1IB6
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![BU of 1ib6 by Molmil](/molmil-images/mine/1ib6) | CRYSTAL STRUCTURE OF R153C E. COLI MALATE DEHYDROGENASE | Descriptor: | MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION | Authors: | Bell, J.K, Yennawar, H.P, Wright, S.K, Thompson, J.R, Viola, R.E, Banaszak, L.J. | Deposit date: | 2001-03-27 | Release date: | 2001-09-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Analyses of a Malate Dehydrogenase with a Variable Active Site J.Biol.Chem., 276, 2001
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8AB2
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![BU of 8ab2 by Molmil](/molmil-images/mine/8ab2) | Crystal Structure of the Lactate Dehydrogenase of Cyanobacterium Aponinum in its apo form. | Descriptor: | 1,2-ETHANEDIOL, L-lactate dehydrogenase, TERBIUM(III) ION, ... | Authors: | Robin, A.Y, Girard, E, Madern, D. | Deposit date: | 2022-07-04 | Release date: | 2022-08-03 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Deciphering Evolutionary Trajectories of Lactate Dehydrogenases Provides New Insights into Allostery. Mol.Biol.Evol., 40, 2023
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4OKN
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![BU of 4okn by Molmil](/molmil-images/mine/4okn) | Crystal structure of human muscle L-lactate dehydrogenase, ternary complex with NADH and oxalate | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, KANAMYCIN A, L-lactate dehydrogenase A chain, ... | Authors: | Kolappan, S, Craig, L. | Deposit date: | 2014-01-22 | Release date: | 2014-12-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms. Acta Crystallogr.,Sect.D, 71, 2015
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4ND5
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![BU of 4nd5 by Molmil](/molmil-images/mine/4nd5) | |
1LDM
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![BU of 1ldm by Molmil](/molmil-images/mine/1ldm) | |
4AJN
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![BU of 4ajn by Molmil](/molmil-images/mine/4ajn) | rat LDHA in complex with 2-((4-(2-((3-((2-methyl-1,3-benzothiazol-6- yl)amino)-3-oxo-propyl)carbamoylamino)ethyl)phenyl)methyl) propanedioic acid | Descriptor: | (4-{2-[({3-[(2-METHYL-1,3-BENZOTHIAZOL-6-YL)AMINO]-3-OXOPROPYL}CARBAMOYL)AMINO]ETHYL}BENZYL)PROPANEDIOIC ACID, GLYCEROL, L-LACTATE DEHYDROGENASE A CHAIN | Authors: | Tucker, J.A, Brassington, C, Hassall, G, Watson, M, Ward, R, Tart, J, Davies, G, Caputo, A, Pearson, S. | Deposit date: | 2012-02-16 | Release date: | 2012-03-21 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Design and Synthesis of Novel Lactate Dehydrogenase a Inhibitors by Fragment-Based Lead Generation J.Med.Chem., 55, 2012
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6BAL
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![BU of 6bal by Molmil](/molmil-images/mine/6bal) | 2.1 Angstrom Resolution Crystal Structure of Malate Dehydrogenase from Haemophilus influenzae in Complex with L-Malate | Descriptor: | (2S)-2-hydroxybutanedioic acid, CHLORIDE ION, Malate dehydrogenase | Authors: | Minasov, G, Wawrzak, Z, Skarina, T, Grimshaw, S, Satchell, K.J.F, Savchenko, A, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2017-10-13 | Release date: | 2017-10-25 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | 2.1 Angstrom Resolution Crystal Structure of Malate Dehydrogenase from Haemophilus influenzae in Complex with L-Malate To Be Published
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6BAD
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1UXI
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![BU of 1uxi by Molmil](/molmil-images/mine/1uxi) | Large improvement in the thermal stability of a tetrameric malate dehydrogenase by single point mutations at the dimer-dimer interface | Descriptor: | FUMARIC ACID, MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Bjork, A, Dalhus, B, Mantzilas, D, Eijsink, V.G.H, Sirevag, R. | Deposit date: | 2004-02-25 | Release date: | 2004-08-26 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Large Improvement in the Thermal Stability of a Tetrameric Malate Dehydrogenase by Single Point Mutations at the Dimer-Dimer Interface. J.Mol.Biol., 341, 2004
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1UXH
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![BU of 1uxh by Molmil](/molmil-images/mine/1uxh) | Large improvement in the thermal stability of a tetrameric malate dehydrogenase by single point mutations at the dimer-dimer interface | Descriptor: | FUMARIC ACID, MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Bjork, A, Dalhus, B, Mantzilas, D, Eijsink, V.G.H, Sirevag, R. | Deposit date: | 2004-02-25 | Release date: | 2004-08-26 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Large Improvement in the Thermal Stability of a Tetrameric Malate Dehydrogenase by Single Point Mutations at the Dimer-Dimer Interface. J.Mol.Biol., 341, 2004
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5ZI3
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![BU of 5zi3 by Molmil](/molmil-images/mine/5zi3) | MDH3 wild type, apo-form | Descriptor: | GLYCEROL, Malate dehydrogenase | Authors: | Moriyama, S, Nishio, K, Mizushima, T. | Deposit date: | 2018-03-14 | Release date: | 2018-10-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of glyoxysomal malate dehydrogenase (MDH3) from Saccharomyces cerevisiae. Acta Crystallogr F Struct Biol Commun, 74, 2018
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5YTA
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1A5Z
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![BU of 1a5z by Molmil](/molmil-images/mine/1a5z) | LACTATE DEHYDROGENASE FROM THERMOTOGA MARITIMA (TMLDH) | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, CADMIUM ION, L-LACTATE DEHYDROGENASE, ... | Authors: | Auerbach, G, Ostendorp, R, Prade, L, Korndoerfer, I, Dams, T, Huber, R, Jaenicke, R. | Deposit date: | 1998-02-18 | Release date: | 1999-03-23 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Lactate dehydrogenase from the hyperthermophilic bacterium thermotoga maritima: the crystal structure at 2.1 A resolution reveals strategies for intrinsic protein stabilization. Structure, 6, 1998
