6CXW
 
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5T0R
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5T0S
 | | Synaptotagmin 1 C2B domain, cadmium-bound | | Descriptor: | CADMIUM ION, SODIUM ION, Synaptotagmin-1 | | Authors: | Taylor, A.B, Hart, P.J, Igumenova, T.I. | | Deposit date: | 2016-08-16 | | Release date: | 2017-06-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.42 Å) | | Cite: | Non-Native Metal Ion Reveals the Role of Electrostatics in Synaptotagmin 1-Membrane Interactions.
Biochemistry, 56, 2017
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6EEL
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5UG6
 | | Perforin C2 Domain - T431D | | Descriptor: | IODIDE ION, Perforin-1 | | Authors: | Law, R.H.P, Conroy, P.J, Voskoboinik, I, Whisstock, J.C. | | Deposit date: | 2017-01-07 | | Release date: | 2018-02-07 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin.
Cell Death Differ., 25, 2018
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6EI6
 | | CC2D1B coordinates ESRCT-III activity during the mitotic reformation of the nuclear envelope | | Descriptor: | Coiled-coil and C2 domain-containing protein 1-like, DI(HYDROXYETHYL)ETHER, SULFATE ION | | Authors: | Ventimiglia, L.N, Cuesta-Geijo, M.A, Martinelli, N, Caballe, A, Macheboeuf, P, Miguet, N, Parnham, I.M, Olmos, Y, Carlton, J.G, Weissehorn, W, martin-Serrano, J. | | Deposit date: | 2017-09-18 | | Release date: | 2018-10-10 | | Last modified: | 2018-12-19 | | Method: | X-RAY DIFFRACTION (2.461 Å) | | Cite: | CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope.
Dev. Cell, 47, 2018
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6EWP
 | | Mus musculus CEP120 third C2 domain (C2C) | | Descriptor: | Centrosomal protein of 120 kDa, HEXAETHYLENE GLYCOL | | Authors: | van Breugel, M, al-Jassar, C. | | Deposit date: | 2017-11-06 | | Release date: | 2018-05-02 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Disease-Associated Mutations in CEP120 Destabilize the Protein and Impair Ciliogenesis.
Cell Rep, 23, 2018
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5UG7
 | | Calcium bound Perforin C2 Domain - T431D | | Descriptor: | CALCIUM ION, Perforin-1 | | Authors: | Law, R.H.P, Conroy, P.J, Voskoboinik, I, Whisstock, J.C. | | Deposit date: | 2017-01-07 | | Release date: | 2018-02-07 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin.
Cell Death Differ., 25, 2018
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6FB4
 | | human KIBRA C2 domain mutant C771A | | Descriptor: | GLYCEROL, PHOSPHATE ION, Protein KIBRA | | Authors: | Crennell, S.J, Posner, M.G, Bagby, S. | | Deposit date: | 2017-12-18 | | Release date: | 2018-05-16 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.415631 Å) | | Cite: | Distinctive phosphoinositide- and Ca2+-binding properties of normal and cognitive performance-linked variant forms of KIBRA C2 domain.
J. Biol. Chem., 293, 2018
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6FJC
 | | Human KIBRA C2 domain mutant C771A in complex with phosphatidylinositol 3,4,5-trisphosphate | | Descriptor: | (2R)-3-{[(S)-{[(2S,3R,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-(1-HYDROXY BUTOXY)PROPYL BUTYRATE, GLYCEROL, Protein KIBRA, ... | | Authors: | Crennell, S.J, Posner, M.G, Bagby, S. | | Deposit date: | 2018-01-22 | | Release date: | 2018-05-16 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.598 Å) | | Cite: | Distinctive phosphoinositide- and Ca2+-binding properties of normal and cognitive performance-linked variant forms of KIBRA C2 domain.
J. Biol. Chem., 293, 2018
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6FJD
 | | Human KIBRA C2 domain mutant C771A in complex with phosphatidylinositol 4,5-bisphosphate | | Descriptor: | (2R)-3-{[(R)-HYDROXY{[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIHYDROXY-4,5-BIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1 ,2-DIYL DIBUTANOATE, GLYCEROL, Protein KIBRA, ... | | Authors: | Crennell, S.J, Posner, M.G, Bagby, S. | | Deposit date: | 2018-01-22 | | Release date: | 2018-05-16 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.898 Å) | | Cite: | Distinctive phosphoinositide- and Ca2+-binding properties of normal and cognitive performance-linked variant forms of KIBRA C2 domain.
