5JDG
| Structural mechanisms of extracellular ion exchange and induced binding-site occlusion in the sodium-calcium exchanger NCX_Mj soaked with 2.5 mM Na+ and 0.1mM Ca2+ | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Liao, J, Jiang, Y.X, Faraldo-Gomez, J.D. | 登録日 | 2016-04-16 | 公開日 | 2016-05-11 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.407 Å) | 主引用文献 | Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger. Nat.Struct.Mol.Biol., 23, 2016
|
|
6LQA
| voltage-gated sodium channel Nav1.5 with quinidine | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Quinidine, Sodium channel protein type 5 subunit alpha | 著者 | Yan, N, Li, Z, Pan, X, Huang, G. | 登録日 | 2020-01-13 | 公開日 | 2021-03-24 | 最終更新日 | 2021-05-19 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Na v 1.5 by the Antiarrhythmic Drug Quinidine*. Angew.Chem.Int.Ed.Engl., 60, 2021
|
|
2PFN
| Na in the active site of DNA Polymerase lambda | 分子名称: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, DNA polymerase lambda, Downstream Primer, ... | 著者 | Garcia-Diaz, M, Bebenek, K, Krahn, J.M, Pedersen, L.C, Kunkel, T.A. | 登録日 | 2007-04-05 | 公開日 | 2007-05-15 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Role of the catalytic metal during polymerization by DNA polymerase lambda. DNA Repair, 6, 2007
|
|
2ON7
| Structure of NaGST-1 | 分子名称: | Na Glutathione S-transferase 1 | 著者 | Asojo, O.A, Ngamelue, M, Homma, H, Goud, G, Zhan, B, Hotez, P.J. | 登録日 | 2007-01-23 | 公開日 | 2007-08-07 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | X-ray structures of Na-GST-1 and Na-GST-2 two glutathione s-transferase from the human hookworm Necator americanus Bmc Struct.Biol., 7, 2007
|
|
3OGC
| KcsA E71A variant in presence of Na+ | 分子名称: | SODIUM ION, Voltage-gated potassium channel, antibody Fab fragment heavy chain, ... | 著者 | McCoy, J.G, Nimigean, C.M. | 登録日 | 2010-08-16 | 公開日 | 2011-03-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Mechanism for selectivity-inactivation coupling in KcsA potassium channels. Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
1SGI
| Crystal structure of the anticoagulant slow form of thrombin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, thrombin | 著者 | Pineda, A.O, Carrell, C.J, Bush, L.A, Prasad, S, Caccia, S, Chen, Z.W, Mathews, F.S, Di Cera, E. | 登録日 | 2004-02-23 | 公開日 | 2004-06-08 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Molecular dissection of na+ binding to thrombin. J.Biol.Chem., 279, 2004
|
|
1SHH
| Slow form of Thrombin Bound with PPACK | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, thrombin | 著者 | Pineda, A.O, Carrell, C.J, Bush, L.A, Prasad, S, Caccia, S, Chen, Z.W, Mathews, F.S, Di Cera, E. | 登録日 | 2004-02-25 | 公開日 | 2004-06-08 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Molecular dissection of na+ binding to thrombin. J.Biol.Chem., 279, 2004
|
|
2BHC
| Na substituted E. coli Aminopeptidase P | 分子名称: | CITRATE ANION, MAGNESIUM ION, SODIUM ION, ... | 著者 | Graham, S.C, Bond, C.S, Freeman, H.C, Guss, J.M. | 登録日 | 2005-01-10 | 公開日 | 2005-09-29 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural and Functional Implications of Metal Ion Selection in Aminopeptidase P, a Metalloprotease with a Dinuclear Metal Center. Biochemistry, 44, 2005
|
|
2D11
| |
8V9G
| GES-5-meropenem complex | 分子名称: | (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, 1,2-ETHANEDIOL, IODIDE ION, ... | 著者 | Smith, C.A, Stewart, N.K, Vakulenko, S.B. | 登録日 | 2023-12-08 | 公開日 | 2024-04-03 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Restricted Rotational Flexibility of the C5 alpha-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the GES-5 Carbapenemase. Acs Infect Dis., 10, 2024
|
|
8THG
| Cryo-EM structure of Nav1.7 with RLZ | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Fan, X, Huang, J, Yan, N. | 登録日 | 2023-07-16 | 公開日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Dual-pocket inhibition of Na v channels by the antiepileptic drug lamotrigine. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8THH
