6RZH
Galectin-3C in complex with para-fluoroaryltriazole galactopyranosyl 1-thio-D-glucopyranoside derivative
Summary for 6RZH
Entry DOI | 10.2210/pdb6rzh/pdb |
Descriptor | Galectin-3, (2~{S},3~{R},4~{S},5~{S},6~{R})-2-[(2~{S},3~{R},4~{S},5~{R},6~{R})-4-[4-(4-fluorophenyl)-1,2,3-triazol-1-yl]-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]sulfanyl-6-(hydroxymethyl)oxane-3,4,5-triol, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | lectin, carbohydrate-binding protein, galactose-specific lectin 3, galactoside-binding protein, galbp, ige-6 binding protein, l-31, laminin-binding protein, lectin l-29, mac-2, sugar binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 16240.00 |
Authors | Kumar, R.,Peterson, K.,Nilsson, U.J.,Logan, D.T. (deposition date: 2019-06-13, release date: 2020-07-08, Last modification date: 2024-01-24) |
Primary citation | Wallerstein, J.,Ekberg, V.,Ignjatovic, M.M.,Kumar, R.,Caldararu, O.,Peterson, K.,Wernersson, S.,Brath, U.,Leffler, H.,Oksanen, E.,Logan, D.T.,Nilsson, U.J.,Ryde, U.,Akke, M. Entropy-Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C. Jacs Au, 1:484-500, 2021 Cited by PubMed: 34467311DOI: 10.1021/jacsau.0c00094 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (0.947 Å) |
Structure validation
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