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5JUB
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BU of 5jub by Molmil
Crystal structure of ComR from S.thermophilus in complex with DNA and its signalling peptide ComS.
Descriptor: ComS, Transcriptional regulator, pComX-for, ...
Authors:Talagas, A, Fontaine, L, Ledesma-Garcia, L, Li de la Sierra-Gallay, I, Hols, P, Nessler, S.
Deposit date:2016-05-10
Release date:2016-10-26
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Structural Insights into Streptococcal Competence Regulation by the Cell-to-Cell Communication System ComRS.
PLoS Pathog., 12, 2016
5JUF
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BU of 5juf by Molmil
Crystal structure of the apo form of ComR from S. thermophilus.
Descriptor: SULFATE ION, Transcriptional regulator
Authors:Talagas, A, Fontaine, L, Ledesma, L, Li de la Sierra-Gallay, I, Hols, P, Nessler, S.
Deposit date:2016-05-10
Release date:2016-10-26
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (1.946 Å)
Cite:Structural Insights into Streptococcal Competence Regulation by the Cell-to-Cell Communication System ComRS.
PLoS Pathog., 12, 2016
5K98
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BU of 5k98 by Molmil
Structure of HipA-HipB-O2-O3 complex
Descriptor: Antitoxin HipB, DNA (5'-D(*CP*TP*AP*TP*CP*CP*CP*CP*TP*TP*AP*AP*GP*GP*GP*GP*AP*TP*AP*GP*GP*GP*A)-3'), DNA (5'-D(*TP*CP*CP*CP*TP*AP*TP*CP*CP*CP*CP*TP*TP*AP*AP*GP*GP*GP*GP*AP*TP*AP*G)-3'), ...
Authors:Schumacher, M.
Deposit date:2016-05-31
Release date:2016-06-22
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.99 Å)
Cite:HipBA-promoter structures reveal the basis of heritable multidrug tolerance.
Nature, 524, 2015
6TRI
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BU of 6tri by Molmil
CI-MOR repressor-antirepressor complex of the temperate bacteriophage TP901-1 from Lactococcus lactis
Descriptor: CI, MOR, SULFATE ION
Authors:Rasmussen, K.K, Blackledge, M, Herrmann, T, Jensen, M.R, Lo Leggio, L.
Deposit date:2019-12-18
Release date:2020-08-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.277 Å)
Cite:Revealing the mechanism of repressor inactivation during switching of a temperate bacteriophage.
Proc.Natl.Acad.Sci.USA, 117, 2020
6U0I
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BU of 6u0i by Molmil
Putative Antitoxin HicB3 from Escherichia coli str. K-12 substr. DH10B
Descriptor: Antitoxin HicB, CHLORIDE ION
Authors:Osipiuk, J, Tesar, C, Endres, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2019-08-14
Release date:2019-08-28
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Putative Antitoxin HicB3 from Escherichia coli str. K-12 substr. DH10B
to be published
6F8S
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BU of 6f8s by Molmil
Toxin-Antitoxin complex GraTA
Descriptor: DI(HYDROXYETHYL)ETHER, Putative Killer protein, SULFATE ION, ...
Authors:Talavera, A, Loris, R.
Deposit date:2017-12-13
Release date:2018-07-11
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT.
Nat Commun, 10, 2019
6W1A
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BU of 6w1a by Molmil
Crystal structure of Streptococcus dysgalactiae SHP pheromone receptor Rgg2 bound to DNA
Descriptor: DNA (30-MER), GLYCEROL, PHOSPHATE ION, ...
Authors:Capodagli, G.C, Neiditch, M.B.
Deposit date:2020-03-03
Release date:2020-10-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-function studies of Rgg binding to pheromones and target promoters reveal a model of transcription factor interplay.
Proc.Natl.Acad.Sci.USA, 117, 2020
5W4M
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BU of 5w4m by Molmil
Crystal structure of Streptococcus dysgalactiae SHP pheromone receptor Rgg2(C45S)
Descriptor: CHLORIDE ION, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Capodagli, G.C, Neiditch, M.B.
Deposit date:2017-06-12
Release date:2017-10-25
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.388 Å)
Cite:Activating mutations in quorum-sensing regulator Rgg2 and its conformational flexibility in the absence of an intermolecular disulfide bond.
J. Biol. Chem., 292, 2017
5W4N
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BU of 5w4n by Molmil
Crystal structure of Streptococcus dysgalactiae SHP pheromone receptor Rgg2(C45S)
Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, Transcriptional regulator
Authors:Neiditch, M.B, Khataokar, A.A, Capodagli, G.C.
