6H54
| CRYSTAL STRUCTURE OF BOVINE HSC70(AA1-554)E213A/D214A IN COMPLEX WITH INHIBITOR VER155008 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile, GLYCEROL, ... | 著者 | Plank, C, Zehe, M, Grimm, C, Sotriffer, C. | 登録日 | 2018-07-23 | 公開日 | 2019-08-14 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct. Acs Chem.Biol., 2024
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6HAB
| Crystal structure of BiP V461F (apo) | 分子名称: | DI(HYDROXYETHYL)ETHER, Endoplasmic reticulum chaperone BiP | 著者 | Yan, Y, Ron, D. | 登録日 | 2018-08-07 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP. Nat Commun, 10, 2019
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5O4P
| Crystal structure of AMPylated GRP78 | 分子名称: | 78 kDa glucose-regulated protein, ADENOSINE MONOPHOSPHATE, SULFATE ION | 著者 | Yan, Y, Chen, R, Ron, D, Read, R. | 登録日 | 2017-05-30 | 公開日 | 2017-11-01 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation. Elife, 6, 2017
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5OBU
| Mycoplasma genitalium DnaK deletion mutant lacking SBDalpha in complex with AMPPNP. | 分子名称: | Chaperone protein DnaK, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Adell, M, Calisto, B, Fita, I, Martinelli, L. | 登録日 | 2017-06-29 | 公開日 | 2018-05-09 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The nucleotide-bound/substrate-bound conformation of the Mycoplasma genitalium DnaK chaperone. Protein Sci., 27, 2018
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5OBW
| Mycoplasma genitalium DnaK-NBD in complex with ATP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Chaperone protein DnaK, GLYCEROL, ... | 著者 | Adell, M, Calisto, B, Fita, I, Martinelli, L. | 登録日 | 2017-06-29 | 公開日 | 2018-05-09 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | The nucleotide-bound/substrate-bound conformation of the Mycoplasma genitalium DnaK chaperone. Protein Sci., 27, 2018
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5OBY
| Mycoplasma genitalium DnaK-NBD in complex with AMP-PNP | 分子名称: | Chaperone protein DnaK, GLYCEROL, MAGNESIUM ION, ... | 著者 | Adell, M, Calisto, B, Fita, I, Martinelli, L. | 登録日 | 2017-06-29 | 公開日 | 2018-05-09 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | The nucleotide-bound/substrate-bound conformation of the Mycoplasma genitalium DnaK chaperone. Protein Sci., 27, 2018
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5OBV
| Mycoplasma genitalium DnaK deletion mutant lacking SBDalpha in complex with ADP and Pi. | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Chaperone protein DnaK, PHOSPHATE ION | 著者 | Adell, M, Calisto, B, Fita, I, Martinelli, L. | 登録日 | 2017-06-29 | 公開日 | 2018-05-09 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | The nucleotide-bound/substrate-bound conformation of the Mycoplasma genitalium DnaK chaperone. Protein Sci., 27, 2018
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5OBX
| Mycoplasma genitalium DnaK-NBD | 分子名称: | Chaperone protein DnaK, GLYCEROL, SULFATE ION, ... | 著者 | Adell, M, Calisto, B, Fita, I, Martinelli, L. | 登録日 | 2017-06-29 | 公開日 | 2018-05-09 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | The nucleotide-bound/substrate-bound conformation of the Mycoplasma genitalium DnaK chaperone. Protein Sci., 27, 2018
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8D1P
| Crystal structure of Plasmodium falciparum GRP78-NBD in complex with 7-Deaza-2'-C-methyladenosine | 分子名称: | 7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Chaperone DnaK, SULFATE ION | 著者 | Mrozek, A, Chen, Y, Antoshchenko, T, Park, H.W. | 登録日 | 2022-05-27 | 公開日 | 2023-05-31 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues. Front Mol Biosci, 9, 2022
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8D1Y
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8D22
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8D1S
| Crystal structure of Plasmodium falciparum GRP78 in complex with Toyocamycin | 分子名称: | 4-amino-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Chaperone DnaK, SULFATE ION | 著者 | Mrozek, A, Chen, Y, Antoshchenko, T, Park, H.W. | 登録日 | 2022-05-27 | 公開日 | 2023-05-31 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues. Front Mol Biosci, 9, 2022
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8D20
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8D24
| Crystal structure of Plasmodium falciparum GRP78-NBD in complex with VER155008 | 分子名称: | 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile, Chaperone DnaK, SULFATE ION | 著者 | Mrozek, A, Park, H.W. | 登録日 | 2022-05-27 | 公開日 | 2023-05-31 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues. Front Mol Biosci, 9, 2022
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8D1W
