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2R3R	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: 3-bromo-5-phenyl-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine, Cell division protein kinase 2 Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2021-07-28 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
1ZFS	Solution structure of S100A1 bound to calcium Descriptor: CALCIUM ION, S-100 protein, alpha chain Authors: Wright, N.T, Varney, K.M, Weber, D.J. Deposit date: 2005-04-20 Release date: 2006-04-11 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: The three-dimensional solution structure of Ca(2+)-bound S100A1 as determined by NMR spectroscopy J.Mol.Biol., 353, 2006
2R3O	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: (5-phenyl-7-(pyridin-3-ylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl)methanol, Cell division protein kinase 2 Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
1YZ5	The crystal structure of 14-3-3-sigma at 2.8 angstrom resolution Descriptor: 14-3-3 protein sigma Authors: Benzinger, A, Popowicz, G.M, Holak, T.A, Hermeking, H. Deposit date: 2005-02-28 Release date: 2005-03-08 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.8 Å) Cite: The crystal structure of the non-liganded 14-3-3sigma protein: insights into determinants of isoform specific ligand binding and dimerization. Cell Res., 15, 2005
2R3M	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: Cell division protein kinase 2, N-((2-aminopyrimidin-5-yl)methyl)-5-(2,6-difluorophenyl)-3-ethylpyrazolo[1,5-a]pyrimidin-7-amine Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2R3F	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: 5-(2,3-dichlorophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine, Cell division protein kinase 2 Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2R3Q	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: 3-((3-bromo-5-o-tolylpyrazolo[1,5-a]pyrimidin-7-ylamino)methyl)pyridine 1-oxide, Cell division protein kinase 2 Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2R3I	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: 5-(2-fluorophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine, Cell division protein kinase 2 Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.28 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2R7G	Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain Descriptor: Early E1A 32 kDa protein, Retinoblastoma-associated protein, SULFATE ION Authors: Liu, X, Marmorstein, R. Deposit date: 2007-09-07 Release date: 2007-10-02 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.671 Å) Cite: Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor Genes Dev., 21, 2007
2P9I	Crystal Structure of bovine Arp2/3 Complex co-crystallized with ADP and crosslinked with gluteraldehyde Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin-like protein 2, Actin-like protein 3, ... Authors: Nolen, B.J, Pollard, T.D. Deposit date: 2007-03-26 Release date: 2007-05-29 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.46 Å) Cite: Insights into the Influence of Nucleotides on Actin Family Proteins from Seven Structures of Arp2/3 Complex. Mol.Cell, 26, 2007
1ZZ1	Crystal structure of a HDAC-like protein with SAHA bound Descriptor: Histone deacetylase-like amidohydrolase, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, POTASSIUM ION, ... Authors: Nielsen, T.K, Hildmann, C, Dickmanns, A, Schwienhorst, A, Ficner, R. Deposit date: 2005-06-13 Release date: 2005-11-29 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.57 Å) Cite: Crystal structure of a bacterial class 2 histone deacetylase homologue J.Mol.Biol., 354, 2005
2AFG	2.0 ANGSTROM X-RAY STRUCTURE OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR Descriptor: ACIDIC FIBROBLAST GROWTH FACTOR, SULFATE ION Authors: Blaber, M, Disalvo, J, Thomas, K.A. Deposit date: 1995-07-21 Release date: 1995-10-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: X-ray crystal structure of human acidic fibroblast growth factor. Biochemistry, 35, 1996
1RHG	THE STRUCTURE OF GRANULOCYTE-COLONY-STIMULATING FACTOR AND ITS RELATIONSHIP TO THOSE OF OTHER GROWTH FACTORS Descriptor: GRANULOCYTE COLONY-STIMULATING FACTOR Authors: Hill, C.P, Osslund, T.D, Eisenberg, D. Deposit date: 1993-01-29 Release date: 1994-01-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The structure of granulocyte-colony-stimulating factor and its relationship to other growth factors. Proc.Natl.Acad.Sci.USA, 90, 1993
2BTS	STRUCTURE OF CDK2 COMPLEXED WITH PNU-230032 Descriptor: 4-[(5-ISOPROPYL-1,3-THIAZOL-2-YL)AMINO]BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2 Authors: Vulpetti, A, Casale, E, Roletto, F, Amici, R, Villa, M, Pevarello, P. Deposit date: 2005-06-06 Release date: 2005-11-09 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Structure-Based Drug Design to the Discovery of New 2-Aminothiazole Cdk2 Inhibitors. J.Mol.Graph.Model., 24, 2006
