PDB: 9 件ウェブページステータス検索Chemie searchBIRD

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6XSW	Structure of the Notch3 NRR in complex with an antibody Fab Fragment 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-N3 Fab Heavy Chain, ... 著者 Bard, J. 登録日 2020-07-16 公開日 2021-07-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.98 Å) 主引用文献 NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells. Cell Rep Med, 2, 2021
4ZLP	Crystal Structure of Notch3 Negative Regulatory Region 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CALCIUM ION, ... 著者 Xu, X, Blacklow, S.C. 登録日 2015-05-01 公開日 2015-08-19 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.479 Å) 主引用文献 Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region. Structure, 23, 2015
5CZX	Crystal structure of Notch3 NRR in complex with 20358 Fab 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 20358 Fab heavy chain, ... 著者 Hu, T, Fryer, C, Chopra, R, Clark, K. 登録日 2015-08-01 公開日 2016-06-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene, 35, 2016
5CZV	Crystal structure of Notch3 NRR in complex with 20350 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Fab 20350 heavy chain, ... 著者 Hu, T, Fryer, C, Chopra, R, Clark, K. 登録日 2015-08-01 公開日 2016-06-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.19 Å) 主引用文献 Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene, 35, 2016
6WQU	CSL (RBPJ) bound to Notch3 RAM and DNA 分子名称: DNA (5'-D(*AP*AP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*AP*CP*CP*GP*TP*GP*GP*GP*AP*AP*AP*GP*A)-3'), Neurogenic locus notch homolog protein 3, ... 著者 Kovall, R.A, Gagliani, E, Hall, D. 登録日 2020-04-29 公開日 2021-03-31 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion. J.Biol.Chem., 296, 2021
8OS0	Solution NMR structure of Notch3 WT TMD 分子名称: Notch 3 extracellular truncation 著者 Guschtschin-Schmidt, N, Muhle-Goll, C. 登録日 2023-04-17 公開日 2023-08-16 最終更新日 2023-08-23 実験手法 SOLUTION NMR 主引用文献 Permissive Conformations of a Transmembrane Helix Allow Intramembrane Proteolysis by gamma-Secretase. J.Mol.Biol., 435, 2023
8ORZ	Solution NMR structure of Notch1 G1740-1743 TMD 分子名称: Notch 1 extracellular truncation 著者 Guschtschin-Schmidt, N, Muhle-Goll, C. 登録日 2023-04-17 公開日 2023-08-16 最終更新日 2023-08-23 実験手法 SOLUTION NMR 主引用文献 Permissive Conformations of a Transmembrane Helix Allow Intramembrane Proteolysis by gamma-Secretase. J.Mol.Biol., 435, 2023
8OR5	Solution NMR structure of Notch1 TMD 分子名称: Notch 1 extracellular truncation 著者 Guschtschin-Schmidt, N, Muhle-Goll, C. 登録日 2023-04-13 公開日 2023-08-16 最終更新日 2023-08-23 実験手法 SOLUTION NMR 主引用文献 Permissive Conformations of a Transmembrane Helix Allow Intramembrane Proteolysis by gamma-Secretase. J.Mol.Biol., 435, 2023
8ORY	Solution NMR structure of Notch1 L1740-1743 TMD 分子名称: Notch 1 extracellular truncation 著者 Guschtschin-Schmidt, N, Muhle-Goll, C. 登録日 2023-04-17 公開日 2023-08-16 最終更新日 2023-08-23 実験手法 SOLUTION NMR 主引用文献 Permissive Conformations of a Transmembrane Helix Allow Intramembrane Proteolysis by gamma-Secretase. J.Mol.Biol., 435, 2023