PDB: 92212 resultsInfo pagesStatus searchChemie searchBIRD

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3GTU	LIGAND-FREE HETERODIMERIC HUMAN GLUTATHIONE S-TRANSFERASE M2-3 (EC 2.5.1.18), MONOCLINIC CRYSTAL FORM Descriptor: GLUTATHIONE S-TRANSFERASE Authors: Patskovsky, Y.V, Patskovska, L.N, Listowsky, I. Deposit date: 1998-07-29 Release date: 1999-07-29 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.8 Å) Cite: An asparagine-phenylalanine substitution accounts for catalytic differences between hGSTM3-3 and other human class mu glutathione S-transferases. Biochemistry, 38, 1999
5AI9	ligand complex structure of soluble epoxide hydrolase Descriptor: 2-bromo-4-tert-butyl-6-{[(3-phenylpropyl)amino]methyl}phenol, BIFUNCTIONAL EPOXIDE HYDROLASE 2, GLYCEROL, ... Authors: Oster, L, Tapani, S, Xue, Y, Kack, H. Deposit date: 2015-02-12 Release date: 2015-05-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
5AKZ	ligand complex structure of soluble epoxide hydrolase Descriptor: 1-CYCLOHEXYL-3-METHYL-UREA, BIFUNCTIONAL EPOXIDE HYDROLASE 2, GLYCEROL, ... Authors: Oster, L, Tapani, S, Xue, Y, Kack, H. Deposit date: 2015-03-05 Release date: 2015-05-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
5AI5	ligand complex structure of soluble epoxide hydrolase Descriptor: 1,3-DIPHENYLUREA, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE Authors: Oster, L, Tapani, S, Xue, Y, Kack, H. Deposit date: 2015-02-12 Release date: 2015-05-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
5AI6	ligand complex structure of soluble epoxide hydrolase Descriptor: 5-BROMOQUINOLINE, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE, ... Authors: Oster, L, Tapani, S, Xue, Y, Kack, H. Deposit date: 2015-02-12 Release date: 2015-05-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
5ALE	ligand complex structure of soluble epoxide hydrolase Descriptor: 4-chloro-2-isoxazol-5-yl-phenol, BIFUNCTIONAL EPOXIDE HYDROLASE 2, GLYCEROL, ... Authors: Oster, L, Tapani, S, Xue, Y, Kack, H. Deposit date: 2015-03-08 Release date: 2015-05-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
3ERD	HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH DIETHYLSTILBESTROL AND A GLUCOCORTICOID RECEPTOR INTERACTING PROTEIN 1 NR BOX II PEPTIDE Descriptor: ACETIC ACID, CHLORIDE ION, DIETHYLSTILBESTROL, ... Authors: Shiau, A.K, Barstad, D, Loria, P.M, Cheng, L, Kushner, P.J, Agard, D.A, Greene, G.L. Deposit date: 1999-03-31 Release date: 1999-04-08 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.03 Å) Cite: The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell(Cambridge,Mass.), 95, 1998
1NYL	Unliganded glutaminyl-tRNA synthetase Descriptor: Glutaminyl-tRNA synthetase Authors: Sherlin, L.D, Perona, J.P. Deposit date: 2003-02-12 Release date: 2003-02-25 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: tRNA-Dependent Active Site Assembly in a Class I Aminoacyl-tRNA Synthetase. Structure, 11, 2003
3ERT	HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH 4-HYDROXYTAMOXIFEN Descriptor: 4-HYDROXYTAMOXIFEN, PROTEIN (ESTROGEN RECEPTOR ALPHA) Authors: Shiau, A.K, Barstad, D, Loria, P.M, Cheng, L, Kushner, P.J, Agard, D.A, Greene, G.L. Deposit date: 1999-03-30 Release date: 1999-04-08 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell(Cambridge,Mass.), 95, 1998
5SWE	Ligand-bound structure of adenine riboswitch aptamer domain converted in crystal from its ligand-free state using ligand mixing serial femtosecond crystallography Descriptor: ADENINE, Vibrio vulnificus strain 93U204 chromosome II, adenine riboswitch aptamer domain Authors: Stagno, J.R, Wang, Y.-X, Liu, Y, Bhandari, Y.R, Conrad, C.E, Nelson, G, Li, C, Wendel, D.R, White, T.A, Barty, A, Tuckey, R.A, Zatsepin, N.A, Grant, T.D, Fromme, P, Tan, K, Ji, X, Spence, J.C.H. Deposit date: 2016-08-08 Release date: 2016-11-23 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3 Å) Cite: Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography. Nature, 541, 2017
4GTU	LIGAND-FREE HOMODIMERIC HUMAN GLUTATHIONE S-TRANSFERASE M4-4 Descriptor: GLUTATHIONE S-TRANSFERASE Authors: Patskovsky, Y.V, Patskovska, L.N, Listowsky, I. Deposit date: 1999-05-12 Release date: 2000-01-14 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.3 Å) Cite: An asparagine-phenylalanine substitution accounts for catalytic differences between hGSTM3-3 and other human class mu glutathione S-transferases. Biochemistry, 38, 1999
1PEB	LIGAND-FREE HIGH-AFFINITY MALTOSE-BINDING PROTEIN Descriptor: Maltose-binding periplasmic protein Authors: Telmer, P.G, Shilton, B.H. Deposit date: 2003-05-21 Release date: 2003-08-12 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Insights into the Conformational Equilibria of Maltose-binding Protein by Analysis of High Affinity Mutants. J.Biol.Chem., 278, 2003
5ACS	Y233A-Investigation of the impact from residues W228 and Y233 in the metallo-beta-lactamase GIM-1 Descriptor: GIM-1 PROTEIN, ZINC ION Authors: Skagseth, S, Carlsen, T.J, Bjerga, G.E.K, Spencer, J, Samuelsen, O, Leiros, H.-K.S. Deposit date: 2015-08-17 Release date: 2015-12-23 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.459 Å) Cite: Role of Residues W228 and Y233 in the Structure and Activity of Metallo-Beta-Lactamase Gim-1. Antimicrob.Agents Chemother., 60, 2015
