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5D0H	Crystal Structure of triple mutant (KDA to EGY) of an adenylyl cyclase Ma1120 from Mycobacterium avium in complex with ATP and calcium ion Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Cyclase Authors: Bharambe, N.G, Suguna, K. Deposit date: 2015-08-03 Release date: 2016-08-10 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Substrate specificity determinants of class III nucleotidyl cyclases Febs J., 283, 2016
6AO9	Crystal structure of monomeric guanylyl cyclase domain of RhoGC fusion protein from the aquatic fungus Blastocladiella emersonii Descriptor: Bacterio-rhodopsin/guanylyl cyclase 1 fusion protein Authors: Prem Kumar, R, Oprian, D.D. Deposit date: 2017-08-15 Release date: 2017-11-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.13 Å) Cite: Structure and monomer/dimer equilibrium for the guanylyl cyclase domain of the optogenetics protein RhoGC. J. Biol. Chem., 292, 2017
6AOA	Monomeric crystal structure of the E497/C566D double mutant of the guanylyl cyclase domain of the RhoGC fusion protein from the aquatic fungus Blastocladiella emersonii Descriptor: Bacterio-rhodopsin/guanylyl cyclase 1 fusion protein Authors: Prem Kumar, R, Oprian, D.D. Deposit date: 2017-08-15 Release date: 2017-11-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Structure and monomer/dimer equilibrium for the guanylyl cyclase domain of the optogenetics protein RhoGC. J. Biol. Chem., 292, 2017
6AOB	Crystal structure of non-canonical dimeric guanylyl cyclase domain of RhoGC fusion protein from the aquatic fungus Blastocladiella emersonii Descriptor: Bacterio-rhodopsin/guanylyl cyclase 1 fusion protein, L(+)-TARTARIC ACID, MANGANESE (II) ION Authors: Prem Kumar, R, Oprian, D.D. Deposit date: 2017-08-15 Release date: 2017-11-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structure and monomer/dimer equilibrium for the guanylyl cyclase domain of the optogenetics protein RhoGC. J. Biol. Chem., 292, 2017
8B75	CRYSTAL STRUCTURE OF HUMAN SOLUBLE ADENYLYL CYCLASE IN COMPLEX WITH THE INHIBITOR TDI-011861 Descriptor: Adenylate cyclase type 10, [(3~{R})-4-[2-[2-[[3-(2-azanyl-6-chloranyl-pyrimidin-4-yl)-1-[bis(fluoranyl)methyl]pyrazol-4-yl]methyl]phenoxy]ethyl]morpholin-3-yl]methanol Authors: Steegborn, C, Kehr, M. Deposit date: 2022-09-28 Release date: 2023-03-29 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates. J.Med.Chem., 65, 2022
8CO7	Crystal structure of human soluble adenylyl cyclase (sAC) in complex with inhibitor TDI-09066 Descriptor: 1,2-ETHANEDIOL, 4-chloranyl-6-[1-methyl-4-(thiophen-2-ylmethyl)pyrazol-3-yl]pyrimidin-2-amine, ACETATE ION, ... Authors: Steegborn, C. Deposit date: 2023-02-27 Release date: 2024-01-03 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation. J.Chem.Inf.Model., 63, 2023
8COJ	Crystal structure of human soluble adenylyl cyclase catalytic domain in complex with the inhibitor TDI-10228 Descriptor: 1,2-ETHANEDIOL, 4-chloranyl-6-[4-[(3-fluorophenyl)methyl]-1-methyl-pyrazol-3-yl]pyrimidin-2-amine, ACETATE ION, ... Authors: Steegborn, C, Fushimi, M. Deposit date: 2023-02-28 Release date: 2023-04-26 Last modified: 2023-05-17 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation. J.Chem.Inf.Model., 63, 2023
8CNH	Crystal structure of human soluble adenylyl cyclase (sAC) in complex with inhibitor TDI-10512 Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Adenylate cyclase type 10, ... Authors: Steegborn, C. Deposit date: 2023-02-23 Release date: 2023-04-26 Last modified: 2023-05-17 Method: X-RAY DIFFRACTION (2 Å) Cite: Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation. J.Chem.Inf.Model., 63, 2023