| Cryo-EM structure of Nav1.7 with LTG | 分子名称: | (6M)-6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Fan, X, Huang, J, Yan, N. | 登録日 | 2023-07-16 | 公開日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Dual-pocket inhibition of Na v channels by the antiepileptic drug lamotrigine. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
4XJK
| Crystal structure of Mn(II) Ca(II) Na(I) bound calprotectin | 分子名称: | CALCIUM ION, MANGANESE (II) ION, Protein S100-A8, ... | 著者 | Drennan, C.L, Bowman, S.E.J. | 登録日 | 2015-01-08 | 公開日 | 2015-04-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Manganese Binding Properties of Human Calprotectin under Conditions of High and Low Calcium: X-ray Crystallographic and Advanced Electron Paramagnetic Resonance Spectroscopic Analysis. J.Am.Chem.Soc., 137, 2015
|
|
6PZW
| CryoEM derived model of NA-22 Fab in complex with N9 Shanghai2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, NA-22 fragment antigen binding heavy chain, ... | 著者 | Ward, A.B, Turner, H.L, Zhu, X. | 登録日 | 2019-08-01 | 公開日 | 2019-12-04 | 最終更新日 | 2023-04-05 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies. Cell Host Microbe, 26, 2019
|
|
6PZZ
| CryoEM derived model of NA-80 Fab in complex with N9 Shanghai2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, NA-80 fragment antibody heavy chain, ... | 著者 | Ward, A.B, Turner, H.L, Zhu, X. | 登録日 | 2019-08-01 | 公開日 | 2019-12-04 | 最終更新日 | 2023-04-05 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies. Cell Host Microbe, 26, 2019
|
|
6PZY
| CryoEM derived model of NA-73 Fab in complex with N9 Shanghai2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, NA-73 fragment antibody heavy chain, ... | 著者 | Ward, A.B, Turner, H.L, Zhu, X. | 登録日 | 2019-08-01 | 公開日 | 2019-12-04 | 最終更新日 | 2023-04-05 | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | 主引用文献 | Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies. Cell Host Microbe, 26, 2019
|
|
7FGB
| A naturally-occurring neuraminidase-inhibitors-resistant NA from asiatic toad influenza B-like virus | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, SULFATE ION, ... | 著者 | Chai, Y, Wu, Y, Gao, F. | 登録日 | 2021-07-26 | 公開日 | 2022-08-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural and inhibitor sensitivity analysis of influenza B-like viral neuraminidases derived from Asiatic toad and spiny eel. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7FGC
| |
7FGE
| |
7FGD
| A naturally-occurring neuraminidase-inhibitors-resistant NA from asiatic toad influenza B-like virus | 分子名称: | (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, CALCIUM ION, toad NA (OSE) | 著者 | Chai, Y, Wu, Y, Gao, F. | 登録日 | 2021-07-26 | 公開日 | 2022-08-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural and inhibitor sensitivity analysis of influenza B-like viral neuraminidases derived from Asiatic toad and spiny eel. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7E21
| Cryo EM structure of a Na+-bound Na+,K+-ATPase in the E1 state with ATP-gamma-S | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Guo, Y.Y, Zhang, Y.Y, Yan, R.H, Huang, B.D, Ye, F.F, Wu, L.S, Chi, X.M, Zhou, Q. | 登録日 | 2021-02-04 | 公開日 | 2022-06-15 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Cryo-EM structures of recombinant human sodium-potassium pump determined in three different states. Nat Commun, 13, 2022
|
|
7TJ8
| Cryo-EM structure of the human Nax channel in complex with beta3 solved in nanodiscs | 分子名称: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Noland, C.L, Kschonsak, M, Ciferri, C, Payandeh, J. | 登録日 | 2022-01-14 | 公開日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure-guided unlocking of Na X reveals a non-selective tetrodotoxin-sensitive cation channel. Nat Commun, 13, 2022
|
|
7TJ9
| Cryo-EM structure of the human Nax channel in complex with beta3 solved in GDN | 分子名称: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Noland, C.L, Kschonsak, M, Ciferri, C, Payandeh, J. | 登録日 | 2022-01-14 | 公開日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structure-guided unlocking of Na X reveals a non-selective tetrodotoxin-sensitive cation channel. Nat Commun, 13, 2022
|
|
6PZF
| |
6PZE
| |