PDB: 95 件ウェブページステータス検索Chemie searchBIRD

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3TDE	Crystal structure of S-adenosylmethionine synthetase Rv1392 from Mycobacterium tuberculosis 分子名称: S-adenosylmethionine synthase, SODIUM ION 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2011-08-10 公開日 2011-08-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
6C07	Crystal Structure of S-Adenosylmethionine synthetase (MetK/Mat) from Cryptosporidium parvum 分子名称: CHLORIDE ION, MAGNESIUM ION, POTASSIUM ION, ... 著者 Ohren, J.F, Viola, R.E. 登録日 2017-12-28 公開日 2019-01-16 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structure of a critical metabolic enzyme: S-adenosylmethionine synthetase from Cryptosporidium parvum. Acta Crystallogr F Struct Biol Commun, 75, 2019
6LTV	Crystal Structure of I122A/I330A variant of S-adenosylmethionine synthetase from Cryptosporidium hominis in complex with ONB-SAM (2-nitro benzyme S-adenosyl-methionine) 分子名称: MAGNESIUM ION, S-adenosylmethionine synthase, TRIPHOSPHATE, ... 著者 Singh, R.K, Michailidou, F, Rentmeister, A, Kuemmel, D. 登録日 2020-01-23 公開日 2020-10-21 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Engineered SAM Synthetases for Enzymatic Generation of AdoMet Analogs with Photocaging Groups and Reversible DNA Modification in Cascade Reactions. Angew.Chem.Int.Ed.Engl., 60, 2021
6FAJ	The structure of Human Methionine Adenosyltransferase II in apo state 分子名称: ACETATE ION, DI(HYDROXYETHYL)ETHER, S-adenosylmethionine synthase isoform type-2, ... 著者 Bradley-Clarke, J, Panmanee, J, Antonyuk, S.V, Hasnain, S.S. 登録日 2017-12-15 公開日 2019-02-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory beta subunit and quinolone-based compounds Febs J., 2020
6VD2	Crystal structure of Arabidopsis thaliana S-adenosylmethionine Synthase 2 (AtMAT2) in complex with S-adenosylmethionine 分子名称: 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... 著者 Sekula, B, Ruszkowski, M, Dauter, Z. 登録日 2019-12-23 公開日 2020-02-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 S-adenosylmethionine synthases in plants: Structural characterization of type I and II isoenzymes from Arabidopsis thaliana and Medicago truncatula. Int.J.Biol.Macromol., 151, 2020
8SWA	Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with SAM and PPNP 分子名称: (DIPHOSPHONO)AMINOPHOSPHONIC ACID, MAGNESIUM ION, POTASSIUM ION, ... 著者 Bruemmer, K.J, Pham, V.N, Toh, J.D.W. 登録日 2023-05-18 公開日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.999 Å) 主引用文献 Formaldehyde regulates S -adenosylmethionine biosynthesis and one-carbon metabolism. Science, 382, 2023
6VD0	Crystal structure of Arabidopsis thaliana S-adenosylmethionine Synthase 2 (AtMAT2) in complex with free Methionine and AMPCPP 分子名称: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, DI(HYDROXYETHYL)ETHER, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... 著者 Sekula, B, Ruszkowski, M, Dauter, Z. 登録日 2019-12-23 公開日 2020-02-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 S-adenosylmethionine synthases in plants: Structural characterization of type I and II isoenzymes from Arabidopsis thaliana and Medicago truncatula. Int.J.Biol.Macromol., 151, 2020
3RV2	Crystal structure of S-adenosylmethionine synthetase from Mycobacterium marinum 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, GLYCEROL, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2011-05-05 公開日 2011-05-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
