8PT9
 
 | | JNK1 covalently bound to BD838 cyclohexenone based inhibitor | | Descriptor: | Mitogen-activated protein kinase 8, methyl (1S,3S)-1-methyl-3-[[3-[[3-methyl-4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]carbamoyl]phenyl]carbamoyl]-4-oxidanylidene-cyclohexane-1-carboxylate | | Authors: | Sok, P, Poti, A, Remenyi, A. | | Deposit date: | 2023-07-13 | | Release date: | 2024-07-24 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Reversible covalent c-Jun N-terminal kinase inhibitors targeting a specific cysteine by precision-guided Michael-acceptor warheads.
Nat Commun, 15, 2024
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8PT8
 | | JNK1 covalently bound to RU135 cyclohexenone based inhibitor | | Descriptor: | GLYCEROL, Mitogen-activated protein kinase 8, methyl (1R,3R)-1-methyl-3-[[3-[[3-methyl-4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]carbamoyl]phenyl]methylcarbamoyl]-4-oxidanylidene-cyclohexane-1-carboxylate | | Authors: | Sok, P, Poti, A, Remenyi, A. | | Deposit date: | 2023-07-13 | | Release date: | 2024-07-24 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.78 Å) | | Cite: | Reversible covalent c-Jun N-terminal kinase inhibitors targeting a specific cysteine by precision-guided Michael-acceptor warheads.
Nat Commun, 15, 2024
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6K1D
 | | Crystal structure of EXD2 exonuclease domain soaked in Mn and GMP | | Descriptor: | Exonuclease 3'-5' domain-containing protein 2, MANGANESE (II) ION | | Authors: | Park, J, Lee, C. | | Deposit date: | 2019-05-10 | | Release date: | 2019-05-22 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.
Nucleic Acids Res., 47, 2019
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6K1C
 | | Crystal structure of EXD2 exonuclease domain soaked in Mg and dGMP | | Descriptor: | Exonuclease 3'-5' domain-containing protein 2, MAGNESIUM ION | | Authors: | Park, J, Lee, C. | | Deposit date: | 2019-05-10 | | Release date: | 2019-05-22 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.
Nucleic Acids Res., 47, 2019
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6K18
 | | Crystal structure of EXD2 exonuclease domain soaked in Mn | | Descriptor: | Exonuclease 3'-5' domain-containing protein 2, MANGANESE (II) ION | | Authors: | Park, J, Lee, C. | | Deposit date: | 2019-05-10 | | Release date: | 2019-05-22 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.303 Å) | | Cite: | The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.
Nucleic Acids Res., 47, 2019
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6K1A
 | | Crystal structure of EXD2 exonuclease domain soaked in Mn and Mg | | Descriptor: | Exonuclease 3'-5' domain-containing protein 2, MAGNESIUM ION, MANGANESE (II) ION | | Authors: | Park, J, Lee, C. | | Deposit date: | 2019-05-10 | | Release date: | 2019-05-22 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.602 Å) | | Cite: | The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.
Nucleic Acids Res., 47, 2019
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6K19
 | | Crystal structure of EXD2 exonuclease domain soaked in Mg | | Descriptor: | Exonuclease 3'-5' domain-containing protein 2, MAGNESIUM ION | | Authors: | Park, J, Lee, C. | | Deposit date: | 2019-05-10 | | Release date: | 2019-05-22 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.202 Å) | | Cite: | The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.
Nucleic Acids Res., 47, 2019
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6K17
 | | Crystal structure of EXD2 exonuclease domain | | Descriptor: | Exonuclease 3'-5' domain-containing protein 2, SODIUM ION | | Authors: | Park, J, Lee, C. | | Deposit date: | 2019-05-10 | | Release date: | 2019-05-22 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.602 Å) | | Cite: | The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.
Nucleic Acids Res., 47, 2019
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6K1E
 | | Crystal structure of EXD2 exonuclease domain soaked in Mg and GMP | | Descriptor: | Exonuclease 3'-5' domain-containing protein 2, MAGNESIUM ION | | Authors: | Park, J, Lee, C. | | Deposit date: | 2019-05-10 | | Release date: | 2019-05-22 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.
Nucleic Acids Res., 47, 2019
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6K1B
 | | Crystal structure of EXD2 exonuclease domain soaked in Mn and dGMP | | Descriptor: | Exonuclease 3'-5' domain-containing protein 2, MANGANESE (II) ION | | Authors: | Park, J, Lee, C. | | Deposit date: | 2019-05-10 | | Release date: | 2019-05-22 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.605 Å) | | Cite: | The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.
Nucleic Acids Res., 47, 2019
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6KBN
 | | Crystal structure of Vac8 (del 19-33) bound to Atg13 | | Descriptor: | Autophagy-related protein 13, Vacuolar protein 8 | | Authors: | Park, J, Lee, C. | | Deposit date: | 2019-06-25 | | Release date: | 2019-11-27 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Quaternary structures of Vac8 differentially regulate the Cvt and PMN pathways.
