5EM0
 
 | | Crystal structure of mugwort allergen Art v 4 | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Pollen allergen Art v 4.01, SODIUM ION | | Authors: | Offermann, L.R, Perdue, M.L, Chruszcz, M. | | Deposit date: | 2015-11-05 | | Release date: | 2016-06-08 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Structural, Functional, and Immunological Characterization of Profilin Panallergens Amb a 8, Art v 4, and Bet v 2.
J.Biol.Chem., 291, 2016
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5EV0
 | | Crystal structure of ragweed profilin Amb a 8 in complex with poly-Pro14 | | Descriptor: | PRO-PRO-PRO-PRO-PRO-PRO-PRO-PRO-PRO, Profilin | | Authors: | Offermann, L.R, He, J.Z, Perdue, M.L, Chruszcz, M. | | Deposit date: | 2015-11-19 | | Release date: | 2016-06-08 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural, Functional, and Immunological Characterization of Profilin Panallergens Amb a 8, Art v 4, and Bet v 2.
J.Biol.Chem., 291, 2016
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8WHA
 | | Structure of DDM1-nucleosome complex in the ADP-BeFx state with DDM1 bound to SHL2 and SHL-2 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase DDM1, BERYLLIUM TRIFLUORIDE ION, ... | | Authors: | Liu, Y, Zhang, Z, Du, J. | | Deposit date: | 2023-09-22 | | Release date: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (4.05 Å) | | Cite: | Molecular basis of chromatin remodelling by DDM1 involved in plant DNA methylation.
Nat.Plants, 10, 2024
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8WH5
 | | Structure of DDM1-nucleosome complex in the apo state | | Descriptor: | ATP-dependent DNA helicase DDM1, DNA (antisense strand), DNA (sense strand), ... | | Authors: | Liu, Y, Zhang, Z, Du, J. | | Deposit date: | 2023-09-22 | | Release date: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (3.58 Å) | | Cite: | Molecular basis of chromatin remodelling by DDM1 involved in plant DNA methylation.
Nat.Plants, 10, 2024
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5DXT
 | | p110alpha with GDC-0326 | | Descriptor: | (2S)-2-({2-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}oxy)propanamide, 1,2-ETHANEDIOL, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | Authors: | Heffron, T.P, Heald, R.A, Ndubaku, C, Wei, B.Q, Augustin, M, Do, S, Edgar, K, Eigenbrot, C, Friedman, L, Gancia, E, Jackson, P.S, Jones, G, Kolesnikov, A, Lee, L.B, Lesnick, J.D, Lewis, C, McLean, N, Mortle, M, Nonomiya, J, Pang, J, Price, S, Prior, W.W, Salphati, L, Sideris, S, Staben, S.T, Steinbacher, S, Tsui, V, Wallin, J, Sampath, D, Olivero, A. | | Deposit date: | 2015-09-23 | | Release date: | 2016-01-27 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | The Rational Design of Selective Benzoxazepin Inhibitors of the alpha-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).
J.Med.Chem., 59, 2016
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1TX4
 | | RHO/RHOGAP/GDP(DOT)ALF4 COMPLEX | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, P50-RHOGAP, ... | | Authors: | Rittinger, K, Walker, P.A, Smerdon, S.J, Gamblin, S.J. | | Deposit date: | 1997-07-29 | | Release date: | 1998-09-16 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue.
Nature, 389, 1997
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8WH8
 | | Structure of DDM1-nucleosome complex in ADP state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase DDM1, DNA (antisense strand), ... | | Authors: | Liu, Y, Zhang, Z, Du, J. | | Deposit date: | 2023-09-22 | | Release date: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Molecular basis of chromatin remodelling by DDM1 involved in plant DNA methylation.
