7XHB
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7E2H
| Cryo-EM structure of hDisp1NNN-3C-Cleavage | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Protein dispatched homolog 1 | Authors: | Li, W, Wang, L, Gong, X. | Deposit date: | 2021-02-05 | Release date: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (3.68 Å) | Cite: | Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release. Nat Commun, 12, 2021
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5ZMD
| Crystal structure of FTO in complex with m6dA modified ssDNA | Descriptor: | Alpha-ketoglutarate-dependent dioxygenase FTO, DNA (5'-D(P*TP*CP*TP*(6MA)P*TP*AP*TP*CP*G)-3'), MANGANESE (II) ION, ... | Authors: | Zhang, X, Wei, L.H, Luo, J, Xiao, Y, Liu, J, Zhang, W, Zhang, L, Jia, G.F. | Deposit date: | 2018-04-02 | Release date: | 2019-04-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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5C53
| Probing the Structural and Molecular Basis of Nucleotide Selectivity by Human Mitochondrial DNA Polymerase gamma | Descriptor: | 2',3'-DIDEOXYCYTIDINE-5'-MONOPHOSPHATE, DNA (26-MER), DNA (5'-D(*AP*AP*AP*AP*CP*GP*AP*GP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*GP*TP*AP*C)-3'), ... | Authors: | Sohl, C.D, Szymanski, M.R, Mislak, A.C, Shumate, C.K, Amiralaei, S, Schinazi, R.F, Anderson, K.S, Yin, Y.W. | Deposit date: | 2015-06-19 | Release date: | 2016-01-27 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.567 Å) | Cite: | Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase gamma. Proc.Natl.Acad.Sci.USA, 112, 2015
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5C51
| Probing the Structural and Molecular Basis of Nucleotide Selectivity by Human Mitochondrial DNA Polymerase gamma | Descriptor: | DNA, DNA (5'-D(*(AD)P*AP*AP*AP*CP*GP*AP*GP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*GP*TP*AP*C)-3'), DNA polymerase subunit gamma-1, ... | Authors: | Sohl, C.D, Szymanski, M.R, Mislak, A.C, Shumate, C.K, Amiralaei, S, Schinazi, R.F, Anderson, K.S, Whitney, Y.Y. | Deposit date: | 2015-06-19 | Release date: | 2016-05-11 | Last modified: | 2016-05-18 | Method: | X-RAY DIFFRACTION (3.426 Å) | Cite: | Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase gamma. Proc.Natl.Acad.Sci.USA, 112, 2015
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5C52
| Probing the Structural and Molecular Basis of Nucleotide Selectivity by Human Mitochondrial DNA Polymerase gamma | Descriptor: | DNA (26-MER), DNA (5'-D(*AP*AP*AP*AP*CP*GP*AP*GP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*GP*TP*AP*C)-3'), DNA polymerase subunit gamma-1, ... | Authors: | Sohl, C.D, Szymanski, M.R, Mislak, A.C, Shumate, C.K, Amiralaei, S, Schinazi, R.F, Anderson, K.S, Yin, Y.W. | Deposit date: | 2015-06-19 | Release date: | 2016-05-11 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.637 Å) | Cite: | Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase gamma. Proc.Natl.Acad.Sci.USA, 112, 2015
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8IO3
| Cryo-EM structure of human HCN3 channel with cilobradine | Descriptor: | 3-[[(3~{S})-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-3-yl]methyl]-7,8-dimethoxy-2,5-dihydro-1~{H}-3-benzazepin-4-one, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | Authors: | Yu, B, Lu, Q.Y, Li, J, Zhang, J. | Deposit date: | 2023-03-10 | Release date: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Cryo-EM structure of human HCN3 channel with cilobradine To Be Published
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6MKS
| Cryo-EM structure of NLRC4-CARD filament | Descriptor: | Chimera protein of NLR family CARD domain-containing protein 4 and EGFP | Authors: | Zheng, W, Matyszewski, M, Sohn, J, Egelman, E.H. | Deposit date: | 2018-09-26 | Release date: | 2018-11-07 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structure of the NLRC4CARDfilament provides insights into how symmetric and asymmetric supramolecular structures drive inflammasome assembly. J. Biol. Chem., 293, 2018
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7V3Z
| Structure of cannabinoid receptor type 1(CB1) | Descriptor: | 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol, CHOLESTEROL, FLAVIN MONONUCLEOTIDE, ... | Authors: | Liu, Z.J, Shen, L, Hua, T, Yao, D.Q, Wu, L.J. | Deposit date: | 2021-08-12 | Release date: | 2021-11-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.29 Å) | Cite: | A Genetically Encoded F-19 NMR Probe Reveals the Allosteric Modulation Mechanism of Cannabinoid Receptor 1. J.Am.Chem.Soc., 143, 2021
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7XB0
| Crystal structure of Omicron BA.2 RBD complexed with hACE2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | Authors: | Li, L, Liao, H, Meng, Y, Li, W. | Deposit date: | 2022-03-19 | Release date: | 2022-07-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1. Cell, 185, 2022
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7XAZ
| Crystal structure of Omicron BA.1.1 RBD complexed with hACE2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | Authors: | Liao, H, Meng, Y, Li, W. | Deposit date: | 2022-03-19 | Release date: | 2022-07-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1. Cell, 185, 2022
