5N2V
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6T9L
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8FTD
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![BU of 8ftd by Molmil](/molmil-images/mine/8ftd) | Structure of Escherichia coli CedA in complex with transcription initiation complex | Descriptor: | CHAPSO, Cell division activator CedA, DNA-directed RNA polymerase subunit alpha, ... | Authors: | Liu, M, Vassyliev, N, Nudler, E. | Deposit date: | 2023-01-11 | Release date: | 2024-01-10 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | General transcription factor from Escherichia coli with a distinct mechanism of action. Nat.Struct.Mol.Biol., 31, 2024
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5PZO
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![BU of 5pzo by Molmil](/molmil-images/mine/5pzo) | CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE C316N IN COMPLEX WITH 2-(4-FLUOROPHENYL)-N-METHYL-5-[3-({2-METHYL-1-OXO-1-[(1,3,4-THIADIAZOL-2-YL)AMINO]PROPAN-2-YL}CARBAMOYL)PHENYL]-1-BENZOFURAN-3-CARBOXAMIDE | Descriptor: | (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, 2-(4-fluorophenyl)-N-methyl-5-[3-({2-methyl-1-oxo-1-[(1,3,4-thiadiazol-2-yl)amino]propan-2-yl}carbamoyl)phenyl]-1-benzofuran-3-carboxamide, GLYCEROL, ... | Authors: | Sheriff, S. | Deposit date: | 2017-02-27 | Release date: | 2017-05-10 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. J. Med. Chem., 60, 2017
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5PZN
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7UIG
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![BU of 7uig by Molmil](/molmil-images/mine/7uig) | Mediator-PIC Early (Mediator A) | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, ... | Authors: | Gorbea Colon, J.J, Chen, S.-F, Tsai, K.L, Murakami, K. | Deposit date: | 2022-03-29 | Release date: | 2023-02-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural basis of a transcription pre-initiation complex on a divergent promoter. Mol.Cell, 83, 2023
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8PID
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![BU of 8pid by Molmil](/molmil-images/mine/8pid) | backtracked E. coli transcription complex paused at ops site and bound to RfaH | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Zuber, P.K, Said, N, Hilal, T, Loll, B, Wahl, M.C, Knauer, S.H. | Deposit date: | 2023-06-21 | Release date: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Concerted transformation of a hyper-paused transcription complex and its reinforcing protein. Nat Commun, 15, 2024
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5PZM
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6C4H
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7DCQ
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![BU of 7dcq by Molmil](/molmil-images/mine/7dcq) | cryo-EM structure of the DEAH-box helicase Prp2 | Descriptor: | PRP2 isoform 1 | Authors: | Bai, R, Wan, R, Yan, C, Jia, Q, Zhang, P, Lei, J, Shi, Y. | Deposit date: | 2020-10-26 | Release date: | 2021-01-06 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2. Science, 371, 2021
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5PZK
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5PZP
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5PZL
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![BU of 5pzl by Molmil](/molmil-images/mine/5pzl) | CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 2-({3-[1-(2-CYCLOPROPYLETHYL)-6-FLUORO-4-HYDROXY-2-OXO-1,2-DIHYDROQUINOLIN-3-YL]-1,1-DIOXO-1,4-DIHYDRO-1LAMBDA~6~,2,4-BENZOTHIADIAZIN-7-YL}OXY)ACETAMIDE | Descriptor: | (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, 2-({3-[1-(2-cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1-dioxo-1,4-dihydro-1lambda~6~,2,4-benzothiadiazin-7-yl}oxy)acetamide, RNA-directed RNA polymerase, ... | Authors: | Sheriff, S. | Deposit date: | 2017-02-27 | Release date: | 2017-05-10 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. J. Med. Chem., 60, 2017
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8CSR
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![BU of 8csr by Molmil](/molmil-images/mine/8csr) | Human mitochondrial small subunit assembly intermediate (State C) | Descriptor: | 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... | Authors: | Harper, N.J, Burnside, C, Klinge, S. | Deposit date: | 2022-05-13 | Release date: | 2022-12-14 | Last modified: | 2023-02-15 | Method: | ELECTRON MICROSCOPY (2.54 Å) | Cite: | Principles of mitoribosomal small subunit assembly in eukaryotes. Nature, 614, 2023
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8CSU
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![BU of 8csu by Molmil](/molmil-images/mine/8csu) | Human mitochondrial small subunit assembly intermediate (State C*) | Descriptor: | 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... | Authors: | Harper, N.J, Burnside, C, Klinge, S. | Deposit date: | 2022-05-13 | Release date: | 2022-12-14 | Last modified: | 2023-02-08 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | Principles of mitoribosomal small subunit assembly in eukaryotes. Nature, 614, 2023
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5OLA