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5ZI4
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![BU of 5zi4 by Molmil](/molmil-images/mine/5zi4) | MDH3 wild type, nad-oaa-form | Descriptor: | Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXALOACETATE ION | Authors: | Moriyama, S, Nishio, K, Mizushima, T. | Deposit date: | 2018-03-14 | Release date: | 2018-10-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of glyoxysomal malate dehydrogenase (MDH3) from Saccharomyces cerevisiae. Acta Crystallogr F Struct Biol Commun, 74, 2018
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3ZH2
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![BU of 3zh2 by Molmil](/molmil-images/mine/3zh2) | Structure of Plasmodium falciparum lactate dehydrogenase in complex with a DNA aptamer | Descriptor: | DNA APTAMER, L-LACTATE DEHYDROGENASE | Authors: | Cheung, Y.W, Kwok, J, Law, A.W.L, Watt, R.M, Kotaka, M, Tanner, J.A. | Deposit date: | 2012-12-20 | Release date: | 2013-09-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Basis for Discriminatory Recognition of Plasmodium Lactate Dehydrogenase by a DNA Aptamer Proc.Natl.Acad.Sci.USA, 110, 2013
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4L4R
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![BU of 4l4r by Molmil](/molmil-images/mine/4l4r) | Structural Characterisation of the Apo-form of Human Lactate Dehydrogenase M Isozyme | Descriptor: | L-lactate dehydrogenase A chain | Authors: | Dempster, S, Harper, S, Moses, J.E, Dreveny, I. | Deposit date: | 2013-06-09 | Release date: | 2014-04-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural characterization of the apo form and NADH binary complex of human lactate dehydrogenase. Acta Crystallogr.,Sect.D, 70, 2014
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3DL2
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![BU of 3dl2 by Molmil](/molmil-images/mine/3dl2) | Hexagonal structure of the LDH domain of Human Ubiquitin-conjugating Enzyme E2-like Isoform A | Descriptor: | PHOSPHATE ION, SODIUM ION, Ubiquitin-conjugating enzyme E2 variant 3 | Authors: | Walker, J.R, Avvakumov, G.V, Xue, S, Newman, E.M, Finerty Jr, P.J, Butler-Cole, C, Bountra, C, Wolkstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2008-06-26 | Release date: | 2008-07-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Investigation Into the L-Lactate Dehydrogenase Domain of Human Ubiquitin-Conjugating Enzyme E2-Like Isoform A. To be Published
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1B8V
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![BU of 1b8v by Molmil](/molmil-images/mine/1b8v) | Malate dehydrogenase from Aquaspirillum arcticum | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PROTEIN (MALATE DEHYDROGENASE) | Authors: | Kim, S.Y, Hwang, K.Y, Kim, S.H, Han, Y.S, Cho, Y. | Deposit date: | 1999-02-02 | Release date: | 1999-07-09 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for cold adaptation. Sequence, biochemical properties, and crystal structure of malate dehydrogenase from a psychrophile Aquaspirillium arcticum. J.Biol.Chem., 274, 1999
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2V7P
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![BU of 2v7p by Molmil](/molmil-images/mine/2v7p) | Crystal structure of lactate dehydrogenase from Thermus Thermophilus HB8 (Holo form) | Descriptor: | L-LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID | Authors: | Coquelle, N, Fioravanti, E, Weik, M, Vellieux, F. | Deposit date: | 2007-07-31 | Release date: | 2007-09-25 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Activity, stability and structural studies of lactate dehydrogenases adapted to extreme thermal environments. J. Mol. Biol., 374, 2007
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2I6T
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![BU of 2i6t by Molmil](/molmil-images/mine/2i6t) | Orthorhombic Structure of the LDH domain of Human Ubiquitin-conjugating Enzyme E2-like Isoform A | Descriptor: | GLYCEROL, SULFATE ION, UBIQUITIN-CONJUGATING ENZYME E2-LIKE ISOFORM A | Authors: | Walker, J.R, Avvakumov, G.V, Xue, S, Newman, E.M, Finerty Jr, P.J, Butler-Cole, C, Tempel, W, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S. | Deposit date: | 2006-08-29 | Release date: | 2006-10-24 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Investigation into the L-lactate Dehydrogenase Domain of Human Ubiquitin-conjugating Enzyme E2-like Isoform A To be Published
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4R68
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![BU of 4r68 by Molmil](/molmil-images/mine/4r68) | Lactate Dehydrogenase in complex with inhibitor compound 31 | Descriptor: | (1S)-1-phenylethyl (4-chloro-3-{[(4S)-4-(2,6-dichlorophenyl)-2-hydroxy-6-oxocyclohex-1-en-1-yl]sulfanyl}phenyl)acetate, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Eigenbrot, C, Ultsch, M. | Deposit date: | 2014-08-22 | Release date: | 2014-12-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.112 Å) | Cite: | Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. Bioorg.Med.Chem.Lett., 25, 2014
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7AOB
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![BU of 7aob by Molmil](/molmil-images/mine/7aob) | Crystal structure of Thermaerobacter marianensis malate dehydrogenase | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Bertrand, Q, Lasalle, L, Girard, E, Madern, D. | Deposit date: | 2020-10-14 | Release date: | 2020-10-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Crystal structure of Thermaerobacter marianensis malate dehydrogenase To Be Published
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4QO7
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4WLU
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4ND1
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![BU of 4nd1 by Molmil](/molmil-images/mine/4nd1) | |