8W0A
 
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8WTK
 | | Crystal structure of Cas3-DExD+MG | | Descriptor: | CRISPR-associated helicase Cas3, MAGNESIUM ION | | Authors: | Mo, X. | | Deposit date: | 2023-10-18 | | Release date: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (3.08 Å) | | Cite: | Structural insight into dynamic characteristic of the polymerized forms of kinetoplastid membrane protein-11
To be published
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8WTL
 | | Crystal structure of Cas3-DExD+MG+ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CRISPR-associated helicase Cas3, MAGNESIUM ION | | Authors: | Mo, X. | | Deposit date: | 2023-10-18 | | Release date: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.94 Å) | | Cite: | Structural insight into dynamic characteristic of the polymerized forms of kinetoplastid membrane protein-11
To be published
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8XXN
 | | Cryo-EM structure of the human 43S ribosome with PDCD4 | | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Ye, X, Huang, Z, Li, Y, Wang, M, Cheng, J. | | Deposit date: | 2024-01-18 | | Release date: | 2024-05-01 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation.
Cell Res., 34, 2024
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8Y6O
 | | Cryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U11 and tri-snRNP part | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, Centrosomal AT-AC splicing factor, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Bai, R, Yuan, M, Zhang, P, Luo, T, Shi, Y, Wan, R. | | Deposit date: | 2024-02-02 | | Release date: | 2024-03-20 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.38 Å) | | Cite: | Structural basis of U12-type intron engagement by the fully assembled human minor spliceosome.
Science, 383, 2024
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8YLE
 | | Crystal structure of Werner syndrome helicase complexed with AMP-PCP | | Descriptor: | 1,2-ETHANEDIOL, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | | Authors: | Yang, Y, Fu, L, Sun, X, Cheng, H, Chen, R. | | Deposit date: | 2024-03-06 | | Release date: | 2024-04-10 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Structure of werner syndrome helicase complexed with AMP-PCP at 1.86 Angstroms resolution.
To Be Published
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8YRS
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9ASJ
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9ASK
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9ASL
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9AVR
 | | Human eIF4A-1 in complex with AMP-PNP, RNA, and the inhibitor silvestrol | | Descriptor: | Eukaryotic initiation factor 4A-I, IODIDE ION, MAGNESIUM ION, ... | | Authors: | Bhatt, G.B, Naineni, S.K, Cencic, R.C, Jiramongkolsiri, E.J, Huang, S.H, Pelletier, J.P, Nagar, B.N. | | Deposit date: | 2024-03-04 | | Release date: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Human eIF4A-1 in complex with AMP-PNP, RNA, and the inhibitor silvestrol
To Be Published
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9BH6
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9BH7
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9BH8
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9BH9
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9BHA
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9BLN
 | | The structure of human Pdcd4 bound to the 40S-eIF4A-eIF3-eIF1 complex | | Descriptor: | 40S ribosomal protein S14, ACETIC ACID, Eukaryotic initiation factor 4A-I, ... | | Authors: | Brito Querido, J, Sokabe, M, Diaz-Lopez, I, Gordiyenko, Y, Zuber, P, Yifei, D, Albacete-Albacete, L, Ramakrishnan, V, S Fraser, C. | | Deposit date: | 2024-04-30 | | Release date: | 2024-09-04 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Human tumor suppressor protein Pdcd4 binds at the mRNA entry channel in the 40S small ribosomal subunit.
Nat Commun, 15, 2024
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9BP9
 | | Human DNA polymerase theta helicase domain in complex with inhibitor AB25583, dimer form | | Descriptor: | (4P)-N-{5-[(4-chlorophenyl)methoxy]-1,3,4-thiadiazol-2-yl}-4-(2-methoxyphenyl)pyridine-3-carboxamide, DNA polymerase theta | | Authors: | Ito, F, Li, Z, Chen, X.S. | | Deposit date: | 2024-05-07 | | Release date: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | Structural basis for a Pol theta helicase small-molecule inhibitor revealed by cryo-EM.
Nat Commun, 15, 2024
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9BPA
 | | Human DNA polymerase theta helicase domain in complex with inhibitor AB25583, tetramer form | | Descriptor: | (4P)-N-{5-[(4-chlorophenyl)methoxy]-1,3,4-thiadiazol-2-yl}-4-(2-methoxyphenyl)pyridine-3-carboxamide, DNA polymerase theta | | Authors: | Ito, F, Li, Z, Chen, X.S. | | Deposit date: | 2024-05-07 | | Release date: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | Structural basis for a Pol theta helicase small-molecule inhibitor revealed by cryo-EM.
Nat Commun, 15, 2024
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9C5Q
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9FMD
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9G8M
 | | human 80S ribosome bound by a SKI2-exosome complex | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | | Authors: | Koegel, A, Keidel, A, Loukeri, M.J, Kuhn, C.C, Langer, L.M, Schaefer, I.B, Conti, E. | | Deposit date: | 2024-07-23 | | Release date: | 2024-10-23 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis of mRNA decay by the human exosome-ribosome supercomplex.
Nature, 2024
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9G8N
 | | 80S-bound human Ski2-exosome complex | | Descriptor: | CrPV-IRES RNA, DIS3-like exonuclease 1, Exosome complex component CSL4, ... | | Authors: | Koegel, A, Keidel, A, Loukeri, M.J, Kuhn, C.C, Langer, L.M, Schaefer, I.B, Conti, E. | | Deposit date: | 2024-07-23 | | Release date: | 2024-10-16 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural basis of mRNA decay by the human exosome-ribosome supercomplex.
Nature, 2024
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9G8O
 | | human 40S ribosome bound by a SKI238-exosome complex | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Koegel, A, Keidel, A, Loukeri, M.J, Kuhn, C.C, Langer, L.M, Schaefer, I.B, Conti, E. | | Deposit date: | 2024-07-23 | | Release date: | 2024-10-16 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural basis of mRNA decay by the human exosome-ribosome supercomplex.
Nature, 2024
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9G8P
 | | 40S-bound human SKI2-exosome complex | | Descriptor: | CrPV-IRES RNA, DIS3-like exonuclease 1, Exosome complex component CSL4, ... | | Authors: | Koegel, A, Keidel, A, Loukeri, M.J, Kuhn, C.C, Langer, L.M, Schaefer, I.B, Conti, E. | | Deposit date: | 2024-07-23 | | Release date: | 2024-10-16 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (7 Å) | | Cite: | Structural basis of mRNA decay by the human exosome-ribosome supercomplex.
Nature, 2024
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