J. Biol. Chem., 293, 2018
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6FD0
 | | Human KIBRA C2 domain mutant M734I S735A | | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Protein KIBRA | | Authors: | Crennell, S.J, Posner, M.G, Bagby, S. | | Deposit date: | 2017-12-21 | | Release date: | 2018-05-16 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.64215851 Å) | | Cite: | Distinctive phosphoinositide- and Ca2+-binding properties of normal and cognitive performance-linked variant forms of KIBRA C2 domain.
J. Biol. Chem., 293, 2018
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6FLK
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6FLJ
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5VFF
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5VFG
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5VFE
 | | Synaptotagmin 1 C2A domain, lead-bound | | Descriptor: | LEAD (II) ION, SULFATE ION, Synaptotagmin-1 | | Authors: | Taylor, A.B, Hart, P.J, Igumenova, T.I. | | Deposit date: | 2017-04-07 | | Release date: | 2018-04-11 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.38 Å) | | Cite: | High affinity interactions of Pb2+with synaptotagmin I.
Metallomics, 10, 2018
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5W4S
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2K3H
 | | Structural determinants for Ca2+ and PIP2 binding by the C2A domain of rabphilin-3A | | Descriptor: | CALCIUM ION, Rabphilin-3A | | Authors: | Coudevylle, N, Montaville, P, Leonov, A, Zweckstetter, M, Becker, S. | | Deposit date: | 2008-05-08 | | Release date: | 2008-10-21 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | Structural Determinants for Ca2+ and Phosphatidylinositol 4,5-Bisphosphate Binding by the C2A Domain of Rabphilin-3A.
J.Biol.Chem., 283, 2008
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2K45
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2JQZ
 | | Solution Structure of the C2 domain of human Smurf2 | | Descriptor: | E3 ubiquitin-protein ligase SMURF2 | | Authors: | Wiesner, S, Ogunjimi, A.A, Wang, H, Rotin, D, Sicheri, F, Wrana, J.L, Forman-Kay, J.D. | | Deposit date: | 2007-06-15 | | Release date: | 2007-09-11 | | Last modified: | 2024-05-08 | | Method: | SOLUTION NMR | | Cite: | Autoinhibition of the HECT-Type Ubiquitin Ligase Smurf2 through Its C2 Domain
Cell(Cambridge,Mass.), 130, 2007
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2LHA
 | | Solution structure of C2B with IP6 | | Descriptor: | INOSITOL HEXAKISPHOSPHATE, Synaptotagmin-1 | | Authors: | Joung, M, Mohan, S.K, Yu, C. | | Deposit date: | 2011-08-08 | | Release date: | 2012-05-02 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Molecular Level Interaction of Inositol Hexaphosphate with the C2B Domain of Human Synaptotagmin I
Biochemistry, 2012
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2NQ3
 | | Crystal structure of the C2 Domain of Human Itchy Homolog E3 Ubiquitin Protein Ligase | | Descriptor: | CHLORIDE ION, Itchy homolog E3 ubiquitin protein ligase | | Authors: | Walker, J.R, Avvakumov, G.V, Xue, S, Butler-Cole, C, Finerty Jr, P.J, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2006-10-30 | | Release date: | 2006-11-14 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The C2 Domain of Human Itchy Homolog E3 Ubiquitin Protein Ligase
To be Published
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2NCE
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2NSQ
 | | Crystal structure of the C2 domain of the human E3 ubiquitin-protein ligase NEDD4-like protein | | Descriptor: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase NEDD4-like protein, GLYCEROL | | Authors: | Walker, J.R, Avvakumov, G.V, Xue, S, Butler-Cole, C, Finerty Jr, P.J, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2006-11-06 | | Release date: | 2006-12-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | The C2 domain of the human E3 ubiquitin-protein ligase NEDD4-like protein
To be Published
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