2XYM
 
 | | HCV-JFH1 NS5B T385A mutant | | Descriptor: | PHOSPHATE ION, RNA-DIRECTED RNA POLYMERASE | | Authors: | Simister, P.C, Caillet-Saguy, C, Bressanelli, S. | | Deposit date: | 2010-11-18 | | Release date: | 2011-01-12 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.774 Å) | | Cite: | A Comprehensive Structure-Function Comparison of Hepatitis C Virus Strains Jfh1 and J6 Polymerases Reveals a Key Residue Stimulating Replication in Cell Culture Across Genotypes.
J.Virol., 85, 2011
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8B7T
 | | CPSF73 CTD3 | | Descriptor: | CPSF73 | | Authors: | Thore, S, Mackereth, C. | | Deposit date: | 2022-10-03 | | Release date: | 2023-05-03 | | Last modified: | 2023-12-06 | | Method: | SOLUTION NMR | | Cite: | Molecular details of the CPSF73-CPSF100 C-terminal heterodimer and interaction with Symplekin.
Open Biology, 13, 2023
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8BA1
 | | CTD12-CTD12 heterodimer from CPSF73 and CPSF100 | | Descriptor: | Cleavage and polyadenylation specificity factor subunit 2, Cleavage and polyadenylation specificity factor subunit 3 | | Authors: | Thore, S, Mackereth, C. | | Deposit date: | 2022-10-10 | | Release date: | 2023-05-03 | | Last modified: | 2023-12-06 | | Method: | SOLUTION NMR | | Cite: | Molecular details of the CPSF73-CPSF100 C-terminal heterodimer and interaction with Symplekin.
Open Biology, 13, 2023
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6W9Q
 | | Peptide-bound SARS-CoV-2 Nsp9 RNA-replicase | | Descriptor: | 3C-like proteinase peptide, Non-structural protein 9 fusion, PHOSPHATE ION | | Authors: | Littler, D.R, Gully, B.S, Riboldi-Tunnicliffe, A, Rossjohn, J. | | Deposit date: | 2020-03-23 | | Release date: | 2020-04-08 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9.
Iscience, 23, 2020
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5WJR
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2Z1I
 | | Crystal structure of E.coli RNase HI surface charged mutant(Q4R/T40E/Q72H/Q76K/Q80E/T92K/Q105K/Q113R/Q115K) | | Descriptor: | Ribonuclease HI | | Authors: | You, D.J, Fukuchi, S, Nishikawa, K, Koga, Y, Takano, K, Kanaya, S. | | Deposit date: | 2007-05-08 | | Release date: | 2007-11-13 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Protein Thermostabilization Requires a Fine-tuned Placement of Surface-charged Residues
J.Biochem.(Tokyo), 142, 2007
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2Z1J
 | | Crystal structure of E.coli RNase HI surface charged mutant(Q4R/T40E/Q72H/Q76K/Q80E/T92K/Q105K/Q113R/Q115K/N143K/T145K) | | Descriptor: | Ribonuclease HI | | Authors: | You, D.J, Fukuchi, S, Nishikawa, K, Koga, Y, Takano, K, Kanaya, S. | | Deposit date: | 2007-05-08 | | Release date: | 2007-11-13 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.38 Å) | | Cite: | Protein Thermostabilization Requires a Fine-tuned Placement of Surface-charged Residues
J.Biochem.(Tokyo), 142, 2007
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8C5M
 | | SARS-CoV-2 nsp10-16 methyltransferase in complex with MTA | | Descriptor: | 1,2-ETHANEDIOL, 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | | Authors: | Kremling, V, Sprenger, J, Oberthuer, D, Falke, S. | | Deposit date: | 2023-01-09 | | Release date: | 2023-03-01 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structures of Tubercidin and Adenosine bound to the active site of the SARS-CoV-2 methyltransferase nsp10-16
To Be Published
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3H3A
 | | The complex structure of CCA-adding enzyme with CTP | | Descriptor: | CYTIDINE-5'-TRIPHOSPHATE, TRNA nucleotidyl transferase-related protein | | Authors: | Toh, Y, Tomita, K. | | Deposit date: | 2009-04-16 | | Release date: | 2009-10-13 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.801 Å) | | Cite: | Mechanism for the definition of elongation and termination by the class II CCA-adding enzyme
Embo J., 28, 2009
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4HFQ
 | | Crystal structure of UDP-X diphosphatase | | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Duong-Ly, K.C, Amzel, L.M, Gabelli, S.B. | | Deposit date: | 2012-10-05 | | Release date: | 2013-08-07 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.39 Å) | | Cite: | A UDP-X diphosphatase from Streptococcus pneumoniae hydrolyzes precursors of peptidoglycan biosynthesis.
