6V8N
 
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6VAJ
 | | Crystal Structure Analysis of human PIN1 | | Descriptor: | 2-chloro-N-(2,2-dimethylpropyl)-N-[(3R)-1,1-dioxo-1lambda~6~-thiolan-3-yl]acetamide, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, SULFATE ION, ... | | Authors: | Seo, H.-S, Dhe-Paganon, S. | | Deposit date: | 2019-12-17 | | Release date: | 2020-12-30 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.42 Å) | | Cite: | Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo.
Nat.Chem.Biol., 17, 2021
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6VAQ
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3DTS
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6VCC
 | | Cryo-EM structure of the Dvl2 DIX filament | | Descriptor: | Segment polarity protein dishevelled homolog DVL-2 | | Authors: | Enos, M, Kan, W, Muennich, S, Chen, D.H, Skiniotis, G, Weis, W.I. | | Deposit date: | 2019-12-20 | | Release date: | 2020-04-29 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Limited Dishevelled/Axin oligomerization determines efficiency of Wnt/ beta-catenin signal transduction.
Elife, 9, 2020
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3DZT
 | | AeD7-leukotriene E4 complex | | Descriptor: | (5S,7E,9E,11Z,14Z)-5-hydroxyicosa-7,9,11,14-tetraenoic acid, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | | Authors: | Andersen, J.F, Calvo, E, Mans, B.J, Ribeiro, J.M. | | Deposit date: | 2008-07-30 | | Release date: | 2009-02-03 | | Last modified: | 2021-03-31 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Multifunctionality and mechanism of ligand binding in a mosquito antiinflammatory protein
Proc.Natl.Acad.Sci.USA, 106, 2009
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3DRJ
 | | Crystal structure of Lactococcal OppA co-crystallized with pTH-related peptide in an open conformation | | Descriptor: | Oligopeptide-binding protein oppA, pTH-related peptide | | Authors: | Berntsson, R.P.-A, Doeven, M.K, Duurkens, R.H, Sengupta, D, Marrink, S.-J, Thunnissen, A.-M, Poolman, B, Slotboom, D.-J. | | Deposit date: | 2008-07-11 | | Release date: | 2009-03-31 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | The structural basis for peptide selection by the transport receptor OppA
Embo J., 28, 2009
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3DLG
 | | Crystal structure of hiv-1 reverse transcriptase in complex with GW564511. | | Descriptor: | N-{4-[amino(dihydroxy)-lambda~4~-sulfanyl]-2-methylphenyl}-2-(4-chloro-2-{[3-fluoro-5-(trifluoromethyl)phenyl]carbonyl}phenoxy)acetamide, P51 RT, PHOSPHATE ION, ... | | Authors: | Ren, J, Chamberlain, P.P, Stammers, D.K. | | Deposit date: | 2008-06-27 | | Release date: | 2008-08-12 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors.
J.Med.Chem., 51, 2008
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6UZV
 | | The structure of a red shifted photosystem I complex | | Descriptor: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, BETA-CAROTENE, ... | | Authors: | Toporik, H, Williams, D, Chiu, P.L, Mazor, Y. | | Deposit date: | 2019-11-15 | | Release date: | 2020-09-16 | | Last modified: | 2020-11-04 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | The structure of a red-shifted photosystem I reveals a red site in the core antenna.
Nat Commun, 11, 2020
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6V22
 | | Cryo-EM structure of Ca2+-bound hsSlo1-beta4 channel complex | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Tao, X, MacKinnon, R. | | Deposit date: | 2019-11-22 | | Release date: | 2019-12-25 | | Last modified: | 2020-10-07 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Molecular structures of the human Slo1 K + channel in complex with beta 4.
Elife, 8, 2019
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6V4M
 | | Trichuris suis BCL-2 | | Descriptor: | BCL-2, CHLORIDE ION, SULFATE ION | | Authors: | Fairlie, W.D, Lee, E.F, Smith, B.J. | | Deposit date: | 2019-11-28 | | Release date: | 2020-10-07 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.599 Å) | | Cite: | Diversity in the intrinsic apoptosis pathway of nematodes.
Commun Biol, 3, 2020
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6VAU
 | | Bare actin filament from a partially cofilin-decorated sample | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | Authors: | Huehn, A.R, Bibeau, J.P, Schramm, A.C, Cao, W, De La Cruz, E.M, Sindelar, C.V. | | Deposit date: | 2019-12-17 | | Release date: | 2020-01-01 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structures of cofilin-induced structural changes reveal local and asymmetric perturbations of actin filaments.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6V75
 | | Crystal Structure of Human PKM2 in Complex with L-aspartate | | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, ASPARTIC ACID, CHLORIDE ION, ... | | Authors: | Nandi, S, Dey, M. | | Deposit date: | 2019-12-07 | | Release date: | 2020-03-18 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Biochemical and structural insights into how amino acids regulate pyruvate kinase muscle isoform 2.
