PDB: 80 resultsInfo pagesStatus searchChemie searchBIRD

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3MP7	Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes Descriptor: Preprotein translocase subunit secE, Preprotein translocase subunit secY Authors: Egea, P.F, Stroud, R.M, Center for Structures of Membrane Proteins (CSMP) Deposit date: 2010-04-26 Release date: 2010-10-06 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes. Proc.Natl.Acad.Sci.USA, 107, 2010
2YXR	The plug domain of the SecY protein stablizes the closed state of the translocation channel and maintains a membrane seal Descriptor: Preprotein translocase secG subunit, Preprotein translocase subunit secE, Preprotein translocase subunit secY Authors: Li, W, Schulman, S. Deposit date: 2007-04-27 Release date: 2007-08-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3.6 Å) Cite: The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal Mol.Cell, 26, 2007
2YXQ	The plug domain of the SecY protein stablizes the closed state of the translocation channel and maintains a membrane seal Descriptor: Preprotein translocase secG subunit, Preprotein translocase subunit secE, Preprotein translocase subunit secY Authors: Li, W, Schulman, S. Deposit date: 2007-04-27 Release date: 2007-08-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3.5 Å) Cite: The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal Mol.Cell, 26, 2007
2ZJS	Crystal Structure of SecYE translocon from Thermus thermophilus with a Fab fragment Descriptor: Fab56 (heavy chain), Fab56 (light chain), Preprotein translocase SecE subunit, ... Authors: Tsukazaki, T, Mori, H, Fukai, S, Ishitani, R, Perederina, A, Vassylyev, D.G, Ito, K, Nureki, O. Deposit date: 2008-03-08 Release date: 2008-10-14 Last modified: 2021-11-10 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Conformational transition of Sec machinery inferred from bacterial SecYE structures Nature, 455, 2008
2ZQP	Crystal Structure of SecYE translocon from Thermus thermophilus Descriptor: Preprotein translocase SecE subunit, Preprotein translocase SecY subunit Authors: Tsukazaki, T, Nureki, O. Deposit date: 2008-08-14 Release date: 2008-10-14 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (6 Å) Cite: Conformational transition of Sec machinery inferred from bacterial SecYE structures Nature, 455, 2008
3BO0	Ribosome-SecY complex Descriptor: 23S RIBOSOMAL RNA, PREPROTEIN TRANSLOCASE SecE SUBUNIT, PREPROTEIN TRANSLOCASE SecY SUBUNIT, ... Authors: Akey, C.W, Menetret, J.F. Deposit date: 2007-12-15 Release date: 2008-12-09 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (9.6 Å) Cite: Ribosome binding of a single copy of the SecY complex: implications for protein translocation Mol.Cell, 28, 2007
3BO1	Ribosome-SecY complex Descriptor: 23S RIBOSOMAL RNA, PREPROTEIN TRANSLOCASE SecE SUBUNIT, PREPROTEIN TRANSLOCASE SecY SUBUNIT, ... Authors: Akey, C.W, Menetret, J.F. Deposit date: 2007-12-15 Release date: 2008-12-09 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (9.6 Å) Cite: Ribosome binding of a single copy of the SecY complex: implications for protein translocation Mol.Cell, 28, 2007
8DNV	Cryo-EM structure of the human Sec61 complex in a partially-open apo state (Class 1) Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-09-06 Method: ELECTRON MICROSCOPY (3.03 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DO1	Cryo-EM structure of the human Sec61 complex inhibited by ipomoeassin F Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-09-06 Method: ELECTRON MICROSCOPY (3.01 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNZ	Cryo-EM structure of the human Sec61 complex inhibited by apratoxin F Descriptor: Apratoxin F peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.57 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNW	Cryo-EM structure of the human Sec61 complex in a partially-open apo state (Class 2) Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-09-06 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DO2	Cryo-EM structure of the human Sec61 complex inhibited by cyclotriazadisulfonamide (CADA) Descriptor: 9-benzyl-1,5-bis(4-methylbenzene-1-sulfonyl)-3-methylidene-1,5,9-triazacyclododecane, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-09-06 Method: ELECTRON MICROSCOPY (2.95 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNY	Cryo-EM structure of the human Sec61 complex inhibited by decatransin Descriptor: Decatransin peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.85 