7QCA
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![BU of 7qca by Molmil](/molmil-images/mine/7qca) | Spraguea lophii ribosome | Descriptor: | 40S Ribosomal protein S19, 40S ribosomal protein S0, 40S ribosomal protein S10, ... | Authors: | Gil Diez, P, McLaren, M, Isupov, M.N, Daum, B, Conners, R, Williams, B. | Deposit date: | 2021-11-22 | Release date: | 2022-11-30 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (2.79 Å) | Cite: | CryoEM reveals that ribosomes in microsporidian spores are locked in a dimeric hibernating state Nat Microbiol, 2023
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5WX6
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![BU of 5wx6 by Molmil](/molmil-images/mine/5wx6) | Alkyldiketide-CoA synthase W332Q mutant from Evodia rutaecarpa | Descriptor: | Alkyldiketide-CoA synthase, COENZYME A, SULFATE ION | Authors: | Matsui, T, Kodama, T, Tadakoshi, T, Morita, H. | Deposit date: | 2017-01-06 | Release date: | 2017-04-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.799 Å) | Cite: | 2-Alkylquinolone alkaloid biosynthesis in the medicinal plant Evodia rutaecarpa involves collaboration of two novel type III polyketide synthases J. Biol. Chem., 292, 2017
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6DAS
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![BU of 6das by Molmil](/molmil-images/mine/6das) | Discovery of Potent 2-Aryl-6,7-Dihydro-5HPyrrolo[ 1,2-a]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design | Descriptor: | N-[(1R)-6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl]-3-methoxy-4-methylbenzamide, WD repeat-containing protein 5 | Authors: | Phan, J, Fesik, S.W. | Deposit date: | 2018-05-01 | Release date: | 2018-07-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design. J. Med. Chem., 61, 2018
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6DN6
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5WAI
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![BU of 5wai by Molmil](/molmil-images/mine/5wai) | Crystal Structure of a Suz12-Rbbp4-Jarid2-Aebp2 Heterotetrameric Complex | Descriptor: | Histone-binding protein RBBP4, Jumonji, AT-rich interactive domain 2, ... | Authors: | Chen, S, Jiao, L, Liu, X. | Deposit date: | 2017-06-26 | Release date: | 2018-03-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding. Mol. Cell, 69, 2018
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6DLO
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6DAK
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![BU of 6dak by Molmil](/molmil-images/mine/6dak) | Discovery of Potent 2-Aryl-6,7-Dihydro-5HPyrrolo[ 1,2-a]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design | Descriptor: | DIMETHYL SULFOXIDE, N-{[3-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)phenyl]methyl}benzamide, WD repeat-containing protein 5 | Authors: | Phan, J, Fesik, S.W. | Deposit date: | 2018-05-01 | Release date: | 2018-09-05 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design. J. Med. Chem., 61, 2018
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1D3Q
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![BU of 1d3q by Molmil](/molmil-images/mine/1d3q) | CRYSTAL STRUCTURE OF HUMAN ALPHA THROMBIN IN COMPLEX WITH BENZO[B]THIOPHENE INHIBITOR 2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[4-(2-PYRROLIDIN-1-YL-ETHOXY)-BENZYL]-2-4-(2-PYRROLIDIN-1-YL-ETHOXY)-PHENYL] -BENZO[B]THIOPHENE, ALPHA-THROMBIN, ... | Authors: | Chirgadze, N.Y. | Deposit date: | 1999-09-30 | Release date: | 2000-10-04 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The crystal structures of human alpha-thrombin complexed with active site-directed diamino benzo[b]thiophene derivatives: a binding mode for a structurally novel class of inhibitors. Protein Sci., 9, 2000
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4DY4
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![BU of 4dy4 by Molmil](/molmil-images/mine/4dy4) | High resolution structure of E.coli WrbA with FMN | Descriptor: | DI(HYDROXYETHYL)ETHER, FLAVIN MONONUCLEOTIDE, Flavoprotein wrbA | Authors: | Kishko, I, Brynda, J, Kuta Smatanova, I, Ettrich, R, Carey, J. | Deposit date: | 2012-02-28 | Release date: | 2013-03-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | High resolution structure of E.coli WrbA with FMN To be Published
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7QTT
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5WX3
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![BU of 5wx3 by Molmil](/molmil-images/mine/5wx3) | Alkyldiketide-CoA synthase from Evodia rutaecarpa | Descriptor: | Alkyldiketide-CoA synthase, COENZYME A, SULFATE ION | Authors: | Matsui, T, Kodama, T, Tadakoshi, T, Morita, H. | Deposit date: | 2017-01-06 | Release date: | 2017-04-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.801 Å) | Cite: | 2-Alkylquinolone alkaloid biosynthesis in the medicinal plant Evodia rutaecarpa involves collaboration of two novel type III polyketide synthases J. Biol. Chem., 292, 2017
