2 Å)
Cite:New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy.
Acta Neuropathol, 145, 2023
8BQW
DownloadVisualize
BU of 8bqw by Molmil
Cryo-EM structure of alpha-synuclein filaments doublet from Juvenile-onset synucleinopathy
Descriptor: Alpha-synuclein, Unknown protein
Authors:Yang, Y, Garringer, J.H, Shi, Y, Lovestam, S, Peak-Chew, S.Y, Zhang, X.J, Kotecha, A, Bacioglu, M, Koto, A, Takao, M, Spillantini, G.M, Ghetti, B, Vidal, R, Murzin, G.A, Scheres, H.W.S, Goedert, M.
Deposit date:2023-01-18
Release date:2023-02-22
Last modified:2023-05-03
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy.
Acta Neuropathol, 145, 2023
7UAK
DownloadVisualize
BU of 7uak by Molmil
Structure of recombinantly assembled A53E alpha-synuclein fibrils
Descriptor: Alpha-synuclein
Authors:Zhou, K, Zhou, H.
Deposit date:2022-03-13
Release date:2023-03-29
Last modified:2023-04-12
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Cryo-EM structure of amyloid fibril formed by alpha-synuclein hereditary A53E mutation reveals a distinct protofilament interface.
J.Biol.Chem., 299, 2023
7V48
DownloadVisualize
BU of 7v48 by Molmil
Type 1D alpha-synuclein fibril seeded by cerebrospinal fluid from a postmortal Parkinson's disease patient
Descriptor: Alpha-synuclein
Authors:Fan, Y, Sun, Y.P, Wang, J, Liu, C.
Deposit date:2021-08-12
Release date:2022-08-17
Last modified:2023-01-25
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease.
Structure, 31, 2023
7V4A
DownloadVisualize
BU of 7v4a by Molmil
Heparin-induced alpha-synuclein fibrils polymorph 1
Descriptor: Alpha-synuclein
Authors:Tao, Y.Q, Sun, Y.P, Liu, C, Li, D.
Deposit date:2021-08-12
Release date:2022-08-17
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Heparin-induced alpha-synuclein fibrils polymorph 1
To Be Published
7V47
DownloadVisualize
BU of 7v47 by Molmil
Type 1A alpha-synuclein fibril seeded by cerebrospinal fluid from a preclinical Parkinson's disease patient
Descriptor: Alpha-synuclein
Authors:Fan, Y, Sun, Y.P, Wang, J, Liu, C.
Deposit date:2021-08-12
Release date:2022-08-17
Last modified:2023-01-25
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease.
Structure, 31, 2023
7V4B
DownloadVisualize
BU of 7v4b by Molmil
Heparin-induced alpha-synuclein fibrils polymorph 3
Descriptor: Alpha-synuclein
Authors:Tao, Y.Q, Sun, Y.P, Liu, C, Li, D.
Deposit date:2021-08-12
Release date:2022-08-17
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Heparin-induced alpha-synuclein fibrils polymorph 3
To Be Published
7V4C
DownloadVisualize
BU of 7v4c by Molmil
Heparin-induced alpha-synuclein fibrils polymorph 4
Descriptor: Alpha-synuclein
Authors:Tao, Y.Q, Sun, Y.P, Liu, C, Li, D.
Deposit date:2021-08-12
Release date:2022-08-17
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Heparin-induced alpha-synuclein fibrils polymorph 4
To Be Published
7V49
DownloadVisualize
BU of 7v49 by Molmil
Type 4 alpha-synuclein fibril seeded by cerebrospinal fluid from a postmortal Parkinson's disease patient
Descriptor: Alpha-synuclein
Authors:Fan, Y, Sun, Y.P, Wang, J, Liu, C.
Deposit date:2021-08-12
Release date:2022-08-17
Last modified:2023-01-25
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease.
Structure, 31, 2023
7V4D
DownloadVisualize
BU of 7v4d by Molmil
Heparin-remodelled alpha-synuclein fibrils
Descriptor: Alpha-synuclein
Authors:Tao, Y.Q, Sun, Y.P, Xia, W.C, Zhao, Q.Y, Liu, C, Li, D.
Deposit date:2021-08-12
Release date:2022-08-17
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Heparin-remodelled alpha-synuclein fibrils
To Be Published
7WO0
DownloadVisualize
BU of 7wo0 by Molmil
CryoEM structure of human alpha-synuclein A53T fibril induced by calcium ions
Descriptor: Alpha-synuclein
Authors:Wu, K.-P, Huang, J.Y.-C.
Deposit date:2022-01-20
Release date:2023-01-25
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Calcium abolishes intramolecular long-range contacts and promotes hereditary alpha-synuclein A53T aggregation
