1SKJ
 
 | | COCRYSTAL STRUCTURE OF UREA-SUBSTITUTED PHOSPHOPEPTIDE COMPLEX | | Descriptor: | 4-[3-CARBOXYMETHYL-3-(4-PHOSPHONOOXY-BENZYL)-UREIDO]-4-[(3-CYCLOHEXYL-PROPYL)-METHYL-CARBAMOYL]BUTYRIC ACID, PP60 V-SRC TYROSINE KINASE TRANSFORMING PROTEIN | | Authors: | Holland, D.R, Rubin, J.R. | | Deposit date: | 1997-09-18 | | Release date: | 1998-02-25 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Design, synthesis, and cocrystal structure of a nonpeptide Src SH2 domain ligand.
J.Med.Chem., 40, 1997
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1A1A
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1A08
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1A09
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1A1E
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1A1C
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1A1B
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1A07
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7WFY
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1AB2
 | | THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE SRC HOMOLOGY 2 DOMAIN OF C-ABL | | Descriptor: | C-ABL TYROSINE KINASE SH2 DOMAIN | | Authors: | Overduin, M, Rios, C.B, Mayer, B.J, Baltimore, D, Cowburn, D. | | Deposit date: | 1993-07-19 | | Release date: | 1994-01-31 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | Three-dimensional solution structure of the src homology 2 domain of c-abl.
Cell(Cambridge,Mass.), 70, 1992
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7T1K
 | | Crystal structure of a superbinder Fes SH2 domain (sFes1) in complex with a high affinity phosphopeptide | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, MALONATE ION, ... | | Authors: | Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. | | Deposit date: | 2021-12-02 | | Release date: | 2022-08-24 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | Engineered SH2 Domains for Targeted Phosphoproteomics.
Acs Chem.Biol., 17, 2022
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7T1L
 | | Crystal structure of a superbinder Fes SH2 domain (sFesS) in complex with a high affinity phosphopeptide | | Descriptor: | CHLORIDE ION, SODIUM ION, Synthetic phosphotyrosine-containing Ezrin-derived peptide, ... | | Authors: | Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. | | Deposit date: | 2021-12-02 | | Release date: | 2022-08-24 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Engineered SH2 Domains for Targeted Phosphoproteomics.
Acs Chem.Biol., 17, 2022
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7T1U
 | | Crystal structure of a superbinder Src SH2 domain (sSrcF) in complex with a high affinity phosphopeptide | | Descriptor: | Proto-oncogene tyrosine-protein kinase Src, Synthetic phosphopeptide, ZINC ION | | Authors: | Martyn, G.D, Singer, A.U, Manczyk, N, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. | | Deposit date: | 2021-12-02 | | Release date: | 2022-08-24 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Engineered SH2 Domains for Targeted Phosphoproteomics.
Acs Chem.Biol., 17, 2022
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1AYB
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1AYD
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1AOT
 | | NMR STRUCTURE OF THE FYN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PEPTIDE, MINIMIZED AVERAGE STRUCTURE | | Descriptor: | FYN PROTEIN-TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE | | Authors: | Mulhern, T.D, Shaw, G.L, Morton, C.J, Day, A.J, Campbell, I.D. | | Deposit date: | 1997-07-10 | | Release date: | 1998-01-14 | | Last modified: | 2021-11-03 | | Method: | SOLUTION NMR | | Cite: | The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity.
Structure, 5, 1997
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1TZE
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5JN0
 | | CRK-II SH2 domain | | Descriptor: | CHLORIDE ION, CRK-II SH2 domain | | Authors: | Cho, J.-H. | | Deposit date: | 2016-04-29 | | Release date: | 2017-08-09 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.677 Å) | | Cite: | CRK-II SH2 domain
To Be Published
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5KAZ
 | | Human SH2D1B structure | | Descriptor: | SH2 domain-containing protein 1B, SULFATE ION | | Authors: | Taha, M, Nezerwa, E, Nam, H.-J. | | Deposit date: | 2016-06-02 | | Release date: | 2017-04-12 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The X-ray Crystallographic Structure of Human EAT2 (SH2D1B).
Protein Pept. Lett., 23, 2016
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1WQU
 | | Solution structure of the human FES SH2 domain | | Descriptor: | Proto-oncogene tyrosine-protein kinase FES/FPS | | Authors: | Scott, A, Pantoja-Uceda, D, Koshiba, S, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Tanaka, A, Sugano, S, Yokoyama, S, Guntert, P, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2004-10-02 | | Release date: | 2005-06-14 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes
J.Biomol.NMR, 31, 2005
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1X0N
 | | NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor | | Descriptor: | 4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAPHTHYLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL]BENZYLPHOSPHONIC ACID, Growth factor receptor-bound protein 2 | | Authors: | Ogura, K, Shiga, T, Yuzawa, S, Yokochi, M, Burke, T.R, Inagaki, F. | | Deposit date: | 2005-03-24 | | Release date: | 2005-04-19 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor
To be Published
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1X6C
 | | Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1 | | Descriptor: | Tyrosine-protein phosphatase, non-receptor type 6 | | Authors: | Sato, M, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-05-17 | | Release date: | 2005-11-17 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1
To be Published
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1BFI
 | | SOLUTION STRUCTURE OF THE C-TERMINAL SH2 DOMAIN OF THE P85ALPHA REGULATORY SUBUNIT OF PHOSPHOINOSITIDE 3-KINASE, NMR, 30 STRUCTURES | | Descriptor: | P85 ALPHA | | Authors: | Siegal, G, Davis, B, Kristensen, S.M, Sankar, A, Linacre, J, Stein, R.C, Panayotou, G, Waterfield, M.D, Driscoll, P.C. | | Deposit date: | 1997-11-18 | | Release date: | 1998-02-25 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the C-terminal SH2 domain of the p85 alpha regulatory subunit of phosphoinositide 3-kinase.
J.Mol.Biol., 276, 1998
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1AYC
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1BHF
 | | P56LCK SH2 DOMAIN INHIBITOR COMPLEX | | Descriptor: | INHIBITOR ACE-IPA-GLU-GLU-ILE, T-LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE P56LCK | | Authors: | Tong, L, Warren, T.C, Lukas, S, Schembri-King, J, Betageri, R, Proudfoot, J.R, Jakes, S. | | Deposit date: | 1998-06-08 | | Release date: | 1998-10-21 | | Last modified: | 2012-12-12 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding.
J.Biol.Chem., 273, 1998
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