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3R6V
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BU of 3r6v by Molmil
Crystal structure of aspartase from Bacillus sp. YM55-1 with bound L-aspartate
Descriptor: ASPARTIC ACID, Aspartase, CALCIUM ION
Authors:Fibriansah, G, Puthan Veetil, V, Poelarends, G.J, Thunnissen, A.-M.W.H.
Deposit date:2011-03-22
Release date:2011-07-13
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for the catalytic mechanism of aspartate ammonia lyase.
Biochemistry, 50, 2011
3R6Q
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BU of 3r6q by Molmil
A triclinic-lattice structure of aspartase from Bacillus sp. YM55-1
Descriptor: Aspartase, CALCIUM ION
Authors:Fibriansah, G, Puthan Veetil, V, Poelarends, G.J, Thunnissen, A.-M.W.H.
Deposit date:2011-03-22
Release date:2011-07-13
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for the catalytic mechanism of aspartate ammonia lyase.
Biochemistry, 50, 2011
3RRP
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BU of 3rrp by Molmil
Crystal structure of fumarate hydratase Fum from Mycobacterium abscessus with malate bound
Descriptor: (2S)-2-hydroxybutanedioic acid, 1,2-ETHANEDIOL, Probable fumarate hydratase Fum
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2011-04-29
Release date:2011-05-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
1TJU
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BU of 1tju by Molmil
Crystal Structure of T161S Duck Delta 2 Crystallin Mutant
Descriptor: Delta crystallin II
Authors:Sampaleanu, L.M, Codding, P.W, Lobsanov, Y.D, Tsai, M, Smith, G.D, Horvatin, C, Howell, P.L.
Deposit date:2004-06-07
Release date:2004-09-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural studies of duck delta2 crystallin mutants provide insight into the role of Thr161 and the 280s loop in catalysis
Biochem.J., 384, 2004
1TJ7
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BU of 1tj7 by Molmil
Structure determination and refinement at 2.44 A resolution of Argininosuccinate lyase from E. coli
Descriptor: Argininosuccinate lyase, GLYCEROL, PHOSPHATE ION
Authors:Bhaumik, P, Koski, M.K, Bergman, U, Wierenga, R.K.
Deposit date:2004-06-03
Release date:2004-10-26
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Structure determination and refinement at 2.44 A resolution of argininosuccinate lyase from Escherichia coli.
Acta Crystallogr.,Sect.D, 60, 2004
1TJV
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BU of 1tjv by Molmil
Crystal Structure of T161D Duck Delta 2 Crystallin Mutant
Descriptor: Delta crystallin II
Authors:Sampaleanu, L.M, Codding, P.W, Lobsanov, Y.D, Tsai, M, Smith, G.D, Horvatin, C, Howell, P.L.
Deposit date:2004-06-07
Release date:2004-09-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural studies of duck delta2 crystallin mutants provide insight into the role of Thr161 and the 280s loop in catalysis
BIOCHEM.J., 384, 2004
1TJW
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BU of 1tjw by Molmil
Crystal Structure of T161D Duck Delta 2 Crystallin Mutant with bound argininosuccinate
Descriptor: ARGININOSUCCINATE, Delta crystallin II
Authors:Sampaleanu, L.M, Codding, P.W, Lobsanov, Y.D, Tsai, M, Smith, G.D, Horvatin, C, Howell, P.L.
Deposit date:2004-06-07
Release date:2004-09-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural studies of duck delta2 crystallin mutants provide insight into the role of Thr161 and the 280s loop in catalysis
Biochem.J., 384, 2004
1U16
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Crystal structure of a duck-delta-crystallin-1 double loop mutant (DLM) in complex with sulfate
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, Delta crystallin I, ...
Authors:Tsai, M, Sampaleanu, L.M, Greene, C, Creagh, L, Haynes, C, Howell, P.L.
Deposit date:2004-07-14
Release date:2004-10-05
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A duck delta1 crystallin double loop mutant provides insight into residues important for argininosuccinate lyase activity.
Biochemistry, 43, 2004
1U15
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Crystal structure of a duck-delta-crystallin-1 double loop mutant (DLM)
Descriptor: Delta crystallin I
Authors:Tsai, M, Sampaleanu, L.M, Greene, C, Creagh, L, Haynes, C, Howell, P.L.
Deposit date:2004-07-14
Release date:2004-10-05
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A duck delta1 crystallin double loop mutant provides insight into residues important for argininosuccinate lyase activity.
