4R68
Lactate Dehydrogenase in complex with inhibitor compound 31
Summary for 4R68
Entry DOI | 10.2210/pdb4r68/pdb |
Related | 4R69 |
Descriptor | L-lactate dehydrogenase A chain, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (6 entities in total) |
Functional Keywords | oxidoreductase, nicotinamide adenine dinucleaotide |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00338 |
Total number of polymer chains | 4 |
Total formula weight | 152372.55 |
Authors | Eigenbrot, C.,Ultsch, M. (deposition date: 2014-08-22, release date: 2014-12-24, Last modification date: 2023-09-20) |
Primary citation | Labadie, S.,Dragovich, P.S.,Chen, J.,Fauber, B.P.,Boggs, J.,Corson, L.B.,Ding, C.Z.,Eigenbrot, C.,Ge, H.,Ho, Q.,Lai, K.W.,Ma, S.,Malek, S.,Peterson, D.,Purkey, H.E.,Robarge, K.,Salphati, L.,Sideris, S.,Ultsch, M.,VanderPorten, E.,Wei, B.,Xu, Q.,Yen, I.,Yue, Q.,Zhang, H.,Zhang, X.,Zhou, A. Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. Bioorg.Med.Chem.Lett., 25:75-82, 2014 Cited by PubMed: 25466195DOI: 10.1016/j.bmcl.2014.11.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.112 Å) |
Structure validation
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