1SAN	THE DES(1-6)ANTENNAPEDIA HOMEODOMAIN: COMPARISON OF THE NMR SOLUTION STRUCTURE AND THE DNA BINDING AFFINITY WITH THE INTACT ANTENNAPEDIA HOMEODOMAIN Descriptor: ANTENNAPEDIA PROTEIN Authors: Qian, Y.Q, Resendez-Perez, D, Gehring, W.J, Wuthrich, K. Deposit date: 1994-01-07 Release date: 1994-04-30 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: The des(1-6)antennapedia homeodomain: comparison of the NMR solution structure and the DNA-binding affinity with the intact Antennapedia homeodomain. Proc.Natl.Acad.Sci.USA, 91, 1994
2C5X	Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design Descriptor: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, HYDROXY(OXO)(3-{[(2Z)-4-[3-(1H-1,2,4-TRIAZOL-1-YLMETHYL)PHENYL]PYRIMIDIN-2(5H)-YLIDENE]AMINO}PHENYL)AMMONIUM Authors: Kontopidis, G, Mcinnes, C, Pandalaneni, S.R, Mcnae, I, Gibson, D, Mezna, M, Thomas, M, Wood, G, Wang, S, Walkinshaw, M.D, Fischer, P.M. Deposit date: 2005-11-03 Release date: 2006-03-01 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design. Chem.Biol., 13, 2006
2BKR	NEDD8 NEDP1 complex Descriptor: NEDDYLIN, SENTRIN-SPECIFIC PROTEASE 8 Authors: Shen, L.N, Liu, H, Dong, C, Xirodimas, D, Naismith, J.H, Hay, R.T. Deposit date: 2005-02-18 Release date: 2005-09-15 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural Basis of Nedd8 Ubiquitin Discrimination by the Deneddylating Enzyme Nedp1 Embo J., 24, 2005
2P9P	Crystal Structure of bovine Arp2/3 complex co-crystallized with ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin-like protein 2, Actin-like protein 3, ... Authors: Nolen, B.J, Pollard, T.D. Deposit date: 2007-03-26 Release date: 2007-05-29 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Insights into the Influence of Nucleotides on Actin Family Proteins from Seven Structures of Arp2/3 Complex. Mol.Cell, 26, 2007
2BTR	STRUCTURE OF CDK2 COMPLEXED WITH PNU-198873 Descriptor: CELL DIVISION PROTEIN KINASE 2, N-(5-ISOPROPYL-THIAZOL-2-YL)-2-PYRIDIN-3-YL-ACETAMIDE Authors: Vulpetti, A, Casale, E, Roletto, F, Amici, R, Villa, M, Pevarello, P. Deposit date: 2005-06-06 Release date: 2005-11-09 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structure-Based Drug Design to the Discovery of New 2-Aminothiazole Cdk2 Inhibitors. J.Mol.Graph.Model., 24, 2006
2OOY	Crystal structure of the adenylate sensor from AMP-activated protein kinase complexed with ATP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CITRATE ANION, Hypothetical protein C1556.08c in chromosome I, ... Authors: Townley, R, Shapiro, L. Deposit date: 2007-01-26 Release date: 2007-02-06 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.88 Å) Cite: Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase. Science, 315, 2007
2C5V	Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design Descriptor: 4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)-N-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE, ALA-ALA-ABA-ARG-SER-LEU-ILE-PFF-NH2, CELL DIVISION PROTEIN KINASE 2, ... Authors: Kontopidis, G, McInnes, C, Pandalaneni, S.R, McNae, I, Gibson, D, Mezna, M, Thomas, M, Wood, G, Wang, S, Walkinshaw, M.D, Fischer, P.M. Deposit date: 2005-11-02 Release date: 2006-03-01 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design. Chem.Biol., 13, 2006
2C5N	Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design Descriptor: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N',N'-DIMETHYL-BENZENE-1,4-DIAMINE Authors: Kontopidis, G, McInnes, C, Pandalaneni, S.R, McNae, I, Gibson, D, Mezna, M, Thomas, M, Wood, G, Wang, S, Walkinshaw, M.D, Fischer, P.M. Deposit date: 2005-10-30 Release date: 2006-03-01 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design. Chem.Biol., 13, 2006
2C6K	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor Descriptor: 4-{[5-(CYCLOHEXYLAMINO)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2 Authors: Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. Deposit date: 2005-11-10 Release date: 2005-12-07 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar. Bioorg.Med.Chem.Lett., 16, 2006
2P9S	Structure of bovine Arp2/3 complex co-crystallized with ATP/Mg2+ Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin-like protein 2, Actin-like protein 3, ... Authors: Nolen, B.J, Pollard, T.D. Deposit date: 2007-03-26 Release date: 2007-05-29 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.68 Å) Cite: Insights into the Influence of Nucleotides on Actin Family Proteins from Seven Structures of Arp2/3 Complex. Mol.Cell, 26, 2007
2C69	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor Descriptor: (5Z)-5-(3-BROMOCYCLOHEXA-2,5-DIEN-1-YLIDENE)-N-(PYRIDIN-4-YLMETHYL)-1,5-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE, CELL DIVISION PROTEIN KINASE 2 Authors: Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. Deposit date: 2005-11-08 Release date: 2005-12-07 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR. Bioorg. Med. Chem. Lett., 16, 2006

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