PDB: 80 件ウェブページステータス検索Chemie searchBIRD

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3MP7	Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes 分子名称: Preprotein translocase subunit secE, Preprotein translocase subunit secY 著者 Egea, P.F, Stroud, R.M, Center for Structures of Membrane Proteins (CSMP) 登録日 2010-04-26 公開日 2010-10-06 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes. Proc.Natl.Acad.Sci.USA, 107, 2010
2YXR	The plug domain of the SecY protein stablizes the closed state of the translocation channel and maintains a membrane seal 分子名称: Preprotein translocase secG subunit, Preprotein translocase subunit secE, Preprotein translocase subunit secY 著者 Li, W, Schulman, S. 登録日 2007-04-27 公開日 2007-08-14 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal Mol.Cell, 26, 2007
2YXQ	The plug domain of the SecY protein stablizes the closed state of the translocation channel and maintains a membrane seal 分子名称: Preprotein translocase secG subunit, Preprotein translocase subunit secE, Preprotein translocase subunit secY 著者 Li, W, Schulman, S. 登録日 2007-04-27 公開日 2007-08-14 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal Mol.Cell, 26, 2007
2ZJS	Crystal Structure of SecYE translocon from Thermus thermophilus with a Fab fragment 分子名称: Fab56 (heavy chain), Fab56 (light chain), Preprotein translocase SecE subunit, ... 著者 Tsukazaki, T, Mori, H, Fukai, S, Ishitani, R, Perederina, A, Vassylyev, D.G, Ito, K, Nureki, O. 登録日 2008-03-08 公開日 2008-10-14 最終更新日 2021-11-10 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Conformational transition of Sec machinery inferred from bacterial SecYE structures Nature, 455, 2008
2ZQP	Crystal Structure of SecYE translocon from Thermus thermophilus 分子名称: Preprotein translocase SecE subunit, Preprotein translocase SecY subunit 著者 Tsukazaki, T, Nureki, O. 登録日 2008-08-14 公開日 2008-10-14 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (6 Å) 主引用文献 Conformational transition of Sec machinery inferred from bacterial SecYE structures Nature, 455, 2008
3BO0	Ribosome-SecY complex 分子名称: 23S RIBOSOMAL RNA, PREPROTEIN TRANSLOCASE SecE SUBUNIT, PREPROTEIN TRANSLOCASE SecY SUBUNIT, ... 著者 Akey, C.W, Menetret, J.F. 登録日 2007-12-15 公開日 2008-12-09 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (9.6 Å) 主引用文献 Ribosome binding of a single copy of the SecY complex: implications for protein translocation Mol.Cell, 28, 2007
3BO1	Ribosome-SecY complex 分子名称: 23S RIBOSOMAL RNA, PREPROTEIN TRANSLOCASE SecE SUBUNIT, PREPROTEIN TRANSLOCASE SecY SUBUNIT, ... 著者 Akey, C.W, Menetret, J.F. 登録日 2007-12-15 公開日 2008-12-09 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (9.6 Å) 主引用文献 Ribosome binding of a single copy of the SecY complex: implications for protein translocation Mol.Cell, 28, 2007
8DNV	Cryo-EM structure of the human Sec61 complex in a partially-open apo state (Class 1) 分子名称: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma 著者 Park, E, Itskanov, S. 登録日 2022-07-12 公開日 2023-05-24 最終更新日 2023-09-06 実験手法 ELECTRON MICROSCOPY (3.03 Å) 主引用文献 A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DO1	Cryo-EM structure of the human Sec61 complex inhibited by ipomoeassin F 分子名称: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma, ... 著者 Park, E, Itskanov, S. 登録日 2022-07-12 公開日 2023-05-24 最終更新日 2023-09-06 実験手法 ELECTRON MICROSCOPY (3.01 Å) 主引用文献 A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNZ	Cryo-EM structure of the human Sec61 complex inhibited by apratoxin F 分子名称: Apratoxin F peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... 著者 Park, E, Itskanov, S. 登録日 2022-07-12 公開日 2023-05-24 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (2.57 Å) 主引用文献 A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNW	Cryo-EM structure of the human Sec61 complex in a partially-open apo state (Class 2) 分子名称: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma 著者 Park, E, Itskanov, S. 登録日 2022-07-12 公開日 2023-05-24 最終更新日 2023-09-06 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DO2	Cryo-EM structure of the human Sec61 complex inhibited by cyclotriazadisulfonamide (CADA) 分子名称: 9-benzyl-1,5-bis(4-methylbenzene-1-sulfonyl)-3-methylidene-1,5,9-triazacyclododecane, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... 著者 Park, E, Itskanov, S. 登録日 2022-07-12 公開日 2023-05-24 最終更新日 2023-09-06 実験手法 ELECTRON MICROSCOPY (2.95 Å) 主引用文献 A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNY	Cryo-EM structure of the human Sec61 complex inhibited by decatransin 分子名称: Decatransin peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... 著者 Park, E, Itskanov, S. 