3VKX
| Structure of PCNA | Descriptor: | 3,5,3'TRIIODOTHYRONINE, CHLORIDE ION, Proliferating cell nuclear antigen, ... | Authors: | Hashimoto, H, Hishiki, A, Shimizu, T, Sato, M, Punchihewa, C, Connelly, M, Actis, M, Waddell, B, Pagala, V, Fujii, N. | Deposit date: | 2011-11-26 | Release date: | 2012-03-14 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication J.Biol.Chem., 287, 2012
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6HVO
| Crystal structure of human PCNA in complex with three peptides of p12 subunit of human polymerase delta | Descriptor: | DNA polymerase delta subunit 4, Proliferating cell nuclear antigen, SULFATE ION | Authors: | Gonzalez-Magana, A, Romano-Moreno, M, Rojas, A.L, Blanco, F.J, De Biasio, A. | Deposit date: | 2018-10-11 | Release date: | 2019-01-23 | Last modified: | 2019-03-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The p12 subunit of human polymerase delta uses an atypical PIP box for molecular recognition of proliferating cell nuclear antigen (PCNA). J.Biol.Chem., 294, 2019
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3WGW
| Structure of PCNA bound to a small molecule inhibitor | Descriptor: | 4-{4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy}phenol, Proliferating cell nuclear antigen, SULFATE ION | Authors: | Hashimoto, H. | Deposit date: | 2013-08-12 | Release date: | 2014-02-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin. J.Biol.Chem., 289, 2014
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3F1W
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5MLO
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5MLW
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5MAV
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6J0J
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3FDS
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5MOM
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6K2M
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3GPM
| Structure of the trimeric form of the E113G PCNA mutant protein | Descriptor: | Proliferating cell nuclear antigen | Authors: | Freudenthal, B.D, Gakhar, L, Ramaswamy, S, Washington, M.T. | Deposit date: | 2009-03-23 | Release date: | 2009-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | A charged residue at the subunit interface of PCNA promotes trimer formation by destabilizing alternate subunit interactions. Acta Crystallogr.,Sect.D, 65, 2009
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3GPN
| Structure of the non-trimeric form of the E113G PCNA mutant protein | Descriptor: | Proliferating cell nuclear antigen | Authors: | Freudenthal, B.D, Gakhar, L, Ramaswamy, S, Washington, M.T. | Deposit date: | 2009-03-23 | Release date: | 2009-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A charged residue at the subunit interface of PCNA promotes trimer formation by destabilizing alternate subunit interactions. Acta Crystallogr.,Sect.D, 65, 2009
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3HI8
| Crystal structure of proliferating cell nuclear antigen (PCNA) from Haloferax volcanii | Descriptor: | Proliferating cell nuclear antigen PcnA | Authors: | Morgunova, E, Gray, F.C, MacNeill, S.A, Ladenstein, R. | Deposit date: | 2009-05-19 | Release date: | 2009-09-29 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.202 Å) | Cite: | Structural insights into the adaptation of proliferating cell nuclear antigen (PCNA) from Haloferax volcanii to a high-salt environment. Acta Crystallogr.,Sect.D, 65, 2009
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6QC0
| PCNA complex with Cdt2 C-terminal PIP-box peptide | Descriptor: | Denticleless protein homolog, Proliferating cell nuclear antigen | Authors: | Perrakis, A.P, von Castelmur, E. | Deposit date: | 2018-12-25 | Release date: | 2019-01-23 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2E3 ligase activity to Cdt1. Life Sci Alliance, 1, 2018
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6QCG
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6QH1
| The structure of Schizosaccharomyces pombe PCNA in complex with an Spd1 derived peptide | Descriptor: | Proliferating cell nuclear antigen, S-phase delaying protein 1 | Authors: | Kragelund, B.B, Nielsen, O, Olsen, J.G, Kassem, N, Prestel, A. | Deposit date: | 2019-01-14 | Release date: | 2020-02-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The structure of Schizosaccharomyces pombe PCNA in complex with an Spd1 derived peptide To Be Published
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6T7Y
| Structure of PCNA bound to cPIP motif of DP2 from P. abyssi | Descriptor: | DNA polymerase sliding clamp, cPIP motif from the DP2 large subunit of PolD | Authors: | Madru, C, Raia, P, Hugonneau Beaufet, I, Delarue, M, Carroni, M, Sauguet, L. | Deposit date: | 2019-10-23 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA. Nat Commun, 11, 2020
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6T7X
| Crystal structure of PCNA from P. abyssi | Descriptor: | DNA polymerase sliding clamp | Authors: | Madru, C, Raia, P, Hugonneau Beaufet, I, Delarue, M, Carroni, M, Sauguet, L. | Deposit date: | 2019-10-23 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA. Nat Commun, 11, 2020
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6W9W
| R80A PCNA mutant defective in BIR | Descriptor: | Proliferating cell nuclear antigen | Authors: | Ripley, B.M, Washington, M.T. | Deposit date: | 2020-03-23 | Release date: | 2020-09-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural analysis of PCNA mutant proteins defective in BIR, FF248-249AA and R80A To be Published
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2HIK
| heterotrimeric PCNA sliding clamp | Descriptor: | PCNA1 (SSO0397), PCNA2 (SSO1047), PCNA3 (SSO0405) | Authors: | Pascal, J.M, Tsodikov, O.V, Ellenberger, T. | Deposit date: | 2006-06-29 | Release date: | 2006-11-07 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | A Flexible Interface between DNA Ligase and PCNA Supports Conformational Switching and Efficient Ligation of DNA. Mol.Cell, 24, 2006
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2HII
| heterotrimeric PCNA sliding clamp | Descriptor: | PCNA1 (SSO0397), PCNA2 (SSO1047), PCNA3 (SSO0405) | Authors: | Pascal, J.M, Tsodikov, O.V, Ellenberger, T. | Deposit date: | 2006-06-29 | Release date: | 2006-11-07 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | A Flexible Interface between DNA Ligase and PCNA Supports Conformational Switching and Efficient Ligation of DNA. Mol.Cell, 24, 2006
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3IFV
| Crystal structure of the Haloferax volcanii proliferating cell nuclear antigen | Descriptor: | PCNA, SODIUM ION | Authors: | Winter, J.A, Christofi, P, Morroll, S, Bunting, K.A. | Deposit date: | 2009-07-26 | Release date: | 2009-09-01 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The crystal structure of Haloferax volcanii proliferating cell nuclear antigen reveals unique surface charge characteristics due to halophilic adaptation Bmc Struct.Biol., 9, 2009
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2IO4
| Crystal structure of PCNA12 dimer from Sulfolobus solfataricus. | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, DNA polymerase sliding clamp B, ... | Authors: | Hlinkova, V, Ling, H. | Deposit date: | 2006-10-09 | Release date: | 2008-04-08 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structures of monomeric, dimeric and trimeric PCNA: PCNA-ring assembly and opening. Acta Crystallogr.,Sect.D, 64, 2008
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3JA9
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