Deposit date:2017-06-12
Release date:2017-10-25
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.198 Å)
Cite:Activating mutations in quorum-sensing regulator Rgg2 and its conformational flexibility in the absence of an intermolecular disulfide bond.
J. Biol. Chem., 292, 2017
6QER
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BU of 6qer by Molmil
Apo Form Of ComR From S. Thermophilus in space group C2
Descriptor: Transcriptional regulator
Authors:Thuillier, J, Nessler, S.
Deposit date:2019-01-08
Release date:2019-02-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.465 Å)
Cite:Molecular dissection of pheromone selectivity in the competence signaling system ComRS of streptococci.
Proc.Natl.Acad.Sci.USA, 117, 2020
4FSC
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BU of 4fsc by Molmil
Crystal Structure of Bacillus thuringiensis PlcR in its apo form
Descriptor: Transcriptional activator PlcR protein
Authors:Grenha, R, Slamti, L, Bouillaut, L, Lereclus, D, Nessler, S.
Deposit date:2012-06-27
Release date:2013-03-13
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:Structural basis for the activation mechanism of the PlcR virulence regulator by the quorum-sensing signal peptide PapR.
Proc.Natl.Acad.Sci.USA, 110, 2013
6KML
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BU of 6kml by Molmil
2.09 Angstrom resolution crystal structure of tetrameric HigBA toxin-antitoxin complex from E.coli
Descriptor: Antitoxin HigA, mRNA interferase toxin HigB
Authors:Jadhav, P, Sinha, V.K, Rothweiler, U, Singh, M.
Deposit date:2019-07-31
Release date:2020-11-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.095 Å)
Cite:2.09 angstrom Resolution structure of E. coli HigBA toxin-antitoxin complex reveals an ordered DNA-binding domain and intrinsic dynamics in antitoxin.
Biochem.J., 477, 2020
6KMQ
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BU of 6kmq by Molmil
2.3 Angstrom resolution structure of dimeric HigBA toxin-antitoxin complex from E. coli
Descriptor: Antitoxin HigA, mRNA interferase toxin HigB
Authors:Jadhav, P, Sinha, V.K, Rothweiler, U, Singh, M.
Deposit date:2019-07-31
Release date:2020-11-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:2.09 angstrom Resolution structure of E. coli HigBA toxin-antitoxin complex reveals an ordered DNA-binding domain and intrinsic dynamics in antitoxin.
Biochem.J., 477, 2020
7JVT
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BU of 7jvt by Molmil
Crystal structure of a lambda-186 hybrid repressor
Descriptor: OL1 bottom, OL1 top, Repressor protein CI
Authors:Truong, J.Q, Bruning, J.B, Shearwin, K.E.
Deposit date:2020-08-23
Release date:2021-09-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:Crystal structure of a hybrid lambda-186 repressor
To Be Published
3IVP
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BU of 3ivp by Molmil
The structure of a possible transposon-related DNA-binding protein from Clostridium difficile 630.
Descriptor: Putative transposon-related DNA-binding protein, TETRAETHYLENE GLYCOL
Authors:Tan, K, Marshall, N, Jedrzejczak, R, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2009-09-01
Release date:2009-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:The structure of a possible transposon-related DNA-binding protein from Clostridium difficile 630.
To be Published
5YCL
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BU of 5ycl by Molmil
Crystal structure of HigBA complex from Shigella flexneri
Descriptor: Antitoxin HigA, mRNA interferase HigB
Authors:Youn, W.S, Seok, S.H, Seo, M.D.
Deposit date:2017-09-07
Release date:2018-09-19
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (3.101 Å)
Cite:Structural changes of antitoxin HigA from Shigella flexneri by binding of its cognate toxin HigB.
Int.J.Biol.Macromol., 130, 2019
4PU3
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BU of 4pu3 by Molmil
Shewanella oneidensis MR-1 Toxin Antitoxin System HipA, HipB and its operator DNA complex (space group P212121)
Descriptor: Operator DNA, Toxin-antitoxin system antidote transcriptional repressor Xre family, Toxin-antitoxin system toxin HipA family
Authors:Wen, Y, Behiels, E, Felix, J, Elegheert, J, Vergauwen, B, Devreese, B, Savvides, S.
