PDB: 680 件ウェブページステータス検索Chemie searchBIRD

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6WAA	K. pneumoniae Topoisomerase IV (ParE-ParC) in complex with DNA and compound 34 (7-[(1S,5R)-1-amino-3-azabicyclo[3.1.0]hexan-3-yl]-4-(aminomethyl)-1-cyclopropyl-3,6-difluoro-8-methylquinolin-2(1H)-one) 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 7-[(1S,5R)-1-amino-3-azabicyclo[3.1.0]hexan-3-yl]-4-(aminomethyl)-1-cyclopropyl-3,6-difluoro-8-methylquinolin-2(1H)-one, CHLORIDE ION, ... 著者 Noeske, J, Shu, W, Bellamacina, C. 登録日 2020-03-24 公開日 2020-07-15 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria. J.Med.Chem., 63, 2020
2CSD	Crystal structure of Topoisomerase V (61 kDa fragment) 分子名称: Topoisomerase V 著者 Taneja, B, Patel, A, Slesarev, A, Mondragon, A. 登録日 2005-05-21 公開日 2006-01-31 最終更新日 2019-07-24 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure of the N-terminal fragment of topoisomerase V reveals a new family of topoisomerases Embo J., 25, 2006
6Z03	DNA Topoisomerase 分子名称: DNA topoisomerase I 著者 Takahashi, T.S, Gadelle, D, Forterre, P, Mayer, C, Petrella, S. 登録日 2020-05-07 公開日 2021-11-17 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states. Nat Commun, 13, 2022
6Z01	DNA Topoisomerase 分子名称: CHLORIDE ION, DNA topoisomerase I 著者 Takahashi, T.S, Gadelle, D, Forterre, P, Mayer, C, Petrella, S. 登録日 2020-05-07 公開日 2021-11-17 最終更新日 2023-05-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states. Nat Commun, 13, 2022
1BJT	TOPOISOMERASE II RESIDUES 409-1201 分子名称: TOPOISOMERASE II 著者 Fass, D, Bogden, C.E, Berger, J.M. 登録日 1998-06-29 公開日 1999-05-04 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands. Nat.Struct.Biol., 6, 1999
5HM5	Crystal structure of Topo-97, an N-terminal 97kDa fragment of topoisomerase V 分子名称: Topoisomerase V 著者 Rajan, R, Osterman, A, Mondragon, A. 登録日 2016-01-15 公開日 2016-03-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Methanopyrus kandleri topoisomerase V contains three distinct AP lyase active sites in addition to the topoisomerase active site. Nucleic Acids Res., 44, 2016
3M7G	Structure of topoisomerase domain of topoisomerase V protein 分子名称: Topoisomerase V 著者 Rajan, R, Taneja, B, Mondragon, A. 登録日 2010-03-16 公開日 2010-08-04 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structures of minimal catalytic fragments of topoisomerase v reveals conformational changes relevant for DNA binding. Structure, 18, 2010
3M7D	Crystal structure of an N-terminal 44 kDA fragment of topoisomerase V in the presence of dioxane 分子名称: Topoisomerase V 著者 Rajan, R, Taneja, B, Mondragon, A. 登録日 2010-03-16 公開日 2010-08-04 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.815 Å) 主引用文献 Structures of minimal catalytic fragments of topoisomerase v reveals conformational changes relevant for DNA binding. Structure, 18, 2010
1BGW	TOPOISOMERASE RESIDUES 410-1202, 分子名称: TOPOISOMERASE 著者 Berger, J.M, Gamblin, S.J, Harrison, S.C, Wang, J.C. 登録日 1996-02-20 公開日 1996-07-11 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structure and mechanism of DNA topoisomerase II. Nature, 379, 1996
2RGR	Topoisomerase IIA bound to G-segment DNA 分子名称: DNA, DNA topoisomerase 2, MAGNESIUM ION 著者 Dong, K.C, Berger, J.M. 登録日 2007-10-04 公開日 2007-12-25 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis for gate-DNA recognition and bending by type IIA topoisomerases. Nature, 450, 2007
8DF8	Structure of M. kandleri topoisomerase V in complex with DNA. 40 base pair symmetric DNA complex 分子名称: DNA (42-MER), PHOSPHATE ION, PHOSPHITE ION, ... 著者 Osterman, A, Mondragon, A. 登録日 2022-06-21 公開日 2022-08-31 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.92 Å) 主引用文献 Structures of topoisomerase V in complex with DNA reveal unusual DNA binding mode and novel relaxation mechanism. Elife, 11, 2022
8DF9	Structure of M. kandleri topoisomerase V in complex with DNA. 38 base pair asymmetric DNA complex 分子名称: DNA (33-MER), DNA (5'-D(P*GP*CP*CP*TP*GP*CP*AP*CP*GP*AP*AP*GP*TP*AP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*CP*TP*GP*CP*AP*CP*GP*AP*AP*GP*TP*AP*AP*GP*CP*A)-3'), ... 著者 Osterman, A, Mondragon, A. 登録日 2022-06-21 公開日 2022-08-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3.24 Å) 主引用文献 Structures of topoisomerase V in complex with DNA reveal unusual DNA binding mode and novel relaxation mechanism. Elife, 11, 2022
8DF7	Structure of M. kandleri topoisomerase V in complex with DNA. 38 base pair symmetric DNA complex 分子名称: DNA (39-MER), POTASSIUM ION, Topoisomerase V 著者 Osterman, A, Mondragon, A. 登録日 2022-06-21 公開日 2022-08-31 実験手法 X-RAY DIFFRACTION (3.52 Å) 主引用文献 Structures of topoisomerase V in complex with DNA reveal unusual DNA binding mode and novel relaxation mechanism. Elife, 11, 2022
