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5KB1
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BU of 5kb1 by Molmil
Crystal Structure of a Tris-thiolate Hg(II) Complex in a de Novo Three Stranded Coiled Coil Peptide
Descriptor: CHLORIDE ION, Hg(II)Zn(II)(GRAND Coil Ser-L16CL30H)3+, MERCURY (II) ION, ...
Authors:Ruckcthong, L, Zastrow, M.L, Stuckey, J.A, Pecoraro, V.L.
Deposit date:2016-06-02
Release date:2016-08-31
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:A Crystallographic Examination of Predisposition versus Preorganization in de Novo Designed Metalloproteins.
J.Am.Chem.Soc., 138, 2016
3C0J
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BU of 3c0j by Molmil
Structure of E. coli dihydrodipicolinate synthase complexed with hydroxypyruvate
Descriptor: Dihydrodipicolinate synthase, GLYCEROL, PHOSPHATE ION, ...
Authors:Dobson, R.C.J.
Deposit date:2008-01-21
Release date:2008-09-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Conserved main-chain peptide distortions: A proposed role for Ile203 in catalysis by dihydrodipicolinate synthase
Protein Sci., 17, 2008
3CDZ
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BU of 3cdz by Molmil
Crystal structure of human factor VIII
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Ngo, J.C, Huang, M, Roth, D.A, Furie, B.C, Furie, B.
Deposit date:2008-02-27
Release date:2008-04-01
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.98 Å)
Cite:Crystal structure of human factor VIII: implications for the formation of the factor IXa-factor VIIIa complex.
Structure, 16, 2008
8G6I
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BU of 8g6i by Molmil
Coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor VIII chimera from human and pig, NB33 heavy chain, ...
Authors:Childers, K.C, Davulcu, O, Haynes, R.M, Lollar, P, Doering, C.B, Coxon, C.H, Spiegel, P.C.
Deposit date:2023-02-15
Release date:2023-05-24
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (4.23 Å)
Cite:Structure of coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor.
Blood, 142, 2023
5K8D
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BU of 5k8d by Molmil
Crystal structure of rFVIIIFc
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COPPER (II) ION, ...
Authors:Leksa, N, Quan, C.
Deposit date:2016-05-29
Release date:2017-06-14
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (4.19 Å)
Cite:The structural basis for the functional comparability of factor VIII and the long-acting variant recombinant factor VIII Fc fusion protein.
J. Thromb. Haemost., 15, 2017
3DEN
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BU of 3den by Molmil
Structure of E. coli DHDPS mutant Y107W
Descriptor: Dihydrodipicolinate synthase, GLYCEROL, PHOSPHATE ION, ...
Authors:Pearce, F.G, Gerrard, J.A, Perugini, M.A, Jameson, G.B.
Deposit date:2008-06-10
Release date:2008-11-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mutating the tight-dimer interface of dihydrodipicolinate synthase disrupts the enzyme quaternary structure: toward a monomeric enzyme
Biochemistry, 47, 2008
5LMX
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BU of 5lmx by Molmil
Monomeric RNA polymerase I at 4.9 A resolution
Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ...
Authors:Torreira, E, Louro, J.A, Gil-Carton, D, Gallego, O, Calvo, O, Fernandez-Tornero, C.
Deposit date:2016-08-02
Release date:2017-03-22
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:The dynamic assembly of distinct RNA polymerase I complexes modulates rDNA transcription.
Elife, 6, 2017
4YM7
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BU of 4ym7 by Molmil
RNA polymerase I structure with an alternative dimer hinge
Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ...
Authors:Kostrewa, D, Kuhn, C.-D, Engel, C, Cramer, P.
Deposit date:2015-03-06
Release date:2015-09-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (5.5 Å)
Cite:An alternative RNA polymerase I structure reveals a dimer hinge.
Acta Crystallogr.,Sect.D, 71, 2015
5M3L
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BU of 5m3l by Molmil
Single-particle cryo-EM using alignment by classification (ABC): the structure of Lumbricus terrestris hemoglobin
Descriptor: Extracellular globin-2, Extracellular globin-3, Extracellular globin-4, ...
