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1T8M	CRYSTAL STRUCTURE OF THE P1 HIS BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX Descriptor: Chymotrypsin A, Pancreatic trypsin inhibitor, SULFATE ION Authors: Czapinska, H, Helland, R, Otlewski, J, Smalas, A.O. Deposit date: 2004-05-13 Release date: 2005-03-08 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structures of five bovine chymotrypsin complexes with P1 BPTI variants. J.Mol.Biol., 344, 2004
1T7C	CRYSTAL STRUCTURE OF THE P1 GLU BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX Descriptor: Chymotrypsin A, Pancreatic trypsin inhibitor, SULFATE ION Authors: Czapinska, H, Helland, R, Otlewski, J, Smalas, A.O. Deposit date: 2004-05-09 Release date: 2005-03-08 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystal structures of five bovine chymotrypsin complexes with P1 BPTI variants. J.Mol.Biol., 344, 2004
1T8O	CRYSTAL STRUCTURE OF THE P1 TRP BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX Descriptor: Chymotrypsin A, Pancreatic trypsin inhibitor, SULFATE ION Authors: Czapinska, H, Helland, R, Otlewski, J, Smalas, A.O. Deposit date: 2004-05-13 Release date: 2005-03-08 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structures of five bovine chymotrypsin complexes with P1 BPTI variants. J.Mol.Biol., 344, 2004
1XG6	The crystal structure of the P1 mutant (Leu to Arg)of a Winged bean chymotrypsin inhibitor(Kunitz)solved at 2.15A resolution Descriptor: Chymotrypsin inhibitor 3 Authors: Sen, U, Dattagupta, J.K, Dasgupta, J, Khamrui, S. Deposit date: 2004-09-16 Release date: 2005-08-30 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Single mutation at P1 of a chymotrypsin inhibitor changes it to a trypsin inhibitor: X-ray structural (2.15 A) and biochemical basis Biochim.Biophys.Acta, 1752, 2005
1MCT	THE REFINED 1.6 ANGSTROMS RESOLUTION CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN PORCINE BETA-TRYPSIN AND MCTI-A, A TRYPSIN INHIBITOR OF SQUASH FAMILY Descriptor: BETA-TRYPSIN, CALCIUM ION, TRYPSIN INHIBITOR A Authors: Huang, Q, Liu, S, Tang, Y. Deposit date: 1992-10-24 Release date: 1994-01-31 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Refined 1.6 A resolution crystal structure of the complex formed between porcine beta-trypsin and MCTI-A, a trypsin inhibitor of the squash family. Detailed comparison with bovine beta-trypsin and its complex. J.Mol.Biol., 229, 1993
4AN6	Kuntiz type trypsin inhibitor with factor Xa inhibitory activity Descriptor: TRYPSIN INHIBITOR Authors: Patil, D.N, Kumar, P. Deposit date: 2012-03-15 Release date: 2012-11-07 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Structural Basis for Dual Inhibitory Role of Tamarind Kunitz Inhibitor (Tki) Against Factor Xa and Trypsin. FEBS J., 279, 2012
1P2N	Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin Descriptor: Chymotrypsinogen A, Pancreatic trypsin inhibitor, SULFATE ION Authors: Helland, R, Czapinska, H, Leiros, I, Olufsen, M, Otlewski, J, Smalaas, A.O. Deposit date: 2003-04-15 Release date: 2004-04-20 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural consequences of accommodation of four non-cognate amino acid residues in the S1 pocket of bovine trypsin and chymotrypsin. J.Mol.Biol., 333, 2003
1P2M	Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin Descriptor: Chymotrypsinogen A, Pancreatic trypsin inhibitor, SULFATE ION Authors: Helland, R, Czapinska, H, Leiros, I, Olufsen, M, Otlewski, J, Smalaas, A.O. Deposit date: 2003-04-15 Release date: 2004-04-20 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural consequences of accommodation of four non-cognate amino acid residues in the S1 pocket of bovine trypsin and chymotrypsin. J.Mol.Biol., 333, 2003