2OBV	Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with the product 分子名称: S-ADENOSYLMETHIONINE, S-adenosylmethionine synthetase isoform type-1, SODIUM ION, ... 著者 Pilka, E.S, Shafqat, N, Kavanagh, K.L, Cooper, C, Hozjan, V, Turnbull, A, von Delft, F, Arrowsmith, C.H, Edwards, A, Weigelt, J, Sundstrom, M, Oppermann, U, Structural Genomics Consortium (SGC) 登録日 2006-12-20 公開日 2007-01-02 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with the product. To be Published
6P9V	Crystal Structure of hMAT Mutant K289L 分子名称: ADENOSINE, MAGNESIUM ION, POTASSIUM ION, ... 著者 Miller, M.D, Xu, W, Huber, T.D, Clinger, J.A, Liu, Y, Thorson, J.S, Phillips Jr, G.N. 登録日 2019-06-10 公開日 2020-04-22 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.051 Å) 主引用文献 Methionine Adenosyltransferase Engineering to Enable Bioorthogonal Platforms for AdoMet-Utilizing Enzymes. Acs Chem.Biol., 15, 2020
5UGH	Crystal structure of Mat2a bound to the allosteric inhibitor PF-02929366 分子名称: 2-(7-chloro-5-phenyl[1,2,4]triazolo[4,3-a]quinolin-1-yl)-N,N-dimethylethan-1-amine, S-adenosylmethionine synthase isoform type-2 著者 Kaiser, S.E, Feng, J, Stewart, A.E. 登録日 2017-01-08 公開日 2017-05-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.062 Å) 主引用文献 Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A. Nat. Chem. Biol., 13, 2017
5T8T	Crystal Structure of a S-adenosylmethionine Synthase from Neisseria gonorrhoeae with bound AMP and Magnesium 分子名称: ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, S-adenosylmethionine synthase 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2016-09-08 公開日 2016-09-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structure of a S-adenosylmethionine Synthase from Neisseria gonorrhoeae with bound AMP and Magnesium to be published
8JZH	C. glutamicum S-adenosylmethionine synthase 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, S-adenosylmethionine synthase, ... 著者 Lee, S, Kim, K.J. 登録日 2023-07-05 公開日 2023-10-25 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural and Biochemical Studies on Product Inhibition of S-Adenosylmethionine Synthetase from Corynebacterium glutamicum . J.Agric.Food Chem., 71, 2023
4NDN	Structural insights of MAT enzymes: MATa2b complexed with SAM and PPNP 分子名称: (DIPHOSPHONO)AMINOPHOSPHONIC ACID, 1,2-ETHANEDIOL, MAGNESIUM ION, ... 著者 Murray, B, Antonyuk, S.V, Marina, A, Lu, S.C, Mato, J.M, Hasnain, S.S, Rojas, A.L. 登録日 2013-10-27 公開日 2014-07-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Structure and function study of the complex that synthesizes S-adenosylmethionine. IUCrJ, 1, 2014
5A19	The structure of MAT2A in complex with PPNP. 分子名称: (DIPHOSPHONO)AMINOPHOSPHONIC ACID, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... 著者 Murray, B, Antonyuk, S.V, Marina, A, Lu, S.C, Mato, J.M, Hasnain, S.S, Rojas, A.L. 登録日 2015-04-28 公開日 2016-02-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Crystallography Captures Catalytic Steps in Human Methionine Adenosyltransferase Enzymes. Proc.Natl.Acad.Sci.USA, 113, 2016
3IML	Crystal Structure Of S-Adenosylmethionine Synthetase From Burkholderia Pseudomallei 分子名称: S-adenosylmethionine synthetase 著者 Staker, B.L, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2009-08-10 公開日 2009-09-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, 2013
6SW5	Crystal structure of the human S-adenosylmethionine synthetase 1 (ligand-free form) 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, S-adenosylmethionine synthase isoform type-1 著者 Panmanee, J, Antoyuk, S.V, Hasnain, S.S. 登録日 2019-09-19 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural basis of the dominant inheritance of hypermethioninemia associated with the Arg264His mutation in the MAT1A gene. Acta Crystallogr D Struct Biol, 76, 2020