Deposit date:2014-03-12
Release date:2014-08-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.39 Å)
Cite:The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Nucleic Acids Res., 42, 2014
4PU4
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BU of 4pu4 by Molmil
Shewanella oneidensis MR-1 Toxin Antitoxin System HipA, HipB and its operator DNA complex (space group P21)
Descriptor: Operator DNA, Toxin-antitoxin system antidote transcriptional repressor Xre family, Toxin-antitoxin system toxin HipA family
Authors:Wen, Y, Behiels, E, Felix, J, Elegheert, J, Vergauwen, B, Devreese, B, Savvides, S.
Deposit date:2014-03-12
Release date:2014-08-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.786 Å)
Cite:The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Nucleic Acids Res., 42, 2014
6AF4
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BU of 6af4 by Molmil
Toxin-Antitoxin module from Streptococcus pneumoniae
Descriptor: HigA antitoxin, HigB toxin
Authors:Kang, S.M, Kim, D.H, Jin, C.
Deposit date:2018-08-08
Release date:2019-08-14
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Toxin-Antitoxin module from Streptococcus pneumoniae
To Be Published
6AF3
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BU of 6af3 by Molmil
Toxin-Antitoxin module from Streptococcus pneumoniae
Descriptor: HigA antitoxin, HigB toxin
Authors:Kang, S.M, Kim, D.H, Jin, C.
Deposit date:2018-08-08
Release date:2019-08-14
Method:X-RAY DIFFRACTION (2.803 Å)
Cite:Toxin-Antitoxin module from Streptococcus pneumoniae
To Be Published
4RYK
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BU of 4ryk by Molmil
Crystal structure of a putative transcriptional regulator from Listeria monocytogenes EGD-e
Descriptor: DI(HYDROXYETHYL)ETHER, L(+)-TARTARIC ACID, Lmo0325 protein, ...
Authors:Filippova, E.V, Wawrzak, Z, Minasov, G, Kiryukhina, O, Jedrzejczak, R, Joachimiak, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG)
Deposit date:2014-12-15
Release date:2015-01-07
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Crystal structure of a putative transcriptional regulator from Listeria monocytogenes EGD-e
To be Published
4YV6
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BU of 4yv6 by Molmil
X-ray crystal structure of Streptococcus dysgalactiae SHP pheromone receptor Rgg2
Descriptor: SULFATE ION, Transcriptional regulator
Authors:Neiditch, M.B, Parashar, V.
Deposit date:2015-03-19
Release date:2015-04-08
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.053 Å)
Cite:Rgg protein structure-function and inhibition by cyclic peptide compounds.
Proc.Natl.Acad.Sci.USA, 112, 2015
3U3W
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BU of 3u3w by Molmil
Crystal Structure of Bacillus thuringiensis PlcR in complex with the peptide PapR7 and DNA
Descriptor: 5'-D(P*AP*TP*AP*TP*GP*AP*AP*AP*TP*AP*TP*TP*GP*CP*AP*TP*AP*G)-3', 5'-D(P*CP*TP*AP*TP*GP*CP*AP*AP*TP*AP*TP*TP*TP*CP*AP*TP*AP*T)-3', C-terminus heptapeptide from PapR protein, ...
Authors:Grenha, R, Slamti, L, Bouillaut, L, Lereclus, D, Nessler, S.
Deposit date:2011-10-06
Release date:2013-01-09
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for the activation mechanism of the PlcR virulence regulator by the quorum-sensing signal peptide PapR.
Proc.Natl.Acad.Sci.USA, 110, 2013
2P5T
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BU of 2p5t by Molmil
Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin system of the human pathogen Streptococcus pneumoniae
Descriptor: PezT, Putative transcriptional regulator PezA, fragment of PezA helix-turn-helix motif
Authors:Loll, B, Meinhart, A.
Deposit date:2007-03-16
Release date:2007-05-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Molecular and Structural Characterization of the PezAT Chromosomal Toxin-Antitoxin System of the Human Pathogen Streptococcus pneumoniae.
J.Biol.Chem., 282, 2007
2QFC
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BU of 2qfc by Molmil
Crystal Structure of Bacillus thuringiensis PlcR complexed with PapR
Descriptor: C-terminus pentapeptide from PapR protein, DI(HYDROXYETHYL)ETHER, PlcR protein
Authors:Declerck, N, Chaix, D, Rugani, N, Hoh, F, Arold, S.T.
Deposit date:2007-06-27
Release date:2007-11-06
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of PlcR: Insights into virulence regulation and evolution of quorum sensing in Gram-positive bacteria
Proc.Natl.Acad.Sci.Usa, 104, 2007

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