4UZM	Shotgun proteolysis: A practical application Descriptor: PUTATIVE MEMBRANE PROTEIN IGAA HOMOLOG Authors: Allen, M.D, Bycroft, M, Freund, S.M.V, Christ, D. Deposit date: 2014-09-05 Release date: 2014-09-17 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Solution Structure of a Soluble Fragment Derived from a Membrane Protein by Shotgun Proteolysis. Protein Eng.Des.Sel., 28, 2015
5WFR	Ligand-bound Ras:SOS:Ras complex Descriptor: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... Authors: Sun, Q, Phan, J, Burns, M.C, Fesik, S.W. Deposit date: 2017-07-12 Release date: 2018-05-23 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.46 Å) Cite: High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling. Anal. Biochem., 548, 2018
5WFP	Ligand-bound Ras:SOS:Ras complex Descriptor: 6-chloranyl-~{N}-(3-chloranyl-4-fluoranyl-phenyl)-1,2,3,4-tetrahydroacridin-9-amine, GTPase HRas, MAGNESIUM ION, ... Authors: Sun, Q, Phan, J, Burns, M.C, Fesik, S.W. Deposit date: 2017-07-12 Release date: 2018-05-23 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.08 Å) Cite: High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling. Anal. Biochem., 548, 2018
5WFO	Ligand-bound Ras:SOS:Ras complex Descriptor: 6-chloranyl-~{N}-(4-fluorophenyl)-1,2,3,4-tetrahydroacridin-9-amine, GTPase HRas, MAGNESIUM ION, ... Authors: Sun, Q, Phan, J, Burns, M.C, Fesik, S.W. Deposit date: 2017-07-12 Release date: 2018-05-23 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.99 Å) Cite: High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling. Anal. Biochem., 548, 2018
5WFQ	Ligand-bound Ras:SOS:Ras complex Descriptor: 7-chloranyl-~{N}-(3-chloranyl-4-fluoranyl-phenyl)-1,2,3,4-tetrahydroacridin-9-amine, GTPase HRas, MAGNESIUM ION, ... Authors: Sun, Q, Phan, J, Burns, M.C, Fesik, S.W. Deposit date: 2017-07-12 Release date: 2018-05-23 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.26 Å) Cite: High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling. Anal. Biochem., 548, 2018
3OL2	Receptor-ligand structure of Human Semaphorin 4D with Plexin B1. Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Plexin-B1, ... Authors: Janssen, B.J.C, Robinson, R.A, Perez-Branguli, F, Bell, C.H, Mitchell, C.J, Siebold, C, Jones, E.Y. Deposit date: 2010-08-25 Release date: 2010-10-13 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.99 Å) Cite: Structural basis of semaphorin-plexin signalling. Nature, 467, 2010
1N3X	Ligand-free High-Affinity Maltose-Binding Protein Descriptor: Maltose-binding periplasmic protein Authors: Telmer, P.G, Shilton, B.H. Deposit date: 2002-10-29 Release date: 2003-08-12 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Insights into the Conformational Equilibria of Maltose-binding Protein by Analysis of High Affinity Mutants. J.Biol.Chem., 278, 2003
4IEX	unliganded room-temp Cysteine Dioxygenase at pH 6.2 Descriptor: Cysteine dioxygenase type 1, FE (II) ION Authors: Driggers, C.M, Cooley, R.B, Karplus, P.A. Deposit date: 2012-12-13 Release date: 2013-06-26 Last modified: 2013-09-11 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Cysteine Dioxygenase Structures from pH4 to 9: Consistent Cys-Persulfenate Formation at Intermediate pH and a Cys-Bound Enzyme at Higher pH. J.Mol.Biol., 425, 2013
6DGV	iGABASnFR Fluorescent GABA Sensor precursor Descriptor: Fluorescent GABA Sensor precursor Authors: Marvin, J.S, Looger, L.L. Deposit date: 2018-05-18 Release date: 2019-04-03 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.8 Å) Cite: A genetically encoded fluorescent sensor for in vivo imaging of GABA. Nat.Methods, 16, 2019
5ECF	Ligand binding domain 1 of Penicillium marneffei MP1 protein complexed with arachidonic acids Descriptor: ARACHIDONIC ACID, Cell wall antigen Authors: Lam, W.H, Zhang, H, Hao, Q. Deposit date: 2015-10-20 Release date: 2016-10-19 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Talaromyces marneffeiMp1 protein, a novel virulence factor, carries two arachidonic acid-binding domains to suppress inflammatory responses in hosts Infect. Immun., 2019
5NI7	Ligand complex of RORg LBD Descriptor: DIMETHYL SULFOXIDE, Nuclear receptor ROR-gamma, SODIUM ION, ... Authors: Xue, Y, Aagaard, A, Narjes, F. Deposit date: 2017-03-23 Release date: 2018-08-22 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Potent and Orally Bioavailable Inverse Agonists of ROR gamma t Resulting from Structure-Based Design. J. Med. Chem., 61, 2018
5NIB	Ligand complex of RORg LBD Descriptor: DIMETHYL SULFOXIDE, Nuclear receptor ROR-gamma, SODIUM ION, ... Authors: Xue, Y, Aagaard, A, Narjes, F. Deposit date: 2017-03-23 Release date: 2018-08-22 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Potent and Orally Bioavailable Inverse Agonists of ROR gamma t Resulting from Structure-Based Design. J. Med. Chem., 61, 2018

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