Biochemistry, 43, 2004
1F1O
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STRUCTURAL STUDIES OF ADENYLOSUCCINATE LYASES
Descriptor: ADENYLOSUCCINATE LYASE
Authors:Toth, E.A, Yeates, T.
Deposit date:2000-05-19
Release date:2001-01-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three disulfide bonds.
J.Mol.Biol., 301, 2000
1FUO
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BU of 1fuo by Molmil
FUMARASE C WITH BOUND CITRATE
Descriptor: CITRIC ACID, D-MALATE, FUMARASE C
Authors:Weaver, T, Banaszak, L.
Deposit date:1996-08-29
Release date:1997-03-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Crystallographic studies of the catalytic and a second site in fumarase C from Escherichia coli.
Biochemistry, 35, 1996
1FUR
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BU of 1fur by Molmil
FUMARASE MUTANT H188N WITH BOUND SUBSTRATE L-MALATE AT PUTATIVE ACTIVATOR SITE
Descriptor: D-MALATE, FUMARASE C
Authors:Weaver, T.M, Lees, M, Banaszak, L.J.
Deposit date:1997-01-09
Release date:1997-07-23
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Mutations of fumarase that distinguish between the active site and a nearby dicarboxylic acid binding site.
Protein Sci., 6, 1997
1FUP
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BU of 1fup by Molmil
FUMARASE WITH BOUND PYROMELLITIC ACID
Descriptor: D-MALATE, FUMARASE C, PYROMELLITIC ACID
Authors:Weaver, T, Banaszak, L.
Deposit date:1996-08-29
Release date:1997-03-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystallographic studies of the catalytic and a second site in fumarase C from Escherichia coli.
Biochemistry, 35, 1996
1FUQ
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BU of 1fuq by Molmil
FUMARASE WITH BOUND 3-TRIMETHYLSILYLSUCCINIC ACID
Descriptor: 3-TRIMETHYLSILYLSUCCINIC ACID, CITRIC ACID, FUMARASE C
Authors:Weaver, T, Banaszak, L.
Deposit date:1996-08-29
Release date:1997-03-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystallographic studies of the catalytic and a second site in fumarase C from Escherichia coli.
Biochemistry, 35, 1996
1HY0
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BU of 1hy0 by Molmil
CRYSTAL STRUCTURE OF WILD TYPE DUCK DELTA 1 CRYSTALLIN (EYE LENS PROTEIN)
Descriptor: DELTA CRYSTALLIN I, SULFATE ION
Authors:Sampaleanu, L.M, Vallee, F, Slingsby, C, Howell, P.L.
Deposit date:2001-01-17
Release date:2001-04-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural studies of duck delta 1 and delta 2 crystallin suggest conformational changes occur during catalysis.
Biochemistry, 40, 2001
1I0A
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BU of 1i0a by Molmil
CRYSTAL STRUCTURE OF WILD TYPE TURKEY DELTA 1 CRYSTALLIN (EYE LENS PROTEIN)
Descriptor: DELTA CRYSTALLIN I
Authors:Sampaleanu, L.M, Vallee, F, Slingsby, C, Howell, P.L.
Deposit date:2001-01-29
Release date:2001-04-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural studies of duck delta 1 and delta 2 crystallin suggest conformational changes occur during catalysis.
Biochemistry, 40, 2001
1HY1
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BU of 1hy1 by Molmil
CRYSTAL STRUCTURE OF WILD TYPE DUCK DELTA 2 CRYSTALLIN (EYE LENS PROTEIN)
Descriptor: DELTA CRYSTALLIN II
Authors:Sampaleanu, L.M, Vallee, F, Slingsby, C, Howell, P.L.
Deposit date:2001-01-17
Release date:2001-04-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural studies of duck delta 1 and delta 2 crystallin suggest conformational changes occur during catalysis.
Biochemistry, 40, 2001
1J3U
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BU of 1j3u by Molmil
Crystal structure of aspartase from Bacillus sp. YM55-1
Descriptor: aspartase
Authors:Fujii, T, Sakai, H, Kawata, Y, Hata, Y.
Deposit date:2003-02-16
Release date:2003-05-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of Thermostable Aspartase from Bacillus sp. YM55-1: Structure-based Exploration of Functional Sites in the Aspartase Family
J.Mol.Biol., 328, 2003
6P3C
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E. coli fumarase mutant - T187A
Descriptor: CITRATE ANION, Fumarate hydratase class II
Authors:May, J.F, Bhattcharyya, B, Weaver, T.M.