To Be Published
7WMM
DownloadVisualize
BU of 7wmm by Molmil
alpha-synuclein fibril-F0502B complex
Descriptor: 2-bromanyl-4-[(~{E})-2-[6-[2-(2-fluoranylethoxy)ethyl-methyl-amino]-5-methyl-1,3-benzothiazol-2-yl]ethenyl]phenol, Alpha-synuclein
Authors:Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D.
Deposit date:2022-01-15
Release date:2023-01-18
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:alpha-synuclein fibril-F0502B complex
To Be Published
7WNZ
DownloadVisualize
BU of 7wnz by Molmil
CryoEM structure of human alpha-synuclein A53T fibril
Descriptor: Alpha-synuclein
Authors:Wu, K.-P, Huang, J.Y.-C.
Deposit date:2022-01-20
Release date:2023-01-25
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Calcium abolishes intramolecular long-range contacts and promotes hereditary alpha-synuclein A53T aggregation
To Be Published
7XO1
DownloadVisualize
BU of 7xo1 by Molmil
Major polymorph in alpha-synuclein fibril seeded by cerebrospinal fluid from a mid-to-late stage (mid-PD-1) Parkinson's disease patient
Descriptor: Alpha-synuclein
Authors:Fan, Y, Sun, Y.P, Wang, J, Liu, C.
Deposit date:2022-04-30
Release date:2022-11-30
Last modified:2023-01-25
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease.
Structure, 31, 2023
7XO3
DownloadVisualize
BU of 7xo3 by Molmil
Type 1C alpha-synuclein fibril seeded by cerebrospinal fluid from a mid-to-late stage (mid-PD-4) Parkinson's disease patient
Descriptor: Alpha-synuclein
Authors:Fan, Y, Sun, Y.P, Wang, J, Liu, C.
Deposit date:2022-04-30
Release date:2022-11-30
Last modified:2023-01-25
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease.
Structure, 31, 2023
7XO0
DownloadVisualize
BU of 7xo0 by Molmil
Minor polymorph inalpha-synuclein fibril seeded by cerebrospinal fluid from a mid-to-late stage (mid-PD-1) Parkinson's disease patient
Descriptor: Alpha-synuclein
Authors:Fan, Y, Sun, Y.P, Wang, J, Liu, C.
Deposit date:2022-04-30
Release date:2022-11-30
Last modified:2023-01-25
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease.
Structure, 31, 2023
7XO2
DownloadVisualize
BU of 7xo2 by Molmil
Minor polymorph in alpha-synuclein fibril seeded by cerebrospinal fluid from a mid-to-late stage (mid-PD-4) Parkinson's disease patient
Descriptor: Alpha-synuclein
Authors:Fan, Y, Sun, Y.P, Wang, J, Liu, C.
Deposit date:2022-04-30
Release date:2022-11-30
Last modified:2023-01-25
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease.
Structure, 31, 2023
7XJX
DownloadVisualize
BU of 7xjx by Molmil
The cryo-EM structure of Fe3+ induced alpha-syn fibril.
Descriptor: Alpha-synuclein
Authors:Zhao, Q.Y, Tao, Y.Q, Zhao, K, Tao, Y.Q, Li, D.
Deposit date:2022-04-18
Release date:2023-01-18
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural Insights of Fe3+ Induced alpha-synuclein Fibrillation in Parkinson' Disease
J.Mol.Biol., 435, 2023
7YK2
DownloadVisualize
BU of 7yk2 by Molmil
Cryo-EM structure of Apo-alpha-syn fibril
Descriptor: Alpha-synuclein
Authors:Xu, Q.H, Xia, W.C, Tao, Y.Q, Liu, C.
Deposit date:2022-07-21
Release date:2023-03-22
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Conformational Dynamics of an alpha-Synuclein Fibril upon Receptor Binding Revealed by Insensitive Nuclei Enhanced by Polarization Transfer-Based Solid-State Nuclear Magnetic Resonance and Cryo-Electron Microscopy.
J.Am.Chem.Soc., 145, 2023
7YK8
DownloadVisualize
BU of 7yk8 by Molmil
Cryo-EM structure of dLAG3-alpha-syn fibril
Descriptor: Alpha-synuclein
Authors:Xu, Q.H, Xia, W.C, Tao, Y.Q, Liu, C.
Deposit date:2022-07-22
Release date:2023-03-22
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Conformational Dynamics of an alpha-Synuclein Fibril upon Receptor Binding Revealed by Insensitive Nuclei Enhanced by Polarization Transfer-Based Solid-State Nuclear Magnetic Resonance and Cryo-Electron Microscopy.
J.Am.Chem.Soc., 145, 2023

220113

數據於2024-05-22公開中

PDB statisticsPDBj update infoContact PDBjnumon