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7BA8	Cys-42-tethered stabilizer 10 of 14-3-3(sigma)/ERa PPI Descriptor: 14-3-3 protein sigma, 2-methyl-2-phenoxy-~{N}-(2-sulfanylethyl)propanamide, Estrogen receptor, ... Authors: Sijbesma, E, Ottmann, C. Deposit date: 2020-12-15 Release date: 2021-07-07 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12, 2021
7B9T	Cys-45-tethered stabilizer 5 of 14-3-3(sigma)/ERa PPI Descriptor: 14-3-3 protein sigma, 2-(4-chlorophenyl)sulfanyl-~{N}-(3-sulfanylpropyl)ethanamide, Estrogen receptor, ... Authors: Sijbesma, E, Ottmann, C. Deposit date: 2020-12-14 Release date: 2021-07-07 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.15 Å) Cite: Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12, 2021
7B9M	Cys-45-tethered stabilizer 3 of 14-3-3(sigma)/ERa PPI Descriptor: 14-3-3 protein sigma, 2-(2-cyanophenyl)sulfanyl-~{N}-(2-sulfanylethyl)benzamide, Estrogen receptor, ... Authors: Sijbesma, E, Ottmann, C. Deposit date: 2020-12-14 Release date: 2021-07-07 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12, 2021
7B9R	Cys-45-tethered stabilizer 4 of 14-3-3(sigma)/ERa PPI Descriptor: 14-3-3 protein sigma, 2-(2-cyanophenyl)sulfanyl-~{N}-(3-sulfanylpropyl)benzamide, Estrogen receptor, ... Authors: Sijbesma, E, Ottmann, C. Deposit date: 2020-12-14 Release date: 2021-07-07 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.15 Å) Cite: Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12, 2021
7B13	14-3-3sigma in complex with SHN3pS542 phosphopeptide crystal structure Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, SHN3pS542 Authors: Soini, L, Leysen, S, Davis, J, Ottmann, C. Deposit date: 2020-11-23 Release date: 2021-09-29 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.37 Å) Cite: 14-3-3 sigma in complex with phosphopeptides To Be Published
7B15	14-3-3sigma in complex with SHN3pT869 phosphopeptide crystal structure Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, SHN3pT869 Authors: Soini, L, Leysen, S, Davis, J, Ottmann, C. Deposit date: 2020-11-23 Release date: 2021-09-29 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.59 Å) Cite: 14-3-3 sigma in complex with phosphopeptides To Be Published
7AZ1	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1013 Descriptor: 1-[4-methyl-3-(trifluoromethyl)phenyl]-2-phenyl-imidazole, 14-3-3 protein sigma, CALCIUM ION, ... Authors: Wolter, M, Dijck, L.v, Ottmann, C. Deposit date: 2020-11-14 Release date: 2021-06-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.15 Å) Cite: Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7AZ2	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1014 Descriptor: 1-[4-methyl-2-(trifluoromethyl)phenyl]-2-phenyl-imidazole, 14-3-3 protein sigma, CALCIUM ION, ... Authors: Wolter, M, Dijck, L.v, Ottmann, C. Deposit date: 2020-11-14 Release date: 2021-06-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.081 Å) Cite: Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7AYF	14-3-3 sigma with Pin1 binding site pS72 and covalently bound TCF521-110 Descriptor: 14-3-3 protein sigma, 6-(2-bromanylimidazol-1-yl)pyridine-3-carbaldehyde, CALCIUM ION, ... Authors: Wolter, M, Dijck, L.v, Ottmann, C. Deposit date: 2020-11-12 Release date: 2021-06-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.752 Å) Cite: Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7AXN	14-3-3 sigma in complex with Pin1 binding site pS72 and covalently bound TCF521-026 Descriptor: 14-3-3 protein sigma, 3-chloranyl-4-imidazol-1-yl-benzaldehyde, CALCIUM ION, ... Authors: Wolter, M, Dijck, L.v, Ottmann, C. Deposit date: 2020-11-10 Release date: 2021-06-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7D9V	CRTC1 pSer245 peptide in complex with 14-3-3 zeta Descriptor: 14-3-3 protein zeta/delta, CRTC1 pSer245 peptide, GLYCEROL Authors: Chen, H, Zhang, H, Xiang, S. Deposit date: 2020-10-14 Release date: 2021-02-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.21 Å) Cite: Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol., 433, 2021
7AOG	14-3-3 sigma in complex with Pin1 binding site pS72 Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... Authors: Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. Deposit date: 2020-10-14 Release date: 2021-06-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7D8H	CRTC1 pSer64 peptide in complex with 14-3-3 zeta Descriptor: 14-3-3 protein zeta/delta, CRTC1 pSer64 peptide Authors: Chen, H, Zhang, H, Xiang, S. Deposit date: 2020-10-08 Release date: 2021-02-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.42 Å) Cite: Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol., 433, 2021