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6DN8
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![BU of 6dn8 by Molmil](/molmil-images/mine/6dn8) | SPRY domain-containing SOCS box protein 2 complexed with (GZJ)VDINNN(CY3) Cyclic peptide inhibitor | Descriptor: | (GZJ)VDINNN(CY3) Cyclic peptide inhibitor, ACETATE ION, SPRY domain-containing SOCS box protein 4, ... | Authors: | Law, R.H.P, Caradoc-Davies, T.T, Norton, R.S. | Deposit date: | 2018-06-06 | Release date: | 2019-04-17 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent. ACS Chem. Biol., 13, 2018
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5WYK
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![BU of 5wyk by Molmil](/molmil-images/mine/5wyk) | Cryo-EM structure of the 90S small subunit pre-ribosome (Mtr4-depleted, Enp1-TAP) | Descriptor: | 13 kDa ribonucleoprotein-associated protein, 18S ribosomal RNA, 40S ribosomal protein S1-A, ... | Authors: | Ye, K, Zhu, X, Sun, Q. | Deposit date: | 2017-01-13 | Release date: | 2017-03-29 | Last modified: | 2017-05-17 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Molecular architecture of the 90S small subunit pre-ribosome. Elife, 6, 2017
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7MTS
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![BU of 7mts by Molmil](/molmil-images/mine/7mts) | CryoEM Structure of mGlu2 - Gi Complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-methoxy-6-propyl-N-(2-{4-[(1H-tetrazol-5-yl)methoxy]phenyl}ethyl)thieno[2,3-d]pyrimidin-4-amine, GLUTAMIC ACID, ... | Authors: | Seven, A.B, Barros-Alvarez, X, Skiniotis, G. | Deposit date: | 2021-05-13 | Release date: | 2021-07-07 | Last modified: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | G-protein activation by a metabotropic glutamate receptor. Nature, 595, 2021
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6DX5
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![BU of 6dx5 by Molmil](/molmil-images/mine/6dx5) | Crystal structure of the viral OTU domain protease from Farallon virus | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, RNA-dependent RNA polymerase | Authors: | Beldon, B.S, Dzimianski, J.V, Daczkowski, C.M, Goodwin, O.Y, Pegan, S.D. | Deposit date: | 2018-06-28 | Release date: | 2018-12-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.224 Å) | Cite: | Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity. PLoS Pathog., 15, 2019
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6DY7
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![BU of 6dy7 by Molmil](/molmil-images/mine/6dy7) | WDR5 in complex with a WIN site inhibitor | Descriptor: | DIMETHYL SULFOXIDE, N-[3-(2,4-dichlorophenoxy)propyl]-1H-imidazol-2-amine, SULFATE ION, ... | Authors: | Phan, J, Wang, F, Fesik, S.W. | Deposit date: | 2018-07-01 | Release date: | 2019-03-13 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep, 26, 2019
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7RAC
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7RAB
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6E1Y
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6DYA
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![BU of 6dya by Molmil](/molmil-images/mine/6dya) | WDR5 in complex with a WIN site inhibitor | Descriptor: | DIMETHYL SULFOXIDE, N-[(3,5-dichlorophenyl)methyl]-3-[(1H-imidazol-1-yl)methyl]benzamide, SULFATE ION, ... | Authors: | Phan, J, Wang, F, Fesik, S.W. | Deposit date: | 2018-07-01 | Release date: | 2019-03-13 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep, 26, 2019
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5XJC
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![BU of 5xjc by Molmil](/molmil-images/mine/5xjc) | Cryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstrom | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Zhang, X, Yan, C, Hang, J, Finci, I.L, Lei, J, Shi, Y. | Deposit date: | 2017-04-30 | Release date: | 2017-07-05 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | An Atomic Structure of the Human Spliceosome Cell, 169, 2017
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6E23
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6E22
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![BU of 6e22 by Molmil](/molmil-images/mine/6e22) | |
6E29
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7RBT
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![BU of 7rbt by Molmil](/molmil-images/mine/7rbt) | cryo-EM structure of human Gastric inhibitory polypeptide receptor GIPR bound to tirzepatide | Descriptor: | 2-fluoro-4-[(1R)-6-methoxy-1-methyl-2-{(1S)-1-[4-(propan-2-yl)phenyl]ethyl}-1,2,3,4-tetrahydroisoquinolin-5-yl]-6-[(2-methylpropyl)amino]phenol, Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. | Deposit date: | 2021-07-06 | Release date: | 2022-04-13 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | Structural determinants of dual incretin receptor agonism by tirzepatide. Proc.Natl.Acad.Sci.USA, 119, 2022
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