Nat.Plants, 10, 2024
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5EVE
 | | Crystal structure of Amb a 8 in complex with poly-Pro10 | | Descriptor: | Poly-Proline peptide, Profilin | | Authors: | Offermann, L.R, Schlachter, C.R, Garrett, J, Chruszcz, M. | | Deposit date: | 2015-11-19 | | Release date: | 2016-06-08 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Structural, Functional, and Immunological Characterization of Profilin Panallergens Amb a 8, Art v 4, and Bet v 2.
J.Biol.Chem., 291, 2016
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1RRF
 | | NON-MYRISTOYLATED RAT ADP-RIBOSYLATION FACTOR-1 COMPLEXED WITH GDP, MONOMERIC CRYSTAL FORM | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RAT ADP-RIBOSYLATION FACTOR-1 | | Authors: | Greasley, S.E, Jhoti, H, Bax, B. | | Deposit date: | 1995-12-16 | | Release date: | 1996-06-20 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms.
Nat.Struct.Biol., 2, 1995
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1RRG
 | | NON-MYRISTOYLATED RAT ADP-RIBOSYLATION FACTOR-1 COMPLEXED WITH GDP, DIMERIC CRYSTAL FORM | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RAT ADP-RIBOSYLATION FACTOR-1 | | Authors: | Greasley, S.E, Jhoti, H, Bax, B. | | Deposit date: | 1995-12-16 | | Release date: | 1996-06-20 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms.
Nat.Struct.Biol., 2, 1995
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5EZ6
 | | Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transforming protein RhoA | | Authors: | Yan, Z, Ma, S, Zhang, Y, Ma, L, Wang, F, Li, J, Miao, L. | | Deposit date: | 2015-11-26 | | Release date: | 2016-12-07 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA
To Be Published
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5FI4
 | | Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model | | Descriptor: | GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, ... | | Authors: | Elling, R.A, Knapp, M.S, Han, W, Daniel, L.M, Xy, Y, Burger, M.T, Ni, Z, Smith, A, Lan, J, Williams, T, Verhagen, J, Huh, K, Merritt, H, Chan, J, Kaufman, S, Voliva, C.F, Pecchi, S. | | Deposit date: | 2015-12-22 | | Release date: | 2016-02-03 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model.
Bioorg.Med.Chem.Lett., 26, 2016
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1I07
 | | EPS8 SH3 DOMAIN INTERTWINED DIMER | | Descriptor: | EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8 | | Authors: | Kishan, K.V.R, Newcomer, M.E. | | Deposit date: | 2001-01-29 | | Release date: | 2001-05-09 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Effect of pH and salt bridges on structural assembly: molecular structures of the monomer and intertwined dimer of the Eps8 SH3 domain.
Protein Sci., 10, 2001
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1I0C
 | | EPS8 SH3 CLOSED MONOMER | | Descriptor: | EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8 | | Authors: | Kishan, K.V.R, Newcomer, M.E. | | Deposit date: | 2001-01-29 | | Release date: | 2001-05-09 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Effect of pH and salt bridges on structural assembly: molecular structures of the monomer and intertwined dimer of the Eps8 SH3 domain.
Protein Sci., 10, 2001
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7KOG
 | | Lethocerus Myosin II complete coiled-coil domain resolved in its native environment | | Descriptor: | Myosin heavy chain isoform Mhc_X1 | | Authors: | Rahmani, H, Hu, Z, Daneshparvar, N, Taylor, D, Taylor, K.A. | | Deposit date: | 2020-11-09 | | Release date: | 2021-03-24 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (4.25 Å) | | Cite: | The myosin II coiled-coil domain atomic structure in its native environment.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7KYW
 | | Crystal structure of timothy grass allergen Phl p 12.0101 reveals an unusual profilin dimer | | Descriptor: | CITRIC ACID, Profilin-1 | | Authors: | O'Malley, A, Kapingidza, A.B, Hyduke, N, Dolamore, C, Chruszcz, M. | | Deposit date: | 2020-12-09 | | Release date: | 2021-03-31 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of timothy grass allergen Phl p 12.0101 reveals an unusual profilin dimer.