7D8P	CRTC1 pSer151 peptide in complex with 14-3-3 zeta Descriptor: 14-3-3 protein zeta/delta, CRTC1 pSer151 peptide, GLYCEROL Authors: Chen, H, Zhang, H, Xiang, S. Deposit date: 2020-10-08 Release date: 2021-02-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol., 433, 2021
7AEW	14-3-3 sigma bound to bis-phosphorylated aminopeptidase N (APN, CD13) via canonical and non-canonical binding motifs Descriptor: 14-3-3 protein sigma, Aminopeptidase N, CHLORIDE ION, ... Authors: Kiehstaller, S, Hennig, S. Deposit date: 2020-09-18 Release date: 2020-11-04 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.2 Å) Cite: MMP activation-associated aminopeptidase N reveals a bivalent 14-3-3 binding motif. J.Biol.Chem., 295, 2020
7A6Y	Structure of 14-3-3 gamma in complex with DAPK2 peptide stabilized by FC-A Descriptor: 14-3-3 protein gamma, DAPK2 C-terminal peptide, FUSICOCCIN Authors: Horvath, M, Obsilova, V, Obsil, T. Deposit date: 2020-08-27 Release date: 2021-08-25 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.5 Å) Cite: 14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites. Commun Biol, 4, 2021
7A6R	Structure of 14-3-3 gamma in complex with DAPK2 peptide containing the 14-3-3 binding motif Descriptor: 14-3-3 protein gamma, DAPK2 C-terminal peptide Authors: Horvath, M, Obsilova, V, Obsil, T. Deposit date: 2020-08-26 Release date: 2021-08-25 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.7 Å) Cite: 14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites. Commun Biol, 4, 2021
6ZVC	14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 48h incubation Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide Authors: Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C. Deposit date: 2020-07-24 Release date: 2021-08-04 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.51 Å) Cite: A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes To Be Published
6ZVB	14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 24h incubation Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide Authors: Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C. Deposit date: 2020-07-24 Release date: 2021-08-04 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.51 Å) Cite: A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes To Be Published
6ZVD	14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 96h incubation Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide Authors: Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C. Deposit date: 2020-07-24 Release date: 2021-08-04 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes To Be Published
6ZVE	14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 1h incubation Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide Authors: Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C. Deposit date: 2020-07-24 Release date: 2021-08-04 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.51 Å) Cite: A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes To Be Published
6ZFD	14-3-3 zeta bound to the phosphorylated 18E6 C-terminus Descriptor: 14-3-3 protein zeta/delta,Protein E6, GLYCEROL Authors: Gogl, G, Tugaeva, K.V, Sluchanko, N.N, Trave, G. Deposit date: 2020-06-17 Release date: 2021-02-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms. Nat Commun, 12, 2021
6ZFG	14-3-3 zeta chimera with 18E6 and fusicoccin Descriptor: 14-3-3 protein zeta/delta,Protein E6, FUSICOCCIN, GLYCEROL Authors: Gogl, G, Tugaeva, K, Sluchanko, N.N, Trave, G. Deposit date: 2020-06-17 Release date: 2021-02-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms. Nat Commun, 12, 2021
6ZCJ	14-3-3sigma in complex with SLP76pS376 phosphopeptide crystal structure Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, SLP76pS376 Authors: Soini, L, Leysen, S, Davis, J, Ottmann, C. Deposit date: 2020-06-11 Release date: 2020-12-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.53 Å) Cite: The 14-3-3/SLP76 protein-protein interaction in T-cell receptor signalling: a structural and biophysical characterization. Febs Lett., 595, 2021
6ZC9	Structure of 14-3-3 gamma in complex with Nedd4-2 14-3-3 binding motif Ser448 Descriptor: 1,1,1,3,3,3-hexafluoropropan-2-ol, 14-3-3 protein gamma, E3 ubiquitin-protein ligase NEDD4-like Authors: Pohl, P, Kalabova, D, Obsil, T, Obsilova, V. Deposit date: 2020-06-10 Release date: 2021-07-21 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.89895988 Å) Cite: 14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains. Commun Biol, 4, 2021

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