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8WPK	Structure of monkeypox virus polymerase complex F8-A22-E4-H5 with exgenous DNA Descriptor: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA polymerase, DNA polymerase processivity factor, ... Authors: Wang, X, Li, N, Gao, N. Deposit date: 2023-10-10 Release date: 2023-11-29 Last modified: 2023-12-27 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Structural insights into the assembly and mechanism of mpox virus DNA polymerase complex F8-A22-E4-H5. Mol.Cell, 83, 2023
8WPE	Structure of monkeypox virus polymerase complex F8-A22-E4-H5 (tag-free A22) with exogenous DNA Descriptor: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, A22R DNA polymerase processivity factor, DNA polymerase, ... Authors: Wang, X, Li, N, Gao, N. Deposit date: 2023-10-10 Release date: 2023-11-29 Last modified: 2023-12-27 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Structural insights into the assembly and mechanism of mpox virus DNA polymerase complex F8-A22-E4-H5. Mol.Cell, 83, 2023
8WPF	Structure of monkeypox virus polymerase complex F8-A22-E4-H5 with exogenous DNA bearing one abasic site Descriptor: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, A22R DNA polymerase processivity factor, DNA polymerase, ... Authors: Wang, X, Li, N, Gao, N. Deposit date: 2023-10-10 Release date: 2023-11-29 Last modified: 2023-12-27 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural insights into the assembly and mechanism of mpox virus DNA polymerase complex F8-A22-E4-H5. Mol.Cell, 83, 2023
8HDZ	Monkeypox virus DNA replication holoenzyme F8, A22 and E4 complex in an apo form Descriptor: A22 DNA replication processivity factor, E4 uracil-DNA glycosylase, F8 DNA polymerase Authors: Xu, Y, Wu, Y, Zhang, Y, Fan, R, Yang, Y, Li, D, Yang, B, Zhang, Z, Dong, C. Deposit date: 2022-11-07 Release date: 2023-11-15 Method: ELECTRON MICROSCOPY (3.05 Å) Cite: Cryo-EM structures of human monkeypox viral replication complexes with and without DNA duplex. Cell Res., 33, 2023
8B76	The crystal structure of M644G variant of DNA Pol Epsilon containing dTTP in the polymerase active site Descriptor: ACETATE ION, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ... Authors: Parkash, V, Johansson, E. Deposit date: 2022-09-28 Release date: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023
8B67	The crystal structure of M644G variant of DNA Pol Epsilon containing CTP in the polymerase active site Descriptor: ACETATE ION, CALCIUM ION, CYTIDINE-5'-TRIPHOSPHATE, ... Authors: Parkash, V, Johansson, E. Deposit date: 2022-09-26 Release date: 2023-10-25 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023
8B6K	The crystal structure of M644G variant of DNA Pol Epsilon containing dCTP in the polymerase active site Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ... Authors: Parkash, V, Johansson, E. Deposit date: 2022-09-27 Release date: 2023-10-25 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023
8B7E	The crystal structure of N828V variant of DNA Pol Epsilon containing UTP in the polymerase active site Descriptor: CALCIUM ION, DNA polymerase epsilon catalytic subunit A, GLYCEROL, ... Authors: Parkash, V, Johansson, E. Deposit date: 2022-09-29 Release date: 2023-10-25 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023
8B77	The crystal structure of N828V variant of DNA Pol Epsilon containing dATP in the polymerase active site Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ... Authors: Parkash, V, Johansson, E. Deposit date: 2022-09-29 Release date: 2023-10-25 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.7 Å) Cite: A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023
8B79	The crystal structure of M644G variant of DNA Pol Epsilon containing UTP in the polymerase active site Descriptor: ACETATE ION, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ... Authors: Parkash, V, Johansson, E. Deposit date: 2022-09-29 Release date: 2023-10-25 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.65 Å) Cite: A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023
8UCW	Complete DNA termination subcomplex 2 of Xenopus laevis DNA polymerase alpha-primase Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA template, ... Authors: Mullins, E.A, Chazin, W.C, Eichman, B.F. Deposit date: 2023-09-27 Release date: 2023-10-11 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.64 Å) Cite: A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase. Nat.Struct.Mol.Biol., 2024
8UCV	Complete DNA termination subcomplex 1 of Xenopus laevis DNA polymerase alpha-primase Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA primase large subunit, ... Authors: Mullins, E.A, Chazin, W.C, Eichman, B.F. Deposit date: 2023-09-27 Release date: 2023-10-11 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.81 Å) Cite: A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase. Nat.Struct.Mol.Biol., 2024