1P2O	Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin Descriptor: Chymotrypsinogen A, Pancreatic trypsin inhibitor, SULFATE ION Authors: Helland, R, Czapinska, H, Leiros, I, Olufsen, M, Otlewski, J, Smalaas, A.O. Deposit date: 2003-04-15 Release date: 2004-04-20 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural consequences of accommodation of four non-cognate amino acid residues in the S1 pocket of bovine trypsin and chymotrypsin. J.Mol.Biol., 333, 2003
4H4F	Crystal structure of human chymotrypsin C (CTRC) bound to inhibitor eglin c from Hirudo medicinalis Descriptor: Chymotrypsin-C, Eglin C, PHOSPHATE ION Authors: Batra, J, Soares, A.S, Radisky, E.S. Deposit date: 2012-09-17 Release date: 2013-02-27 Last modified: 2013-04-24 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Long-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme Activation. J.Biol.Chem., 288, 2013
1UTM	Trypsin specificity as elucidated by LIE calculations, X-ray structures and association constant measurements Descriptor: 2-PHENYLETHYLAMINE, CALCIUM ION, TRYPSIN I Authors: Leiros, H.-K.S, Brandsdal, B.O, Andersen, O.A, Os, V, Leiros, I, Helland, R, Otlewski, J, Willassen, N.P, Smalas, A.O. Deposit date: 2003-12-09 Release date: 2004-01-09 Last modified: 2019-07-24 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Trypsin Specificity as Elucidated by Lie Calculations, X-Ray Structures, and Association Constant Measurements Protein Sci., 13, 2004
1GL1	structure of the complex between bovine alpha-chymotrypsin and PMP-C, an inhibitor from the insect Locusta migratoria Descriptor: ALPHA-CHYMOTRYPSIN, CADMIUM ION, PROTEASE INHIBITOR LCMI II Authors: Roussel, A, Kellenberger, C. Deposit date: 2001-08-22 Release date: 2001-11-28 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Complexation of Two Proteic Insect Inhibitors to the Active Site of Chymotrypsin Suggests Decoupled Roles for Binding and Selectivity J.Biol.Chem., 276, 2001
2AH4	guanidinobenzoyl-trypsin acyl-enzyme at 1.13 A resolution Descriptor: 4-carbamimidamidobenzoic acid, CALCIUM ION, SULFATE ION, ... Authors: Radisky, E.S, Lee, J.M, Lu, C.J, Koshland Jr, D.E. Deposit date: 2005-07-26 Release date: 2006-05-16 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.13 Å) Cite: Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates Proc.Natl.Acad.Sci.USA, 103, 2006
1UTK	Trypsin specificity as elucidated by LIE calculations, X-ray structures and association constant measurements Descriptor: CALCIUM ION, SULFATE ION, TRYPSIN I Authors: Leiros, H.-K.S, Brandsdal, B.O, Andersen, O.A, Os, V, Leiros, I, Helland, R, Otlewski, J, Willassen, N.P, Smalas, A.O. Deposit date: 2003-12-09 Release date: 2004-01-29 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Trypsin Specificity as Elucidated by Lie Calculations, X-Ray Structures, and Association Constant Measurements Protein Sci., 13, 2004
2A31	Trypsin in complex with borate Descriptor: BORATE ION, CALCIUM ION, GUANIDINE-3-PROPANOL, ... Authors: Transue, T.R, Gabel, S.A, London, R.E. Deposit date: 2005-06-23 Release date: 2006-07-04 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.25 Å) Cite: NMR and crystallographic characterization of adventitious borate binding by trypsin. Bioconjug.Chem., 17, 2006
2CGA	BOVINE CHYMOTRYPSINOGEN A. X-RAY CRYSTAL STRUCTURE ANALYSIS AND REFINEMENT OF A NEW CRYSTAL FORM AT 1.8 ANGSTROMS RESOLUTION Descriptor: CHYMOTRYPSINOGEN A Authors: Wang, D, Bode, W, Huber, R. Deposit date: 1987-01-16 Release date: 1987-04-16 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Bovine chymotrypsinogen A X-ray crystal structure analysis and refinement of a new crystal form at 1.8 A resolution. J.Mol.Biol., 185, 1985
1UTL	Trypsin specificity as elucidated by LIE calculations, X-ray structures and association constant measurements Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 3-PHENYLPROPYLAMINE, CALCIUM ION, ... Authors: Leiros, H.-K.S, Brandsdal, B.O, Andersen, O.A, Os, V, Leiros, I, Helland, R, Otlewski, J, Willassen, N.P, Smalas, A.O. Deposit date: 2003-12-09 Release date: 2004-01-15 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Trypsin Specificity as Elucidated by Lie Calculations, X-Ray Structures, and Association Constant Measurements Protein Sci., 13, 2004
