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3QV2	Structure Analysis of Entamoeba histolytica methyltransferase EhMeth Descriptor: 5-cytosine DNA methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION Authors: Schulz, E.C, Roth, H.M, Ankri, S, Ficner, R. Deposit date: 2011-02-25 Release date: 2012-04-11 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Crystal Structure Analysis of Entamoeba histolytica Methyltransferase To be Published
4DA4	Structure of mouse DNMT1 (731-1602) bound to hemimethylated CpG DNA Descriptor: CITRIC ACID, DNA (cytosine-5)-methyltransferase 1, DNA_LOWER_STRAND, ... Authors: Song, J, Patel, D.J. Deposit date: 2012-01-12 Release date: 2012-02-22 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure-Based Mechanistic Insights into DNMT1-Mediated Maintenance DNA Methylation. Science, 335, 2012
3SWR	Structure of human DNMT1 (601-1600) in complex with Sinefungin Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA (cytosine-5)-methyltransferase 1, ... Authors: Hashimoto, H, Cheng, X. Deposit date: 2011-07-14 Release date: 2011-08-10 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.49 Å) Cite: Structure of human DNMT1 (residues 600-1600) in complex with Sinefungin To be Published
3AV4	Crystal structure of mouse DNA methyltransferase 1 Descriptor: DNA (cytosine-5)-methyltransferase 1, ZINC ION Authors: Takeshita, K, Suetake, I, Yamashita, E, Suga, M, Narita, H, Nakagawa, A, Tajima, S. Deposit date: 2011-02-22 Release date: 2011-05-04 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1). Proc.Natl.Acad.Sci.USA, 108, 2011
3AV5	Crystal structure of mouse DNA methyltransferase 1 with AdoHcy Descriptor: DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION Authors: Takeshita, K, Suetake, I, Yamashita, E, Suga, M, Narita, H, Nakagawa, A, Tajima, S. Deposit date: 2011-02-22 Release date: 2011-05-04 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1). Proc.Natl.Acad.Sci.USA, 108, 2011
3AV6	Crystal structure of mouse DNA methyltransferase 1 with AdoMet Descriptor: DNA (cytosine-5)-methyltransferase 1, S-ADENOSYLMETHIONINE, ZINC ION Authors: Takeshita, K, Suetake, I, Yamashita, E, Suga, M, Narita, H, Nakagawa, A, Tajima, S. Deposit date: 2011-02-22 Release date: 2011-05-04 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.09 Å) Cite: Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1). Proc.Natl.Acad.Sci.USA, 108, 2011
3PT6	Crystal structure of mouse DNMT1(650-1602) in complex with DNA Descriptor: DNA (5'-D(*CP*CP*TP*GP*CP*GP*GP*AP*GP*GP*CP*TP*CP*AP*CP*GP*GP*GP*A)-3'), DNA (5'-D(*TP*CP*CP*CP*GP*TP*GP*AP*GP*CP*CP*TP*CP*CP*GP*CP*AP*GP*G)-3'), DNA (cytosine-5)-methyltransferase 1, ... Authors: Song, J, Patel, D.J. Deposit date: 2010-12-02 Release date: 2010-12-29 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (3 Å) Cite: Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science, 331, 2011
3PTA	Crystal structure of human DNMT1(646-1600) in complex with DNA Descriptor: DNA (5'-D(*CP*CP*TP*GP*CP*GP*GP*AP*GP*GP*CP*TP*CP*AP*CP*GP*GP*GP*A)-3'), DNA (5'-D(*TP*CP*CP*CP*GP*TP*GP*AP*GP*CP*CP*TP*CP*CP*GP*CP*AP*GP*G)-3'), DNA (cytosine-5)-methyltransferase 1, ... Authors: Song, J, Patel, D.J. Deposit date: 2010-12-02 Release date: 2010-12-29 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science, 331, 2011
3PT9	Crystal structure of mouse DNMT1(731-1602) in the free state Descriptor: DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION Authors: Song, J, Patel, D.J. Deposit date: 2010-12-02 Release date: 2010-12-29 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science, 331, 2011