8UCU	Partial DNA termination subcomplex of Xenopus laevis DNA polymerase alpha-primase Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA template, ... Authors: Mullins, E.A, Chazin, W.J, Eichman, B.F. Deposit date: 2023-09-27 Release date: 2023-10-11 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (2.85 Å) Cite: A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase. Nat.Struct.Mol.Biol., 2024
8B9B	S. cerevisiae replisome + Ctf4, bound by pol alpha. Complex engaged with a fork DNA substrate containing a 60 nucleotide lagging strand. Descriptor: Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha catalytic subunit A, ... Authors: Jones, M.L, Yeeles, J.T.P. Deposit date: 2022-10-05 Release date: 2023-08-09 Last modified: 2023-08-30 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication. Mol.Cell, 83, 2023
8B9D	Human replisome bound by Pol Alpha Descriptor: Cell division control protein 45 homolog, Claspin, DNA Molecule, ... Authors: Jones, M.L, Yeeles, J.T.P. Deposit date: 2022-10-05 Release date: 2023-08-09 Last modified: 2023-08-30 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication. Mol.Cell, 83, 2023
8B9A	S. cerevisiae replisome + Ctf4, bound by pol alpha primase. Complex engaged with a fork DNA substrate containing a 60 nucleotide lagging strand. Descriptor: Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha catalytic subunit A, ... Authors: Jones, M.L, Yeeles, J.T.P. Deposit date: 2022-10-05 Release date: 2023-08-09 Last modified: 2023-08-30 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication. Mol.Cell, 83, 2023
8B9C	S. cerevisiae pol alpha - replisome complex Descriptor: Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha catalytic subunit A, ... Authors: Jones, M.L, Yeeles, J.T.P. Deposit date: 2022-10-05 Release date: 2023-08-09 Last modified: 2023-08-30 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication. Mol.Cell, 83, 2023
8FOD	Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in Apo state conformation II Descriptor: DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... Authors: Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. Deposit date: 2022-12-30 Release date: 2023-05-31 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
8FOH	Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the RNA synthesis state Descriptor: DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... Authors: Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. Deposit date: 2022-12-30 Release date: 2023-05-31 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
8FOJ	Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the post RNA handoff state Descriptor: DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... Authors: Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. Deposit date: 2022-12-30 Release date: 2023-05-31 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (4.8 Å) Cite: Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
8FOE	Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex bound to a template DNA Descriptor: DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... Authors: Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. Deposit date: 2022-12-30 Release date: 2023-05-31 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (5.6 Å) Cite: Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
8FOK	Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the DNA elongation state Descriptor: DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... Authors: Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. Deposit date: 2022-12-30 Release date: 2023-05-31 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.56 Å) Cite: Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
8FOC	Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase in Apo state conformation I Descriptor: DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... Authors: Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. Deposit date: 2022-12-30 Release date: 2023-05-31 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
8HM0	F8-A22-E4 complex of MPXV in trimeric form Descriptor: DNA polymerase, DNA polymerase processivity factor component A20, E4R Authors: Li, Y.N, Shen, Y.P, Hu, Z.W, Yan, R.H. Deposit date: 2022-12-02 Release date: 2023-05-31 Last modified: 2023-12-13 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural basis for the assembly of the DNA polymerase holoenzyme from a monkeypox virus variant. Sci Adv, 9, 2023
8HLZ	F8-A22-E4 complex of MPXV in hexameric form Descriptor: DNA polymerase, DNA polymerase processivity factor component A20, E4R Authors: Li, Y.N, Shen, Y.P, Hu, Z.W, Yan, R.H. Deposit date: 2022-12-02 Release date: 2023-05-31 Last modified: 2023-12-13 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structural basis for the assembly of the DNA polymerase holoenzyme from a monkeypox virus variant. Sci Adv, 9, 2023

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