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![BU of 5ola by Molmil](/molmil-images/mine/5ola) | Structure of mitochondrial transcription elongation complex in complex with elongation factor TEFM | Descriptor: | DNA (30-MER), DNA (5'-D(P*AP*TP*GP*GP*TP*GP*TP*AP*AP*CP*GP*CP*CP*AP*GP*AP*CP*GP*AP*AP*C)-3'), DNA-directed RNA polymerase, ... | Authors: | Hillen, H.S, Parshin, A.V, Agaronyan, K, Morozov, Y, Graber, J.J, Chernev, A, Schwinghammer, K, Urlaub, H, Anikin, M, Cramer, P, Temiakov, D. | Deposit date: | 2017-07-27 | Release date: | 2017-10-18 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.904 Å) | Cite: | Mechanism of Transcription Anti-termination in Human Mitochondria. Cell, 171, 2017
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7QWP
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![BU of 7qwp by Molmil](/molmil-images/mine/7qwp) | CryoEM structure of bacterial transcription close complex (RPc) | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Ye, F.Z, Zhang, X.D. | Deposit date: | 2022-01-25 | Release date: | 2022-11-09 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Mechanisms of DNA opening revealed in AAA+ transcription complex structures. Sci Adv, 8, 2022
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7U22
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![BU of 7u22 by Molmil](/molmil-images/mine/7u22) | Mycobacterium tuberculosis RNA polymerase sigma A holoenzyme open promoter complex containing UMN-7 | Descriptor: | (9S,14S,15R,16S,17R,18R,19R,20S,21S,25R)-5,6,18,20-tetrahydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-(2-methylpropyl)-10,26-dioxo-1,3,9,10-tetrahydrospiro[9,4-(epoxypentadecanoimino)furo[2',3':7,8]naphtho[1,2-d]imidazole-2,4'-piperidin]-16-yl benzoate, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Molodtsov, V, Ebright, R.H. | Deposit date: | 2022-02-22 | Release date: | 2022-10-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.87 Å) | Cite: | Redesign of Rifamycin Antibiotics to Overcome ADP-Ribosylation-Mediated Resistance. Angew.Chem.Int.Ed.Engl., 61, 2022
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4N0A
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![BU of 4n0a by Molmil](/molmil-images/mine/4n0a) | Crystal structure of Lsm2-3-Pat1C complex from Saccharomyces cerevisiae | Descriptor: | DNA topoisomerase 2-associated protein PAT1, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3 | Authors: | Wu, D.H. | Deposit date: | 2013-10-01 | Release date: | 2013-12-04 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Lsm2 and Lsm3 bridge the interaction of the Lsm1-7 complex with Pat1 for decapping activation Cell Res., 24, 2014
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8HIH
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![BU of 8hih by Molmil](/molmil-images/mine/8hih) | Cryo-EM structure of Mycobacterium tuberculosis transcription initiation complex with transcription factor GlnR | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Lin, W, Shi, J, Xu, J.C. | Deposit date: | 2022-11-20 | Release date: | 2023-06-07 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.66 Å) | Cite: | Structural insights into the transcription activation mechanism of the global regulator GlnR from actinobacteria. Proc.Natl.Acad.Sci.USA, 120, 2023
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6KJ6
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![BU of 6kj6 by Molmil](/molmil-images/mine/6kj6) | cryo-EM structure of Escherichia coli Crl transcription activation complex | Descriptor: | DNA (51-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Xu, J, Zhang, Y. | Deposit date: | 2019-07-21 | Release date: | 2020-01-01 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Crl activates transcription by stabilizing active conformation of the master stress transcription initiation factor. Elife, 8, 2019
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7EVN
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![BU of 7evn by Molmil](/molmil-images/mine/7evn) | The cryo-EM structure of the DDX42-SF3b complex | Descriptor: | ATP-dependent RNA helicase DDX42, PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, ... | Authors: | Zhang, X, Zhan, X, Shi, Y. | Deposit date: | 2021-05-21 | Release date: | 2022-08-03 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural insights into branch site proofreading by human spliceosome Nat.Struct.Mol.Biol., 2024
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3BW1
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![BU of 3bw1 by Molmil](/molmil-images/mine/3bw1) | Crystal structure of homomeric yeast Lsm3 exhibiting novel octameric ring organisation | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, SULFATE ION, U6 snRNA-associated Sm-like protein LSm3 | Authors: | Naidoo, N, Harrop, S.J, Curmi, P.M.G, Mabbutt, B.C. | Deposit date: | 2008-01-07 | Release date: | 2008-03-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of Lsm3 octamer from Saccharomyces cerevisiae: implications for Lsm ring organisation and recruitment J.Mol.Biol., 377, 2008
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8JO2
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![BU of 8jo2 by Molmil](/molmil-images/mine/8jo2) | Structural basis of transcriptional activation by the OmpR/PhoB-family response regulator PmrA | Descriptor: | DNA (65-MER), DNA-binding transcriptional regulator BasR, DNA-directed RNA polymerase subunit alpha, ... | Authors: | Lou, Y.-C, Huang, H.-Y, Chen, C, Wu, K.-P. | Deposit date: | 2023-06-06 | Release date: | 2023-08-30 | Last modified: | 2023-10-25 | Method: | ELECTRON MICROSCOPY (2.74 Å) | Cite: | Structural basis of transcriptional activation by the OmpR/PhoB-family response regulator PmrA. Nucleic Acids Res., 51, 2023
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7QV9
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