7LPB
| Cryo-EM structure of full-length TRPV1 with capsaicin at 25 degrees Celsius | Descriptor: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, ... | Authors: | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | Deposit date: | 2021-02-11 | Release date: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7LPD
| Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an intermediate state, class 2 | Descriptor: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... | Authors: | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | Deposit date: | 2021-02-11 | Release date: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.55 Å) | Cite: | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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4E15
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7LP9
| Cryo-EM structure of full-length TRPV1 at 4 degrees Celsius | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, Phosphatidylinositol, ... | Authors: | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | Deposit date: | 2021-02-11 | Release date: | 2021-07-28 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.63 Å) | Cite: | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7LPC
| Cryo-EM structure of full-length TRPV1 at 48 degrees Celsius | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, Phosphatidylinositol, ... | Authors: | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | Deposit date: | 2021-02-11 | Release date: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7KKF
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4NIA
| Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints | Descriptor: | Coat protein, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Larson, S.B, Day, J.S, McPherson, A. | Deposit date: | 2013-11-05 | Release date: | 2014-09-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Satellite tobacco mosaic virus refined to 1.4 angstrom resolution. Acta Crystallogr.,Sect.D, 70, 2014
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4QRT
| Crystal Structure of HLA B*0801 in complex with ELN_YYM, ELNRKMIYM | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | Authors: | Gras, S, Twist, K.-A, Rossjohn, J. | Deposit date: | 2014-07-02 | Release date: | 2014-07-16 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Molecular imprint of exposure to naturally occurring genetic variants of human cytomegalovirus on the T cell repertoire. Sci Rep, 4, 2014
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6S2W
| Structure of S. pombe Erh1, a protein important for meiotic mRNA decay in mitosis and meiosis progression. | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETIC ACID, ... | Authors: | Hazra, D, Graille, M. | Deposit date: | 2019-06-22 | Release date: | 2020-02-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Formation of S. pombe Erh1 homodimer mediates gametogenic gene silencing and meiosis progression. Sci Rep, 10, 2020
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2FYC
| Crystal structure of the catalytic domain of bovine beta1,4-galactosyltransferase-I in complex with alpha-lactalbumin, Ca and UDP-galactose | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Alpha-lactalbumin, CALCIUM ION, ... | Authors: | Ramakrishnan, B, Ramasamy, V, Qasba, P.K. | Deposit date: | 2006-02-07 | Release date: | 2006-03-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Snapshots of beta-1,4-Galactosyltransferase-I Along the Kinetic Pathway. J.Mol.Biol., 357, 2006
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5BU4
| RIBONUCLEASE T1 COMPLEX WITH 2'GMP | Descriptor: | CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, PROTEIN (RIBONUCLEASE T1) | Authors: | Loris, R, Devos, S, Langhorst, U, Decanniere, K, Bouckaert, J, Maes, D, Transue, T.R, Steyaert, J. | Deposit date: | 1998-09-15 | Release date: | 1998-09-23 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Conserved water molecules in a large family of microbial ribonucleases. Proteins, 36, 1999
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5AM5
| ligand complex structure of soluble epoxide hydrolase | Descriptor: | 5-cyclohexyl-3-propyl-1H-pyridin-2-one, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE | Authors: | Oster, L, Tapani, S, Xue, Y, Kack, H. | Deposit date: | 2015-03-09 | Release date: | 2015-05-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
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4TXD
| Crystal structure of Thermofilum pendens Csc2 | Descriptor: | Csc2, ZINC ION | Authors: | Hrle, A, Conti, E. | Deposit date: | 2014-07-03 | Release date: | 2014-08-27 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.818 Å) | Cite: | Structural analyses of the CRISPR protein Csc2 reveal the RNA-binding interface of the type I-D Cas7 family. Rna Biol., 11, 2014
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5AM3