Plos One, 8, 2013
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1J1G
 | | Crystal structure of the RNase MC1 mutant N71S in complex with 5'-GMP | | Descriptor: | GUANOSINE-5'-MONOPHOSPHATE, Ribonuclease MC1 | | Authors: | Numata, T, Suzuki, A, Kakuta, Y, Kimura, K, Yao, M, Tanaka, I, Yoshida, Y, Ueda, T, Kimura, M. | | Deposit date: | 2002-12-04 | | Release date: | 2003-05-20 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal Structures of the Ribonuclease MC1 Mutants N71T and N71S in Complex with 5'-GMP: Structural Basis for Alterations in Substrate Specificity
Biochemistry, 42, 2003
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3H39
 | | The complex structure of CCA-adding enzyme with ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, TRNA nucleotidyl transferase-related protein | | Authors: | Toh, Y, Tomita, K. | | Deposit date: | 2009-04-16 | | Release date: | 2009-10-13 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.854 Å) | | Cite: | Mechanism for the definition of elongation and termination by the class II CCA-adding enzyme
Embo J., 28, 2009
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3AF6
 | | The crystal structure of an archaeal CPSF subunit, PH1404 from Pyrococcus horikoshii complexed with RNA-analog | | Descriptor: | 5'-R(*(SSU)P*(SSU)P*(SSU)P*(SSU)P*(SSU)P*(SSU))-3', Putative uncharacterized protein PH1404, SULFATE ION, ... | | Authors: | Nishida, Y, Ishikawa, H, Nakagawa, N, Masui, R, Kuramitsu, S. | | Deposit date: | 2010-02-24 | | Release date: | 2010-04-21 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of an archaeal cleavage and polyadenylation specificity factor subunit from Pyrococcus horikoshii
Proteins, 78, 2010
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8Q4P
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8Q3G
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8Q4W
 | | Crystal structure of YTHDC1 in complex with Compound 40 (CS_3a) | | Descriptor: | 5-chloranyl-3-[(3-chlorophenyl)methyl]-~{N}-methyl-2~{H}-pyrazolo[4,3-d]pyrimidin-7-amine, SULFATE ION, YTH domain-containing protein 1 | | Authors: | Bedi, R.K, Zalesak, F, Caflisch, A. | | Deposit date: | 2023-08-07 | | Release date: | 2023-12-06 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (1.61 Å) | | Cite: | Structure-Based Design of a Potent and Selective YTHDC1 Ligand.
J.Med.Chem., 67, 2024
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8Q2X
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8Q3A
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8Q4N
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8Q2S
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8Q2V
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8Q35
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8Q39
 | | Crystal structure of YTHDC1 in complex with Compound 21 (ZA_515) | | Descriptor: | 2-chloranyl-N-methyl-9-[[3-(1H-1,2,3,4-tetrazol-5-yl)phenyl]methyl]purin-6-amine, SULFATE ION, YTH domain-containing protein 1 | | Authors: | Bedi, R.K, Zalesak, F, Caflisch, A. | | Deposit date: | 2023-08-03 | | Release date: | 2023-12-06 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (1.42 Å) | | Cite: | Structure-Based Design of a Potent and Selective YTHDC1 Ligand.
J.Med.Chem., 67, 2024
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8Q4T
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8Q2U
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