Autophagy, 16, 2020
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5DBT
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5DBU
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5B26
 | | Crystal structure of mouse SEL1L | | Descriptor: | Protein sel-1 homolog 1 | | Authors: | Jeong, H, Lee, C. | | Deposit date: | 2016-01-09 | | Release date: | 2016-04-27 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of SEL1L: Insight into the roles of SLR motifs in ERAD pathway
Sci Rep, 6, 2016
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5YK6
 | | Crystal Structure of Mmm1 | | Descriptor: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, Maintenance of mitochondrial morphology protein 1 | | Authors: | Jeong, H, Park, J, Lee, C. | | Deposit date: | 2017-10-12 | | Release date: | 2018-01-10 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structures of Mmm1 and Mdm12-Mmm1 reveal mechanistic insight into phospholipid trafficking at ER-mitochondria contact sites.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5YK7
 | | Crystal Structure of Mdm12-Mmm1 complex | | Descriptor: | Maintenance of mitochondrial morphology protein 1, Mitochondrial distribution and morphology protein 12, PHOSPHATE ION | | Authors: | Jeong, H, Park, J, Lee, C. | | Deposit date: | 2017-10-12 | | Release date: | 2018-01-10 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.799 Å) | | Cite: | Crystal structures of Mmm1 and Mdm12-Mmm1 reveal mechanistic insight into phospholipid trafficking at ER-mitochondria contact sites.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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2CKX
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6I0C
 | | Human butyrylcholinesterase in complex with the R enantiomer of a chlorotacrine-tryptophan multi-target inhibitor. | | Descriptor: | (2~{R})-2-azanyl-~{N}-[6-[(6-chloranyl-1,2,3,4-tetrahydroacridin-9-yl)amino]hexyl]-3-(1~{H}-indol-3-yl)propanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Brazzolotto, X, Nachon, F. | | Deposit date: | 2018-10-25 | | Release date: | 2019-03-27 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.675 Å) | | Cite: | Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.
Eur.J.Med.Chem., 168, 2019
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6I0B
 | | Human butyrylcholinesterase in complex with the S enantiomer of a chlorotacrine-tryptophan multi-target inhibitor. | | Descriptor: | (2~{S})-2-azanyl-~{N}-[6-[(6-chloranyl-1,2,3,4-tetrahydroacridin-9-yl)amino]hexyl]-3-(1~{H}-indol-3-yl)propanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Brazzolotto, X, Nachon, F. | | Deposit date: | 2018-10-25 | | Release date: | 2019-03-27 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.384 Å) | | Cite: | Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.
Eur.J.Med.Chem., 168, 2019
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6J10
 | | Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly | | Descriptor: | 6-cyclohexyl-4-methyl-1-oxidanyl-pyridin-2-one, Capsid protein | | Authors: | Park, S, Jin, M.S, Cho, Y, Kang, J, Kim, S, Park, M, Park, H, Kim, J, Park, S, Hwang, J, Kim, Y, Kim, Y.J. | | Deposit date: | 2018-12-27 | | Release date: | 2019-04-17 | | Last modified: | 2019-05-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly.
Nat Commun, 10, 2019
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5H60
 | | Structure of Transferase mutant-C23S,C199S | | Descriptor: | MANGANESE (II) ION, Transferase, URIDINE-5'-DIPHOSPHATE | | Authors: | Park, J.B, Yoo, Y, Kim, J. | | Deposit date: | 2016-11-10 | | Release date: | 2017-12-20 | | Last modified: | 2018-10-31 | | Method: | X-RAY DIFFRACTION (3.64 Å) | | Cite: | Structural basis for arginine glycosylation of host substrates by bacterial effector proteins.
Nat Commun, 9, 2018
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5H61
 | | Structure of Transferase mutant-C23S,C199S | | Descriptor: | Transferase | | Authors: | Park, J.B, Yoo, Y, Kim, J. | | Deposit date: | 2016-11-10 | | Release date: | 2017-12-27 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Structural basis for arginine glycosylation of host substrates by bacterial effector proteins.
Nat Commun, 9, 2018
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5H5Y
 | | Structure of Transferase mutant-C23S,C199S | | Descriptor: | Non-LEE encoded effector protein NleB | | Authors: | Park, J.B, Yoo, Y, Kim, J. | | Deposit date: | 2016-11-10 | | Release date: | 2017-12-27 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for arginine glycosylation of host substrates by bacterial effector proteins.
Nat Commun, 9, 2018
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5H63
 | | Structure of Transferase mutant-C23S,C199S | | Descriptor: | MANGANESE (II) ION, Transferase, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE | | Authors: | Park, J.B, Yoo, Y, Kim, J. | | Deposit date: | 2016-11-10 | | Release date: | 2017-12-20 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Structural basis for arginine glycosylation of host substrates by bacterial effector proteins.
Nat Commun, 9, 2018
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5H62
 | | Structure of Transferase mutant-C23S,C199S | | Descriptor: | 1,2-ETHANEDIOL, MANGANESE (II) ION, Transferase, ... | | Authors: | Park, J.B, Yoo, Y, Kim, J. | | Deposit date: | 2016-11-10 | | Release date: | 2017-12-27 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Structural basis for arginine glycosylation of host substrates by bacterial effector proteins.
Nat Commun, 9, 2018
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