PDB: 340 resultsInfo pagesStatus searchChemie searchBIRD

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6BGK	Caspase-3 Mutant- D9A,D28A,T152D Descriptor: ACE-ASP-GLU-VAL-ASP-0QE, AZIDE ION, CHLORIDE ION, ... Authors: Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C. Deposit date: 2017-10-28 Release date: 2018-02-21 Last modified: 2018-04-25 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Modifications to a common phosphorylation network provide individualized control in caspases. J. Biol. Chem., 293, 2018
6BGS	Caspase-3 Mutant - S150Y Descriptor: Ac-Asp-Glu-Val-Asp-CMK, Caspase-3 Authors: Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C. Deposit date: 2017-10-29 Release date: 2018-02-21 Last modified: 2018-04-25 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Modifications to a common phosphorylation network provide individualized control in caspases. J. Biol. Chem., 293, 2018
6BH9	Caspase-3 Mutant - T152A Descriptor: Ac-Asp-Glu-Val-Asp-CMK, CHLORIDE ION, Caspase-3, ... Authors: Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C. Deposit date: 2017-10-30 Release date: 2018-02-21 Last modified: 2018-04-25 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Modifications to a common phosphorylation network provide individualized control in caspases. J. Biol. Chem., 293, 2018
4DCP	Crystal Structure of caspase 3, L168F mutant Descriptor: Caspase Inhibitor AC-DEVD-CHO, Caspase-3 subunit p12, Caspase-3 subunit p17 Authors: Chung, S.J, Kang, H.J, Kim, S.J. Deposit date: 2012-01-18 Release date: 2012-12-12 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Molecular insight into the role of the leucine residue on the L2 loop in the catalytic activity of caspases 3 and 7 Biosci.Rep., 32, 2012
4DCO	Crystal Structure of caspase 3, L168Y mutant Descriptor: Caspase Inhibitor AC-DEVD-CHO, Caspase-3 subunit p12, Caspase-3 subunit p17 Authors: Chung, S.J, Kang, H.J, Kim, S.J. Deposit date: 2012-01-18 Release date: 2012-12-12 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Molecular insight into the role of the leucine residue on the L2 loop in the catalytic activity of caspases 3 and 7 Biosci.Rep., 32, 2012
4DCJ	Crystal structure of caspase 3, L168D mutant Descriptor: Caspase Inhibitor AC-DEVD-CHO, Caspase-3 subunit p12, Caspase-3 subunit p17 Authors: Chung, S.J, Kang, H.J, Kim, S.J. Deposit date: 2012-01-17 Release date: 2012-12-12 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Molecular insight into the role of the leucine residue on the L2 loop in the catalytic activity of caspases 3 and 7 Biosci.Rep., 32, 2012
4EHA	Allosteric Modulation of Caspase-3 through Mutagenesis Descriptor: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 Authors: Walters, J, Schipper, J.L, Swartz, P.D, Mattos, C, Clark, A.C. Deposit date: 2012-04-02 Release date: 2012-06-06 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.696 Å) Cite: Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012
4EHH	Allosteric Modulation of Caspase-3 through Mutagenesis Descriptor: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 Authors: Walters, J, Schipper, J.L, Swartz, P.D, Mattos, C, Clark, A.C. Deposit date: 2012-04-02 Release date: 2012-06-06 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012
4EHL	Allosteric Modulation of Caspase-3 through Mutagenesis Descriptor: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 Authors: Walters, J, Schipper, J.L, Swartz, P.D, Mattos, C, Clark, A.C. Deposit date: 2012-04-02 Release date: 2012-06-06 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.799 Å) Cite: Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012
4EHD	Allosteric Modulation of Caspase-3 through Mutagenesis Descriptor: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 Authors: Walters, J, Schipper, J.L, Swartz, P, Mattos, C, Clark, A.C. Deposit date: 2012-04-02 Release date: 2012-06-06 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.581 Å) Cite: Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012
4EHN	Allosteric Modulation of Caspase-3 through Mutagenesis Descriptor: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 Authors: Walters, J, Schipper, J.L, Swartz, P.D, Mattos, C, Clark, A.C. Deposit date: 2012-04-02 Release date: 2012-06-06 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.69 Å) Cite: Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012
4EHF	Allosteric Modulation of Caspase-3 through Mutagenesis Descriptor: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 Authors: Walters, J, Schipper, J.L, Swartz, P.D, Mattos, C, Clark, A.C. Deposit date: 2012-04-02 Release date: 2012-06-06 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.655 Å) Cite: Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012