Authors:Afanasyev, P, Linnemayr-Seer, C, Ravelli, R.B.G, Matadeen, R, De Carlo, S, Alewijnse, B, Portugal, R.V, Pannu, N.S, Schatz, M, van Heel, M.
Deposit date:2016-10-15
Release date:2017-09-13
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Single-particle cryo-EM using alignment by classification (ABC): the structure of Lumbricus terrestris haemoglobin.
IUCrJ, 4, 2017
5A7U
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BU of 5a7u by Molmil
Single-particle cryo-EM of co-translational folded adr1 domain inside the E. coli ribosome exit tunnel.
Descriptor: REGULATORY PROTEIN ADR1, ZINC ION
Authors:Nilsson, O.B, Hedman, R, Marino, J, Wickles, S, Bischoff, L, Johansson, M, Muller-Lucks, A, Trovato, F, Puglisi, J.D, O'Brien, E, Beckmann, R, von Heijne, G.
Deposit date:2015-07-10
Release date:2015-09-16
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Cotranslational Protein Folding Inside the Ribosome Exit Tunnel.
Cell Rep., 12, 2015
5M3F
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BU of 5m3f by Molmil
Yeast RNA polymerase I elongation complex at 3.8A
Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ...
Authors:Neyer, S, Kunz, M, Geiss, C, Hantsche, M, Hodirnau, V.-V, Seybert, A, Engel, C, Scheffer, M.P, Cramer, P, Frangakis, A.S.
Deposit date:2016-10-14
Release date:2016-11-23
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of RNA polymerase I transcribing ribosomal DNA genes.
Nature, 540, 2016
5M3M
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BU of 5m3m by Molmil
Free monomeric RNA polymerase I at 4.0A resolution
Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ...
Authors:Neyer, S, Kunz, M, Geiss, C, Hantsche, M, Hodirnau, V.-V, Seybert, A, Engel, C, Scheffer, M.P, Cramer, P, Frangakis, A.S.
Deposit date:2016-10-15
Release date:2016-11-23
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structure of RNA polymerase I transcribing ribosomal DNA genes.
Nature, 540, 2016
3DU0
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BU of 3du0 by Molmil
E. coli dihydrodipicolinate synthase with first substrate, pyruvate, bound in active site
Descriptor: CHLORIDE ION, Dihydrodipicolinate synthase, GLYCEROL, ...
Authors:Dobson, R.C.J, Devenish, S.R.A, Gerrard, J.A, Jameson, G.B.
Deposit date:2008-07-16
Release date:2008-11-18
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:The high-resolution structure of dihydrodipicolinate synthase from Escherichia coli bound to its first substrate, pyruvate.
Acta Crystallogr.,Sect.F, 64, 2008
5UWY
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BU of 5uwy by Molmil
The crystal structure of thioredoxin reductase from Streptococcus pyogenes MGAS5005
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, PHOSPHATE ION, Thioredoxin reductase
Authors:Tan, K, Zhou, M, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2017-02-21
Release date:2017-03-15
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:The crystal structure of thioredoxin reductase from Streptococcus pyogenes MGAS5005
To Be Published
5W66
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BU of 5w66 by Molmil
RNA polymerase I Initial Transcribing Complex State 3
Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ...
Authors:Han, Y, He, Y.
Deposit date:2017-06-16
Release date:2017-07-26
Last modified:2019-11-27
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural mechanism of ATP-independent transcription initiation by RNA polymerase I.
Elife, 6, 2017
4C3H
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BU of 4c3h by Molmil
Structure of 14-subunit RNA polymerase I at 3.27 A resolution, crystal form C2-93
Descriptor: DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14, ...
Authors:Fernandez-Tornero, C, Moreno-Morcillo, M, Rashid, U.J, Taylor, N.M.I, Ruiz, F.M, Gruene, T, Legrand, P, Steuerwald, U, Muller, C.W.
Deposit date:2013-08-24
Release date:2013-10-23
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.27 Å)
Cite:Crystal Structure of the 14-Subunit RNA Polymerase I
Nature, 502, 2013
4BTJ
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BU of 4btj by Molmil
TTBK1 in complex with ATP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, ...
Authors:Xue, Y, Wan, P, Hillertz, P, Schweikart, F, Zhao, Y, Wissler, L, Dekker, N.