8COT	Complex of human soluble adenylyl cyclase 10 catalytic core with inhibitor TDI-10962 Descriptor: 1,2-ETHANEDIOL, 2-(dimethylamino)ethyl 5-(2-azanyl-6-chloranyl-pyrimidin-4-yl)-2-methyl-4-(phenylmethyl)pyrazole-3-carboxylate, ACETATE ION, ... Authors: Steegborn, C, Fushimi, M. Deposit date: 2023-02-28 Release date: 2023-04-26 Last modified: 2023-05-17 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation. J.Chem.Inf.Model., 63, 2023
4USW	Crystal structure of human soluble Adenylyl Cyclase with ATP Descriptor: ACETATE ION, ADENOSINE-5'-TRIPHOSPHATE, ADENYLATE CYCLASE TYPE 10, ... Authors: Kleinboelting, S, Steegborn, C. Deposit date: 2014-07-13 Release date: 2014-07-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structural Analysis of Human Soluble Adenylyl Cyclase and Crystal Structures of its Nucleotide Complexes -Implications for Cyclase Catalysis and Evolution. FEBS J., 281, 2014
4USU	Crystal structure of human soluble Adenylyl Cyclase in complex with alpha,beta-methyleneadenosine-5'-triphosphate Descriptor: 1,2-ETHANEDIOL, ADENYLATE CYCLASE TYPE 10, CALCIUM ION, ... Authors: Kleinboelting, S, Steegborn, C. Deposit date: 2014-07-13 Release date: 2014-07-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structural Analysis of Human Soluble Adenylyl Cyclase and Crystal Structures of its Nucleotide Complexes -Implications for Cyclase Catalysis and Evolution. FEBS J., 281, 2014
1AB8	RAT TYPE II ADENYLYL CYCLASE C2 DOMAIN/FORSKOLIN COMPLEX Descriptor: ADENYLYL CYCLASE, FORSKOLIN Authors: Zhang, G, Hurley, J.H. Deposit date: 1997-02-04 Release date: 1997-05-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure of the adenylyl cyclase catalytic core. Nature, 386, 1997
4WP9	Crystal structure of Adenylyl cyclase MA1120 from Mycobacterium Avium bound to 2'5'-DD-3'-ATP, Calcium and Magnesium ion Descriptor: 2',5'-dideoxyadenosine 3'-(tetrahydrogen triphosphate), CALCIUM ION, MAGNESIUM ION, ... Authors: Bharambe, N.G, Barathy, D.V, Suguna, K. Deposit date: 2014-10-17 Release date: 2015-09-02 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.382 Å) Cite: Autoinhibitory mechanism and activity-related structural changes in a mycobacterial adenylyl cyclase J.Struct.Biol., 190, 2015
4WP8	Crystal structure of Adenylyl cyclase Ma1120 from Mycobacterium Avium in complex with 2'5'-DD-3'-ATP and Manganese ion Descriptor: 2',5'-dideoxyadenosine 3'-(tetrahydrogen triphosphate), CHLORIDE ION, MANGANESE (II) ION, ... Authors: Barathy, D.V, Bharambe, N.G, Suguna, K. Deposit date: 2014-10-17 Release date: 2015-09-02 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Autoinhibitory mechanism and activity-related structural changes in a mycobacterial adenylyl cyclase J.Struct.Biol., 190, 2015
7OVD	Human soluble adenylyl cyclase in complex with the inhibitor TDI10229 Descriptor: 1,2-ETHANEDIOL, 4-chloranyl-6-[1,5-dimethyl-4-(phenylmethyl)pyrazol-3-yl]pyrimidin-2-amine, ACETATE ION, ... Authors: Steegborn, C, Quast, J. Deposit date: 2021-06-14 Release date: 2021-10-06 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10). Acs Med.Chem.Lett., 12, 2021
4WP3	Crystal Structure of Adenylyl cyclase from Mycobacterium avium Ma1120 wild type Descriptor: CHLORIDE ION, Ma1120 Authors: Barathy, D.V, Bharambe, N.G, Suguna, K. Deposit date: 2014-10-17 Release date: 2015-09-02 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Autoinhibitory mechanism and activity-related structural changes in a mycobacterial adenylyl cyclase J.Struct.Biol., 190, 2015
