2AZX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2azx by Molmil](/molmil-images/mine/2azx) | Charged and uncharged tRNAs adopt distinct conformations when complexed with human tryptophanyl-tRNA synthetase | Descriptor: | 72-MER, GLYCEROL, MAGNESIUM ION, ... | Authors: | Yang, X.L, Otero, F.J, Ewalt, K.L, Liu, J, Swairjo, M.A, Kohrer, C, RajBhandary, U.L, Skene, R.J, McRee, D.E, Schimmel, P. | Deposit date: | 2005-09-12 | Release date: | 2006-08-01 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis. Embo J., 25, 2006
|
|
7U8F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7u8f by Molmil](/molmil-images/mine/7u8f) | Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2) and the molecular glue DKY709 | Descriptor: | (3S)-3-[5-(1-benzylpiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA damage-binding protein 1, ... | Authors: | Ma, X, Ornelas, E, Clifton, M.C. | Deposit date: | 2022-03-08 | Release date: | 2023-03-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy. Cell Chem Biol, 30, 2023
|
|
6RJJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6rjj by Molmil](/molmil-images/mine/6rjj) | Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide | Descriptor: | (4-CARBOXYPHENYL)(CHLORO)MERCURY, 2,3-bis(fluoranyl)benzenesulfonamide, Carbonic anhydrase 2, ... | Authors: | Gloeckner, S, Heine, A, Klebe, G. | Deposit date: | 2019-04-27 | Release date: | 2020-04-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.056 Å) | Cite: | The Influence of Varying Fluorination Patterns on the Thermodynamics and Kinetics of Benzenesulfonamide Binding to Human Carbonic Anhydrase II. Biomolecules, 10, 2020
|
|
1RTS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1rts by Molmil](/molmil-images/mine/1rts) | THYMIDYLATE SYNTHASE FROM RAT IN TERNARY COMPLEX WITH DUMP AND TOMUDEX | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE, TOMUDEX | Authors: | Sotelo-Mundo, R.R, Ciesla, J, Dzik, J.M, Rode, W, Maley, F, Maley, G, Hardy, L.W, Montfort, W.R. | Deposit date: | 1998-06-19 | Release date: | 1999-02-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug. Biochemistry, 38, 1999
|
|
6RQI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6rqi by Molmil](/molmil-images/mine/6rqi) | Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide | Descriptor: | (4-CARBOXYPHENYL)(CHLORO)MERCURY, 3-fluorobenzenesulfonamide, Carbonic anhydrase 2, ... | Authors: | Gloeckner, S, Heine, A, Klebe, G. | Deposit date: | 2019-05-15 | Release date: | 2020-04-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (0.95 Å) | Cite: | The Influence of Varying Fluorination Patterns on the Thermodynamics and Kinetics of Benzenesulfonamide Binding to Human Carbonic Anhydrase II. Biomolecules, 10, 2020
|
|
1CC3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1cc3 by Molmil](/molmil-images/mine/1cc3) | PURPLE CUA CENTER | Descriptor: | COPPER (II) ION, PROTEIN (CUA AZURIN) | Authors: | Robinson, H, Ang, M.C, Gao, Y.-G, Hay, M.T, Lu, Y, Wang, A.H.-J. | Deposit date: | 1999-03-03 | Release date: | 1999-12-23 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural basis of electron transfer modulation in the purple CuA center. Biochemistry, 38, 1999
|
|
3P0P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3p0p by Molmil](/molmil-images/mine/3p0p) | Human Tankyrase 2 - Catalytic PARP domain in complex with an inhibitor | Descriptor: | 2-[4-(4-fluorophenyl)piperazin-1-yl]-6-methylpyrimidin-4(3H)-one, SULFATE ION, Tankyrase-2, ... | Authors: | Karlberg, T, Siponen, M.I, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, I, Kotenyova, T, Kouznetsova, E, Moche, M, Nordlund, P, Nyman, T, Persson, C, Schutz, P, Sehic, A, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Wahlberg, E, Weigelt, J, Welin, M, Schuler, H, Structural Genomics Consortium (SGC) | Deposit date: | 2010-09-29 | Release date: | 2010-10-20 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors Nat.Biotechnol., 30, 2012
|
|
5CAE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5cae by Molmil](/molmil-images/mine/5cae) | |