登録日 2022-07-12 公開日 2023-05-24 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (2.85 Å) 主引用文献 A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNX	Cryo-EM structure of the human Sec61 complex inhibited by cotransin 分子名称: Cotransin analogue peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... 著者 Park, E, Itskanov, S. 登録日 2022-07-12 公開日 2023-05-24 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (2.98 Å) 主引用文献 A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DO0	Cryo-EM structure of the human Sec61 complex inhibited by mycolactone 分子名称: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma, ... 著者 Park, E, Itskanov, S. 登録日 2022-07-12 公開日 2023-05-24 最終更新日 2023-09-06 実験手法 ELECTRON MICROSCOPY (2.86 Å) 主引用文献 A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DO3	Cryo-EM structure of the human Sec61 complex inhibited by eeyarestatin I 分子名称: N'-(4-chlorophenyl)-N-[(4R)-3-(4-chlorophenyl)-5,5-dimethyl-1-(2-{(2E)-2-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]hydrazinyl}-2-oxoethyl)-2-oxoimidazolidin-4-yl]-N-hydroxyurea, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... 著者 Park, E, Itskanov, S. 登録日 2022-07-12 公開日 2023-05-24 最終更新日 2023-09-06 実験手法 ELECTRON MICROSCOPY (3.22 Å) 主引用文献 A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
7AFT	Cryo-EM structure of the signal sequence-engaged post-translational Sec translocon 分子名称: Mating factor alpha-1,Mating factor alpha-1, Protein translocation protein SEC63, Protein transport protein SBH1, ... 著者 Weng, T.-H, Beatrix, B, Berninghausen, O, Becker, T, Cheng, J, Beckmann, R. 登録日 2020-09-20 公開日 2020-12-02 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Architecture of the active post-translational Sec translocon. Embo J., 40, 2021
6W6L	Cryo-EM structure of the human ribosome-TMCO1 translocon 分子名称: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... 著者 Keenan, R.J, McGilvray, P.T. 登録日 2020-03-17 公開日 2020-09-02 実験手法 ELECTRON MICROSCOPY (3.84 Å) 主引用文献 An ER translocon for multi-pass membrane protein biogenesis. Elife, 9, 2020
6FTJ	Cryo-EM Structure of the Mammalian Oligosaccharyltransferase Bound to Sec61 and the Non-programmed 80S Ribosome 分子名称: 28S rRNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... 著者 Braunger, K, Becker, T, Beckmann, R. 登録日 2018-02-22 公開日 2018-03-21 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (4.7 Å) 主引用文献 Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum. Science, 360, 2018
5GAE	RNC in complex with a translocating SecYEG 分子名称: 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... 著者 Jomaa, A, Boehringer, D, Leibundgut, M, Ban, N. 登録日 2015-11-25 公開日 2016-01-27 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (3.33 Å) 主引用文献 Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon. Nat Commun, 7, 2016
6R7Q	Structure of XBP1u-paused ribosome nascent chain complex with Sec61. 分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... 著者 Shanmuganathan, V, Cheng, J, Braunger, K, Berninghausen, O, Beatrix, B, Beckmann, R. 登録日 2019-03-29 公開日 2019-07-10 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
7TM3	Structure of the rabbit 80S ribosome stalled on a 2-TMD Rhodopsin intermediate in complex with the multipass translocon 分子名称: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... 著者 Kim, M.K, Lewis, A.J.O, Keenan, R.J, Hegde, R.S. 登録日 2022-01-19 公開日 2022-10-19 最終更新日 2022-11-16 実験手法 ELECTRON MICROSCOPY (3.25 Å) 主引用文献 Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature, 611, 2022
6N3Q	Cryo-EM structure of the yeast Sec complex 分子名称: Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... 著者 Park, E, Itskanov, S. 登録日 2018-11-16 公開日 2018-12-19 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.68 Å) 主引用文献 Structure of the posttranslational Sec protein-translocation channel complex from yeast. Science, 363, 2019
6ND1	CryoEM structure of the Sec Complex from yeast 分子名称: Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... 著者 Wu, X, Cabanos, C, Rapoport, T.A. 登録日 2018-12-13 公開日 2019-01-09 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structure of the post-translational protein translocation machinery of the ER membrane. Nature, 566, 2019
7TUT	Structure of the rabbit 80S ribosome stalled on a 4-TMD Rhodopsin intermediate in complex with the multipass translocon 分子名称: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... 著者 Kim, M.K, Lewis, A.J.O, Keenan, R.J, Hegde, R.S. 登録日 2022-02-03 公開日 2022-10-19 最終更新日 2022-11-16 実験手法 ELECTRON MICROSCOPY (3.88 Å) 主引用文献 Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature, 611, 2022

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