PDB: 95574 resultsInfo pagesStatus searchChemie searchBIRD

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8VCI	SARS-CoV-2 Frameshift Stimulatory Element with Upstream Multibranch Loop Descriptor: Frameshift Stimulatory Element with Upstream Multi-branch Loop Authors: Peterson, J.M, Becker, S.T, O'Leary, C.A, Juneja, P, Yang, Y, Moss, W.N. Deposit date: 2023-12-14 Release date: 2024-01-17 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (6.1 Å) Cite: Structure of the SARS-CoV-2 Frameshift Stimulatory Element with an Upstream Multibranch Loop. Biochemistry, 63, 2024
7LK4	Crystal structure of BAK L100A in complex with activating antibody fragments Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 7D10 antibody VH fragment, 7D10 antibody VL fragment, ... Authors: Robin, Y.A, Colman, P.M. Deposit date: 2021-02-01 Release date: 2022-02-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structure of the BAK-activating antibody 7D10 bound to BAK reveals an unexpected role for the alpha 1-alpha 2 loop in BAK activation. Cell Death Differ., 29, 2022
6GQH	Structure of GFPmut2 crystallized at pH 8.5 and transferred to pH 6 Descriptor: CALCIUM ION, Green fluorescent protein Authors: Pasqualetto, E, Lolli, G, Battistutta, R. Deposit date: 2018-06-07 Release date: 2018-12-19 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Insight into GFPmut2 pH Dependence by Single Crystal Microspectrophotometry and X-ray Crystallography. J.Phys.Chem.B, 122, 2018
8E1M	Cryo-EM structure of the endogenous core TIM23 complex from S. cerevisiae Descriptor: Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, CARDIOLIPIN, ... Authors: Sim, S.I, Park, E. Deposit date: 2022-08-10 Release date: 2023-06-21 Last modified: 2023-10-04 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural basis of mitochondrial protein import by the TIM23 complex. Nature, 621, 2023
8BU2	Structure of DDB1 bound to DS18-engaged CDK12-cyclin K Descriptor: Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... Authors: Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. Deposit date: 2022-11-30 Release date: 2023-09-13 Last modified: 2024-01-03 Method: X-RAY DIFFRACTION (3.13 Å) Cite: Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUI	Structure of DDB1 bound to DRF-053-engaged CDK12-cyclin K Descriptor: (2~{R})-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)amino]purin-2-yl]amino]butan-1-ol, 1,2-ETHANEDIOL, Cyclin-K, ... Authors: Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. Deposit date: 2022-11-30 Release date: 2023-09-13 Last modified: 2024-01-03 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUA	Structure of DDB1 bound to 919278-engaged CDK12-cyclin K Descriptor: (2~{R})-~{N}-(1~{H}-benzimidazol-2-yl)-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)propanamide, CITRIC ACID, Cyclin-K, ... Authors: Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. Deposit date: 2022-11-30 Release date: 2023-09-13 Last modified: 2024-01-03 Method: X-RAY DIFFRACTION (3.193 Å) Cite: Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUR	Structure of DDB1 bound to DS50-engaged CDK12-cyclin K Descriptor: Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... Authors: Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. Deposit date: 2022-11-30 Release date: 2023-09-13 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (3.64 Å) Cite: Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BU4	Structure of DDB1 bound to DS22-engaged CDK12-cyclin K Descriptor: (2~{R})-2-[[6-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methylamino]-9-(1-methylpyrazol-4-yl)purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... Authors: Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. Deposit date: 2022-11-30 Release date: 2023-09-13 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (3.09 Å) Cite: Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUF	Structure of DDB1 bound to Z12-engaged CDK12-cyclin K Descriptor: 2-(6,7-dihydro-4~{H}-thieno[3,2-c]pyridin-5-ylmethyl)-6,7-dimethoxy-3~{H}-quinazolin-4-one, Cyclin-K, Cyclin-dependent kinase 12, ... Authors: Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. Deposit date: 2022-11-30 Release date: 2023-09-13 Last modified: 2024-01-03 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUJ	Structure of DDB1 bound to DS06-engaged CDK12-cyclin K Descriptor: (2~{R})-2-[[6-(octylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... Authors: Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. Deposit date: 2022-11-30 Release date: 2023-09-13 Last modified: 2024-01-03 Method: X-RAY DIFFRACTION (3.62 Å) Cite: Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BU9	Structure of DDB1 bound to roscovitine-engaged CDK12-cyclin K Descriptor: Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... Authors: Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. Deposit date: 2022-11-30 Release date: 2023-09-13 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (3.51 Å) Cite: Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BU1	Structure of DDB1 bound to DS17-engaged CDK12-cyclin K Descriptor: (2~{R})-2-[[6-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methylamino]-9-(1-methylpyrazol-4-yl)purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... Authors: Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. Deposit date: 2022-11-30 Release date: 2023-09-13 Last modified: 2024-01-03 Method: X-RAY DIFFRACTION (2.98 Å) Cite: Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUP	Structure of DDB1 bound to DS30-engaged CDK12-cyclin K Descriptor: (2~{R})-2-[[6-[3-(3-methylphenyl)propylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... Authors: Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. Deposit date: 2022-11-30 Release date: 2023-09-13 Last modified: 2024-01-03 Method: X-RAY DIFFRACTION (3.41 Å) Cite: Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUO	Structure of DDB1 bound to DS24-engaged CDK12-cyclin K Descriptor: (2~{R})-2-[[6-[(3-fluoranyl-4-pyridin-2-yl-phenyl)methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... Authors: Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. Deposit date: 2022-11-30 Release date: 2023-09-13 Last modified: 2024-01-03 Method: X-RAY DIFFRACTION (3.58 Å) Cite: Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BU6	Structure of DDB1 bound to DS55-engaged CDK12-cyclin K Descriptor: Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... Authors: Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. Deposit date: 2022-11-30 Release date: 2023-09-13 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (3.45 Å) Cite: Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUK	Structure of DDB1 bound to DS08-engaged CDK12-cyclin K Descriptor: (2~{R})-2-[[6-(naphthalen-2-ylmethylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, CITRIC ACID, Cyclin-K, ... Authors: Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. Deposit date: 2022-11-30 Release date: 2023-09-13 Last modified: 2024-01-03 Method: X-RAY DIFFRACTION (3.41 Å) Cite: Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BU3	Structure of DDB1 bound to DS19-engaged CDK12-cyclin K Descriptor: 1,2-ETHANEDIOL, 2-morpholin-4-yl-9-propan-2-yl-~{N}-[(4-pyridin-2-ylphenyl)methyl]purin-6-amine, Cyclin-K, ... Authors: Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. Deposit date: 2022-11-30 Release date: 2023-09-13 Last modified: 2024-01-03 Method: X-RAY DIFFRACTION (3.42 Å) Cite: Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUB	Structure of DDB1 bound to dCeMM4-engaged CDK12-cyclin K Descriptor: CITRIC ACID, Cyclin-K, Cyclin-dependent kinase 12, ... Authors: Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. Deposit date: 2022-11-30 Release date: 2023-09-13 Last modified: 2024-01-03 Method: X-RAY DIFFRACTION (3.42 Å) Cite: Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUQ	Structure of DDB1 bound to DS43-engaged CDK12-cyclin K Descriptor: (2~{R})-2-[[6-[[1-(3-chlorophenyl)pyrazol-3-yl]methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, CITRIC ACID, Cyclin-K, ... Authors: Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. Deposit date: 2022-11-30 Release date: 2023-09-13 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUL	Structure of DDB1 bound to DS11-engaged CDK12-cyclin K Descriptor: (2~{R})-2-[[6-(3-phenylpropylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, 1,2-ETHANEDIOL, Cyclin-K, ... Authors: Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. Deposit date: 2022-11-30 Release date: 2023-09-13 Last modified: 2024-01-03 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BU5	Structure of DDB1 bound to SR-4835-engaged CDK12-cyclin K Descriptor: CITRIC ACID, Cyclin-K, Cyclin-dependent kinase 12, ... Authors: Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. Deposit date: 2022-11-30 Release date: 2023-09-13 Last modified: 2024-01-03 Method: X-RAY DIFFRACTION (3.134 Å) Cite: Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUS	Structure of DDB1 bound to DS59-engaged CDK12-cyclin K Descriptor: 1,3-dimethyl-5-[[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]methyl]pyrazole-4-sulfonamide, Cyclin-K, Cyclin-dependent kinase 12, ... Authors: Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. Deposit date: 2022-11-30 Release date: 2023-09-13 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (3.26 Å) Cite: Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUH	Structure of DDB1 bound to WX3-engaged CDK12-cyclin K Descriptor: 6-[[[2-[[(2~{R})-1-oxidanylbutan-2-yl]amino]-9-propan-2-yl-purin-6-yl]amino]methyl]-3-pyridin-2-yl-1~{H}-pyridin-2-one, Cyclin-K, Cyclin-dependent kinase 12, ... Authors: Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. Deposit date: 2022-11-30 Release date: 2023-09-13 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (3.79 Å) Cite: Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUC	Structure of DDB1 bound to dCeMM3-engaged CDK12-cyclin K Descriptor: 2-(1~{H}-benzimidazol-2-ylsulfanyl)-~{N}-(5-chloranylpyridin-2-yl)ethanamide, CITRIC ACID, Cyclin-K, ... Authors: Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. Deposit date: 2022-11-30 Release date: 2023-09-13 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (3.85 Å) Cite: Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024

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