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7XCP
| Cryo-EM structure of Omicron RBD complexed with ACE2 and 304 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of 304 Fab, ... | Authors: | Zhao, Z, Qi, J, Gao, F.G. | Deposit date: | 2022-03-24 | Release date: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape Nat Commun, 13, 2022
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7XB1
| Crystal structure of Omicron BA.3 RBD complexed with hACE2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | Authors: | Li, W, Meng, Y, Liao, H. | Deposit date: | 2022-03-19 | Release date: | 2022-07-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1. Cell, 185, 2022
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7WVI
| Crystal structure of SIA28 | Descriptor: | Heavy chain of SIA28, Light chain of SIA28 | Authors: | Chen, Y, Qi, J, Gao, G.F. | Deposit date: | 2022-02-10 | Release date: | 2023-01-18 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes. Nat Commun, 13, 2022
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6RAS
| Pmar-Lig_Pre. | Descriptor: | ADENOSINE MONOPHOSPHATE, ATP-dependent DNA ligase, DNA, ... | Authors: | Leiros, H.K.S, Williamson, A. | Deposit date: | 2019-04-07 | Release date: | 2019-07-10 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural intermediates of a DNA-ligase complex illuminate the role of the catalytic metal ion and mechanism of phosphodiester bond formation. Nucleic Acids Res., 47, 2019
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6RAU
| PostS3_Pmar_lig4_WT | Descriptor: | ADENOSINE MONOPHOSPHATE, ATP-dependent DNA ligase, DNA (5'-D(*AP*TP*TP*GP*CP*GP*AP*CP*CP*CP*CP*AP*CP*TP*AP*TP*CP*GP*GP*AP*A)-3'), ... | Authors: | Leiros, H.K.S, Williamson, A. | Deposit date: | 2019-04-08 | Release date: | 2019-07-10 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structural intermediates of a DNA-ligase complex illuminate the role of the catalytic metal ion and mechanism of phosphodiester bond formation. Nucleic Acids Res., 47, 2019
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6LR2
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7U8G
| Cryo-EM structure of the core human NADPH oxidase NOX2 | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 7G5 - heavy chain, ... | Authors: | Noreng, S, Ota, N, Sun, Y, Masureel, M, Payandeh, J, Yi, T, Koerber, J.T. | Deposit date: | 2022-03-08 | Release date: | 2022-10-26 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of the core human NADPH oxidase NOX2. Nat Commun, 13, 2022
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7FBV
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7FBR
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8HCO
| Substrate-engaged TOM complex from yeast | Descriptor: | Mitochondrial import receptor subunit TOM22, Mitochondrial import receptor subunit TOM40, Mitochondrial import receptor subunit TOM5, ... | Authors: | Zhou, X.Y, Yang, Y.Q, Wang, G.P, Wang, S.S. | Deposit date: | 2022-11-02 | Release date: | 2023-09-13 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Molecular pathway of mitochondrial preprotein import through the TOM-TIM23 supercomplex. Nat.Struct.Mol.Biol., 30, 2023
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8U1U
| Structure of a class A GPCR/agonist complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C-C motif chemokine 1,C-C chemokine receptor type 8,EGFP fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Sun, D, Johnson, M, Masureel, M. | Deposit date: | 2023-09-02 | Release date: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8. Nat Commun, 14, 2023
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8CPX
| Human apoferritin after 488 nm laser exposure in presence of rsEGFP2 | Descriptor: | Ferritin heavy chain, N-terminally processed, MAGNESIUM ION, ... | Authors: | Last, M.G.F, Noteborn, W.E.M, Sharp, T.H. | Deposit date: | 2023-03-03 | Release date: | 2023-03-15 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (1.76 Å) | Cite: | Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM. J.Struct.Biol., 215, 2023
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8CPW
| Human apoferritin after 405 nm + 488 nm laser exposure in presence of rsEGFP2 | Descriptor: | Ferritin heavy chain, N-terminally processed, MAGNESIUM ION, ... | Authors: | Last, M.G.F, Noteborn, W.E.M, Sharp, T.H. | Deposit date: | 2023-03-03 | Release date: | 2023-03-15 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (1.79 Å) | Cite: | Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM. J.Struct.Biol., 215, 2023
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4TS0
| Crystal structure of the Spinach RNA aptamer in complex with DFHBI, barium ions | Descriptor: | (5Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one, BARIUM ION, POTASSIUM ION, ... | Authors: | Warner, K.D, Chen, M.C, Song, W, Strack, R.L, Thorn, A, Jaffrey, S.R, Ferre-D'Amare, A.R. | Deposit date: | 2014-06-18 | Release date: | 2014-07-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for activity of highly efficient RNA mimics of green fluorescent protein. Nat.Struct.Mol.Biol., 21, 2014
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