1WAK
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![BU of 1wak by Molmil](/molmil-images/mine/1wak) | X-ray structure of SRPK1 | Descriptor: | 1,2-ETHANEDIOL, SERINE/THREONINE-PROTEIN KINASE SPRK1 | Authors: | Ngo, J.C, Gullingsrud, J, Chakrabarti, S, Nolen, B, Aubol, B.E, Fu, X.D, Adams, J.A, Mccammon, J.A, Ghosh, G. | Deposit date: | 2004-10-26 | Release date: | 2006-07-11 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Sr Protein Kinase 1 is Resilient to Inactivation. Structure, 15, 2007
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7PSA
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![BU of 7psa by Molmil](/molmil-images/mine/7psa) | The acetogenin-bound complex I of Mus musculus resolved to 3.4 angstroms | Descriptor: | (3~{S},5~{S})-5-methyl-3-[(13~{R})-13-oxidanyl-13-[(2~{R},5~{R})-5-[(2~{R},5~{R})-5-[(1~{R})-1-oxidanylundecyl]oxolan-2-yl]oxolan-2-yl]tridecyl]oxolan-2-one, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | Authors: | Grba, D, Hirst, J. | Deposit date: | 2021-09-22 | Release date: | 2022-04-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-electron microscopy reveals how acetogenins inhibit mitochondrial respiratory complex I. J.Biol.Chem., 298, 2022
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7QSD
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![BU of 7qsd by Molmil](/molmil-images/mine/7qsd) | Bovine complex I in the active state at 3.1 A | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | Authors: | Bridges, H.R, Blaza, J.N, Yin, Z, Chung, I, Hirst, J. | Deposit date: | 2022-01-13 | Release date: | 2022-03-02 | Last modified: | 2023-03-08 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides. Science, 379, 2023
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7QSL
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![BU of 7qsl by Molmil](/molmil-images/mine/7qsl) | Bovine complex I in lipid nanodisc, Active-apo | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | Authors: | Chung, I, Bridges, H.R, Hirst, J. | Deposit date: | 2022-01-13 | Release date: | 2022-05-25 | Last modified: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy. Nat Commun, 13, 2022
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7QSM
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![BU of 7qsm by Molmil](/molmil-images/mine/7qsm) | Bovine complex I in lipid nanodisc, Deactive-ligand (composite) | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | Authors: | Chung, I, Bridges, H.R, Hirst, J. | Deposit date: | 2022-01-13 | Release date: | 2022-05-25 | Last modified: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy. Nat Commun, 13, 2022
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7QSN
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![BU of 7qsn by Molmil](/molmil-images/mine/7qsn) | Bovine complex I in lipid nanodisc, Deactive-apo | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | Authors: | Chung, I, Bridges, H.R, Hirst, J. | Deposit date: | 2022-01-13 | Release date: | 2022-05-25 | Last modified: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (2.81 Å) | Cite: | Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy. Nat Commun, 13, 2022
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7QSK
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![BU of 7qsk by Molmil](/molmil-images/mine/7qsk) | Bovine complex I in lipid nanodisc, Active-Q10 | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | Authors: | Chung, I, Bridges, H.R, Hirst, J. | Deposit date: | 2022-01-13 | Release date: | 2022-05-25 | Last modified: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy. Nat Commun, 13, 2022
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7QSO
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![BU of 7qso by Molmil](/molmil-images/mine/7qso) | Bovine complex I in lipid nanodisc, State 3 (Slack) | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | Authors: | Chung, I, Bridges, H.R, Hirst, J. | Deposit date: | 2022-01-13 | Release date: | 2022-05-25 | Last modified: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy. Nat Commun, 13, 2022
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6ZIX
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![BU of 6zix by Molmil](/molmil-images/mine/6zix) | Structure of RcsB from Salmonella enterica serovar Typhimurium bound to promoter P1flhDC in the presence of phosphomimetic BeF3- | Descriptor: | BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, P1flhDC promoter sequence of 23 bp, ... | Authors: | Huesa, J, Marina, A, Casino, P. | Deposit date: | 2020-06-26 | Release date: | 2021-02-17 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structure-based analyses of Salmonella RcsB variants unravel new features of the Rcs regulon. Nucleic Acids Res., 49, 2021