| ligand complex structure of soluble epoxide hydrolase | Descriptor: | 4-[(trans-4-{[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]dec-1-ylcarbamoyl]amino}cyclohexyl)oxy]benzoic acid, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DI(HYDROXYETHYL)ETHER, ... | Authors: | Oster, L, Tapani, S, Xue, Y, Kack, H. | Deposit date: | 2015-03-09 | Release date: | 2015-05-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
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1ZKY
| Human Estrogen Receptor Alpha Ligand-Binding Domain In Complex With OBCP-3M and A Glucocorticoid Receptor Interacting Protein 1 Nr Box II Peptide | Descriptor: | 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL, Estrogen receptor, Nuclear receptor coactivator 2 | Authors: | Rajan, S.S, Hsieh, R.W, Sharma, S.K, Hahm, J.B, Nettles, K.W, Greene, G.L. | Deposit date: | 2005-05-04 | Release date: | 2006-05-09 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Identification of ligands with bicyclic scaffolds provides insights into mechanisms of estrogen receptor subtype selectivity. J.Biol.Chem., 281, 2006
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4TUR
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6RZH
| Galectin-3C in complex with para-fluoroaryltriazole galactopyranosyl 1-thio-D-glucopyranoside derivative | Descriptor: | (2~{S},3~{R},4~{S},5~{S},6~{R})-2-[(2~{S},3~{R},4~{S},5~{R},6~{R})-4-[4-(4-fluorophenyl)-1,2,3-triazol-1-yl]-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]sulfanyl-6-(hydroxymethyl)oxane-3,4,5-triol, CHLORIDE ION, Galectin-3 | Authors: | Kumar, R, Peterson, K, Nilsson, U.J, Logan, D.T. | Deposit date: | 2019-06-13 | Release date: | 2020-07-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (0.947 Å) | Cite: | Entropy-Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C. Jacs Au, 1, 2021
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6S03
| Carbonic Anhydrase CAIX mimic in complex with inhibitor I39LT379 | Descriptor: | 4-[[4-[5,5-dimethyl-2-(6-methylpyridin-2-yl)-4,6-dihydropyrrolo[1,2-b]pyrazol-3-yl]pyridin-2-yl]amino]benzenesulfonamide, Carbonic anhydrase 2, ZINC ION | Authors: | Kugler, M, Brynda, J, Rezacova, P. | Deposit date: | 2019-06-13 | Release date: | 2020-06-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Identification of Novel Carbonic Anhydrase IX Inhibitors Using High-Throughput Screening of Pooled Compound Libraries by DNA-Linked Inhibitor Antibody Assay (DIANA). SLAS Discov, 25, 2020
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5E0M
| LC8 - Chica (468-476) Complex | Descriptor: | Dynein light chain 1, cytoplasmic, Protein Chica peptide, ... | Authors: | Clark, S.A, Barbar, E.B, Karplus, P.A. | Deposit date: | 2015-09-29 | Release date: | 2015-12-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The Anchored Flexibility Model in LC8 Motif Recognition: Insights from the Chica Complex. Biochemistry, 55, 2016
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5E33
| Structure of human DPP3 in complex with met-enkephalin | Descriptor: | Dipeptidyl peptidase 3, MAGNESIUM ION, Met-enkephalin, ... | Authors: | Kumar, P, Reithofer, V, Reisinger, M, Pavkov-Keller, T, Wallner, S, Macheroux, P, Gruber, K. | Deposit date: | 2015-10-01 | Release date: | 2016-04-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.837 Å) | Cite: | Substrate complexes of human dipeptidyl peptidase III reveal the mechanism of enzyme inhibition. Sci Rep, 6, 2016
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1BW4
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4TUS
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3GN2
| Structure of Pteridine Reductase 1 (PTR1) from TRYPANOSOMA BRUCEI in ternary complex with cofactor (NADP+) and inhibitor (DDD00066730) | Descriptor: | 1-(3,4-dichlorobenzyl)-1H-benzimidazol-2-amine, ACETATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Tulloch, L.B, Brenk, R, Hunter, W.N. | Deposit date: | 2009-03-16 | Release date: | 2009-12-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening. J.Med.Chem., 52, 2009
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4TUQ
| Human DNA polymerase beta inserting dCMPNPP opposite GG template (GG0b). | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*CP*CP*CP*AP*CP*GP*GP*CP*CP*CP*AP*TP*CP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*GP*AP*TP*GP*GP*GP*C)-3'), ... | Authors: | Koag, M.C, Lee, S. | Deposit date: | 2014-06-24 | Release date: | 2014-10-01 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.367 Å) | Cite: | Structural Basis for the Inefficient Nucleotide Incorporation Opposite Cisplatin-DNA Lesion by Human DNA Polymerase beta. J.Biol.Chem., 289, 2014
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1JL5
| Novel Molecular Architecture of YopM-a Leucine-rich Effector Protein from Yersinia pestis | Descriptor: | CALCIUM ION, outer protein YopM | Authors: | Evdokimov, A.G, Anderson, D.E, Routzahn, K.M, Waugh, D.S. | Deposit date: | 2001-07-15 | Release date: | 2001-10-10 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Unusual molecular architecture of the Yersinia pestis cytotoxin YopM: a leucine-rich repeat protein with the shortest repeating unit. J.Mol.Biol., 312, 2001
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