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNX	Cryo-EM structure of the human Sec61 complex inhibited by cotransin Descriptor: Cotransin analogue peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.98 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DO0	Cryo-EM structure of the human Sec61 complex inhibited by mycolactone Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-09-06 Method: ELECTRON MICROSCOPY (2.86 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DO3	Cryo-EM structure of the human Sec61 complex inhibited by eeyarestatin I Descriptor: N'-(4-chlorophenyl)-N-[(4R)-3-(4-chlorophenyl)-5,5-dimethyl-1-(2-{(2E)-2-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]hydrazinyl}-2-oxoethyl)-2-oxoimidazolidin-4-yl]-N-hydroxyurea, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-09-06 Method: ELECTRON MICROSCOPY (3.22 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
7AFT	Cryo-EM structure of the signal sequence-engaged post-translational Sec translocon Descriptor: Mating factor alpha-1,Mating factor alpha-1, Protein translocation protein SEC63, Protein transport protein SBH1, ... Authors: Weng, T.-H, Beatrix, B, Berninghausen, O, Becker, T, Cheng, J, Beckmann, R. Deposit date: 2020-09-20 Release date: 2020-12-02 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Architecture of the active post-translational Sec translocon. Embo J., 40, 2021
6W6L	Cryo-EM structure of the human ribosome-TMCO1 translocon Descriptor: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... Authors: Keenan, R.J, McGilvray, P.T. Deposit date: 2020-03-17 Release date: 2020-09-02 Method: ELECTRON MICROSCOPY (3.84 Å) Cite: An ER translocon for multi-pass membrane protein biogenesis. Elife, 9, 2020
6FTJ	Cryo-EM Structure of the Mammalian Oligosaccharyltransferase Bound to Sec61 and the Non-programmed 80S Ribosome Descriptor: 28S rRNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... Authors: Braunger, K, Becker, T, Beckmann, R. Deposit date: 2018-02-22 Release date: 2018-03-21 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (4.7 Å) Cite: Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum. Science, 360, 2018
5GAE	RNC in complex with a translocating SecYEG Descriptor: 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... Authors: Jomaa, A, Boehringer, D, Leibundgut, M, Ban, N. Deposit date: 2015-11-25 Release date: 2016-01-27 Last modified: 2019-12-11 Method: ELECTRON MICROSCOPY (3.33 Å) Cite: Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon. Nat Commun, 7, 2016
6R7Q	Structure of XBP1u-paused ribosome nascent chain complex with Sec61. Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... Authors: Shanmuganathan, V, Cheng, J, Braunger, K, Berninghausen, O, Beatrix, B, Beckmann, R. Deposit date: 2019-03-29 Release date: 2019-07-10 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
7TM3	Structure of the rabbit 80S ribosome stalled on a 2-TMD Rhodopsin intermediate in complex with the multipass translocon Descriptor: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... Authors: Kim, M.K, Lewis, A.J.O, Keenan, R.J, Hegde, R.S. Deposit date: 2022-01-19 Release date: 2022-10-19 Last modified: 2022-11-16 Method: ELECTRON MICROSCOPY (3.25 Å) Cite: Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature, 611, 2022
6N3Q	Cryo-EM structure of the yeast Sec complex Descriptor: Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... Authors: Park, E, Itskanov, S. Deposit date: 2018-11-16 Release date: 2018-12-19 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.68 Å) Cite: Structure of the posttranslational Sec protein-translocation channel complex from yeast. Science, 363, 2019
6ND1	CryoEM structure of the Sec Complex from yeast Descriptor: Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... Authors: Wu, X, Cabanos, C, Rapoport, T.A. Deposit date: 2018-12-13 Release date: 2019-01-09 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Structure of the post-translational protein translocation machinery of the ER membrane. Nature, 566, 2019
7TUT	Structure of the rabbit 80S ribosome stalled on a 4-TMD Rhodopsin intermediate in complex with the multipass translocon Descriptor: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... Authors: Kim, M.K, Lewis, A.J.O, Keenan, R.J, Hegde, R.S. Deposit date: 2022-02-03 Release date: 2022-10-19 Last modified: 2022-11-16 Method: ELECTRON MICROSCOPY (3.88 Å) Cite: Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature, 611, 2022

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