4WPA	Crystal structure of Adenylyl cyclase Ma1120 from Mycobacterium Avium bound to Pyrophosphate and Calcium Descriptor: CALCIUM ION, Ma1120, PYROPHOSPHATE Authors: Bharambe, N.G, Barathy, D.V, Suguna, K. Deposit date: 2014-10-17 Release date: 2015-09-02 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Autoinhibitory mechanism and activity-related structural changes in a mycobacterial adenylyl cyclase J.Struct.Biol., 190, 2015
7PDG	structure of adenylyl cyclase 9 in complex with DARPin C4 and ATP-aS Descriptor: Adenylate cyclase 9, DARPin C4 Authors: Qi, C, Korkhov, V.M. Deposit date: 2021-08-05 Release date: 2022-01-19 Last modified: 2022-03-09 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Structural basis of adenylyl cyclase 9 activation. Nat Commun, 13, 2022
7PD4	structure of Adenylyl cyclase 9 in complex with MANT-GTP Descriptor: Adenylate cyclase 9 Authors: Qi, C, Korkhov, V.M. Deposit date: 2021-08-04 Release date: 2022-01-19 Last modified: 2022-03-09 Method: ELECTRON MICROSCOPY (4.9 Å) Cite: Structural basis of adenylyl cyclase 9 activation. Nat Commun, 13, 2022
7PDH	structure of adenylyl cyclase 9 in complex with DARPin C4 and ATP-aS Descriptor: Adenylate cyclase 9, DARPin C4 Authors: Qi, C, Korkhov, V.M. Deposit date: 2021-08-05 Release date: 2022-01-19 Last modified: 2022-03-09 Method: ELECTRON MICROSCOPY (4 Å) Cite: Structural basis of adenylyl cyclase 9 activation. Nat Commun, 13, 2022
7PDD	Focus refinement of soluble domain of Adenylyl cyclase 9 in complex with DARPin C4 and MANT-GTP Descriptor: Adenylate cyclase 9, DARPin C4 Authors: Qi, C, Korkhov, V.M. Deposit date: 2021-08-05 Release date: 2022-01-19 Last modified: 2022-03-09 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Structural basis of adenylyl cyclase 9 activation. Nat Commun, 13, 2022
7PD8	Structure of Adenylyl cyclase 9 in complex with DARPin C4 and MANT-GTP Descriptor: Adenylate cyclase 9, DARPin C4 Authors: Qi, C, Korkhov, V.M. Deposit date: 2021-08-04 Release date: 2022-01-19 Last modified: 2022-03-09 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Structural basis of adenylyl cyclase 9 activation. Nat Commun, 13, 2022
1WC5	Soluble adenylyl cyclase CyaC from S. platensis in complex with alpha, beta-methylene-ATP in presence of bicarbonate Descriptor: ADENYLATE CYCLASE, CALCIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... Authors: Steegborn, C, Litvin, T.N, Levin, L.R, Buck, J, Wu, H. Deposit date: 2004-11-08 Release date: 2004-12-20 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Bicarbonate Activation of Adenylyl Cyclase Via Promotion of Catalytic Active Site Closure and Metal Recruitment Nat.Struct.Mol.Biol., 12, 2005
1WC4	Soluble adenylyl cyclase CyaC from S. platensis in complex with alpha, beta-methylene-ATP and Europium Descriptor: ADENYLATE CYCLASE, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, EUROPIUM (III) ION Authors: Steegborn, C, Litvin, T.N, Levin, L.R, Buck, J, Wu, H. Deposit date: 2004-11-08 Release date: 2004-12-20 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Bicarbonate Activation of Adenylyl Cyclase Via Promotion of Catalytic Active Site Closure and Metal Recruitment Nat.Struct.Mol.Biol., 12, 2005
1WC3	Soluble adenylyl cyclase CyaC from S. platensis in complex with alpha, beta-methylene-ATP and Strontium Descriptor: ADENYLATE CYCLASE, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, STRONTIUM ION Authors: Steegborn, C, Litvin, T.N, Levin, L.R, Buck, J, Wu, H. Deposit date: 2004-11-08 Release date: 2004-12-20 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Bicarbonate Activation of Adenylyl Cyclase Via Promotion of Catalytic Active Site Closure and Metal Recruitment Nat.Struct.Mol.Biol., 12, 2005

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