8JZG	C. glutamicum S-adenosylmethionine synthase co-crystallized with Adenosine, triphosphate, and SAM 分子名称: ADENOSINE, GLYCEROL, MAGNESIUM ION, ... 著者 Lee, S, Kim, K.J. 登録日 2023-07-05 公開日 2023-10-25 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Structural and Biochemical Studies on Product Inhibition of S-Adenosylmethionine Synthetase from Corynebacterium glutamicum . J.Agric.Food Chem., 71, 2023
7RW5	Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor Compound 1 分子名称: (3'R)-N-(cyclopropylmethyl)-1'-[(2-fluorophenyl)methyl]-4-methyl-5H,7H-spiro[pyrano[4,3-d]pyrimidine-8,3'-pyrrolidin]-2-amine, S-ADENOSYLMETHIONINE, S-adenosylmethionine synthase isoform type-2 著者 Jin, L, Padyana, A.K. 登録日 2021-08-19 公開日 2022-03-23 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.48 Å) 主引用文献 Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads. J.Med.Chem., 65, 2022
7LNH	S-adenosylmethionine synthetase co-crystallized with UppNHp 分子名称: (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl-methyl-$l^{3}-sulfanyl]butanoic acid, 1,2-ETHANEDIOL, S-adenosylmethionine synthase isoform type-2 著者 Tan, L.L, Jackson, C.J. 登録日 2021-02-07 公開日 2022-03-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Substrate Dynamics Contribute to Enzymatic Specificity in Human and Bacterial Methionine Adenosyltransferases. Jacs Au, 1, 2021
1RG9	S-Adenosylmethionine synthetase complexed with SAM and PPNP 分子名称: (DIPHOSPHONO)AMINOPHOSPHONIC ACID, MAGNESIUM ION, POTASSIUM ION, ... 著者 Komoto, J, Yamada, T, Takata, Y, Markham, G.D, Takusagawa, F. 登録日 2003-11-11 公開日 2004-03-02 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of the S-adenosylmethionine synthetase ternary complex: a novel catalytic mechanism of s-adenosylmethionine synthesis from ATP and MET. Biochemistry, 43, 2004
1P7L	S-Adenosylmethionine synthetase complexed with AMPPNP and Met. 分子名称: (DIPHOSPHONO)AMINOPHOSPHONIC ACID, MAGNESIUM ION, METHIONINE, ... 著者 Takusagawa, F, Komoto, J. 登録日 2003-05-02 公開日 2004-03-02 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of the s-adenosylmethionine synthetase ternary complex: a novel catalytic mechanism of s-adenosylmethionine synthesis from ATP and MET. Biochemistry, 43, 2004
6WKB	Human S-adenosylmethionine synthetase co-crystallized with UppNHp and Met 分子名称: 1,2-ETHANEDIOL, 5'-deoxyuridine, D-METHIONINE, ... 著者 Tan, L.L, Jackson, C.J. 登録日 2020-04-15 公開日 2021-04-21 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 S-adenosylmethionine synthetase To Be Published
4KTT	Structural insights of MAT enzymes: MATa2b complexed with SAM 分子名称: 1,2-ETHANEDIOL, MAGNESIUM ION, Methionine adenosyltransferase 2 subunit beta, ... 著者 Murray, B, Antonyuk, S.V, Marina, A, Lu, S.C, Mato, J.M, Hasnain, S.S, Rojas, A.L. 登録日 2013-05-21 公開日 2014-07-16 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 Structure and function study of the complex that synthesizes S-adenosylmethionine. IUCrJ, 1, 2014
1QM4	Methionine Adenosyltransferase Complexed with a L-Methionine Analogue 分子名称: L-2-AMINO-4-METHOXY-CIS-BUT-3-ENOIC ACID, MAGNESIUM ION, METHIONINE ADENOSYLTRANSFERASE, ... 著者 Gonzalez, B, Pajares, M.A, Hermoso, J.A, Sanz-Aparicio, J. 登録日 1999-09-20 公開日 2000-09-21 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.66 Å) 主引用文献 The Crystal Structure of Tetrameric Methionine Adenosyltransferase from Rat Liver Reveals the Methionine-Binding Site J.Mol.Biol., 300, 2000

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