Acta Biochim.Pol., 68, 2021
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1IJE
 | | Nucleotide Exchange Intermediates in the eEF1A-eEF1Ba Complex | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, elongation factor 1-alpha, elongation factor 1-beta | | Authors: | Andersen, G.R, Valente, L, Pedersen, L, Kinzy, T.G, Nyborg, J. | | Deposit date: | 2001-04-26 | | Release date: | 2001-05-09 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structures of nucleotide exchange intermediates in the eEF1A-eEF1Balpha complex.
Nat.Struct.Biol., 8, 2001
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3SU8
 | | Crystal structure of a truncated intracellular domain of Plexin-B1 in complex with Rac1 | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Plexin-B1, ... | | Authors: | Bell, C.H, Aricescu, A.R, Jones, E.Y, Siebold, C. | | Deposit date: | 2011-07-11 | | Release date: | 2011-09-28 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | A Dual Binding Mode for RhoGTPases in Plexin Signalling.
Plos Biol., 9, 2011
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1IJF
 | | Nucleotide exchange mechanisms in the eEF1A-eEF1Ba complex | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, elongation factor 1-alpha, ... | | Authors: | Andersen, G.R, Valente, L, Pedersen, L, Kinzy, T.G, Nyborg, J. | | Deposit date: | 2001-04-26 | | Release date: | 2001-05-09 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structures of nucleotide exchange intermediates in the eEF1A-eEF1Balpha complex.
Nat.Struct.Biol., 8, 2001
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3SBD
 | | Crystal structure of RAC1 P29S mutant | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related C3 botulinum toxin substrate 1 | | Authors: | Ha, B.H, Boggon, T.J. | | Deposit date: | 2011-06-03 | | Release date: | 2012-07-18 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Nat.Genet., 44, 2012
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3SUA
 | | Crystal structure of the intracellular domain of Plexin-B1 in complex with Rac1 | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Plexin-B1, ... | | Authors: | Bell, C.H, Aricescu, A.R, Jones, E.Y, Siebold, C. | | Deposit date: | 2011-07-11 | | Release date: | 2011-09-07 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (4.39 Å) | | Cite: | A Dual Binding Mode for RhoGTPases in Plexin Signalling.
Plos Biol., 9, 2011
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1CC0
 | | CRYSTAL STRUCTURE OF THE RHOA.GDP-RHOGDI COMPLEX | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, rho GDP dissociation inhibitor alpha, ... | | Authors: | Longenecker, K.L, Read, P, Derewenda, U, Dauter, Z, Garrard, S, Walker, L, Somlyo, A.V, Somlyo, A.P, Nakamoto, R.K, Derewenda, Z.S. | | Deposit date: | 1999-03-03 | | Release date: | 2000-01-07 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (5 Å) | | Cite: | How RhoGDI binds Rho.
Acta Crystallogr.,Sect.D, 55, 1999
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1W9K
 | | Dictyostelium discoideum Myosin II motor domain S456E with bound MgADP-BeFx | | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... | | Authors: | Morris, C.A, Coureux, P.-D, Wells, A.L, Houdusse, A, Sweeney, H.L. | | Deposit date: | 2004-10-13 | | Release date: | 2006-03-16 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structure-Function Analysis of Myosin II Backdoor Mutants
To be Published
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1W9J
 | | Myosin II Dictyostelium discoideum motor domain S456Y bound with MgADP-AlF4 | | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Morris, C.A, Coureux, P.-D, Wells, A.L, Houdusse, A, Sweeney, H.L. | | Deposit date: | 2004-10-13 | | Release date: | 2006-03-16 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure-Function Analysis of Myosin II Backdoor Mutants
To be Published
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1W9L
 | | Myosin II Dictyostelium discoideum motor domain S456E bound with MgADP-AlF4 | | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Morris, C.A, Coureux, P.-D, Wells, A.L, Houdusse, A, Sweeney, H.L. | | Deposit date: | 2004-10-13 | | Release date: | 2006-03-16 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structure-Function Analysis of Myosin II Backdoor Mutants
To be Published
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