6C4D
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![BU of 6c4d by Molmil](/molmil-images/mine/6c4d) | Structure based design of RIP1 kinase inhibitors | Descriptor: | (3S)-3-(2-benzyl-3-chloro-7-oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-8-carbonitrile, Receptor-interacting serine/threonine-protein kinase 1 | Authors: | Saikatendu, K.S, Yoshikawa, M. | Deposit date: | 2018-01-11 | Release date: | 2018-03-21 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships. J. Med. Chem., 61, 2018
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1UEL
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![BU of 1uel by Molmil](/molmil-images/mine/1uel) | Solution structure of ubiquitin-like domain of hHR23B complexed with ubiquitin-interacting motif of proteasome subunit S5a | Descriptor: | 26S proteasome non-ATPase regulatory subunit 4, UV excision repair protein RAD23 homolog B | Authors: | Fujiwara, K, Tenno, T, Jee, J.G, Sugasawa, K, Ohki, I, Kojima, C, Tochio, H, Hiroaki, H, Hanaoka, H, Shirakawa, M, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2003-05-19 | Release date: | 2004-02-10 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Structure of the Ubiquitin-interacting Motif of S5a Bound to the Ubiquitin-like Domain of HR23B J.Biol.Chem., 279, 2004
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6CJE
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![BU of 6cje by Molmil](/molmil-images/mine/6cje) | Crystal Structure of Mnk2-D228G in complex with Inhibitor | Descriptor: | 4-[(9H-purin-6-yl)amino]benzamide, MAP kinase-interacting serine/threonine-protein kinase 2, ZINC ION | Authors: | Han, Q. | Deposit date: | 2018-02-26 | Release date: | 2018-05-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.36 Å) | Cite: | Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition. J. Med. Chem., 61, 2018
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6CK6
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![BU of 6ck6 by Molmil](/molmil-images/mine/6ck6) | Crystal Structure of Mnk2-D228G in complex with Inhibitor | Descriptor: | 6'-[(6-aminopyrimidin-4-yl)amino]-8'-methyl-2'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'-dione, MAP kinase-interacting serine/threonine-protein kinase 2, ZINC ION | Authors: | Han, Q. | Deposit date: | 2018-02-27 | Release date: | 2018-05-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.32 Å) | Cite: | Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition. J. Med. Chem., 61, 2018
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3RK6
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![BU of 3rk6 by Molmil](/molmil-images/mine/3rk6) | |
5HX6
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![BU of 5hx6 by Molmil](/molmil-images/mine/5hx6) | Crystal structure of RIP1 kinase with a benzo[b][1,4]oxazepin-4-one | Descriptor: | 5-benzyl-N-[(3S)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamide, Receptor-interacting serine/threonine-protein kinase 1 | Authors: | Campobasso, N, Ward, P. | Deposit date: | 2016-01-29 | Release date: | 2016-03-02 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors. J.Med.Chem., 59, 2016
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7EXH
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![BU of 7exh by Molmil](/molmil-images/mine/7exh) | Crystal structure of D383A mutant from Arabidopsis thaliana complexed with Galactinol. | Descriptor: | Probable galactinol--sucrose galactosyltransferase 6, galactinol | Authors: | Chuankhayan, P, Guan, H.H, Lin, C.C, Chen, N.C, Huang, Y.C, Yoshimura, M, Nakagawa, A, Lee, R.H, Chen, C.J. | Deposit date: | 2021-05-27 | Release date: | 2022-11-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | Structural insight into the hydrolase and synthase activities of an alkaline alpha-galactosidase from Arabidopsis from complexes with substrate/product. Acta Crystallogr D Struct Biol, 79, 2023
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4YVA