6RKN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6rkn by Molmil](/molmil-images/mine/6rkn) | Human Carbonic Anhydrase II in complex with a fluorinated Benzenesulfonamide. | Descriptor: | (4-CARBOXYPHENYL)(CHLORO)MERCURY, 4-FLUOROBENZENESULFONAMIDE, Carbonic anhydrase 2, ... | Authors: | Gloeckner, S, Heine, A, Klebe, G. | Deposit date: | 2019-04-30 | Release date: | 2020-04-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (0.959 Å) | Cite: | The Influence of Varying Fluorination Patterns on the Thermodynamics and Kinetics of Benzenesulfonamide Binding to Human Carbonic Anhydrase II. Biomolecules, 10, 2020
|
|
4WP4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wp4 by Molmil](/molmil-images/mine/4wp4) | Hev b 6.02 (hevein) extracted from surgical gloves | Descriptor: | Pro-hevein, THIOUREA | Authors: | Galicia, C, Rodriguez-Romero, A. | Deposit date: | 2014-10-17 | Release date: | 2015-03-04 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | Impact of the vulcanization process on the structural characteristics and IgE recognition of two allergens, Hev b 2 and Hev b 6.02, extracted from latex surgical gloves. Mol.Immunol., 65, 2015
|
|
3PH7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ph7 by Molmil](/molmil-images/mine/3ph7) | Crystal structure of Plasmodium vivax putative polyprenyl pyrophosphate synthase in complex with geranylgeranyl diphosphate | Descriptor: | Farnesyl pyrophosphate synthase, GERANYLGERANYL DIPHOSPHATE | Authors: | Wernimont, A.K, Dunford, J, Lew, J, Zhao, Y, Kozieradzki, I, Cossar, D, Schapiro, M, Bochkarev, A, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Hui, R, Artz, J.D, Structural Genomics Consortium (SGC) | Deposit date: | 2010-11-03 | Release date: | 2010-11-17 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites. J.Biol.Chem., 286, 2011
|
|
8GUH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8guh by Molmil](/molmil-images/mine/8guh) | Serine Palmitoyltransferase from Sphingobacterium multivorum complexed with Tris | Descriptor: | 1,2-ETHANEDIOL, Serine palmitoyltransferase, [4-[[[2-(hydroxymethyl)-1,3-bis(oxidanyl)propan-2-yl]amino]methyl]-6-methyl-5-oxidanyl-pyridin-3-yl]methyl dihydrogen phosphate | Authors: | Murakami, T, Takahashi, A, Katayama, A, Miyahara, I, Kamiya, N, Ikushiro, H, Yano, T. | Deposit date: | 2022-09-12 | Release date: | 2023-07-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal structure of Sphingobacterium multivorum serine palmitoyltransferase complexed with tris(hydroxymethyl)aminomethane. Acta Crystallogr.,Sect.F, 78, 2022
|
|
7KA0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ka0 by Molmil](/molmil-images/mine/7ka0) | Crystal structure of the complex of M. tuberculosis PheRS with cognate precursor tRNA and phenylalanine | Descriptor: | ACETATE ION, GLYCEROL, MAGNESIUM ION, ... | Authors: | Chang, C, Michalska, K, Jedrzejczak, R, Wower, J, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2020-09-29 | Release date: | 2021-05-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation. Nucleic Acids Res., 49, 2021
|
|
7KAB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7kab by Molmil](/molmil-images/mine/7kab) | M. tuberculosis PheRS complex with cognate precursor tRNA and phenylalanine | Descriptor: | GLYCEROL, MAGNESIUM ION, PHENYLALANINE, ... | Authors: | Chang, C, Michalska, K, Jedrzejczak, R, Wower, J, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2020-09-30 | Release date: | 2021-05-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation. Nucleic Acids Res., 49, 2021
|
|
1DV2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1dv2 by Molmil](/molmil-images/mine/1dv2) | The structure of biotin carboxylase, mutant E288K, complexed with ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, BIOTIN CARBOXYLASE | Authors: | Thoden, J.B, Blanchard, C.Z, Holden, H.M, Waldrop, G.L. | Deposit date: | 2000-01-19 | Release date: | 2000-06-09 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Movement of the biotin carboxylase B-domain as a result of ATP binding. J.Biol.Chem., 275, 2000