3EEO	M. HhaI co-crystallized with synthetic dsDNA containing a propane diol in place of the deoxycytidine residue targeted for methylation. Descriptor: 5'-D(P*DCP*DCP*DAP*DTP*DGP*DCP*DGP*DCP*DTP*DGP*DAP*DC)-3', 5'-D(P*DGP*DTP*DCP*DAP*DGP*(PDI)P*DGP*DCP*DAP*DTP*DGP*DG)-3', Modification methylase HhaI, ... Authors: Porta, J.C, Christman, J.K, Borgstahl, G.E.O. Deposit date: 2008-09-05 Release date: 2010-03-02 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.94 Å) Cite: M. HhaI co-crystallized with synthetic dsDNA containing a propane diol in place of the deoxycytidine residue targeted for methylation. To be Published
3G7U	Crystal structure of putative DNA modification methyltransferase encoded within prophage Cp-933R (E.coli) Descriptor: CHLORIDE ION, Cytosine-specific methyltransferase, GLYCEROL Authors: Patskovsky, Y, Ramagopal, U.A, Toro, R, Gilmore, M, Iizuka, M, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) Deposit date: 2009-02-10 Release date: 2009-02-24 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Crystal Structure of DNA Modification Methyltransferase Encoded within Prophage Cp-933R (E.coli) To be Published
2UZ4	HhaI DNA methyltransferase R165N mutant complex with 13mer GCGC-GMGC oligonucleotide and SAH Descriptor: 5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP *CP*C)-3', 5'-D(*TP*GP*GP*AP*TP*GP*5CMP*GP*CP*TP*GP *AP*C)-3', GLYCEROL, ... Authors: Daujotyte, D, Leinartaite, L, Grazulis, S. Deposit date: 2007-04-25 Release date: 2008-06-03 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: DNA Methyltransferase R165N Mutant To be Published
2UYC	HhaI DNA methyltransferase R163N mutant complex with 13mer GCGC-GMGC oligonucleotide and SAH Descriptor: 5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP *CP*C)-3', 5'-D(*TP*GP*GP*AP*TP*GP*5CMP*GP*CP*TP *GP*AP*C)-3', GLYCEROL, ... Authors: Daujotyte, D, Grazulis, S. Deposit date: 2007-04-03 Release date: 2008-05-27 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: HhaI DNA Methyltransferase R163N Mutant Complex with 13mer Gcgc-Gmgc Oligonucleotide and Sah To be Published
2UYH	HhaI DNA methyltransferase S87Q-Q237S mutant complex with 13mer GCGC- GMGC oligonucleotide and SAH Descriptor: 5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP *CP*C)-3', 5'-D(*TP*GP*GP*AP*TP*G*5CMP*GP*CP*TP*GP *AP*C)-3', MODIFICATION METHYLASE HHAI, ... Authors: Daujotyte, D, Grazulis, S. Deposit date: 2007-04-06 Release date: 2008-05-27 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.63 Å) Cite: HhaI DNA Methyltransferase S87Q-Q237S Mutant Complex with 13mer Gcgc-Gmgc Oligonucleotide and Sah To be Published
2ZCJ	Ternary structure of the Glu119Gln M.HhaI, C5-Cytosine DNA methyltransferase, with unmodified DNA and AdoHcy Descriptor: DNA (5'-D(*DGP*DAP*DTP*DAP*DGP*DCP*DGP*DCP*DTP*DAP*DTP*DC)-3'), DNA (5'-D(*DTP*DGP*DAP*DTP*DAP*DGP*DCP*DGP*DCP*DTP*DAP*DTP*DC)-3'), Modification methylase HhaI, ... Authors: Shieh, F.K, Reich, N.O. Deposit date: 2007-11-09 Release date: 2007-12-04 Last modified: 2021-11-10 Method: X-RAY DIFFRACTION (2.75 Å) Cite: AdoMet-dependent Methyl-transfer: Glu(119) Is Essential for DNA C5-Cytosine Methyltransferase M.HhaI J.Mol.Biol., 373, 2007
2QRV	Structure of Dnmt3a-Dnmt3L C-terminal domain complex Descriptor: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE Authors: Jia, D, Cheng, X. Deposit date: 2007-07-29 Release date: 2007-12-04 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.89 Å) Cite: Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature, 449, 2007
2Z6U	Ternary structure of the Glu119Ala M.HhaI, C5-Cytosine DNA methyltransferase, with unmodified DNA and AdoHcy Descriptor: DNA (5'-D(*DGP*DAP*DTP*DAP*DGP*DCP*DGP*DCP*DTP*DAP*DTP*DC)-3'), DNA (5'-D(*DTP*DGP*DAP*DTP*DAP*DGP*DCP*DGP*DCP*DTP*DAP*DTP*DC)-3'), Modification methylase HhaI, ... Authors: Shieh, F.K. Deposit date: 2007-08-09 Release date: 2007-11-20 Last modified: 2021-11-10 Method: X-RAY DIFFRACTION (2.72 Å) Cite: AdoMet-dependent Methyl-transfer: Glu(119) Is Essential for DNA C5-Cytosine Methyltransferase M.HhaI J.Mol.Biol., 373, 2007