4EHK	Allosteric Modulation of Caspase-3 through Mutagenesis Descriptor: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 Authors: Walters, J, Schipper, J.L, Swartz, P.D, Mattos, C, Clark, A.C. Deposit date: 2012-04-02 Release date: 2012-06-06 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.668 Å) Cite: Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012
4EJF	Allosteric peptides that bind to a caspase zymogen and mediate caspase tetramerization Descriptor: Caspase-6, PHOSPHATE ION, phage-derived peptide 419 Authors: Murray, J.M. Deposit date: 2012-04-06 Release date: 2012-06-20 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.6465 Å) Cite: Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization. Nat.Chem.Biol., 8, 2012
4F6P	Crystal structure of the yeast metacaspase Yca1 C276A mutant Descriptor: 1,1-diphenylethanol, Metacaspase-1 Authors: Wong, A.H, Yan, C.Y, Shi, Y.G. Deposit date: 2012-05-15 Release date: 2013-03-27 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.619 Å) Cite: Crystal structure of the metacaspase Yca1 To be Published
4FDL	Crystal structure of Caspase-7 Descriptor: Caspase-7 Authors: Kabaleeswaran, V. Deposit date: 2012-05-28 Release date: 2012-08-01 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.801 Å) Cite: A class of allosteric caspase inhibitors identified by high-throughput screening. Mol.Cell, 47, 2012
4FEA	Crystal structure of CASPASE-7 in Complex with allosteric inhibitor Descriptor: Caspase-7, chloro{methyl hydrogenato(3-)-kappa~2~N,S [pyridin-2-yl(pyridin-2(1H)-ylidene-kappaN)methyl]carbonodithiohydrazonate}copper Authors: Kabaleeswaran, V. Deposit date: 2012-05-29 Release date: 2012-08-01 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.79 Å) Cite: A class of allosteric caspase inhibitors identified by high-throughput screening. Mol.Cell, 47, 2012
4F6O	Crystal structure of the yeast metacaspase Yca1 Descriptor: 1,1-diphenylethanol, Metacaspase-1 Authors: Wong, A.H, Yan, C.Y, Shi, Y.G. Deposit date: 2012-05-15 Release date: 2012-07-11 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.681 Å) Cite: Crystal structure of the yeast metacaspase Yca1. J.Biol.Chem., 287, 2012
4FXO	Zinc-mediated allosteric inhibiton of caspase-6 Descriptor: Caspase-6, ZINC ION Authors: Velazquez-Delgado, E.M, Hardy, J.A. Deposit date: 2012-07-03 Release date: 2012-08-22 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Zinc-mediated Allosteric Inhibition of Caspase-6. J.Biol.Chem., 287, 2012
4HQR	Crystal Structure of mutant form of Caspase-7 Descriptor: Ac-Asp-Glu-Val-Asp-Aldehyde, Caspase-7 Authors: Lee, Y, Kang, H.J, Bae, K.-H, Kim, S.J, Chung, S.J. Deposit date: 2012-10-26 Release date: 2013-09-11 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural asymmetry of procaspase-7 bound to a specific inhibitor Acta Crystallogr.,Sect.D, 69, 2013
3D6M	Crystal structure of human caspase-1 with a naturally-occurring Lys319->Arg substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK) Descriptor: Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide Authors: Rosen-Wolff, A, Roesler, J, Romanowski, M.J. Deposit date: 2008-05-19 Release date: 2010-03-02 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever). To be Published, 2008
3D6F	Crystal structure of human caspase-1 with a naturally-occurring Arg240->Gln substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK) Descriptor: Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide Authors: Rosen-Wolff, A, Roesler, J, Romanowski, M.J. Deposit date: 2008-05-19 Release date: 2010-03-02 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever). To be Published
3D6H	Crystal structure of human caspase-1 with a naturally-occurring Asn263->Ser substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK) Descriptor: Caspase-1, Caspase-1 precursor, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide Authors: Rosen-Wolff, A, Roesler, J, Romanowski, M.J. Deposit date: 2008-05-19 Release date: 2010-03-02 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2 Å) Cite: Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever). To be Published, 2008
4HQ0	Crystal Structure of mutant form of Caspase-7 Descriptor: Caspase-7 Authors: Lee, Y, Kang, H.J, Bae, K.-H, Kim, S.J, Chung, S.J. Deposit date: 2012-10-25 Release date: 2013-09-11 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural asymmetry of procaspase-7 bound to a specific inhibitor Acta Crystallogr.,Sect.D, 69, 2013
4HVA	Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6 Descriptor: Caspase-6, N-[(2R)-1-(3-cyanophenyl)-3-hydroxypropan-2-yl]-5-(3,4-dimethoxyphenyl)furan-3-carboxamide, VEID Inhibitor Authors: Murray, J.M, Steffek, M. Deposit date: 2012-11-05 Release date: 2013-03-20 Method: X-RAY DIFFRACTION (2.074 Å) Cite: Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. Plos One, 7, 2012

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