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6ZIL
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![BU of 6zil by Molmil](/molmil-images/mine/6zil) | |
6ZJ2
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![BU of 6zj2 by Molmil](/molmil-images/mine/6zj2) | Structure of RcsB from Salmonella enterica serovar Typhimurium bound to promoter rprA in the presence of phosphomimetic BeF3- | Descriptor: | BERYLLIUM TRIFLUORIDE ION, DNA (5'-D(P*CP*CP*GP*AP*TP*CP*AP*GP*AP*TP*TP*CP*GP*TP*CP*TP*CP*AP*AP*TP*AP*GP*G)-3'), MAGNESIUM ION, ... | Authors: | Huesa, J, Marina, A, Casino, P. | Deposit date: | 2020-06-27 | Release date: | 2021-02-17 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.38 Å) | Cite: | Structure-based analyses of Salmonella RcsB variants unravel new features of the Rcs regulon. Nucleic Acids Res., 49, 2021
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6ZII
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![BU of 6zii by Molmil](/molmil-images/mine/6zii) | |
5LDX
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![BU of 5ldx by Molmil](/molmil-images/mine/5ldx) | Structure of mammalian respiratory Complex I, class3. | Descriptor: | Acyl carrier protein, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ... | Authors: | Vinothkumar, K.R, Zhu, J, Hirst, J. | Deposit date: | 2016-06-28 | Release date: | 2016-09-14 | Last modified: | 2019-10-23 | Method: | ELECTRON MICROSCOPY (5.6 Å) | Cite: | Structure of mammalian respiratory complex I. Nature, 536, 2016
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5LC5
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![BU of 5lc5 by Molmil](/molmil-images/mine/5lc5) | Structure of mammalian respiratory Complex I, class2 | Descriptor: | Acyl carrier protein, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ... | Authors: | Vinothkumar, K.R, Zhu, J, Hirst, J. | Deposit date: | 2016-06-19 | Release date: | 2016-09-07 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (4.35 Å) | Cite: | Structure of mammalian respiratory complex I. Nature, 536, 2016
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4O21
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![BU of 4o21 by Molmil](/molmil-images/mine/4o21) | Product complex of metal-free PKAc, ATP-gamma-S and SP20. | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Thio-phosphorylated peptide pSP20, cAMP-dependent protein kinase catalytic subunit alpha | Authors: | Das, A, Kovalevsky, A.Y, Gerlits, O, Langan, P, Heller, W.T, Keshwani, M, Taylor, S. | Deposit date: | 2013-12-16 | Release date: | 2014-05-28 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Metal-Free cAMP-Dependent Protein Kinase Can Catalyze Phosphoryl Transfer. Biochemistry, 53, 2014
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4V4P
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![BU of 4v4p by Molmil](/molmil-images/mine/4v4p) | Crystal structure of 70S ribosome with thrS operator and tRNAs. | Descriptor: | 16S rRNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Jenner, L, Romby, P, Rees, B, Schulze-Briese, C, Springer, M, Ehresmann, C, Ehresmann, B, Moras, D, Yusupova, G, Yusupov, M. | Deposit date: | 2005-01-19 | Release date: | 2014-07-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (5.5 Å) | Cite: | Translational operator of mRNA on the ribosome: how repressor proteins exclude ribosome binding. Science, 308, 2005
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8OLT
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![BU of 8olt by Molmil](/molmil-images/mine/8olt) | Mitochondrial complex I from Mus musculus in the active state bound with piericidin A | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | Authors: | Grba, D.N, Chung, I, Bridges, H.R, Agip, A.N.A, Hirst, J. | Deposit date: | 2023-03-30 | Release date: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Investigation of hydrated channels and proton pathways in a high-resolution cryo-EM structure of mammalian complex I. Sci Adv, 9, 2023
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8OM1
