PDB: 707 resultsInfo pagesStatus searchChemie searchBIRD

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6CMP	Closed structure of inactive SHP2 mutant C459E Descriptor: Tyrosine-protein phosphatase non-receptor type 11 Authors: Padua, R.A.P, Sun, Y, Marko, I, Pitsawong, W, Kern, D. Deposit date: 2018-03-06 Release date: 2018-11-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nat Commun, 9, 2018
6CRF	Crystal Structure of Shp2 E76K GOF Mutant in the Open Conformation Descriptor: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 11 Authors: Stams, T, Fodor, M. Deposit date: 2018-03-17 Release date: 2018-11-07 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.62 Å) Cite: Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. Nat Commun, 9, 2018
6CMQ	Structure of human SHP2 without N-SH2 domain Descriptor: Tyrosine-protein phosphatase non-receptor type 11 Authors: Padua, R.A.P, Sun, Y, Marko, I, Pitsawong, W, Kern, D. Deposit date: 2018-03-06 Release date: 2018-11-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nat Commun, 9, 2018
7EMN	The atomic structure of SHP2 E76A mutant Descriptor: Tyrosine-protein phosphatase non-receptor type 11 Authors: Luo, F, Xie, J.J, Zhu, J.D, Liu, C. Deposit date: 2021-04-14 Release date: 2021-05-05 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3 Å) Cite: A novel partially open state of SHP2 points to a "multiple gear" regulation mechanism. J.Biol.Chem., 296, 2021
2B3O	Crystal structure of human tyrosine phosphatase SHP-1 Descriptor: Tyrosine-protein phosphatase, non-receptor type 6 Authors: Yang, J, Liu, L, He, D, Song, X, Liang, X, Zhao, Z.J, Zhou, G.W. Deposit date: 2005-09-20 Release date: 2005-10-25 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal structure of human protein-tyrosine phosphatase SHP-1. J.Biol.Chem., 278, 2003
7JVN	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Compound 24 Descriptor: 6-(4-amino-4-methylpiperidin-1-yl)-3-[(2,3-dichlorophenyl)sulfanyl]pyrazin-2-amine, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 Authors: Fodor, M, Stams, T. Deposit date: 2020-08-21 Release date: 2020-09-23 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.917 Å) Cite: Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer. J.Med.Chem., 63, 2020
7JVM	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor TNO155 Descriptor: (3S,4S)-8-{6-amino-5-[(2-amino-3-chloropyridin-4-yl)sulfanyl]pyrazin-2-yl}-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 Authors: Fodor, M, Stams, T. Deposit date: 2020-08-21 Release date: 2020-09-23 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.166 Å) Cite: Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer. J.Med.Chem., 63, 2020

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