J.Biol.Chem., 295, 2020
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3DRH
 | | Crystal structure of Lactococcal OppA co-crystallized with Leu-enkephalin in an open conformation | | Descriptor: | Oligopeptide-binding protein oppA, peptide AAAAAA | | Authors: | Berntsson, R.P.-A, Doeven, M.K, Duurkens, R.H, Sengupta, D, Marrink, S.-J, Thunnissen, A.-M, Poolman, B, Slotboom, D.-J. | | Deposit date: | 2008-07-11 | | Release date: | 2009-03-31 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The structural basis for peptide selection by the transport receptor OppA
Embo J., 28, 2009
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3DU2
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6VEC
 | | Cryo-EM structure of F-actin/Plastin2-ABD2 complex | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | Authors: | Zheng, W, Kudryashov, D.S, Egelman, E.H. | | Deposit date: | 2019-12-31 | | Release date: | 2020-12-09 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Osteogenesis imperfecta mutations in plastin 3 lead to impaired calcium regulation of actin bundling.
Bone Res, 8, 2020
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6V38
 | | Cryo-EM structure of Ca2+-bound hsSlo1 channel | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL, ... | | Authors: | Tao, X, MacKinnon, R. | | Deposit date: | 2019-11-25 | | Release date: | 2019-12-25 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Molecular structures of the human Slo1 K + channel in complex with beta 4.
Elife, 8, 2019
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3CTT
 | | Crystal complex of N-terminal Human Maltase-Glucoamylase with Casuarine | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CASUARINE, GLYCEROL, ... | | Authors: | Sim, L, Rose, D.R. | | Deposit date: | 2008-04-14 | | Release date: | 2009-02-24 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Total syntheses of casuarine and its 6-O-alpha-glucoside: complementary inhibition towards glycoside hydrolases of the GH31 and GH37 families
Chemistry, 15, 2009
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6V63
 | | SETD3 WT in Complex with an Actin Peptide with His73 Replaced with Glutamine | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Actin, ... | | Authors: | Dai, S, Horton, J.R, Cheng, X. | | Deposit date: | 2019-12-04 | | Release date: | 2020-01-22 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation.
J.Biol.Chem., 295, 2020
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6V18
 | | immune receptor complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fibrinogen beta, GLYCEROL, ... | | Authors: | Lim, J.J, Rossjohn, J. | | Deposit date: | 2019-11-20 | | Release date: | 2020-11-25 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR.
Sci Immunol, 6, 2021
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3CSJ
 | | Human glutathione s-transferase p1-1 in complex with chlorambucil | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORAMBUCIL, CHLORIDE ION, ... | | Authors: | Parker, L.J. | | Deposit date: | 2008-04-09 | | Release date: | 2008-07-01 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants.
J.Mol.Biol., 380, 2008
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6V3B
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6VAO
 | | Human cofilin-1 decorated actin filament | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | Authors: | Huehn, A.R, Bibeau, J.P, Schramm, A.C, Cao, W, De La Cruz, E.M, Sindelar, C.V. | | Deposit date: | 2019-12-17 | | Release date: | 2020-01-08 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structures of cofilin-induced structural changes reveal local and asymmetric perturbations of actin filaments.
Proc.Natl.Acad.Sci.USA, 117, 2020
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3CWA
 | | Crystal Structure of an AlkA Host/Guest Complex 8oxoGuanine:Cytosine Base Pair | | Descriptor: | DNA (5'-D(*(8OG)P*DAP*DCP*DAP*DTP*DGP*DAP*DGP*DTP*DGP*DCP*DC)-3'), DNA (5'-D(*DGP*DGP*DCP*DAP*DCP*DTP*DCP*DAP*DTP*DGP*DTP*DC)-3'), DNA-3-methyladenine glycosylase 2 | | Authors: | Bowman, B.R, Lee, S, Wang, S, Verdine, G.L. | | Deposit date: | 2008-04-21 | | Release date: | 2008-09-02 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure of the E. coli DNA Glycosylase AlkA Bound to the Ends of Duplex DNA: A System for the Structure Determination of Lesion-Containing DNA.
Structure, 16, 2008
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3CZ7
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