Deposit date:2013-06-18
Release date:2013-09-25
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:X-Ray Structural Analysis of Tau-Tubulin Kinase 1 and its Interactions with Small Molecular Inhibitors.
Chemmedchem, 8, 2013
4C2M
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BU of 4c2m by Molmil
Structure of RNA polymerase I at 2.8 A resolution
Descriptor: DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14, ...
Authors:Engel, C, Sainsbury, S, Cheung, A.C, Kostrewa, D, Cramer, P.
Deposit date:2013-08-19
Release date:2013-10-23
Last modified:2015-08-19
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:RNA Polymerase I Structure and Transcription Regulation.
Nature, 502, 2013
4C3I
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BU of 4c3i by Molmil
Structure of 14-subunit RNA polymerase I at 3.0 A resolution, crystal form C2-100
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135, ...
Authors:Fernandez-Tornero, C, Moreno-Morcillo, M, Rashid, U.J, Taylor, N.M.I, Ruiz, F.M, Gruene, T, Legrand, P, Steuerwald, U, Muller, C.W.
Deposit date:2013-08-24
Release date:2013-10-23
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structure of the 14-Subunit RNA Polymerase I
Nature, 502, 2013
8TY1
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BU of 8ty1 by Molmil
Cryo-EM structure of coagulation factor VIII bound to NB2E9
Descriptor: Coagulation factor VIII, NB2E9 heavy chain, NB2E9 light chain, ...
Authors:Childers, K.C, Spiegel, P.C.
Deposit date:2023-08-24
Release date:2023-09-13
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Structural basis for inhibition of coagulation factor VIII reveals a shared immunogenic hot-spot on the C1 domain
To Be Published
4ADB
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BU of 4adb by Molmil
Structural and functional study of succinyl-ornithine transaminase from E. coli
Descriptor: MAGNESIUM ION, PYRIDOXAL-5'-PHOSPHATE, SODIUM ION, ...
Authors:Newman, J, Peat, T.S.
Deposit date:2011-12-23
Release date:2013-01-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Determination of the Structure of the Catabolic N-Succinylornithine Transaminase (Astc) from Escherichia Coli.
Plos One, 8, 2013
4ADE
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BU of 4ade by Molmil
Structural and functional study of succinyl-ornithine transaminase from E. coli
Descriptor: SUCCINYLORNITHINE TRANSAMINASE
Authors:Newman, J, Peat, T.S.
Deposit date:2011-12-23
Release date:2013-01-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Determination of the Structure of the Catabolic N-Succinylornithine Transaminase (Astc) from Escherichia Coli.
Plos One, 8, 2013
7JXY
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BU of 7jxy by Molmil
Structure of TTBK1 kinase domain in complex with Compound 18
Descriptor: (3S)-1-[1-(2-aminopyrimidin-4-yl)-1H-pyrazolo[4,3-c]pyridin-6-yl]-3-methylpent-1-yn-3-ol, Tau-tubulin kinase 1
Authors:Chodaprambil, J.V.
Deposit date:2020-08-28
Release date:2021-05-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo.
J.Med.Chem., 64, 2021
7JXX
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BU of 7jxx by Molmil
Structure of TTBK1 kinase domain in complex with Compound 3
Descriptor: 4-(2-amino-5,6,7,8-tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-b]indol-11-yl)-2-methylbut-3-yn-2-ol, SODIUM ION, Tau-tubulin kinase 1
Authors:Chodaprambil, J.V.
Deposit date:2020-08-28
Release date:2021-05-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo.
J.Med.Chem., 64, 2021
5WTB
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BU of 5wtb by Molmil
Complex Structure of Staphylococcus aureus SdrE with human complement factor H
Descriptor: Peptide from Complement factor H, Serine-aspartate repeat-containing protein E
Authors:Wu, M, Zhang, Y, Hang, T, Wang, C, Yang, Y, Zang, J, Zhang, M, Zhang, X.
Deposit date:2016-12-10
Release date:2017-07-19
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Staphylococcus aureus SdrE captures complement factor H's C-terminus via a novel 'close, dock, lock and latch' mechanism for complement evasion
Biochem. J., 474, 2017

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