8JSW
| Human VMAT2 complex with serotonin | 分子名称: | SEROTONIN, Synaptic vesicular amine transporter | 著者 | Jiang, D.H, Wu, D. | 登録日 | 2023-06-20 | 公開日 | 2023-11-29 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | 主引用文献 | Transport and inhibition mechanisms of human VMAT2. Nature, 626, 2024
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8JT9
| Human VMAT2 complex with ketanserin | 分子名称: | 3-[2-[4-(4-fluorophenyl)carbonylpiperidin-1-yl]ethyl]-1~{H}-quinazoline-2,4-dione, Synaptic vesicular amine transporter | 著者 | Jiang, D.H, Wu, D. | 登録日 | 2023-06-21 | 公開日 | 2023-11-29 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Transport and inhibition mechanisms of human VMAT2. Nature, 626, 2024
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8JTC
| Human VMAT2 complex with reserpine | 分子名称: | Synaptic vesicular amine transporter, reserpine | 著者 | Jiang, D.H, Wu, D. | 登録日 | 2023-06-21 | 公開日 | 2023-11-29 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | 主引用文献 | Transport and inhibition mechanisms of human VMAT2. Nature, 626, 2024
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8KAE
| 16d-bound human SPNS2 | 分子名称: | 3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine, NbFab chain L, NbFab-H chain, ... | 著者 | He, Y, Duan, Y. | 登録日 | 2023-08-03 | 公開日 | 2024-01-03 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | 主引用文献 | Structural basis of Sphingosine-1-phosphate transport via human SPNS2. Cell Res., 34, 2024
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8JHR
| Cryo-EM structure of human S1P transporter SPNS2 bound with an inhibitor 16d | 分子名称: | 3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine, Sphingosine-1-phosphate transporter SPNS2 | 著者 | Pang, B, Yu, L.Y, Ren, R.B. | 登録日 | 2023-05-25 | 公開日 | 2024-01-10 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | 主引用文献 | Molecular basis of Spns2-facilitated sphingosine-1-phosphate transport. Cell Res., 34, 2024
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8JTZ
| hOCT1 in complex with spironolactone in outward facing partially occluded conformation | 分子名称: | SPIRONOLACTONE, Solute carrier family 22 member 1 | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | 登録日 | 2023-06-22 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition. Cell Discov, 10, 2024
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8JTT
| hOCT1 in complex with metformin in outward occluded conformation | 分子名称: | Metformin, Solute carrier family 22 member 1 | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | 登録日 | 2023-06-22 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition. Cell Discov, 10, 2024
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8JTW
| hOCT1 in complex with nb5660 in inward facing partially open 1 conformation | 分子名称: | Solute carrier family 22 member 1, nanobody 56 | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | 登録日 | 2023-06-22 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition. Cell Discov, 10, 2024
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8JTS
| hOCT1 in complex with metformin in outward open conformation | 分子名称: | Metformin, Solute carrier family 22 member 1 | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | 登録日 | 2023-06-22 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition. Cell Discov, 10, 2024
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8JTX
| hOCT1 in complex with nb5660 in inward facing fully open conformation | 分子名称: | Solute carrier family 22 member 1, nanobody 56 | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | 登録日 | 2023-06-22 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition. Cell Discov, 10, 2024
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8JTY
| hOCT1 in complex with nb5660 in inward facing partially open 2 conformation | 分子名称: | Solute carrier family 22 member 1, nanobody 56 | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | 登録日 | 2023-06-22 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition. Cell Discov, 10, 2024
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8JU0
| hOCT1 in complex with spironolactone in inward facing occluded conformation | 分子名称: | SPIRONOLACTONE, Solute carrier family 22 member 1 | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | 登録日 | 2023-06-23 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition. Cell Discov, 10, 2024
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8JTV
| hOCT1 in complex with metformin in inward occluded conformation | 分子名称: | Metformin, Solute carrier family 22 member 1 | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | 登録日 | 2023-06-22 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.77 Å) | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition. Cell Discov, 10, 2024
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8JLI
| Cryo-EM structure of SV2A dimer in complex levetiracetam | 分子名称: | (2S)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide, Synaptic vesicle glycoprotein 2A | 著者 | Yamagata, A. | 登録日 | 2023-06-02 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | 主引用文献 | Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A. Nat Commun, 15, 2024
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8JT5
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8JTB
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8JSX
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8OMU
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8PNL
| Outward-open conformation of a Major Facilitator Superfamily (MFS) transporter MHAS2168, a homologue of Rv1410 from M. tuberculosis, in complex with an alpaca nanobody | 分子名称: | Nb_H2, Putative triacylglyceride transporter | 著者 | Remm, S, Schoeppe, J, Hutter, C.A.J, Gonda, I, Seeger, M.A. | 登録日 | 2023-06-30 | 公開日 | 2023-10-18 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis for triacylglyceride extraction from mycobacterial inner membrane by MFS transporter Rv1410. Nat Commun, 14, 2023
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8SC1
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8SC4
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8SDZ
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8SDY
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8SC2
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8SDU
| Structure of rat organic anion transporter 1 (OAT1) | 分子名称: | Solute carrier family 22 member 6 | 著者 | Dou, T, Jiang, J. | 登録日 | 2023-04-07 | 公開日 | 2023-10-18 | 最終更新日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (2.05 Å) | 主引用文献 | The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM. Nat.Struct.Mol.Biol., 30, 2023
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