|
|
3D7O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3d7o by Molmil](/molmil-images/mine/3d7o) | Human hemoglobin, nitrogen dioxide anion modified | Descriptor: | Hemoglobin subunit alpha, Hemoglobin subunit beta, NITRITE ION, ... | Authors: | Yi, J, Safo, M.K, Richter-Addo, G.B. | Deposit date: | 2008-05-21 | Release date: | 2009-05-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The nitrite anion binds to human hemoglobin via the uncommon O-nitrito mode. Biochemistry, 47, 2008
|
|
1QW0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1qw0 by Molmil](/molmil-images/mine/1qw0) | Crystal Structure of Haemophilus influenzae N175L mutant Holo Ferric ion-Binding Protein A | Descriptor: | FE (III) ION, Iron-utilization periplasmic protein, PHOSPHATE ION | Authors: | Shouldice, S.R, Skene, R.J, Dougan, D.R, McRee, D.E, Tari, L.W, Schryvers, A.B. | Deposit date: | 2003-08-29 | Release date: | 2003-11-04 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Presence of ferric hydroxide clusters in mutants of Haemophilus influenzae ferric ion-binding protein A Biochemistry, 42, 2003
|
|
6B1P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6b1p by Molmil](/molmil-images/mine/6b1p) | |
6AO8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ao8 by Molmil](/molmil-images/mine/6ao8) | |
2RAC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2rac by Molmil](/molmil-images/mine/2rac) | AMICYANIN REDUCED, PH 7.7, 1.3 ANGSTROMS | Descriptor: | COPPER (I) ION, PROTEIN (AMICYANIN) | Authors: | Cunane, L.M, Chen, Z.-W, Durley, R.C.E, Mathews, F.S. | Deposit date: | 1998-10-02 | Release date: | 1998-10-07 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Molecular basis for interprotein complex-dependent effects on the redox properties of amicyanin. Biochemistry, 37, 1998
|
|
1GT3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1gt3 by Molmil](/molmil-images/mine/1gt3) | Complex of Bovine Odorant Binding Protein with dihydromyrcenol | Descriptor: | (3S)-1-octen-3-ol, 2,6-DIMETHYL-7-OCTEN-2-OL, ODORANT-BINDING PROTEIN | Authors: | Vincent, F, Ramoni, R, Spinelli, S, Grolli, S, Conti, V, Cambillau, C, Tegoni, M. | Deposit date: | 2002-01-10 | Release date: | 2003-10-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structures of Bovine Odorant-Binding Protein in Complex with Odorant Molecules. Eur.J.Biochem., 271, 2004
|
|
4YKP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ykp by Molmil](/molmil-images/mine/4ykp) | |
2VP1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2vp1 by Molmil](/molmil-images/mine/2vp1) | Fe-FutA2 from Synechocystis PCC6803 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, FE (III) ION, ... | Authors: | Badarau, A, Firbank, S.J, Banfield, M.J, Dennison, C. | Deposit date: | 2008-02-26 | Release date: | 2008-03-25 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Futa2 is a Ferric Binding Protein from Synechocystis Pcc 6803. J.Biol.Chem., 283, 2008
|
|
5AJ0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5aj0 by Molmil](/molmil-images/mine/5aj0) | Cryo electron microscopy of actively translating human polysomes (POST state). | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | Authors: | Behrmann, E, Loerke, J, Budkevich, T.V, Yamamoto, K, Schmidt, A, Penczek, P.A, Vos, M.R, Burger, J, Mielke, T, Scheerer, P, Spahn, C.M.T. | Deposit date: | 2015-02-19 | Release date: | 2015-05-20 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural Snapshots of Actively Translating Human Ribosomes Cell(Cambridge,Mass.), 161, 2015
|
|
3SEM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3sem by Molmil](/molmil-images/mine/3sem) | SEM5 SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR | Descriptor: | SEX MUSCLE ABNORMAL PROTEIN 5, SH3 PEPTOID INHIBITOR | Authors: | Nguyen, J.T, Turck, C.W, Cohen, F.E, Zuckermann, R.N, Lim, W.A. | Deposit date: | 1998-11-02 | Release date: | 1999-01-06 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors. Science, 282, 1998
|
|