8SDU
 
 | | Structure of rat organic anion transporter 1 (OAT1) | | 分子名称: | Solute carrier family 22 member 6 | | 著者 | Dou, T, Jiang, J. | | 登録日 | 2023-04-07 | | 公開日 | 2023-10-18 | | 最終更新日 | 2023-11-22 | | 実験手法 | ELECTRON MICROSCOPY (2.05 Å) | | 主引用文献 | The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM.
Nat.Struct.Mol.Biol., 30, 2023
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8SDZ
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8SC1
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8SC2
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8SC6
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8SDY
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8T6B
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8T69
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8T6A
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8THR
 | | Structure of the human vesicular monoamine transporter 2 (VMAT2) bound to tetrabenazine in an occluded conformation | | 分子名称: | (3S,5R,11bS)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one, fluorescent protein mVenus,Synaptic vesicular amine transporter,GFP nano body,Synaptic vesicular amine transporter,Synaptic vesicular amine transporter | | 著者 | Dalton, M.P, Coleman, J.A. | | 登録日 | 2023-07-17 | | 公開日 | 2023-10-25 | | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | | 主引用文献 | Structure of the human vesicular monoamine transporter 2 (VMAT2) bound to tetrabenazine in an occluded conformation
To Be Published
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8JSW
 | | Human VMAT2 complex with serotonin | | 分子名称: | SEROTONIN, Synaptic vesicular amine transporter | | 著者 | Jiang, D.H, Wu, D. | | 登録日 | 2023-06-20 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | | 主引用文献 | Transport and inhibition mechanisms of human VMAT2.
Nature, 626, 2024
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8JTA
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8JTC
 | | Human VMAT2 complex with reserpine | | 分子名称: | Synaptic vesicular amine transporter, reserpine | | 著者 | Jiang, D.H, Wu, D. | | 登録日 | 2023-06-21 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | | 主引用文献 | Transport and inhibition mechanisms of human VMAT2.
Nature, 626, 2024
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8JT9
 | | Human VMAT2 complex with ketanserin | | 分子名称: | 3-[2-[4-(4-fluorophenyl)carbonylpiperidin-1-yl]ethyl]-1~{H}-quinazoline-2,4-dione, Synaptic vesicular amine transporter | | 著者 | Jiang, D.H, Wu, D. | | 登録日 | 2023-06-21 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | | 主引用文献 | Transport and inhibition mechanisms of human VMAT2.
Nature, 626, 2024
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8KAE
 | | 16d-bound human SPNS2 | | 分子名称: | 3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine, NbFab chain L, NbFab-H chain, ... | | 著者 | He, Y, Duan, Y. | | 登録日 | 2023-08-03 | | 公開日 | 2024-01-03 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | | 主引用文献 | Structural basis of Sphingosine-1-phosphate transport via human SPNS2.
Cell Res., 34, 2024
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8JHR
 | | Cryo-EM structure of human S1P transporter SPNS2 bound with an inhibitor 16d | | 分子名称: | 3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine, Sphingosine-1-phosphate transporter SPNS2 | | 著者 | Pang, B, Yu, L.Y, Ren, R.B. | | 登録日 | 2023-05-25 | | 公開日 | 2024-01-10 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | | 主引用文献 | Molecular basis of Spns2-facilitated sphingosine-1-phosphate transport.
Cell Res., 34, 2024
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8JTZ
 | | hOCT1 in complex with spironolactone in outward facing partially occluded conformation | | 分子名称: | SPIRONOLACTONE, Solute carrier family 22 member 1 | | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | | 登録日 | 2023-06-22 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
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8JTX
 | | hOCT1 in complex with nb5660 in inward facing fully open conformation | | 分子名称: | Solute carrier family 22 member 1, nanobody 56 | | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | | 登録日 | 2023-06-22 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
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8JU0
 | | hOCT1 in complex with spironolactone in inward facing occluded conformation | | 分子名称: | SPIRONOLACTONE, Solute carrier family 22 member 1 | | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | | 登録日 | 2023-06-23 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
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8JTT
 | | hOCT1 in complex with metformin in outward occluded conformation | | 分子名称: | Metformin, Solute carrier family 22 member 1 | | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | | 登録日 | 2023-06-22 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
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8JTW
 | | hOCT1 in complex with nb5660 in inward facing partially open 1 conformation | | 分子名称: | Solute carrier family 22 member 1, nanobody 56 | | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | | 登録日 | 2023-06-22 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
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8JTY
 | | hOCT1 in complex with nb5660 in inward facing partially open 2 conformation | | 分子名称: | Solute carrier family 22 member 1, nanobody 56 | | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | | 登録日 | 2023-06-22 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
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8JTS
 | | hOCT1 in complex with metformin in outward open conformation | | 分子名称: | Metformin, Solute carrier family 22 member 1 | | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | | 登録日 | 2023-06-22 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
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8JTV
 | | hOCT1 in complex with metformin in inward occluded conformation | | 分子名称: | Metformin, Solute carrier family 22 member 1 | | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | | 登録日 | 2023-06-22 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.77 Å) | | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
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8JHQ
 | | Cryo-EM structure of human S1P transporter SPNS2 bound with S1P | | 分子名称: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Sphingosine-1-phosphate transporter SPNS2,GlgA glycogen synthase | | 著者 | Pang, B, Yu, L.Y, Ren, R.B. | | 登録日 | 2023-05-25 | | 公開日 | 2024-01-10 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Molecular basis of Spns2-facilitated sphingosine-1-phosphate transport.
Cell Res., 34, 2024
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