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![BU of 4yva by Molmil](/molmil-images/mine/4yva) | Cathepsin K co-crystallized with actinomycetes extract | Descriptor: | Cathepsin K, SULFATE ION | Authors: | Aguda, A.H, Nguyen, N.T, Bromme, D, Brayer, G.D. | Deposit date: | 2015-03-19 | Release date: | 2016-05-04 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts. J.Nat.Prod., 79, 2016
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3S97
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![BU of 3s97 by Molmil](/molmil-images/mine/3s97) | PTPRZ CNTN1 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Contactin-1, Receptor-type tyrosine-protein phosphatase zeta | Authors: | Bouyain, S. | Deposit date: | 2011-05-31 | Release date: | 2011-09-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.2971 Å) | Cite: | A complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells. Proc.Natl.Acad.Sci.USA, 108, 2011
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1LXD
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![BU of 1lxd by Molmil](/molmil-images/mine/1lxd) | CRYSTAL STRUCTURE OF THE RAS INTERACTING DOMAIN OF RALGDS, A GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR OF RAL PROTEIN | Descriptor: | RALGDSB | Authors: | Huang, L, Weng, X.W, Hofer, F, Martin, G.S, Kim, S.H. | Deposit date: | 1997-03-05 | Release date: | 1998-03-11 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Three-dimensional structure of the Ras-interacting domain of RalGDS. Nat.Struct.Biol., 4, 1997
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5LQ4
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![BU of 5lq4 by Molmil](/molmil-images/mine/5lq4) | The Structure of ThcOx, the First Oxidase Protein from the Cyanobactin Pathways | Descriptor: | CyaGox, FLAVIN MONONUCLEOTIDE | Authors: | Bent, A.F, Wagner, A, Naismith, J.H. | Deposit date: | 2016-08-16 | Release date: | 2016-11-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structure of the cyanobactin oxidase ThcOx from Cyanothece sp. PCC 7425, the first structure to be solved at Diamond Light Source beamline I23 by means of S-SAD. Acta Crystallogr D Struct Biol, 72, 2016
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4YV8
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![BU of 4yv8 by Molmil](/molmil-images/mine/4yv8) | Crystal structure of cathepsin K bound to the covalent inhibitor lichostatinal | Descriptor: | Cathepsin K, Lichostatinal, SULFATE ION | Authors: | Aguda, A.H, Nguyen, N.T, Bromme, D, Brayer, G.D. | Deposit date: | 2015-03-19 | Release date: | 2016-05-04 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts. J.Nat.Prod., 79, 2016
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1KPA
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![BU of 1kpa by Molmil](/molmil-images/mine/1kpa) | PKCI-1-ZINC | Descriptor: | HUMAN PROTEIN KINASE C INTERACTING PROTEIN 1 (ZINC PROTEIN) | Authors: | Lima, C.D, Klein, M.G, Weinstein, I.B, Hendrickson, W.A. | Deposit date: | 1996-01-06 | Release date: | 1996-07-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Three-dimensional structure of human protein kinase C interacting protein 1, a member of the HIT family of proteins. Proc.Natl.Acad.Sci.USA, 93, 1996
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1KPB
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![BU of 1kpb by Molmil](/molmil-images/mine/1kpb) | PKCI-1-APO | Descriptor: | HUMAN PROTEIN KINASE C INTERACTING PROTEIN 1 (ZINC PROTEIN) | Authors: | Lima, C.D, Klein, M.G, Weinstein, I.B, Hendrickson, W.A. | Deposit date: | 1996-01-06 | Release date: | 1996-07-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Three-dimensional structure of human protein kinase C interacting protein 1, a member of the HIT family of proteins. Proc.Natl.Acad.Sci.USA, 93, 1996
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1KPC