| Crystal structure of Plasmodium falciparum GRP78 in complex with (2R,3R,4S,5R)-2-(6-amino-8-((2-chlorobenzyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol | 分子名称: | 8-{[(2-chlorophenyl)methyl]amino}adenosine, Chaperone DnaK, SULFATE ION | 著者 | Mrozek, A, Chen, Y, Antoshchenko, T, Park, H.W, Smil, D, Zepeda, C.A.V. | 登録日 | 2022-05-27 | 公開日 | 2023-05-31 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Targeting Plasmodium falciparum GRP78: nucleoside analogues as agents against the malaria chaperone Frontiers in Molecular Bioscience, 2022
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8D1Q
| Crystal structure of Plasmodium falciparum GRP78-NBD in complex with 8-Aminoadenosine | 分子名称: | (2R,3R,4S,5R)-2-(6,8-diaminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol, Chaperone DnaK, SULFATE ION | 著者 | Mrozek, A, Chen, Y, Antoshchenko, T, Park, H.W. | 登録日 | 2022-05-27 | 公開日 | 2023-05-31 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues. Front Mol Biosci, 9, 2022
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5OOW
| Crystal structure of lobe II from the nucleotide binding domain of DnaK in complex with AMPPCP | 分子名称: | Chaperone protein DnaK, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | 著者 | Jakob, R.P, Bauer, D, Meinhold, S, Stigler, J, Merkel, U, Maier, T, Rief, M, Zoldak, G. | 登録日 | 2017-08-09 | 公開日 | 2018-04-25 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | A folding nucleus and minimal ATP binding domain of Hsp70 identified by single-molecule force spectroscopy. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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7FGM
| The complex crystals structure of the FAF1 UBL1_L-Hsp70 NBD with ADP and phosphate | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, FAS-associated factor 1, Heat shock 70 kDa protein 1A, ... | 著者 | Kim, E.E, ParK, J.K, Shin, S.C. | 登録日 | 2021-07-27 | 公開日 | 2022-07-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The complex of Fas-associated factor 1 with Hsp70 stabilizes the adherens junction integrity by suppressing RhoA activation J Mol Cell Biol, 14, 2022
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7F4X
| Joint neutron and X-ray crystal structure of the nucleotide-binding domain of Hsp72 in complex with ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1B, MAGNESIUM ION, ... | 著者 | Yokoyama, T, Ostermann, A, Schrader, T.E. | 登録日 | 2021-06-21 | 公開日 | 2022-06-29 | 最終更新日 | 2024-04-03 | 実験手法 | NEUTRON DIFFRACTION (1.6 Å), X-RAY DIFFRACTION | 主引用文献 | Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP. Iucrj, 9, 2022
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7F50
| X-ray crystal structure of Y149A mutated Hsp72-NBD in complex with AMPPnP | 分子名称: | CHLORIDE ION, Heat shock 70 kDa protein 1B, MAGNESIUM ION, ... | 著者 | Yokoyama, T, Fujii, S, Nabeshima, Y, Mizuguchi, M. | 登録日 | 2021-06-21 | 公開日 | 2022-06-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.703 Å) | 主引用文献 | Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP. Iucrj, 9, 2022
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7F4Z
| X-ray crystal structure of Y149A mutated Hsp72-NBD in complex with ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Heat shock 70 kDa protein 1B, ... | 著者 | Yokoyama, T, Fujii, S, Nabeshima, Y, Mizuguchi, M. | 登録日 | 2021-06-21 | 公開日 | 2022-06-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP. Iucrj, 9, 2022
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7JNE
| Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide RGSQLRIASR | 分子名称: | Alkaline phosphatase peptide, Chaperone protein DnaK, SULFATE ION | 著者 | Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C. | 登録日 | 2020-08-04 | 公開日 | 2020-08-26 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | 主引用文献 | Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein. Proc.Natl.Acad.Sci.USA, 118, 2021
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7JMM
| Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide RAKNIILLSR | 分子名称: | Alkaline phosphatase, Chaperone protein DnaK, SULFATE ION | 著者 | Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C. | 登録日 | 2020-08-02 | 公開日 | 2020-08-26 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein. Proc.Natl.Acad.Sci.USA, 118, 2021
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7JN8
| Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide RGNTLVIVSR | 分子名称: | Alkaline phosphatase peptide, Chaperone protein DnaK, SULFATE ION | 著者 | Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C. | 登録日 | 2020-08-04 | 公開日 | 2020-08-26 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | 主引用文献 | Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein. Proc.Natl.Acad.Sci.USA, 118, 2021
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6ZHI
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