2Z6Q	Ternary structure of Arg165Ala M.HhaI C5-Cytosine DNA methyltransferase with unmodified DNA and AdoHcy Descriptor: 2'-DEOXYCYTIDINE, DNA (5'-D(*DGP*DAP*DTP*DAP*DGP*DCP*DGP*DCP*DTP*DAP*DTP*DC)-3'), DNA (5'-D(*DGP*DCP*DTP*DAP*DTP*DC)-3'), ... Authors: Shieh, F.K. Deposit date: 2007-08-08 Release date: 2007-08-28 Last modified: 2021-11-10 Method: X-RAY DIFFRACTION (2.79 Å) Cite: The role of Arg165 towards base flipping, base stabilization and catalysis in M.HhaI J.Mol.Biol., 362, 2006
2Z6A	S-Adenosyl-L-methionine-Dependent Methyl Transfer: Observable Precatalytic Intermediates during DNA Cytosine Methylation Descriptor: DNA (5'-D(*DGP*DAP*DTP*DAP*DGP*DCP*DGP*DCP*DTP*DAP*DTP*DC)-3'), DNA (5'-D(*DTP*DGP*DAP*DTP*DAP*DGP*DCP*DGP*DCP*DTP*DAP*DTP*DC)-3'), Modification methylase HhaI, ... Authors: Shieh, F.K. Deposit date: 2007-07-25 Release date: 2007-08-21 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.88 Å) Cite: S-Adenosyl-l-methionine-Dependent Methyl Transfer: Observable Precatalytic Intermediates during DNA Cytosine Methylation Biochemistry, 46, 2007
2I9K	Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase M.HhaI Descriptor: 5'-D(*T*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3', Modification methylase HhaI, S-ADENOSYL-L-HOMOCYSTEINE Authors: Youngblood, B, Shieh, F.K, De Los Rios, S, Perona, J.J, Reich, N.O. Deposit date: 2006-09-05 Release date: 2006-10-10 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase M.HhaI J.Mol.Biol., 362, 2006
2HR1	Ternary structure of WT M.HhaI C5-Cytosine DNA methyltransferase with unmodified DNA and AdoHcy Descriptor: 5'-D(*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3', 5'-D(*TP*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3', Modification methylase HhaI, ... Authors: Shieh, F. Deposit date: 2006-07-19 Release date: 2006-09-19 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.96 Å) Cite: The Role of Arg165 Towards Base Flipping, Base Stabilization and Catalysis in M.HhaI. J.Mol.Biol., 362, 2006
2C7P	HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine opposite to the target base (GCGC:GMPC) and SAH Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-D(*G*GP*AP*TP*GP*(5CM*2PR)*CP*TP*GP*AP*C)-3', 5'-D(*G*TP*CP*AP*GP*CP*GP*CP*AP*TP*CP*C)-3', ... Authors: Neely, R.K, Daujotyte, D, Grazulis, S, Magennis, S.W, Dryden, D.T.F, Klimasauskas, S, Jones, A.C. Deposit date: 2005-11-25 Release date: 2005-12-14 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes. Nucleic Acids Res., 33, 2005
2C7O	HhaI DNA methyltransferase complex with 13mer oligonucleotide containing 2-aminopurine adjacent to the target base (PCGC:GMGC) and SAH Descriptor: 5'-D(*T*GP*GP*AP*TP*GP*(5CM)*GP*CP*TP*GP*AP *C)-3', 5'-D(*T*GP*TP*CP*AP*(2PR)*CP*GP*CP*AP*TP*CP *C)-3', MODIFICATION METHYLASE HHAI, ... Authors: Daujotyte, D, Grazulis, S. Deposit date: 2005-11-25 Release date: 2005-12-14 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes. Nucleic Acids Res., 33, 2005
2C7R	HhaI DNA methyltransferase (T250G mutant) complex with oligonucleotide containing 2-aminopurine as a target base (GPGC:GMGC) and SAH Descriptor: 5'-D(*G*GP*AP*TP*GP*(5CM)*GP*CP*TP*GP*AP*C)-3', 5'-D(*G*TP*CP*AP*GP*(2PR)*GP*CP*AP*TP*CP*C)-3', GLYCEROL, ... Authors: Daujotyte, D, Grazulis, S. Deposit date: 2005-11-27 Release date: 2005-12-14 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes. Nucleic Acids Res., 33, 2005
2C7Q	HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine outside the recognition sequence (paired with G) and SAH Descriptor: 5'-D(*T*GP*GP*(2PR)*GP*GP*(5CM)*GP*CP*TP*GP* AP*C)-3', 5'-D(*T*GP*TP*CP*AP*GP*CP*GP*CP*CP*GP*CP*C)-3', CITRIC ACID, ... Authors: Daujotyte, D, Grazulis, S. Deposit date: 2005-11-27 Release date: 2005-12-14 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes Nucleic Acids Res., 33, 2005

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