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![BU of 8om1 by Molmil](/molmil-images/mine/8om1) | Mitochondrial complex I from Mus musculus in the active state | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Grba, D.N, Chung, I, Bridges, H.R, Agip, A.N.A, Hirst, J. | Deposit date: | 2023-03-31 | Release date: | 2023-08-09 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (2.39 Å) | Cite: | Investigation of hydrated channels and proton pathways in a high-resolution cryo-EM structure of mammalian complex I. Sci Adv, 9, 2023
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6G2J
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![BU of 6g2j by Molmil](/molmil-images/mine/6g2j) | Mouse mitochondrial complex I in the active state | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Agip, A.N.A, Blaza, J.N, Bridges, H.R, Viscomi, C, Rawson, S, Muench, S.P, Hirst, J. | Deposit date: | 2018-03-23 | Release date: | 2018-06-06 | Last modified: | 2021-06-02 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states. Nat. Struct. Mol. Biol., 25, 2018
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5LDW
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![BU of 5ldw by Molmil](/molmil-images/mine/5ldw) | Structure of mammalian respiratory Complex I, class1 | Descriptor: | Acyl carrier protein, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ... | Authors: | Vinothkumar, K.R, Zhu, J, Hirst, J. | Deposit date: | 2016-06-28 | Release date: | 2016-09-07 | Last modified: | 2019-10-23 | Method: | ELECTRON MICROSCOPY (4.27 Å) | Cite: | Structure of mammalian respiratory complex I. Nature, 536, 2016
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7AK6
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![BU of 7ak6 by Molmil](/molmil-images/mine/7ak6) | Cryo-EM structure of ND6-P25L mutant respiratory complex I from Mus musculus at 3.8 A | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Yin, Z, Bridges, H.R, Grba, D, Hirst, J. | Deposit date: | 2020-09-29 | Release date: | 2021-02-03 | Last modified: | 2021-02-10 | Method: | ELECTRON MICROSCOPY (3.82 Å) | Cite: | Structural basis for a complex I mutation that blocks pathological ROS production. Nat Commun, 12, 2021
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7AK5
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![BU of 7ak5 by Molmil](/molmil-images/mine/7ak5) | Cryo-EM structure of respiratory complex I in the deactive state from Mus musculus at 3.2 A | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Yin, Z, Bridges, H.R, Grba, D, Hirst, J. | Deposit date: | 2020-09-29 | Release date: | 2021-02-03 | Last modified: | 2021-02-10 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | Structural basis for a complex I mutation that blocks pathological ROS production. Nat Commun, 12, 2021
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6ZTQ
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![BU of 6ztq by Molmil](/molmil-images/mine/6ztq) | Cryo-EM structure of respiratory complex I from Mus musculus inhibited by piericidin A at 3.0 A | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Bridges, H.R, Blaza, J.N, Agip, A.N.A, Hirst, J. | Deposit date: | 2020-07-20 | Release date: | 2020-10-21 | Last modified: | 2020-10-28 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure of inhibitor-bound mammalian complex I. Nat Commun, 11, 2020
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6ZR2
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![BU of 6zr2 by Molmil](/molmil-images/mine/6zr2) | Cryo-EM structure of respiratory complex I in the active state from Mus musculus at 3.1 A | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Bridges, H.R, Blaza, J.N, Agip, A.N.A, Hirst, J. | Deposit date: | 2020-07-10 | Release date: | 2020-10-21 | Last modified: | 2020-10-28 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure of inhibitor-bound mammalian complex I. Nat Commun, 11, 2020
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3UUG
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![BU of 3uug by Molmil](/molmil-images/mine/3uug) | Crystal structure of the periplasmic sugar binding protein ChvE | Descriptor: | Multiple sugar-binding periplasmic receptor ChvE, beta-D-glucopyranuronic acid | Authors: | Hu, X, Zhao, J, Binns, A, Degrado, W. | Deposit date: | 2011-11-28 | Release date: | 2012-11-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Agrobacterium tumefaciens recognizes its host environment using ChvE to bind diverse plant sugars as virulence signals. Proc.Natl.Acad.Sci.USA, 110, 2013
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