8DFB	Structure of M. kandleri topoisomerase V in complex with DNA. 39 base pair symmetric DNA complex 分子名称: DNA (40-MER), POTASSIUM ION, Topoisomerase V 著者 Osterman, A, Mondragon, A. 登録日 2022-06-21 公開日 2022-08-31 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (3.17 Å) 主引用文献 Structures of topoisomerase V in complex with DNA reveal unusual DNA binding mode and novel relaxation mechanism. Elife, 11, 2022
2CSB	Crystal structure of Topoisomerase V from Methanopyrus kandleri (61 kDa fragment) 分子名称: MAGNESIUM ION, Topoisomerase V 著者 Taneja, B, Patel, A, Slesarev, A, Mondragon, A. 登録日 2005-05-21 公開日 2006-01-31 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of the N-terminal fragment of topoisomerase V reveals a new family of topoisomerases Embo J., 25, 2006
2HKJ	Topoisomerase VI-B bound to radicicol 分子名称: DIMETHYL SULFOXIDE, MAGNESIUM ION, RADICICOL, ... 著者 Corbett, K.D, Berger, J.M. 登録日 2006-07-04 公開日 2006-08-29 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for topoisomerase VI inhibition by the anti-Hsp90 drug radicicol Nucleic Acids Res., 34, 2006
1S16	Crystal Structure of E. coli Topoisomerase IV ParE 43kDa subunit complexed with ADPNP 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SULFATE ION, ... 著者 Wei, Y, Gross, C.H. 登録日 2004-01-05 公開日 2004-05-04 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase. Antimicrob.Agents Chemother., 48, 2004
1A31	HUMAN RECONSTITUTED DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX 分子名称: DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*5IUP*5IU*TP*GP*AP*AP*AP*AP*AP*5IUP*5IUP*5IUP*5IUP*T)-3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*5IUP*5IUP*5IUP*5IUP*CP*AP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'), PROTEIN (TOPOISOMERASE I) 著者 Redinbo, M.R, Stewart, L, Kuhn, P, Champoux, J.J, Hol, W.G.J. 登録日 1998-01-27 公開日 1998-08-28 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science, 279, 1998
1A35	HUMAN TOPOISOMERASE I/DNA COMPLEX 分子名称: DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*(BRU)P*(BRU)P*TP*TP*T)-3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*+UP*+UP*+UP*+UP*CP*+UP*AP*AP*GP*TP*CP*TP*TP*TP*+ UP*T)-3'), PROTEIN (DNA TOPOISOMERASE I) 著者 Redinbo, M.R, Stewart, L, Kuhn, P, Champoux, J.J, Hol, W.G. 登録日 1998-01-29 公開日 1998-08-28 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science, 279, 1998
1WP5	Crystal structure of the C-terminal domain of DNA topoisomerase IV 分子名称: topoisomerase IV 著者 Hsieh, T.-J, Farh, L, Huang, W.M, Chan, N.-L. 登録日 2004-08-30 公開日 2004-10-12 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Structure of the topoisomerase IV C-terminal domain: a broken beta-propeller implies a role as geometry facilitator in catalysis J.Biol.Chem., 279, 2004
1S14	Crystal structure of Escherichia coli Topoisomerase IV ParE 24kDa subunit 分子名称: NOVOBIOCIN, Topoisomerase IV subunit B 著者 Wei, Y, Gross, C.H. 登録日 2004-01-05 公開日 2004-05-04 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase. Antimicrob.Agents Chemother., 48, 2004
1YUA	C-TERMINAL DOMAIN OF ESCHERICHIA COLI TOPOISOMERASE I 分子名称: TOPOISOMERASE I 著者 Yu, L, Zhu, C.-X, Tse-Dinh, Y.-C, Fesik, S.W. 登録日 1995-03-02 公開日 1996-03-08 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Solution structure of the C-terminal single-stranded DNA-binding domain of Escherichia coli topoisomerase I. Biochemistry, 34, 1995
5ZAD	Human topoisomerase II beta in complex with DNA 分子名称: DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta 著者 Sun, L.Y, Zhu, L.W, Tang, Y.J. 登録日 2018-02-07 公開日 2019-03-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.54 Å) 主引用文献 Increasing the distance between two monomers of topoisomerase II beta under the action of antitumor agent 4 beta-sulfur-(benzimidazole) 4'-demethylepipodophyllotoxin. Sci Rep, 8, 2018
3M6Z	Crystal structure of an N-terminal 44 kDa fragment of topoisomerase V in the presence of guanidium hydrochloride 分子名称: CHLORIDE ION, GUANIDINE, MAGNESIUM ION, ... 著者 Rajan, R, Taneja, B, Mondragon, A. 登録日 2010-03-16 公開日 2010-08-04 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structures of minimal catalytic fragments of topoisomerase v reveals conformational changes relevant for DNA binding. Structure, 18, 2010
1A36	TOPOISOMERASE I/DNA COMPLEX 分子名称: DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*A P*TP*TP*TP*TP*T)- 3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*C P*TP*TP*TP*TP*T)- 3'), TOPOISOMERASE I 著者 Stewart, L, Redinbo, M.R, Qiu, X, Champoux, J.J, Hol, W.G.J. 登録日 1998-01-29 公開日 1998-08-12 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 A model for the mechanism of human topoisomerase I. Science, 279, 1998

 

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