Deposit date:2019-05-23
Release date:2020-05-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.459 Å)
Cite:Fumarase C variant at the active site
To Be Published
6S7U
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Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(5-(Azepan-1-ylsulfonyl)-2-methoxyphenyl)-2-(1H-indol-3-yl)acetamide
Descriptor: FORMIC ACID, Fumarate hydratase class II, MAGNESIUM ION, ...
Authors:Whitehouse, A.J, Libardo, M.D, Kasbekar, M, Brear, P, Fischer, G, Thomas, C.J, Barry, C.E, Boshoff, H.I, Coyne, A.G, Abell, C.
Deposit date:2019-07-06
Release date:2019-09-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Targeting of Fumarate Hydratase fromMycobacterium tuberculosisUsing Allosteric Inhibitors with a Dimeric-Binding Mode.
J.Med.Chem., 62, 2019
6RX8
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BU of 6rx8 by Molmil
EDDS lyase variant D290M/Y320M with bound fumarate
Descriptor: Argininosuccinate lyase, FUMARIC ACID, SODIUM ION
Authors:Grandi, E, Poelarends, G.J, Thunnissen, A.M.W.H.
Deposit date:2019-06-07
Release date:2019-10-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Engineered C-N Lyase: Enantioselective Synthesis of Chiral Synthons for Artificial Dipeptide Sweeteners.
Angew.Chem.Int.Ed.Engl., 59, 2020
6S43
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BU of 6s43 by Molmil
Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(5-(Azocan-1-ylsulfonyl)-2-methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
Descriptor: FORMIC ACID, Fumarate hydratase class II, MAGNESIUM ION, ...
Authors:Whitehouse, A.J, Libardo, M.D, Kasbekar, M, Brear, P, Fischer, G, Thomas, C.J, Barry, C.E, Boshoff, H.I, Coyne, A.G, Abell, C.
Deposit date:2019-06-26
Release date:2019-09-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Targeting of Fumarate Hydratase fromMycobacterium tuberculosisUsing Allosteric Inhibitors with a Dimeric-Binding Mode.
J.Med.Chem., 62, 2019
6S7W
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BU of 6s7w by Molmil
Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(5-(Azepan-1-ylsulfonyl)-2-methoxyphenyl)-2-(quinolin-4-yl)acetamide
Descriptor: FORMIC ACID, Fumarate hydratase class II, MAGNESIUM ION, ...
Authors:Whitehouse, A.J, Libardo, M.D, Kasbekar, M, Brear, P, Fischer, G, Thomas, C.J, Barry, C.E, Boshoff, H.I, Coyne, A.G, Abell, C.
Deposit date:2019-07-07
Release date:2019-09-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Targeting of Fumarate Hydratase fromMycobacterium tuberculosisUsing Allosteric Inhibitors with a Dimeric-Binding Mode.
J.Med.Chem., 62, 2019
6S7K
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BU of 6s7k by Molmil
Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(2-Methoxy-5-(N-methylsulfamoyl)phenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
Descriptor: FORMIC ACID, Fumarate hydratase class II, MAGNESIUM ION, ...
Authors:Whitehouse, A.J, Libardo, M.D, Kasbekar, M, Brear, P, Fischer, G, Thomas, C.J, Barry, C.E, Boshoff, H.I, Coyne, A.G, Abell, C.
Deposit date:2019-07-05
Release date:2019-09-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Targeting of Fumarate Hydratase fromMycobacterium tuberculosisUsing Allosteric Inhibitors with a Dimeric-Binding Mode.
J.Med.Chem., 62, 2019
6S7S
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BU of 6s7s by Molmil
Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(2-Methoxy-5-(N-phenylsulfamoyl)phenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
Descriptor: FORMIC ACID, Fumarate hydratase class II, ~{N}-[2-methoxy-5-(phenylsulfamoyl)phenyl]-2-(4-oxidanylidene-3~{H}-phthalazin-1-yl)ethanamide
Authors:Whitehouse, A.J, Libardo, M.D, Kasbekar, M, Brear, P, Fischer, G, Thomas, C.J, Barry, C.E, Boshoff, H.I, Coyne, A.G, Abell, C.
Deposit date:2019-07-05
Release date:2019-09-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Targeting of Fumarate Hydratase fromMycobacterium tuberculosisUsing Allosteric Inhibitors with a Dimeric-Binding Mode.
J.Med.Chem., 62, 2019

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