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![BU of 1kpc by Molmil](/molmil-images/mine/1kpc) | PKCI-1-APO+ZINC | Descriptor: | HUMAN PROTEIN KINASE C INTERACTING PROTEIN 1 (ZINC PROTEIN) | Authors: | Lima, C.D, Klein, M.G, Weinstein, I.B, Hendrickson, W.A. | Deposit date: | 1996-01-06 | Release date: | 1996-07-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Three-dimensional structure of human protein kinase C interacting protein 1, a member of the HIT family of proteins. Proc.Natl.Acad.Sci.USA, 93, 1996
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7MLD
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![BU of 7mld by Molmil](/molmil-images/mine/7mld) | PYL10 bound to the ABA pan-antagonist antabactin | Descriptor: | Abscisic acid receptor PYL10, CITRIC ACID, antabactin | Authors: | Peterson, F.C, Vaidya, A.S, Volkman, B.F, Cutler, S.R. | Deposit date: | 2021-04-28 | Release date: | 2021-09-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Click-to-lead design of a picomolar ABA receptor antagonist with potent activity in vivo. Proc.Natl.Acad.Sci.USA, 118, 2021
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1EQX
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![BU of 1eqx by Molmil](/molmil-images/mine/1eqx) | SOLUTION STRUCTURE DETERMINATION AND MUTATIONAL ANALYSIS OF THE PAPILLOMAVIRUS E6-INTERACTING PEPTIDE OF E6AP | Descriptor: | PAPILLOMAVIRUS E6-ASSOCIATED PROTEIN | Authors: | Be, X, Hong, Y, Androphy, E.J, Chen, J.J, Baleja, J.D. | Deposit date: | 2000-04-06 | Release date: | 2001-02-28 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure determination and mutational analysis of the papillomavirus E6 interacting peptide of E6AP. Biochemistry, 40, 2001
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6VFF
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![BU of 6vff by Molmil](/molmil-images/mine/6vff) | Dimer of Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence derived from human GLI1 gene | Descriptor: | Double-stranded RNA-specific editase 1, INOSITOL HEXAKISPHOSPHATE, RNA (5-R(*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*UP*(8AZ)P*GP*AP*GP*GP*GP*CP* UP*CP*UP*GP*AP*UP*AP*GP*CP*UP*AP*CP*G)-3), ... | Authors: | Thuy-boun, A.S, Fisher, A.J, Beal, P.A. | Deposit date: | 2020-01-03 | Release date: | 2020-07-01 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition. Nucleic Acids Res., 48, 2020
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1AYP
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![BU of 1ayp by Molmil](/molmil-images/mine/1ayp) | |
1JMK
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![BU of 1jmk by Molmil](/molmil-images/mine/1jmk) | Structural Basis for the Cyclization of the Lipopeptide Antibiotic Surfactin by the Thioesterase Domain SrfTE | Descriptor: | SULFATE ION, Surfactin Synthetase | Authors: | Bruner, S.D, Weber, T, Kohli, R.M, Schwarzer, D, Marahiel, M.A, Walsh, C.T, Stubbs, M.T. | Deposit date: | 2001-07-18 | Release date: | 2002-03-27 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE. Structure, 10, 2002
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5UR4
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![BU of 5ur4 by Molmil](/molmil-images/mine/5ur4) | |
5NVJ
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![BU of 5nvj by Molmil](/molmil-images/mine/5nvj) | |
1D5Q
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![BU of 1d5q by Molmil](/molmil-images/mine/1d5q) | SOLUTION STRUCTURE OF A MINI-PROTEIN REPRODUCING THE CORE OF THE CD4 SURFACE INTERACTING WITH THE HIV-1 ENVELOPE GLYCOPROTEIN | Descriptor: | CHIMERIC MINI-PROTEIN | Authors: | Vita, C, Drakopoulou, E, Vizzanova, J, Rochette, S, Martin, L, Menez, A, Roumestand, C, Yang, Y.S, Ylisastigui, L, Benjouad, A, Gluckman, J.C. | Deposit date: | 1999-10-11 | Release date: | 2000-10-11 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Rational engineering of a miniprotein that reproduces the core of the CD4 site interacting with HIV-1 envelope glycoprotein. Proc.Natl.Acad.Sci.USA, 96, 1999
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3BXW
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![BU of 3bxw by Molmil](/molmil-images/mine/3bxw) | |
3NO1
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![BU of 3no1 by Molmil](/molmil-images/mine/3no1) | |