1YYY	Trypsin inhibitors with rigid tripeptidyl aldehydes Descriptor: 2-{(3S)-3-[(benzylsulfonyl)amino]-2-oxopiperidin-1-yl}-N-{(2S)-1-[(3S)-1-carbamimidoylpiperidin-3-yl]-3-oxopropan-2-yl}acetamide, CALCIUM ION, TRYPSIN Authors: Krishnan, R, Zhang, E, Hakansson, K, Arni, R.K, Tulinsky, A, Lim-Wilby, M.S.L, Levy, O.E, Semple, J.E, Brunck, T.K. Deposit date: 1998-06-03 Release date: 1999-06-08 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes. Biochemistry, 37, 1998
3GCT	STRUCTURE OF GAMMA-*CHYMOTRYPSIN IN THE RANGE $P*H 2.0 TO $P*H 10.5 SUGGESTS THAT GAMMA-CHYMOTRYPSIN IS A COVALENT ACYL-ENZYME ADDUCT AT LOW $P*H Descriptor: GAMMA-CHYMOTRYPSIN A, SULFATE ION, UNK PRO GLY ALA TYR PEPTIDE Authors: Dixon, M.M, Matthews, B.W. Deposit date: 1990-09-04 Release date: 1991-10-15 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structure of gamma-chymotrypsin in the range pH 2.0 to pH 10.5 suggests that gamma-chymotrypsin is a covalent acyl-enzyme adduct at low pH. Int.J.Biol.Macromol., 13, 1991
1ZZZ	Trypsin inhibitors with rigid tripeptidyl aldehydes Descriptor: 2-{(3S)-3-[(benzylsulfonyl)amino]-2-oxopiperidin-1-yl}-N-{(2S)-1-[(3R)-1-carbamimidoylpiperidin-3-yl]-3-oxopropan-2-yl}acetamide, CALCIUM ION, TRYPSIN Authors: Krishnan, R, Zhang, E, Hakansson, K, Arni, R.K, Tulinsky, A, Lim-Wilby, M.S.L, Levy, O.E, Semple, J.E, Brunck, T.K. Deposit date: 1998-06-02 Release date: 1999-06-15 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes. Biochemistry, 37, 1998
1UTJ	Trypsin specificity as elucidated by LIE calculations, X-ray structures and association constant measurements Descriptor: BENZYLAMINE, CALCIUM ION, TRYPSIN I Authors: Leiros, H.-K.S, Brandsdal, B.O, Andersen, O.A, Os, V, Leiros, I, Helland, R, Otlewski, J, Willassen, N.P, Smalas, A.O. Deposit date: 2003-12-09 Release date: 2004-01-15 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Trypsin Specificity as Elucidated by Lie Calculations, X-Ray Structures, and Association Constant Measurements Protein Sci., 13, 2004
1AB9	CRYSTAL STRUCTURE OF BOVINE GAMMA-CHYMOTRYPSIN Descriptor: GAMMA-CHYMOTRYPSIN, PENTAPEPTIDE (TPGVY), SULFATE ION Authors: Sugio, S, Kashima, A, Inoue, Y, Maeda, I, Nose, T, Shimohigashi, Y. Deposit date: 1997-02-05 Release date: 1997-08-20 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (1.6 Å) Cite: X-ray crystal structure of a dipeptide-chymotrypsin complex in an inhibitory interaction. Eur.J.Biochem., 255, 1998
1YKT	Trypsin/Bpti complex mutant Descriptor: CALCIUM ION, Pancreatic trypsin inhibitor, SULFATE ION, ... Authors: Brown, C.K, Ohlendorf, D.H. Deposit date: 2005-01-18 Release date: 2006-04-25 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Partially folded bovine pancreatic trypsin inhibitor analogues attain fully native structures when co-crystallized with S195A rat trypsin J.Mol.Biol., 375, 2008
2A32	Trypsin in complex with benzene boronic acid Descriptor: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, BORATE ION, CALCIUM ION, ... Authors: Transue, T.R, Gabel, S.A, London, R.E. Deposit date: 2005-06-23 Release date: 2006-07-04 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.5 Å) Cite: NMR and crystallographic characterization of adventitious borate binding by trypsin. Bioconjug.Chem., 17, 2006
2AGG	succinyl-AAPK-trypsin acyl-enzyme at 1.28 A resolution Descriptor: CALCIUM ION, Cationic trypsin, SULFATE ION, ... Authors: Radisky, E.S, Lee, J.M, Lu, C.J, Koshland Jr, D.E. Deposit date: 2005-07-26 Release date: 2006-05-16 Last modified: 2024-04-24 Method: X-RAY DIFFRACTION (1.28 Å) Cite: Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates Proc.Natl.Acad.Sci.USA, 103, 2006

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